CHCHD2 (NM_016139) Human Untagged Clone

CAT#: SC114478

CHCHD2 (untagged)-Human coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2), nuclear gene encoding mitochondrial protein


  "NM_016139" in other vectors (4)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

Product Images

Other products for "CHCHD2"

Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CHCHD2
Synonyms C7orf17; MIX17B; MNRR1; NS2TP; PARK22
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC114478 sequence for NM_016139 edited (data generated by NextGen Sequencing)
ATGCCGCGTGGAAGCCGAAGCCGCACCTCCCGCATGGCCCCTCCGGCCAGCCGGGCCCCT
CAGATGAGAGCTGCACCCAGGCCAGCACCAGTCGCTCAGCCACCAGCAGCGGCACCCCCA
TCTGCAGTTGGCTCTTCTGCTGCTGCGCCCCGGCAGCCAGGTCTGATGGCCCAGATGGCA
ACCACTGCAGCTGGCGTGGCTGTGGGCTCTGCTGTGGGGCACACATTGGGTCACGCCATT
ACTGGGGGCTTCAGTGGAGGAAGTAATGCTGAGCCTGCGAGGCCTGACATCACTTACCAG
GAGCCTCAGGGAACCCAGCCAGCACAGCAGCAGCAGCCTTGCCTCTATGAGATCAAACAG
TTTCTGGAGTGTGCCCAGAACCAGGGTGACATCAAGCTCTGTGAGGGTTTCAATGAGGTG
CTGAAACAGTGCCGACTTGCAAACGGATTGGCCTAA

Clone variation with respect to NM_016139.2
>OriGene 5' read for NM_016139 unedited
TGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCTTCGGTGGTTGTCCC
ACGTCCGGAGGCCTAGCCGTCGCTTACCTAGGATGCCGCGTGGAAGCCGAAGCCGCACCT
CCCGCATGGCCCCTCCGGCCAGCCGGGCCCCTCAGATGAGAGCTGCACCCAGGCCAGCAC
CAGTCGCTCAGCCACCAGCAGCGGCACCCCCATCTGCAGTTGGCTCTTCTGCTGCTGCGC
CCCGGCAGCCAGGTCTGATGGCCCAGATGGCAACCACTGCAGCTGGCGTGGCTGTGGGCT
CTGCTGTGGGGCACACATTGGGTCACGCCATTACTGGGGGCTTCAGTGGAGGAAGTAATG
CTGAGCCTGCGAGGCCTGACATCACTTACCAGGAGCCTCAGGGAACCCAGCCAGCACAGC
AGCAGCAGCCTTGCCTCTATGAGATCAAACAGTTTCTGGAGTGTGCCCAGAACCAGGGTG
ACATCAAGCTCTGTGAGGGTTTCAATGAGGTGCTGAAACAGTGCCGACTTGCAAACGGAT
TGGCCTAATGAAGAAGTTCAACCTGGAGAGATGGAAAATCAGCTCTCATAACTAAGTTAA
TTTAGTATAAAAATAGAATTGATAGTGAGGGTATAAAGTGTAACCATCAGTTAAACCTCT
CCTGTCATTCCTGGCTTCCTTTGCTCAGAATTGAAATGGAAGTGGGGGGTGCCCNTACTC
TGTANAATCTGGGACTGGGCANATGGTTGTGTGGCCTCCNTAAACTAGCTGGTATGGTAT
GATTNTATNCTTTTGGGAGTTAAATAGAAATAAGTCATTNTCTTNCCAGGTATGGGNTTA
AAAAAAAAAAAAAAACTCGACTCTAGATTGCGGCCGCGGTCATAGCTGTTTCCTGAACAG
ATCCCGGGTGGGATC
>OriGene 3' read for NM_016139 unedited
GGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTAACCATACCTTGGAAGAAAAT
GACTTTATTCTAATTAACTCACAAAGAATAAAATCATAACATAACAGCTAGTTTAAGGAG
GCCACACAAACATTTGCCCAGTCCCAGATTCTACAGAGTAGGGACACCCCCACTTCCATT
TCAATTCTGAAGCAAGGAAGCCAGGAATGACAGGAGAGGTTTAACTGATGGTTACACTTT
ATACCCTCACTATCAATTCTATTTTTATACTAAATTAACTTAGTTATGAGAGCTGATTTT
CCATCTCTCCAGGTTGAACTTCTTCATTAGGCCAATCCGTTTGCAAGTCGGCACTGTTTC
AGCACCTCATTGAAACCCTCACAGAGCTTGATGTCACCCTGGTTCTGGGCACACTCCAGA
AACTGTTTGATCTCATAGAGGCAAGGCTGCTGCTGCTGTGCTGGCTGGGTTCCCTGAGGC
TCCTGGTAAGTGATGTCAGGCCTCGCAGGCTCAGCATTACTTCCTCCACTGAAGCCCCCA
GTAATGGCGTGACCCAATGTGTGCCCCACAGCAGAGCCCACAGCCACGCCAGCTGCAGTG
GTTGCCATCTGGGCCATCAGACCTGGCTGCCGGGGCGCAGCAGCAGAAGAGCCAACTGCA
GATGGGGGTGCCGCTGCTGGTGGCTGANCGACTGGTGCTGGCCTGGGTGCAGCTCTCATC
TGAGGGGCCCNNGCTGCCGNAGGGGCATGCNGGAGGTGCGGCTTCGGCTCCCGCGGCATC
CTAGTAAGCGACGGCTAGGCCTCCGGACGTGGGACACCCACCGAAGCCTCGTGCCGATTC
CGGGCGCCCTATATGAGTCGTATACAAATTCTGAGGGTCACTAACGAGCTTGCTATATAG
ACCTCCACGTACAGCCTACCGGCATNGCGTAACGGGCCGGGTATTACAACTTTGGAAGGC
CGCTGATTGGGGCCAAAAACTCCTGGAGN
Restriction Sites NotI-NotI     
ACCN NM_016139
ORF Size 456 bp
Insert Size 840
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Reference Data
RefSeq NM_016139.2, NP_057223.1
RefSeq Size 831
RefSeq ORF 456
Locus ID 51142
Domains DUF657
Gene Summary The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1.

Other Versions

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.