HP1 gamma (CBX3) (NM_016587) Human Untagged Clone

CAT#: SC114184

CBX3 (untagged)-Human chromobox homolog 3 (CBX3), transcript variant 2


  "NM_016587" in other vectors (4)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CBX3
Synonyms HECH; HP1-GAMMA; HP1Hs-gamma
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF sequence for NM_016587 edited
ATGGCCTCCAACAAAACTACATTGCAAAAAATGGGAAAAAAACAGAATGGAAAGAGTAAA
AAAGTTGAAGAGGCAGAGCCTGAAGAATTTGTCGTGGAAAAAGTACTAGATCGACGTGTA
GTGAATGGGAAAGTGGAATATTTCCTGAAGTGGAAGGGATTTACAGATGCTGACAATACT
TGGGAACCTGAAGAAAATTTAGATTGTCCAGAATTGATTGAAGCGTTTCTTAACTCTCAG
AAAGCTGGCAAAGAAAAAGATGGTACAAAAAGAAAATCTTTATCTGACAGTGAATCTGAT
GACAGCAAATCAAAGAAGAAAAGAGATGCTGCTGACAAACCAAGAGGATTTGCCAGAGGT
CTTGATCCTGAAAGAATAATTGGTGCCACAGACAGCAGTGGAGAATTGATGTTTCTCATG
AAATGGAAAGATTCAGATGAGGCAGACTTGGTGCTGGCGAAAGAGGCAAATATGAAGTGT
CCTCAAATTGTAATTGCTTTTTATGAAGAGAGACTAACTTGGCATTCTTGTCCAGAAGAT
GAAGCTCAATAA
>OriGene 5' read for NM_016587 unedited
GATTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCTTGGGGACCA
CCGGGCGCCACGCCGCGAACGTAATAGCTCTTCAAGTCTGCAATAAAAAATGGCCTCCAA
CAAAACTACATTGCAAAAAATGGGGAAAAAAACAGAATGGAAAGAGTAAAAAAGTTGAAG
AGGCAGAGCCTGAAGAATTTGTCGTGGAAAAAGTACTAGATCGACGTGTAGTGAATGGGA
AAGTGGAATATTTCCTGAAGTGGAAGGGATTTACAGATGCTGACAATACTTGGGAACCTG
AAGAAAATTTAGATTGTCCAGAATTGATTGAAGCGTTTCTTAACTCTCAGAAAGCTGGCA
AAGAAAAAGATGGTACAAAAAGAAAATCTTTATCTGACAGTGAATCTGATGACAGCAAAT
CAAAGAAGAAAAGAGATGCTGCTGACAAACCAAGAGGATTTGCCAGAGGTCTTGATCCTG
AAAGAATAATTGGTGCCACAGACAGCAGTGGAGAATTGATGTTTCTCATGAAATGGAAAG
ATTCAGATGAGGCAGACTTGGTGCTGGCGAAAGAGGCAAATATGAAGTGTCCTCAAATTG
TAATTGCTTTTTATGAAGAGAGACTAACTTGGCATTCTTGTCCAGAAGATGAAGCTCAAT
AATTGTTCACATTGGTCTTTTATATATATTTATATATATATATAAAAATTGGGTCTTAGA
TTTTGATTTACTAGTGTGACAAAATAACTACATCCTAATGAAAAATCAAGTTGATATGTT
TTGTTTGAAAGTANCGTGGAAAGAAGTGNTGGNGGGTTTTTTGCATCCATAGCACTGGTT
ACTTTTGACAAATAATAANNAGCTTCTGTAGTTGCTTCCTTTATCAGAAAAGACATTTGA
TACATGGTATATCATTTCCTCTTCATT
>OriGene 3' read for NM_016587 unedited
CGGCCGCAATCTAAAGTCGAGTTTTTTTTTTTTTTTTTTTTTTGCATAAAGGAATATAAA
ACTATTTATTAACCACTGTTCACCAGTATTTACAATAAAGTAAACAATATACAGTTGGAT
AACATTTTGATTACTACAAAGTTGTTCTTCCTGGCTTTTGCTGAACCAGTAAAGCAAACT
CAAGATTGAGCCTCCATGTAATGAATTGGGGTAAAGAAAAAACATGCAGGTCAATAGGTT
AGGTTACAAAAGGTTGTTCACACATTTATGACAGCAGGTCCTAAACTGCCAACACCTCTA
ACCATCTGATTAGGTTTCTATGAGCCAAGTCTTACATATTCCATTCATCATGACCTTTTA
GTCAATGTAGCAACAGGGATTCCAACATTTTGCTAAGGAATGGCCCGCTAGGGAAACTTT
TAAATGTTCATTTAACTTAGTTTTGTTTAGCTAGTTAAAACACACTAGCATTTGTCTAGT
TTCCTCATCTGGATGAGGAAACCTGCTGTGATGGCAGTGATAAAATTTTTCCTTTTAGGA
ATTTTGCAAATAAACCACTGCAATTATAGACACTTTAAAATTATCCAATTTAAATTGTCC
TATCTAGAATTACTTATTTCACTTGAAATGTATGGTTTCAGGAAAATTTTCAATTTAACT
TGAAGGGATTATCTCTTATTTTGCTTGGAATAATGGCATCTCAGAAACATGGGTCTACCT
GTGATTTTTTTGTTTGGGTGAATGCTTAAAAACAAAAAAAATTACATATGCATTTTATGG
ATACACACACACACCCACACCCACACACAAAAAACACGTAATAAATCTAAAATGGTCCTT
AGGCTCATGAGAACACAGTTTGACTGAGTATGACATTGACCTTCCCCCACATTAAAAACT
GTTCTCTATGAGAGGAATGATTACATGGTTCAAAGTCTTTCTGAAAGGACACTCCGAGCT
TATTATTGTC
Restriction Sites NotI-NotI     
ACCN NM_016587
ORF Size 552 bp
Insert Size 1790
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Reference Data
RefSeq NM_016587.2, NP_057671.2
RefSeq Size 1851
RefSeq ORF 552
Locus ID 11335
Domains CHROMO
Protein Families Druggable Genome, Transcription Factors
Gene Summary At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene. [provided by RefSeq, Mar 2011]
Transcript Variant: This variant (2) contains an alternate 5' exon but encodes the same protein as transcript variant 1.

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