SMPD4 (NM_017751) Human Untagged Clone

CAT#: SC114022

SMPD4 (untagged)-Human sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) (SMPD4), transcript variant 1


  "NM_017751" in other vectors (5)

Reconstitution Protocol

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    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol SMPD4
Synonyms NET13; NSMASE-3; NSMASE3; SKNY
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_017751, the custom clone sequence may differ by one or more nucleotides


ATGACGACTTTCGGCGCCGTGGCGGAATGGCGGCTTCCATCTCTGAGGCGAGCGACGCTATGGATCCCAC
AGTGGTTTGCTAAGAAGGCCATTTTCAACTCTCCACTGGAGGCTGCTATGGCGTTCCCTCACCTGCAGCA
GCCCAGCTTTCTACTGGCTAGCCTGAAAGCTGACTCTATAAATAAGCCCTTTGCACAGCAGTGCCAAGAC
TTGGTTAAAGTCATTGAGGACTTTCCAGCAAAGGAGCTGCACACCATCTTCCCATGGCTGGTAGAAAGCA
TTTTTGGCAGCCTAGATGGTGTCCTCGTTGGCTGGAACCTCCGCTGCTTACAGGGGCGCGTGAATCCTGT
GGAGTACAGCATCGTGATGGAATTTCTCGACCCTGGTGGCCCAATGATGAAGTTGGTTTATAAGCTTCAA
GCTGAAGACTATAAGTTCGACTTTCCTGTCTCCTACTTGCCTGGTCCTGTGAAGGCGTCCATCCAGGAGT
GCATCCTCCCTGACAGTCCTCTGTACCACAACAAGGTCCAGTTCACCCCTACTGGGGGCCTTGGTCTGAA
CTTGGCCCTGAATCCGTTCGAGTATTACATATTCTTCTTTGCCTTGAGCCTCATCACTCAGAAGCCACTT
CCTGTGTCCCTCCACGTCCGTACTTCAGACTGTGCCTATTTCATCCTGGTGGACAGGTACCTGTCATGGT
TCCTGCCCACCGAAGGCAGTGTGCCCCCACCACTCTCCTCCAGCCCAGGGGGGACCAGCCCCTCACCACC
TCCCAGGACACCAGCCATACCCTTTGCTTCCTATGGCCTCCACCACACTAGCCTCCTAAAGCGACACATC
TCTCATCAGACGTCTGTGAATGCAGACCCCGCCTCCCACGAGATCTGGAGGTCAGAAACTCTGCTCCAGG
TTTTTGTTGAAATGTGGCTTCATCACTATTCCTTGGAGATGTATCAAAAAATGCAGTCCCCTCATGCCAA
GGAGTCGTTCACGCCTACTGAGGAGCATGTGTTGGTGGTGCGCCTGCTGCTGAAGCACCTGCACGCCTTT
GCCAACAGCCTGAAGCCAGAGCAGGCCTCACCCTCCGCCCACTCCCACGCCACCAGCCCCCTGGAGGAGT
TCAAACGGGCTGCTGTCCCGAGGTTCGTCCAGCAGAAACTCTACCTCTTCTTGCAGCATTGCTTTGGCCA
CTGGCCCCTGGACGCATCGTTCAGAGCTGTCCTGGAGATGTGGCTGAGCTACCTGCAGCCGTGGCGGTAC
GCGCCTGACAAGCAGGCTCCGGGCAGCGACTCCCAGCCCCGGTGTGTGTCGGAGAAATGGGCACCCTTTG
TCCAGGAGAACCTGCTGATGTACACCAAGTTGTTTGTGGGCTTTCTGAACCGCGCGCTCCGCACAGACCT
GGTCAGCCCCAAGCACGCGCTCATGGTGTTCCGAGTGGCCAAAGTCTTTGCCCAGCCCAACCTGGCTGAG
ATGATTCAGAAAGGTGAGCAGCTATTCCTGGAGCCAGAGCTGGTCATCCCCCACCGCCAGCACCGACTCT
TCACGGCCCCCACATTCACTGGGAGCTTCCTGTCACCCTGGCCACCAGCGGTCACTGATGCCTCCTTCAA
GGTGAAGAGCCACGTCTACAGCCTGGAGGGCCAGGACTGCAAGTACACCCCGATGTTTGGGCCCGAGGCC
CGCACCCTGGTCCTGCGCCTCGCTCAGCTCATCACACAGGCCAAACACACAGCCAAGTCCATCTCCGACC
AGTGTGCGGAGAGCCCGGCTGGCCACTCCTTCCTCTCATGGCTGGGCTTTAGCTCCATGGACACCAATGG
CTCCTACACAGCCAACGACCTGGACGAGATGGGGCAAGACAGTGTCCGGAAGACAGATGAATACCTGGAG
AAGGCCCTGGAGTACCTGCGCCAGATATTCCGGCTCAGCGAAGCGCAGCTCAGGCAGTTCACACTCGCCT
TGGGCACCACCCAGGATGAGAATGGAAAAAAGCAACTCCCCGACTGCATCGTGGGTGAGGACGGACTCAT
CCTTACGCCCCTGGGGCGGTACCAGATCATCAATGGGCTGCGAAGGTTTGAAATTGAGTACCAGGGGGAC
CCGGAGCTGCAGCCCATCCGGAGCTATGAGATCGCCAGCTTGGTCCGCACACTCTTTAGGCTGTCGTCTG
CCATCAACCACAGATTTGCAGGACAGATGGCGGCTCTGTGTTCCCGGGATGACTTCCTCGGCAGCTTCTG
TCGCTACCACCTCACAGAACCTGGGCTGGCCAGCAGGCACCTGCTGAGCCCTGTGGGGCGGAGGCAGGTG
GCCGGCCACACCCGCGGCCCCAGGCTCAGCCTGCGCTTCCTGGGCAGTTACCGGACGCTGGTCTCGCTGC
TGCTGGCCTTCTTCGTGGCCTCTCTGTTCTGCGTCGGGCCCCTCCCATGCACGCTGCTGCTCACCCTGGG
CTATGTCCTCTACGCCTCTGCCATGACACTGCTGACCGAGCGGGGGAAGCTGCACCAGCCCTGA


>OriGene 5' read for NM_017751 unedited
CCATTATGATACGACTCACTTAGGCGGCCGCGAATCGCACGAGGCGGAATGGCGGCTTCC
ACCTCTGAAGCGGGCGACGCTATGGGTCCCACAGTGGTTTGCTAAGAAGGCCATTTTCAA
CTCTCCATTGGAGGCTGCTATGGCGTTCCCTCACCTGCAGCAGCCCAGCTTTCTACTGGC
CAGCCTGAAAGCTGACTCTATAAATAAGCCCTTTGCACAGCAGTGCCAAGACTTGATTAA
AGCCATTGAGGATTTTCCAGCAAAGGAGCTGCACACCATCTTCCCATGGCTGGCAGAGAG
CATTTTCGGCAGCCTAGATGGTGTCCTCGTTGGCTGGAACCTCCGCTGCTTACAGGGGCG
TGTGAATCCTGTGGAGTACAGCATCGTGATGGAATTTCTCGACACTGGGTAGTGGCCCAA
TGATGAAGTTGGTTTATAAGCTTCAAGCTGAAGACTATAAGTTCGACTTTCCTGTCTCCT
ACCTGCCTGGTCCTGTGAAGGCGTCCATCCAGGAGTGCATCCTCCCTGACAGTCCTCTGT
ACCACAGCAAGGTCCAGTTCACCCCTACTGGGGGCCTTGGTCTGAACCTGGCCCTGAATC
CATTCGAGTATTACATACTCTTCTTTGCCCTGAGCCTCATCACTCAGAAGCCACTCCCTG
TGTCCCTTCACGTCCGTACTTTAGACTGTGCCTATTTCATCCTGGCGGACAGGCACCTGT
CATGGTTCCTGCCCACCGAAGCTAGTGTGCCCTGCCACTCTCCTCCAGCCAGGGGGGACC
AGCCCCTCACCGCCTCCCAAAAATGTATATGCGGGCTGGGAGTGGCGGCTGACCCCTGTA
ATTCCACCCTTGGGCGGGCCCAGCGGACGGACCCCCTGGGCCACGATTCCAAACCGCCTG
GCCAAATGTGAAACCCCTTCCTCAATACACCAAGTTC
>OriGene 3' read for NM_017751 unedited
GTCTCATGTNACACGACGGNCACGGCAATTCTTAGAATACGAAGGTTTTTTCTTTTTTTT
CTTTTTTTCTTTTTTTCTTTTTTTCTTTTACAAAACCAGGGAACAGTGTTTTATTCAGAA
CCCATGGGGCGTTACAAGCTTATTTTTTGGCCACAGGCCCTAAAAGGCCTTTATTCTAAG
TTTACATAAAAATACAAAGCCCAACTTTTACAATTTAAAAAACATTAAAGCAAACCCCCA
AAACCCCACACCGAAAAACAAAGGTTGGGTTGGGAAATAACCACTGAAATGCTGTTCTCC
CTCGAATGTCCCCTGGGGGGGGAATGAAGGGGAAAACCCCGGGCTGGTTTTTGTAAAAAA
ATCTGAAGTTGTATATTTGGAATACTTAAGTACCACTGAACGGTGGCCATGTTTTTGACC
ACTTGATGTTACTGAAGGGACAATGCTTCTGACCATTTTTGGCTGCAAAGCAAAAACTGG
AAAAATCCGACCCCATCGACCCAGAAGTGTCCCCAACGCCTGAGGACCGGCCCCCATTTG
TGACAAGGCACAGGGGTCCGCGATGTTGGCCACTGCTTTGGGGGATGGGCTCAATGGTTT
GGGGCCTGCGGGGAACCACCTGGGCTCTGGGAGGGTTTTAGGCCTCCTGAAAATGGAATT
CACGGCCCATTCTTGGAACAGCTGGGAAAACATGAAAAACGCCCCCCAGAGGGAAGAATC
AGGAAAGCCACTCTTTGGTTTTCTCACACCTTTAAAAATTTTGATTCTTTCCTGGAGGGG
AGACTTAACCCACCGGCCCTGGTCCCAACAAAGAAAGAGGAGGCGCCAAAACCCACTCTG
GCTTACTTAAGGCCACCCAGTGGTGAGGGCCGGCCCAGGCAATTTTTGGGAGGTTGGTCC
CAAACTTTGGTGAACAAAATACCACATAGGCCCCTGGAAAAAGGCCCCGGAAGATGGCTC
TGGGCATGAATCTTTGGCAAAGGAAGGGAAAAGGCCGCCTTTAACTCTGGCTTGTAN
Restriction Sites NotI-NotI     
ACCN NM_017751
ORF Size 2397 bp
Insert Size 3410
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_017751.1, NP_060221.1
RefSeq Size 3833
RefSeq ORF 2397
Locus ID 55627
Protein Families Transmembrane
Protein Pathways Metabolic pathways, Sphingolipid metabolism
Gene Summary The protein encoded by this gene is a sphingomyelinase that catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. This gene is activated by DNA damage, cellular stress, and tumor necrosis factor, but it is downregulated by wild-type p53. The encoded protein localizes to the endoplasmic reticulum and Golgi network. [provided by RefSeq, Mar 2017]
Transcript Variant: This variant (1) lacks an alternate in-frame exon in the central coding region, compared to variant 2, resulting in an isoform (1) that is shorter than isoform 2. CCDS Note: This CCDS representation uses the 5'-most in-frame start codon. While this start codon is well-conserved, it should be noted that other than human and chimp, all other species have indels that follow this start codon. Other primates and rodents have frameshifting indels, and thus cannot use this start codon. However, some mammalian species, including cow, pig and dog, contain additional compensating indels that bring them back in frame; these species could therefore use the start codon represented in this CCDS. An alternative downstream start codon, which is more widely conserved and has a stronger Kozak signal, also exists. It is possible that leaky scanning by ribosomes would allow the downstream start codon to be used, at least some of the time. The use of the downstream start codon would result in a protein that is 39 aa shorter at the N-terminus. There is no experimental evidence showing which start codon is preferentially used in vivo.

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