KLHL3 (NM_017415) Human Untagged Clone

CAT#: SC114103

KLHL3 (untagged)-Human kelch-like 3 (Drosophila) (KLHL3)


  "NM_017415" in other vectors (4)

Reconstitution Protocol

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    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol KLHL3
Synonyms PHA2D
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC114103 sequence for NM_017415 edited (data generated by NextGen Sequencing)
ATGGAGGGTGAAAGTGTCAAGCTGAGCTCCCAGACTCTGATACAGGCTGGGGATGATGAG
AAGAACCAGAGGACGATCACTGTCAACCCTGCCCACATGGGGAAAGCATTCAAGGTTATG
AATGAACTGCGGAGTAAACAGCTGTTGTGTGACGTGATGATTGTGGCAGAAGATGTCGAG
ATAGAAGCCCACCGTGTGGTCCTGGCAGCCTGCAGCCCCTACTTCTGTGCGATGTTCACA
GGTGACATGTCTGAGAGTAAAGCCAAAAAGATAGAAATCAAGGACGTGGATGGGCAGACG
CTGAGTAAGCTGATTGACTACATCTATACTGCTGAAATCGAGGTGACTGAAGAGAATGTC
CAGGTGCTGCTCCCGGCAGCCAGCTTGCTGCAGCTCATGGATGTTCGGCAGAACTGCTGT
GACTTCCTGCAGTCTCAGTTGCATCCCACCAATTGCCTGGGCATCCGTGCATTTGCAGAT
GTACACACCTGCACTGACCTTCTGCAGCAGGCCAATGCCTACGCAGAGCAGCACTTTCCA
GAGGTGATGCTAGGAGAAGAATTTCTTAGCCTGAGTCTGGACCAGGTGTGCAGCTTGATA
TCCAGCGACAAGCTGACCGTTTCTTCAGAAGAGAAGGTGTTTGAAGCTGTGATCTCATGG
ATCAATTATGAGAAAGAAACCCGTTTAGAGCACATGGCAAAGCTGATGGAACATGTCCGA
CTTCCTCTCTTACCTAGGGACTACCTAGTCCAAACGGTTGAAGAAGAAGCTTTGATAAAG
AATAACAACACCTGTAAAGACTTCCTCATTGAGGCCATGAAATACCATCTCCTCCCTCTG
GATCAGAGACTATTGATTAAGAACCCAAGGACCAAGCCCAGGACTCCAGTCAGCCTTCCC
AAGGTCATGATTGTGGTTGGCGGCCAGGCACCCAAGGCAATCCGCAGTGTGGAGTGCTAT
GATTTCGAGGAGGACCGGTGGGATCAGATTGCTGAGCTTCCTTCCAGAAGATGCAGAGCA
GGTGTGGTGTTCATGGCTGGCCACGTGTATGCCGTGGGAGGGTTTAATGGCTCACTGCGG
GTGCGGACAGTGGATGTGTATGACGGCGTGAAGGACCAGTGGACGTCCATTGCCAGCATG
CAGGAGCGCCGGAGCACACTGGGCGCAGCGGTGCTCAATGACTTGCTCTACGCAGTGGGA
GGCTTTGATGGCAGTACTGGCCTAGCATCGGTGGAAGCCTACAGCTACAAGACCAACGAG
TGGTTCTTTGTGGCCCCGATGAACACGCGGCGGAGCAGTGTGGGTGTGGGCGTTGTGGAG
GGGAAGCTATATGCTGTTGGGGGTTATGATGGAGCTTCCCGCCAGTGTCTGAGCACTGTG
GAGCAGTACAACCCAGCGACCAATGAATGGATATACGTGGCGGACATGAGCACCCGCCGC
AGTGGCGCAGGGGTTGGAGTGCTTAGCGGACAGCTGTACGCCACAGGTGGGCATGATGGG
CCTTTGGTGAGGAAGAGCGTTGAGGTTTACGATCCTGGAACAAATACCTGGAAGCAAGTG
GCAGACATGAACATGTGCCGGCGCAACGCAGGGGTCTGTGCAGTAAATGGGCTCCTGTAT
GTGGTTGGAGGGGATGATGGATCCTGCAACTTGGCTTCGGTGGAGTACTACAATCCTGTC
ACTGACAAATGGACGCTGCTTCCAACGAACATGAGCACGGGGCGGAGCTATGCAGGTGTT
GCCGTGATTCACAAGTCCTTGTGA

Clone variation with respect to NM_017415.2
>OriGene 5' read for NM_017415 unedited
TTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCCTCGTGCCGAATTC
GGCACGAGGCGAGTGCATACACAGTTCAGCAGCTACCACCCTGGCTGGGCCTCACACAAT
GGAGGGTGAAAGTGTCAAGCTGAGCTCCCAGACTCTGATACAGGCTGGGGATGATGAGAA
GAACCAGAGGACGATCACTGTCAACCCTGCCCACATGGGGAAAGCATTCAAGGTTATGAA
TGAACTGCGGAGTAAACAGCTGTTGTGTGACGTGATGATTGTGGCAGAAGATGTCGAGAT
AGAAGCCCACCGTGTGGTCCTGGCAGCCTGCAGCCCCTACTTCTGTGCGATGTTCACAGG
TGACATGTCTGAGAGTAAAGCCAAAAAGATAGAAATCAAGGACGTGGATGGGCAGACGCT
GAGTAAGCTGATTGACTACATCTATACTGCTGAAATCGAGGTGACTGAAGAGAATGTCCA
GGTGCTGCTCCCGGCAGCCAGCTTGCTGCAGCTCATGGATGTTCGGCAGAACTGCTGTGA
CTTCCTGCAGTCTCAGTTGCATCCCACCAATTGCCTGNGCATCCGTGCATTTGCAGATGT
ACACACCTGCACTGACCTTCTGCAGCAGGCCAATGCCTACGCAGAGCAGCACTTTCCAGA
GGTGATGCTAGGAGAAGAATTTCTTACCCTGAGTCTGGACCAAGGGTGCAGCTTGATATC
CACCGACAACCTGACCCGTTTCTCCAAAAGAAAAAGGTGCTTGAAGCTGTGATCTCATGG
ATCAATATGAGAAAGAACCCGTTTAGAGCCATGGCAAAGCTGATGGACCATGTTCGACTT
CCTCTTTTACCTAGGGACTACCTTATCCCAACGGTGGAGGAAGAACTTTGATAAAAAATA
CCACCCCGGCAAGAGTTCCTATTGGAGCCATAAAATCCCTCTCCTCCTCTGAACACAGAC
ATGGATC
>OriGene 3' read for NM_017415 unedited
GTGGGCCAAGNNNNNNNNNAACTTTTTACTTGGACCCGGCCGCAATCTAGATCGAGTTTT
TTTTTTTTTTTTTTGGTTTGGTTTGTTTTTAAGTGTTACCCGAGCTTCTCTGAAGACTAG
TTTTCCCAGCTGAAGAGATATAACACCTCCCAGGCCTGGAATCTATGACATCAAAGACCA
ATGGCCTAAACCTGAAGACTGGGCAGTTCTCATCTGCTTTCCTGTAGGGAGAACTCAAAG
GAAAAACAGTGGAGCTTGAGAACCCCAGGGAACCCCTTTGGGCCCCTTTATCTAACCCCA
CAAAAGGACCCGGGGCCACTTTTAAAAAATTTTTCCCCAATTTTTTTTGGAAACAAAGTC
CCCCGGGTTTTTAAAAAGCCCCTAAAGGGGGGGGGGGGGCCCAAAAAACACCCCCCCTTC
CCGGGGTTTTTTGGGGATCCCCAAAGGGCACGGGGCTCTTAAAAAAAAAAACCTTTTTTT
TTTTTGGGGCCCCCCGGGGGAAACACCCAAAAAAAGGGGCCCCCCCCCTTTTTTTTTTCT
CCCCCCGGGGGGGGGGGTTTTAAAAAAAAAATTGTGGGGGGTGGCCCCCCCCCCCCCCCC
CCCCCTAAAAAAAAAAAAAAAAAAAAAAAGGGGTGTTTCTCCCCCCCCCCCCCCCCCCCC
CCCCCCCCCCGGGTTTGTTTTTTTTTTTTTTTAAAAAAAAAAAAAAAAAAAAAAA
Restriction Sites NotI-NotI     
ACCN NM_017415
ORF Size 1764 bp
Insert Size 3340
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_017415.1, NP_059111.1
RefSeq Size 6485
RefSeq ORF 1764
Locus ID 26249
Domains BTB, Kelch
Gene Summary This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
Transcript Variant: This variant (1) encodes the longest isoform (1; also known as KLHL3a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.

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