UPB1 (NM_016327) Human Untagged Clone

CAT#: SC114316

UPB1 (untagged)-Human ureidopropionase, beta (UPB1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: UPB1
• Synonyms: BUP1
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC114316 sequence for NM_016327 edited (data generated by NextGen Sequencing)
  ATGGCGGGCGCTGAGTGGAAGTCGCTGGAGGAATGCTTGGAGAAGCACCTGCCGCTCCCC
  GACTTGCAGGAAGTGAAGCGCGTTCTCTATGGCAAGGAACTCAGGAAGCTTGATCTGCCC
  AGGGAAGCTTTCGAAGCTGCCTCCAGAGAAGACTTTGAACTGCAGGGATATGCCTTTGAA
  GCAGCGGAGGAGCAGCTGAGACGACCCCGCATTGTGCACGTGGGGCTGGTTCAGAACAGA
  ATCCCCCTCCCCGCAAATGCCCCTGTGGCAGAACAGGTCTCTGCCCTTCATAGACGCATA
  AAGGCTATCGTAGAGGTGGCTGCAATGTGTGGAGTCAACATCATCTGTTTCCAGGAAGCA
  TGGACTATGCCCTTTGCCTTCTGTACGAGAGAGAAGCTTCCTTGGACAGAATTTGCTGAG
  TCAGCAGAGGATGGGCCCACCACCAGATTCTGTCAGAAGCTGGCGAAGAACCATGACATG
  GTGGTGGTGTCTCCCATCCTGGAACGAGACAGCGAGCATGGGGATGTTTTGTGGAATACA
  GCCGTGGTGATCTCCAATTCCGGAGCAGTCCTGGGAAAGACCAGGAAAAACCACATCCCC
  AGAGTGGGTGATTTCAACGAGTCAACTTACTACATGGAGGGAAACCTGGGCCACCCCGTG
  TTCCAGACGCAGTTCGGAAGGATCGCGGTGAACATTTGCTACGGGCGGCACCACCCCCTC
  AACTGGCTTATGTACAGCATCAACGGGGCTGAGATCATCTTCAACCCCTCGGCCACGATA
  GGAGCACTCAGCGAGTCCCTGTGGCCCATCGAGGCCAGAAACGCAGCCATTGCCAATCAC
  TGCTTCACCTGCGCCATCAATCGAGTGGGCACCGAGCACTTCCCGAACGAGTTTACCTCG
  GGAGATGGAAAGAAAGCTCACCAGGACTTTGGCTACTTTTATGGCTCGAGCTATGTGGCA
  GCCCCTGACAGCAGCCGGACTCCTGGGCTGTCCCGTAGCCGGGATGGACTGCTAGTTGCT
  AAGCTCGACCTAAACCTCTGCCAGCAGGTGAATGATGTCTGGAACTTCAAGATGACGGGC
  AGGTATGAGATGTACGCACGGGAGCTCGCCGAAGCTGTCAAGTCCAACTACAGCCCCACC
  ATCGTGAAAGAGTAG
  
  Clone variation with respect to NM_016327.2
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_016327 unedited
  NNNNGGGGGGNNNNNNNNCCCCCNNNNNNNNNNGGGTCCAGAAATTGTNATACGACTCAC
  TATAGGCGGCCGCGAATTCGCACCAGCGGGCAAAGGCAGGCAGTTCGTGCGCGGACACAA
  GCACTGGCGGACCGTGGCCATGGCGGGCGCTGAGTGGAAGTCGCTGGAGGAATGCTTGGA
  GAAGCACCTGCCGCTCCCCGACTTGCAGGAAGTGAAGCGCGTTCTCTATGGCAAGGAACT
  CAGGAAGCTTGATCTGCCCAGGGAAGCTTTCGAAGCTGCCTCCAGAGAAGACTTTGAACT
  GCAGGGATATGCCTTTGAAGCAGCGGAGGAGCAGCTGAGACGACCCCGCATTGTGCACGT
  GGGGCTGGTTCAGAACAGAATCCCCCTCCCCGCAAATGCCCCTGTGGCAGAACAGGTCTC
  TGCCCTTCATAGACGCATAAAGGCTATCGTAGAGGTGGCTGCAATGTGTGGAGTCAACAT
  CATCTGTTTCCAGGAAGCATGGACTATGCCCTTTGCCTTCTGTACGAGAGAGAAGCTTCC
  TTGGACAGAATTTGCTGAGTCAGCAGAGGATGGGCCCACCACCAGATTCTGTCAGAAGCT
  GGCGAAGAACCATGACATGGTGGTGGTGTCTCCCATCCTGNAACGAGACAGCGAGCATGG
  NGATGTTNTGTGGAATACAGCCGTGGTGATCTCCAATTCCGGAGCAGTCCTGNGAAAGAC
  CAGAANAAACCACANTCCCAGAGTGGGTGATTTCAACGAGTCAACTTACTACATGGAGGG
  GAAACCTGNGCCACCCCGTGTTCCANAACGCATTCNGAAAGGAATCGCGTGAAACATTTG
  CTACGGGCGGGCACACCCCCNTCACTGGCTTATGTACAGCATCAAACGGGGCTGAGATCA
  TTTTCAACCCTTCGNCCACCATAGGAGCACTCAGCCGAGTCCCTTGTGGGCCAT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_016327 unedited
  NNTTTTTGACTCATGCCCCGCGGNCCGCATNCTANGATCGAGTTTTTTTTTTTTTTTTTT
  TTTTTTTAGGGGATATATTGAGATTTATTGCAAGGAATTGACTTCAGTGATTGTAGGAGC
  TGGCTAGTCATGTCTAAACTCTGTGAGGCAGGCTATCAAAAGGGCAGACTGTCAGGAACT
  CTCGCCAAGCACTGGGCTGCTGTCCTCAGGCAGAATTTCTTCCTCAGGGAAACCCTTAGC
  TCTGTTCTTTAGGCCTTCTGACTAATCAGGTCAGGCTGACCCAGATTATCTGAGATAATC
  TCACTTACTTAGTCAATTGGGAATGGACTTCTGTCACATCTACAAAATACCTTCACAGAA
  ATACCTAGATTAGTGTCTGATTGAATTACTGGTGACTGTGGCCTAGCTAAGCTGACACAT
  CCAAAGACCATCCGACCCACCACAGCCTTGCTGTAGGCTCAGGGTCTCTGGATCAGCCCT
  CACCCTCTTCCCACTGGTGTACGGGATGGACAGCATCATCTGCCTAACCTCAAATCCACC
  TGCACAAGCAGTACCTGGGCATTTTTTTTTTTAGTTGAGGTAAAATTTACATAACAAACA
  TTCTGAAGTATACAAATTCAGTGGCATTTAGTACATTCACCTCTACCTAGTCCCCAAACA
  TTTCCAATACCCCAGAAGTAAGCAGCCCCTTACCCATTAAGAAGTCACTCCCCATGCCAC
  TCTCCCCCTGCCTGGGAATTNTAAAACCAACCTGGACAATGTTATTGGGGAAGAACCTGG
  ACATGTTAAGCCTGCCACACTTGCTAATCCACTGGGGCAGAGGTGTCTTCCTCACCCCAA
  AGCAGCACTGAAGCCGGCTACTCTTTCACGATGGTGGGGCTGTANTGGNACTTGACAGNN
  CTCGCGAAGCTCCGTGCGTACATCTCATACCT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_016327
• ORF Size: 1155 bp
• Insert Size: 2170
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_016327.2, NP_057411.1
• RefSeq Size: 2167
• RefSeq ORF: 1155
• Locus ID: 51733
• Domains: CN_hydrolase
• Protein Pathways: beta-Alanine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Pantothenate and CoA biosynthesis, Pyrimidine metabolism
• Gene Summary: This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity. [provided by RefSeq, Jul 2008]