COQ3 (NM_017421) Human Untagged Clone

CAT#: SC114104

COQ3 (untagged)-Human coenzyme Q3 homolog, methyltransferase (S. cerevisiae) (COQ3)


  "NM_017421" in other vectors (5)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol COQ3
Synonyms bA9819.1; DHHBMT; DHHBMTASE; UG0215E05
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC114104 sequence for NM_017421 edited (data generated by NextGen Sequencing)
ATGTGGAGTGGCCGTAAGCTGGGCTCCTCCGGGGGTTGGTTTTTAAGAGTGCTGGGGCCT
GGAGGCTGTAATACAAAAGCTGCGCGTCCCTTAATTTCCTCGGCGGTTTATGTGAAGAAC
CAGCTCAGTGGGACTCTACAGATTAAACCAGGGGTTTTCAATGAATACAGAACCATATGG
TTCAAATCCTACAGGACGATCTTTTCCTGTTTGAACAGAATAAAGAGTTTCAGGTACCCT
TGGGCGAGACTGTACAGTACTTCCCAAACCACTGTCGACAGCGGTGAGGTAAAAACCTTC
TTGGCCCTGGCTCACAAATGGTGGGATGAACAAGGAGTATATGCACCTCTTCATTCCATG
AATGACCTGAGGGTGCCATTTATTAGGGACAATCTTCTGAAAACAATTCCTAATCACCAG
CCAGGAAAACCTTTGTTGGGGATGAAGATTCTTGACGTTGGCTGTGGTGGTGGGCTGTTA
ACTGAACCTCTAGGGCGGCTTGGGGCTTCAGTTATTGGAATCGACCCTGTGGATGAGAAC
ATTAAAACAGCACAATGCCATAAATCATTTGATCCAGTCCTGGATAAGAGAATAGAGTAC
AGAGTGTGTTCCCTGGAAGAGATTGTGGAAGAGACTGCAGAAACATTTGATGCTGTTGTA
GCTTCTGAAGTTGTAGAACATGTGATTGATCTAGAAACATTTTTACAGTGCTGCTGTCAA
GTGTTAAAACCCGGTGGTTCTTTATTCATTACTACAATCAACAAAACACAACTTTCCTAT
GCCTTGGGAATTGTTTTTTCAGAGCAAATTGCAGGTATTGTACCAAAAGGTACTCATACA
TGGGAGAAGTTTGTTTCACCTGAAACACTAGAGAGCATTCTGGAATCAAATGGTCTGTCA
GTTCAAACAGTGGTAGGAATGCTCTATAACCCCTTCTCAGGTTACTGGCATTGGAGTGAA
AATACCAGCCTTAACTATGCAGCTCATGCTGTGAAATCCAGGGTCCAGGAACACCCAGCC
TCTGCTGAGTTTGTTTTAAAGGGAGAAACAGAAGAGCTCCAAGCTAATGCCTGCACCAAT
CCAGCTGTGCATGAAAAGCTGAAGAAATGA

Clone variation with respect to NM_017421.3
814 a=>g;985 t=>c
>OriGene 5' read for NM_017421 unedited
TTTGTAATACGACTCACTATAGGGCGGCCGCNGATTCGGCACGAGGGTCGCGATGTGGAG
TGGCCGTAAGCTGGGCTCCTCCGGGGGTTGGTTTTTAAGAGTGCTGGGGCCTGGAGGCTG
TAATACAAAAGCTGCGCGTCCCTTAATTTCCTCGGCGGTTTATGTGAAGAACCAGCTCAG
TGGGACTCTACAGATTAAACCAGGGGTTTTCAATGAATACAGAACCATATGGTTCAAATC
CTACAGGACGATCTTTTCCTGTTTGAACAGAATAAAGAGTTTCAGGTACCCTTGGGCGAG
ACTGTACAGTACTTCCCAAACCACTGTCGACAGCGGTGAGGTAAAAACCTTCTTGGCCCT
GGCTCACAAATGGTGGGATGAACAAGGAGTATATGCACCTCTTCATTCCATGAATGACCT
GAGGGTGCCATTTATTAGGGACAATCTTCTGAAAACAATTCCTAATCACCAGCCAGGAAA
ACCTTTGTTGGGGATGAAGATTCTTGACGTTGGCTGTGGTGGTGGGCTGTTAACTGAACC
TCTAGGGCGGCTTGGGGCTTCAGTTATTGGAATCGACCCTGTGGATGAGAACATTAAAAC
AGCACAATGCCATAAATCATTTGATCCAGTCCTGGATAAGAGAATAGAGTACAGAGTGGT
GTTCCCTGGAAGAGATTGTGGAAGAGACTGCAGAAACATTTGATGCTGTTGTAGCTTCTG
AAAGTGTAGAACATGTGATTGATCTAGAACATTTTTACAGTGCTGCTGTCAAGTGTTAAA
ACCCGGTGGTTCTTTATTCATTACNTACATCAACANNACACNACTTTCCTATGCTTNGNG
NATNGTTTTTTCAGAGCAAATGCAGGTATTGACCAAAAGTACTCTACATGGGAGAAGTTG
NTTCACTGAACCTANAGACATCTGGATCAATGGTCTGCAGTCAACAG
>OriGene 3' read for NM_017421 unedited
TATGGACCGGCGGCCGCAATCTAGNATCGAGTTTTTTTTTTTTTTTTTTCCAGGTTTTAG
CCCTTTTTATTGACCTTCTTTTCTTCATGATTCTCTCTCAAGGATAAATTGTACATTTCT
TGTATTTGAAAACATCAGATATCCAAGCCATATTACTATAGTTCTCAGAAACAATTCATT
TCTTCAGCTTTTCATGCACAGCTGGATTGGTGCAGGCATTAGCTTGGAGCTCTTCTGTTT
CTCCCTTTAAAACAAACTCAGCAGAGGCTGGGTGTTCCTGGACCCTGGATTTCACAGCAT
GAGCTGCATAGTTAAGGCTGGTATTTTCACTCCAATGCCAGTAACCTGAGAAGGGGTTAT
AGAGCATTCCTACCACTGTTTGAACTGACAGACCATTTGATTCCAGAATGCTCTCTAGTG
TTTCAGGTGAAACAAACTTCTCCCATGTATGAGTACCTTTTGGTACAATACCTGCAATTT
GCTCTGAAAAAACAATTCCCAAGGCATAGGAAAGTTGTGTTTTGTTGATTGTAGTAATGA
ATAAAGAACCACCGGGTTTTAACACTTGACAGCAGCACTGTAAAAATGTTTCTAGATCAA
TCACATGTTCTACAACTTCAGAAGCTACAACAGCATCAAATGTTTCTGCAGTCTCTTCCA
AATCTCTTCCAGGGAACCACTCTGTACTCTATTCTCTTATCCAGGACTGGATCAAATGAT
TTATGGCATTGCGCTGGTTTATTGTTCTCATCCACAGGGGCCGATTCCAATACCTGAAGC
CCCAAGCCGCCCTAAAGGTCATTTAACAGCCCCCCCCCACAGCCACGGTCAGAATTTTCA
TCCCCACACAGGCTTCTCGGGCTGCGGAATAGGATATGTTTCAAAC
Restriction Sites NotI-NotI     
ACCN NM_017421
ORF Size 1110 bp
Insert Size 1220
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_017421.2, NP_059117.2
RefSeq Size 1279
RefSeq ORF 1110
Locus ID 51805
Protein Families Druggable Genome
Protein Pathways Metabolic pathways, Ubiquinone and other terpenoid-quinone biosynthesis
Gene Summary Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol. [supplied by OMIM, Mar 2008]

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