UBP43 (USP18) (NM_017414) Human Untagged Clone

CAT#: SC114102

USP18 (untagged)-Human ubiquitin specific peptidase 18 (USP18)


  "NM_017414" in other vectors (6)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol USP18
Synonyms ISG43; PTORCH2; UBP43
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_017414 edited
GAATTCGGCACGAGGCCTCGTGCCGAATTCGGCACGAGGCTGGAAGTCTGGAGCAGGTGC
GCGGCTGCAACGGCAGCCGCGGGAAGCTCGGGCCGGCAGGGTTTCCCCGCACGCTGGCGC
CCAGCTCCCGGCGCGGAGGCCGCTGTAAGTTTCGCTTTCCATTCAGTGGAAAACGAAAGC
TGGGCGGGGTGCCACGAGCGCGGGGCCAGACCAAGGCGGGCCCGGAGCGGAACTTCGGTC
CCAGCTCGGTCCCCGGCTCAGTCCCGACGTGGAACTCAGCAGCGGAGGCTGGACGCTTGC
ATGGCGCTTGAGAGATTCCATCGTGCCTGGCTCACATAAGCGCTTCCTGGAAGTGAAGTC
GTGCTGTCCTGAACGCGGGCCAGGCAGCTGCGGCCTGGGGGTTTTGGAGTGATCACGAAT
GAGCAAGGCGTTTGGGCTCCTGAGGCAAATCTGTCAGTCCATCCTGGCTGAGTCCTCGCA
GTCCCCGGCAGATCTTGAAGAAAAGAAGGAAGAAGACAGCAACATGAAGAGAGAGCAGCC
CAGAGAGCGTCCCAGGGCCTGGGACTACCCTCATGGCCTGGTTGGTTTACACAACATTGG
ACAGACCTGCTGCCTTAACTCCTTGATTCAGGTGTTCGTAATGAATGTGGACTTCACCAG
GATATTGAAGAGGATCACGGTGCCCAGGGGAGCTGACGAGCAGAGGAGAAGCGTCCCTTT
CCAGATGCTTCTGCTGCTGGAGAAGATGCAGGACAGCCGGCAGAAAGCAGTGCGGCCCCT
GGAGCTGGCCTACTGCCTGCAGAAGTGCAACGTGCCCTTGTTTGTCCAACATGATGCTGC
CCAACTGTACCTCAAACTCTGGAACCTGATTAAGGACCAGATCACTGATGTGCACTTGGT
GGAGAGACTGCAGGCCCTGTATACGATCCGGGTGAAGGACTCCTTGATTTGCGTTGACTG
TGCCATGGAGAGTAGCAGAAACAGCAGCATGCTCACCCTCCCACTTTCTCTTTTTGATGT
GGACTCAAAGCCCCTGAAGACACTGGAGGACGCCCTGCACTGCTTCTTCCAGCCCAGGGA
GTTATCAAGCAAAAGCAAGTGCTTCTGTGAGAACTGTGGGAAGAAGACCCGTGGGAAACA
GGTCTTGAAGCTGACCCATTTGCCCCAGACCCTGACAATCCACCTCATGCGATTCTCCAT
CAGGAATTCACAGACGAGAAAGATCTGCCACTCCCTGTACTTCCCCCAGAGCTTGGATTT
CAGCCAGATCCTTCCAATGAAGCGAGAGTCTTGTGATGCTGAGGAGCAGTCTGGAGGGCA
GTATGAGCTTTTTGCTGTGATTGCGCACGTGGGAATGGCAGACTCCGGTCATTACTGTGT
CTACATCCGGAATGCTGTGGATGGAAAATGGTTCTGCTTCAATGACTCCAATATTTGCTT
GGTGTCCTGGGAAGACATCCAGTGTACCTACGGAAATCCTAACTACCACTGGCAGGAAAC
TGCATATCTTCTGGTTTACATGAAGATGGAGTGCTAATGGAAATGCCCAAAACCTTCAGA
GATTGACACGCTGTCATTTTCCATTTCCGTTCCTGGATCTACGGAGTCTTCTAAGAGATT
TTGCAATGAGGAGAAGCATTGTTTTCAAACTATATAACTGAGCCTTATTTATAATTAGGG
ATATTATCAAAATATGTAACCATGAGGCCCCTCAGGTCCTGATCAGTCAGAATGGATGCT
TTCACCAGCAGACCCGGCCATGTGGCTGCTCGGTCCTGGGTGCTCGCTGCTGTGCAAGAC
ATTAGCCCTTTAGTTATGAGCCTGTGGGAACTTCAGGGGTTCCCAGTGGGGAGAGCAGTG
GCAGTGGGAGGCATCTGGGGGCCAAAGGTCAGTGGCAGGGGGTATTTCAGTATTATACAA
CTGCTGTGACCAGACTTGTATACTGGCTGAATATCAGTGCTGTTTGTAATTTTTCACTTT
GAGAACCAACATTAATTCCATATGAATCAAGTGTTTTGTAACTGCTATTCATTTATTCAG
CAAATATTTATTGATCATCTCTTCTCCATAAGATAGTGTGATAAACACAGTCATGAATAA
AGTTATTTTCCACAAAAAAAAAAAAAAAAAACTCGAC
>OriGene 5' read for NM_017414 unedited
NTGTTCAGATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGCCTCGTGC
CGAATTCGGCACGAGGCTGGAAGTCTGGAGCAGGTGCGCGGCTGCAACGGCAGCCGCGGG
AAGCTCGGGCCGGCAGGGTTTCCCCGCACGCTGGCGCCCAGCTCCCGGCGCGGAGGCCGC
TGTAAGTTTCGCTTTCCATTCAGTGGAAAACGAAAGCTGGGCGGGGTGCCACGAGCGCGG
GGCCAGACCAAGGCGGGCCCGGAGCGGAACTTCGGTCCCAGCTCGGTCCCCGGCTCAGTC
CCGACGTGGAACTCAGCAGCGGAGGCTGGACGCTTGCATGGCGCTTGAGAGATTCCATCG
TGCCTGGCTCACATAAGCGCTTCCTGGAAGTGAAGTCGTGCTGTCCTGAACGCGGGCCAG
GCAGCTGCGGCCTGGGGGTTTTGGAGTGATCACGAATGAGCAAGGCGTTTGGGCTCCTGA
GGCAAATCTGTCAGTCCATCCTGGCTGAGTCCTCGCAGTCCCCGGCAGATCTTGAAGAAA
AGAAGGAAGAAGACAGCAACATGAAGAGAGAGCAGCCCAGAGAGCGTCCCAGGGCCTGGG
ACTACCCTCATGGCCTGGTTGGTTTACACAACATTGGACAGACCTGCTGCCTTAACTCCT
TGATTCAGGTGTTCGTAATGAATGTGGACTTCACCAGGATATTGAAGAGGATCACGGTGC
CCAGNGGAGCTGACGAGCAGAGGAGAAGCGTCCCTTTCCAGATGCTTCTGCTGCTGGAGA
AGATGCANGACAGCCGGCAGAAAGCAGTGCGGCCCCTGGAGCTGGCCTACTGCCTGCAGA
AGTGCAACGTGCCCTTGNNTTGTCCACATGATGCTGCCCAACTGTACCTCANAACTCTGG
AACTG
>OriGene 3' read for NM_017414 unedited
NACCGCGGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTGTGGAAAATAACTTT
ATTCATGACTGTGTTTATCACACTATCTTATGGAGAAGAGATGATCAATAAATATTTGCT
GAATAAATGAATAGCAGTTACAAAACACTTGATTCATATGGAATTAATGTTGGTTCTCAA
AGTGAAAAATTACAAACAGCACTGATATTCAGCCAGTATACAAGTCTGGTCACAGCAGTT
GTATAATACTGAAATACCCCCTGCCACTGACCTTTGGCCCCCAGATGCCTCCCACTGCCA
CTGCTCTCCCCACTGGGAACCCCTGAAGTTCCCACAGGCTCATAACTAAAGGGCTAATGT
CTTGCACAGCAGCGAGCACCCAGGACCGAGCAGCCACATGGCCGGGTCTGCTGGTGAAAG
CATCCATTCTGACTGATCAGGACCTGAGGGGCCTCATGGTTACATATTTTGATAATATCC
CTAATTATAAATAAGGCTCAGTTATATAGTTTGAAAACAATGCTTCTCCTCATTGCAAAA
TCTCTTAGAAGACTCCGTAGATCCAGGAACGGAAATGGAAAATGACAGCGTGTCAATCTC
TGAAGGTTTTGGGCATTTCCATTAGCACTCCATCTTCATGTAAACCAGAAGATATGCAGT
TTCCTGCCAGTGGTAGTTAGGATTTCCGTAGGTACACTGGATGTCTTCCCAGGACACCAA
GCAAATATTGGAGTCATTGAAGCAGAACCATTTTCCATTCACAGCATTCCGGATGTAGAA
CAGTAATGACCGGAGTCTGCCATTCCCACGTGCGCAATCACAGCAAAAGCTCATACTGGC
CTTCAGACTGCTNCTCAGCATCACAAGACTCTCGCTTCATTGGAAAGATCTGGCTGAAAT
CCAGCTCTGGGGGAAGTCAAGGAGTGCAGAATCTTCTTCTCTGTGAT
Restriction Sites NotI-NotI     
ACCN NM_017414
ORF Size 1119 bp
Insert Size 2300
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_017414.2, NP_059110.2
RefSeq Size 2054
RefSeq ORF 1119
Locus ID 11274
Domains UCH
Protein Families Druggable Genome, Protease
Gene Summary The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]

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