HP1 gamma (CBX3) (NM_016587) Human Untagged Clone

CAT#: SC114184

CBX3 (untagged)-Human chromobox homolog 3 (CBX3), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CBX3
• Synonyms: HECH; HP1-GAMMA; HP1Hs-gamma
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_016587 edited
  ATGGCCTCCAACAAAACTACATTGCAAAAAATGGGAAAAAAACAGAATGGAAAGAGTAAA
  AAAGTTGAAGAGGCAGAGCCTGAAGAATTTGTCGTGGAAAAAGTACTAGATCGACGTGTA
  GTGAATGGGAAAGTGGAATATTTCCTGAAGTGGAAGGGATTTACAGATGCTGACAATACT
  TGGGAACCTGAAGAAAATTTAGATTGTCCAGAATTGATTGAAGCGTTTCTTAACTCTCAG
  AAAGCTGGCAAAGAAAAAGATGGTACAAAAAGAAAATCTTTATCTGACAGTGAATCTGAT
  GACAGCAAATCAAAGAAGAAAAGAGATGCTGCTGACAAACCAAGAGGATTTGCCAGAGGT
  CTTGATCCTGAAAGAATAATTGGTGCCACAGACAGCAGTGGAGAATTGATGTTTCTCATG
  AAATGGAAAGATTCAGATGAGGCAGACTTGGTGCTGGCGAAAGAGGCAAATATGAAGTGT
  CCTCAAATTGTAATTGCTTTTTATGAAGAGAGACTAACTTGGCATTCTTGTCCAGAAGAT
  GAAGCTCAATAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_016587 unedited
  GATTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCTTGGGGACCA
  CCGGGCGCCACGCCGCGAACGTAATAGCTCTTCAAGTCTGCAATAAAAAATGGCCTCCAA
  CAAAACTACATTGCAAAAAATGGGGAAAAAAACAGAATGGAAAGAGTAAAAAAGTTGAAG
  AGGCAGAGCCTGAAGAATTTGTCGTGGAAAAAGTACTAGATCGACGTGTAGTGAATGGGA
  AAGTGGAATATTTCCTGAAGTGGAAGGGATTTACAGATGCTGACAATACTTGGGAACCTG
  AAGAAAATTTAGATTGTCCAGAATTGATTGAAGCGTTTCTTAACTCTCAGAAAGCTGGCA
  AAGAAAAAGATGGTACAAAAAGAAAATCTTTATCTGACAGTGAATCTGATGACAGCAAAT
  CAAAGAAGAAAAGAGATGCTGCTGACAAACCAAGAGGATTTGCCAGAGGTCTTGATCCTG
  AAAGAATAATTGGTGCCACAGACAGCAGTGGAGAATTGATGTTTCTCATGAAATGGAAAG
  ATTCAGATGAGGCAGACTTGGTGCTGGCGAAAGAGGCAAATATGAAGTGTCCTCAAATTG
  TAATTGCTTTTTATGAAGAGAGACTAACTTGGCATTCTTGTCCAGAAGATGAAGCTCAAT
  AATTGTTCACATTGGTCTTTTATATATATTTATATATATATATAAAAATTGGGTCTTAGA
  TTTTGATTTACTAGTGTGACAAAATAACTACATCCTAATGAAAAATCAAGTTGATATGTT
  TTGTTTGAAAGTANCGTGGAAAGAAGTGNTGGNGGGTTTTTTGCATCCATAGCACTGGTT
  ACTTTTGACAAATAATAANNAGCTTCTGTAGTTGCTTCCTTTATCAGAAAAGACATTTGA
  TACATGGTATATCATTTCCTCTTCATT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_016587 unedited
  CGGCCGCAATCTAAAGTCGAGTTTTTTTTTTTTTTTTTTTTTTGCATAAAGGAATATAAA
  ACTATTTATTAACCACTGTTCACCAGTATTTACAATAAAGTAAACAATATACAGTTGGAT
  AACATTTTGATTACTACAAAGTTGTTCTTCCTGGCTTTTGCTGAACCAGTAAAGCAAACT
  CAAGATTGAGCCTCCATGTAATGAATTGGGGTAAAGAAAAAACATGCAGGTCAATAGGTT
  AGGTTACAAAAGGTTGTTCACACATTTATGACAGCAGGTCCTAAACTGCCAACACCTCTA
  ACCATCTGATTAGGTTTCTATGAGCCAAGTCTTACATATTCCATTCATCATGACCTTTTA
  GTCAATGTAGCAACAGGGATTCCAACATTTTGCTAAGGAATGGCCCGCTAGGGAAACTTT
  TAAATGTTCATTTAACTTAGTTTTGTTTAGCTAGTTAAAACACACTAGCATTTGTCTAGT
  TTCCTCATCTGGATGAGGAAACCTGCTGTGATGGCAGTGATAAAATTTTTCCTTTTAGGA
  ATTTTGCAAATAAACCACTGCAATTATAGACACTTTAAAATTATCCAATTTAAATTGTCC
  TATCTAGAATTACTTATTTCACTTGAAATGTATGGTTTCAGGAAAATTTTCAATTTAACT
  TGAAGGGATTATCTCTTATTTTGCTTGGAATAATGGCATCTCAGAAACATGGGTCTACCT
  GTGATTTTTTTGTTTGGGTGAATGCTTAAAAACAAAAAAAATTACATATGCATTTTATGG
  ATACACACACACACCCACACCCACACACAAAAAACACGTAATAAATCTAAAATGGTCCTT
  AGGCTCATGAGAACACAGTTTGACTGAGTATGACATTGACCTTCCCCCACATTAAAAACT
  GTTCTCTATGAGAGGAATGATTACATGGTTCAAAGTCTTTCTGAAAGGACACTCCGAGCT
  TATTATTGTC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_016587
• ORF Size: 552 bp
• Insert Size: 1790
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_016587.2, NP_057671.2
• RefSeq Size: 1851
• RefSeq ORF: 552
• Locus ID: 11335
• Domains: CHROMO
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene. [provided by RefSeq, Mar 2011]
  Transcript Variant: This variant (2) contains an alternate 5' exon but encodes the same protein as transcript variant 1.