Cytohesin 2 (CYTH2) (NM_017457) Human Untagged Clone

CAT#: SC114117

CYTH2 (untagged)-Human cytohesin 2 (CYTH2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CYTH2
• Synonyms: ARNO; CTS18; CTS18.1; cytohesin-2; PSCD2; PSCD2L; SEC7L; Sec7p-L; Sec7p-like
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC114117 sequence for NM_017457 edited (data generated by NextGen Sequencing)
  ATGGAGGACGGCGTCTATGAACCCCCAGACCTGACTCCGGAGGAGCGGATGGAGCTGGAG
  AACATCCGGCGGCGGAAGCAGGAGCTGCTGGTGGAGATTCAGCGCCTGCGGGAGGAGCTC
  AGTGAAGCCATGAGCGAGGTGGAGGGGCTGGAGGCCAATGAGGGCAGTAAGACCTTGCAA
  CGGAACCGGAAGATGGCAATGGGCAGGAAGAAGTTCAACATGGACCCCAAGAAGGGGATC
  CAGTTCTTGGTGGAGAATGAACTGCTGCAGAACACACCCGAGGAGATCGCCCGCTTCCTG
  TACAAGGGCGAGGGGCTGAACAAGACAGCCATCGGGGACTACCTGGGGGAGAGGGAAGAA
  CTGAACCTGGCAGTGCTCCATGCTTTTGTGGATCTGCATGAGTTCACCGACCTCAATCTG
  GTGCAGGCCCTCAGGCAGTTTCTATGGAGCTTTCGCCTACCCGGAGAGGCCCAGAAAATT
  GACCGGATGATGGAGGCCTTCGCCCAGCGATACTGCCTGTGCAACCCTGGGGTTTTCCAG
  TCCACAGACACGTGCTATGTGCTGTCCTTCGCCGTCATCATGCTCAACACCAGTCTCCAC
  AATCCCAATGTCCGGGACAAGCCGGGCCTGGAGCGCTTTGTGGCCATGAACCGGGGCATC
  AACGAGGGCGGGGACCTGCCTGAGGAGCTGCTCAGGAACCTGTACGACAGCATCCGAAAT
  GAGCCCTTCAAGATTCCTGAGGATGACGGGAATGACCTGACCCACACCTTCTTCAACCCG
  GACCGGGAGGGCTGGCTCCTGAAGCTGGGAGGGGGCCGGGTGAAGACGTGGAAGCGGCGC
  TGGTTTATCCTCACAGACAACTGCCTCTACTACTTTGAGTACACCACGGACAAGGAGCCC
  CGAGGAATCATCCCCCTGGAGAATCTGAGCATCCGAGAGGTGGACGACCCCCGGAAACCG
  AACTGCTTTGAACTTTACATCCCCAACAACAAGGGGCAGCTCATCAAAGCCTGCAAAACT
  GAGGCGGACGGCCGAGTGGTGGAGGGAAACCACATGGTGTACCGGATCTCGGCCCCCACG
  CAGGAGGAGAAGGACGAGTGGATCAAGTCCATCCAGGCGGCTGTGAGTGTGGACCCCTTC
  TATGAGATGCTGGCAGCGAGAAAGAAGCGGATTTCAGTCAAGAAGAAGCAGGAGCAGCCC
  TGA
  
  Clone variation with respect to NM_017457.5
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_017457 unedited
  CCCGCCCCGTTGACGCAATTGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAG
  TTTATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGAATT
  CGGCACGAGGTGAGGAGGCGGCGGTGGCTCCCGGGGCGTTTGAGCGGGCTCACCCGAGCC
  CGCGGGCCAACGCGGATCCAGGCCCGACTGGCGGGACCGCCCCGGATTCCCCGCGGGCCT
  TCCTAGCCGCCATGGAGGACGGCGTCTATGAACCCCCAGACCTGACTCCGGAGGAGCGGA
  TGGAGCTGGAGAACATCCGGCGGCGGAAGCAGGAGCTGCTGGTGGAGATTCAGCGCCTGC
  GGGAGGAGCTCAGTGAAGCCATGAGCGAGGTGGAGGGGCTGGAGGCCAATGAGGGCAGTA
  AGACCTTGCAACGGAACCGGAAGATGGCAATGGGCAGGAAGAAGTTCAACATGGACCCCA
  AGAAGGGGATCCAGTTCTTGGTGGAGAATGAACTGCTGCAGAACACACCCGAGGAGATCG
  CCCGCTTCCTGTACAAGGGCGAGGGGCTGAACAAGACAGCCATCGGGGACTACCTTGGGG
  AGAGGGAAGAACTGAACCTGGCAGTGCTCCATGCTTTTGTGGATCTGCATGAGTTCACCG
  ACCTCAATCTGGTGCAGGCCCTCAGGCAGTTTCTATGGAGCTTTCGCCTACCCGGAGAGG
  CCCCAGAAATTGACCGGATGATGGAGGCCTTTCGCCAGCGATACTGCCTGTGCACCCNTG
  GGTTTTNCAGTCACAGACACTGCTATGTGCTGTCCTTTCGCGNATCATGCTCACACCAGT
  CTNCACATCCNATGTNCGGNACANGCGGNCCTGNAGCGCTTTGTGGCATGACCGNGCATC
  ACGAGGGCCGGGACCTGCTGAGAGCTGTCAGAACCTGTCACAGCATCGATGAGCCTTAGA
  TCCTGAGTTGACAGGATGACTGACACC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_017457 unedited
  TTTTTGGATTTAGCTATGNNACCGCGGCCGCTTNCTANGATCGAGTTTTTTTTTTTTTTT
  TTTGCTGGGGGTTAGGATTTTAATATAAAGTTTTTTGTGGGGGTGGGGGAGACACAATTT
  GATCCGTGCTGAGTCCATTTTGTGTTGCTCTGACAGAAGACCTGAGGCTGGGTCTTTATA
  AAGGAAGAGGTTGATTTGGCTCAGATTCTGATGGCTGGAAGGTTCAAGACTGGGCAGGTG
  CACTCACTGAGGACCTCCCTCATCCCTGAGGCTGCTGCTGCTTCTGGGGGAGGGCAGAAG
  GATGCAGCTGTGTGCACAGAGATCACATGGTGCTGAAGGAAGCAAGGGAGAGAAAACCAA
  ATTCCCAAATTCCCAAGGGTGAGCACTCACTCACCCCTTAAGGCAGGCATTAATCTATCC
  ATGAGGACTCCACCTCCAAGACCACACAGCTCCTATGAGGCCCCACATCCCAACACCTGC
  CACACTGGGGGCTCGAATCTCAACATGAATTTTAGTGAAGACAAACGATATCCAAACCAT
  TGCCACCCAAAAGAAGTGGGGCTGAAGCCTGGCGCGGTGGCTCACACCTGTAATCCCCAC
  ACTTTTGGGAGGCTGAAACAAATGGGTCCCCCTGAAGTCAAGAATTTCCAGACCAGCTTG
  GGCCATATGGGGAAACCCCCTCTTTTCTAAAATCCCAAATTTGCTGGGTACGGGGCTCCC
  ATCTTTAATCCCACTTCCCCGGAAACTTAGCCAGGGAAATCCTTTGCCCTCGGGAGTGGA
  GGGTTCACATAAACCCAAATGGCCCCTTTGCCCTCCCGTTTTAGGCACAAATGGTGACCT
  CCCTTTCAAAAAAAAAAAAAAAAAAAAAC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_017457
• ORF Size: 1203 bp
• Insert Size: 4700
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_017457.3, NP_059431.1
• RefSeq Size: 1545
• RefSeq ORF: 1203
• Locus ID: 9266
• Domains: Sec7, PH
• Protein Families: Druggable Genome
• Gene Summary: The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.