COQ3 (NM_017421) Human Untagged Clone

CAT#: SC324338

COQ3 (untagged)-Human coenzyme Q3 homolog, methyltransferase (S. cerevisiae) (COQ3)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: COQ3
• Synonyms: bA9819.1; DHHBMT; DHHBMTASE; UG0215E05
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_017421.3 GCTATGTGGAGTGGCCGTAAGCTGGGCTCCTCCGGGGGTTGGTTTTTAAGAGTGCTGGGG
  CCTGGAGGCTGTAATACAAAAGCTGCGCGTCCCTTAATTTCCTCGGCGGTTTATGTGAAG
  AACCAGCTCAGTGGGACTCTACAGATTAAACCAGGGGTTTTCAATGAATACAGAACCATA
  TGGTTCAAATCCTACAGGACGATCTTTTCCTGTTTGAACAGAATAAAGAGTTTCAGGTAC
  CCTTGGGCGAGACTGTACAGTACTTCCCAAACCACTGTCGACAGCGGTGAGGTAAAAACC
  TTCTTGGCCCTGGCTCACAAATGGTGGGATGAACAAGGAGTATATGCACCTCTTCATTCC
  ATGAATGACCTGAGGGTGCCATTTATTAGGGACAATCTTCTGAAAACAATTCCTAATCAC
  CAGCCAGGAAAACCTTTGTTGGGGATGAAGATTCTTGACGTTGGCTGTGGTGGTGGGCTG
  TTAACTGAACCTCTAGGGCGGCTTGGGGCTTCAGTTATTGGAATCGACCCTGTGGATGAG
  AACATTAAAACAGCACAATGCCATAAATCATTTGATCCAGTCCTGGATAAGAGAATAGAG
  TACAGAGTGTGTTCCCTGGAAGAGATTGTGGAAGAGACTGCAGAAACATTTGATGCTGTT
  GTAGCTTCTGAAGTTGTAGAACATGTGATTGATCTAGAAACATTTTTACAGTGCTGCTGT
  CAAGTGTTAAAACCCGGTGGTTCTTTATTCATTACTACAATCAACAAAACACAACTTTCC
  TATGCCTTGGGAATTGTTTTTTCAGAGCAAATTGCAGGTATTGTACCAAAAGGTACTCAT
  ACATGGGAGAAGTTTGTTTCACCTGAAACACTAGAGAGCATTCTGGAATCAAATGGTCTG
  TCAGTTCAAACAGTGGTAGGAATGCTCTATAACCCCTTCTCAGGTTACTGGCATTGGAGT
  GAAAATACCAGCCTTAACTATGCAGCTCATGCTGTGAAATCCAGGGTCCAGGAACACCCA
  GCCTCTGCTGAGTTTGTTTTAAAGGGAGAAACAGAAGAGCTCCAAGCTAATGCCTGCACC
  AATCCAGCTGTGCATGAAAAGCTGAAGAAATGAATTGTTTCTGAGAACTATAGTAATATG
  GCTTGGATATCTGATGTTTTCAAATACAAGAAATGTACAATTTATCCTTTGAGAGAGAAT
  CATGAAGAAAAGAAGGTCAATAAAAAGGGCTAAAACCTTGGAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_017421.3 unedited
  GGCCAAGCCTGTAAGCATCCCGCTTGTTTTGACCTCCATAGAAGACACCGGGACCGATCC
  AGCCTCCGGACTCTAGCCTAGGCCGCGGGACGGATAACAATTTCACACAGGAAACAGCTA
  TGACCATTAGGCCTATTTAGGTGACACTATAGAACAAGTTTGTACAAAAAAGCAGGCTGG
  TACCGGTCCGGAATTCCCGGGATGCTATGTGGAGTGGCCGTAAGCTGGGCTCCTCCGGGG
  GTTGGTTTTTAAGAGTGCTGGGGCCTGGAGGCTGTAATACAAAAGCTGCGCGTCCCTTAA
  TTTCCTCGGCGGTTTATGTGAAGAACCAGCTCAGTGGGACTCTACAGATTAAACCAGGGG
  TTTTCAATGAATACAGAACCATATGGTTCAAATCCTACAGGACGATCTTTTCCTGTTTGA
  ACAGAATAAAGAGTTTCAGGTACCCTTGGGCGAGACTGTACAGTACTTCCCAAACCACTG
  TCGACAGCGGTGAGGTAAAAACCTTCTTGGCCCTGGCTCACAAATGGTGGGATGAACAAG
  GAGTATATGCACCTCTTCATTCCATGAATGACCTGAGGGTGCCATTTATTAGGGACAATC
  TTCTGAAAACAATTCCTAATCACCAGCCAGGAAAACCTTTGTTGGGGATGAAGATTCTTG
  ACGTTGGCTGTGGTGGTGGGCTGTTAACTGAACCTCTAGGGCGGCTTGGGGCTTCAGTTA
  TTGGAAATCGACCCTGTGGATGAGAACATTAAAACAGCACAATGCCATAAAATCATTTGA
  TCCAGTCCTGATAGAGAATAGAGTACAGAGTGTGTTCCCTGCAGAGATTGTGAGAGACTG
  CAGAAAACATTTGATGCTGTTGTAGCTCTGAGTTGTAGACATGTGGATGATCTAGACATT
  TTACAGGGCTGCTGTCCAGTGTAAACCCGGTGGTTCTTTATTCATAACTACAATTCCACC
  AAAACACACTTTCTCTATGGC
• Restriction Sites: Please inquire
• ACCN: NM_017421
• ORF Size: 1110 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_017421.3, NP_059117.3
• RefSeq Size: 1265
• RefSeq ORF: 1110
• Locus ID: 51805
• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Ubiquinone and other terpenoid-quinone biosynthesis
• Gene Summary: Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol. [supplied by OMIM, Mar 2008]