S2P (MBTPS2) (NM_015884) Human Untagged Clone

CAT#: SC114571

MBTPS2 (untagged)-Human membrane-bound transcription factor peptidase, site 2 (MBTPS2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MBTPS2
• Synonyms: BRESEK; IFAP; KFSD; KFSDX; OI19; OLMSX; S2P
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC114571 sequence for NM_015884 edited (data generated by NextGen Sequencing)
  ATGATTCCGGTGTCGCTGGTGGTGGTGGTGGTGGGTGGCTGGACTGTCGTCTACCTGACC
  GACTTGGTGCTGAAGTCATCTGTCTATTTTAAACATTCTTATGAAGACTGGCTGGAAAAC
  AACGGACTGAGCATCTCCCCTTTCCACATAAGATGGCAAACTGCTGTTTTCAATCGTGCC
  TTTTACAGTTGGGGACGGCGGAAAGCAAGGATGCTTTACCAATGGTTCAATTTTGGAATG
  GTGTTTGGCGTAATTGCCATGTTTAGCTCATTTTTTCTCCTTGGAAAAACGCTGATGCAG
  ACTTTGGCACAAATGATGGCTGACTCTCCCTCTTCTTATTCTTCCTCCTCTTCTTCCTCT
  TCCTCCTCTTCTTCCTCTTCCTCTTCTTCATCTTCTTCCTCTTCCTCGCTTCACAATGAA
  CAGGTGTTACAAGTTGTGGTTCCTGGTATAAATTTACCCGTCAATCAACTGACCTATTTC
  TTCACGGCAGTTCTCATTAGTGGTGTTGTACATGAAATTGGACATGGGATAGCAGCTATT
  AGGGAACAAGTTCGATTTAATGGCTTTGGGATTTTTCTCTTCATTATTTATCCTGGAGCA
  TTTGTTGATCTGTTCACCACTCATTTGCAACTTATATCGCCAGTCCAGCAGCTAAGGATA
  TTTTGTGCAGGTATCTGGCATAATTTTGTCCTTGCACTCTTGGGTATTTTAGCTCTTGTT
  CTCCTCCCAGTAATTCTCTTGCCATTTTACTACACTGGAGTTGGGGTGCTCATCACTGAA
  GTTGCTGAGGACTCTCCTGCCATTGGACCCAGAGGCCTTTTTGTGGGAGACCTTGTCACC
  CATCTACAGGATTGTCCTGTTACTAATGTGCAAGATTGGAATGAATGTTTAGATACCATC
  GCCTATGAGCCCCAAATTGGTTACTGTATAAGTGCATCAACTTTACAGCAGTTAAGTTTC
  CCAGTTAGAGCATACAAACGACTAGATGGTTCAACTGAATGCTGTAACAATCACAGCCTC
  ACAGATGTGTGCTTTTCCTACAGAAATAATTTTAATAAGCGTTTGCATACATGTCTTCCT
  GCCCGGAAAGCAGTTGAAGCAACTCAAGTTTGCAGAACCAATAAAGACTGTAAAAAAAGC
  TCAAGTTCAAGTTTCTGTATAATACCTTCTTTGGAAACTCACACTCGCTTAATAAAAGTA
  AAACACCCACCTCAGATTGATATGTTATACGTAGGACATCCTCTGCATCTTCACTACACA
  GTGAGCATCACCAGTTTTATCCCACGTTTTAACTTTCTAAGCATAGATCTGCCAGTGGTT
  GTGGAGACATTTGTCAAGTACCTGATTTCCCTCTCAGGAGCTCTGGCTATTGTTAATGCA
  GTACCCTGCTTTGCTTTGGATGGACAATGGATTCTAAACTCTTTCTTGGATGCCACCCTT
  ACCTCAGTGATTGGAGACAATGATGTCAAAGATCTAATAGGGTTTTTCATCTTGCTGGGT
  GGCAGTGTACTTTTGGCTGCCAATGTGACCCTGGGACTCTGGATGGTTACAGCACGGTAA
  
  Clone variation with respect to NM_015884.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_015884 unedited
  TACGACTCCTATAGGCGGCCGCGACTTCGGCACGAGGGCTGGGGCTGTAAGGCGCGCGCG
  GTCAGCTGTTGGCGGTGCAGGGAGGAAGACGCCGGGGCTCGCCTTCCCTCCTCTGCCGCC
  GCTGCCGCCATGATTCCGGTGTCGCTGGTGGTGGTGGTGGTGGGTGGCTGGACTGTCGTC
  TACCTGACCGACTTGGTGCTGAAGTCATCTGTCTATTTTAAACATTCTTATGAAGACTGG
  CTGGAAAACAACGGACTGAGCATCTCCCCTTTCCACATAAGATGGCAAACTGCTGTTTTC
  AATCGTGCCTTTTACAGTTGGGGACGGCGGAAAGCAAGGATGCTTTACCAATGGTTCAAT
  TTTGGAATGGTGTTTGGCGTAATTGCCATGTTTAGCTCATTTTTTCTCCTTGGAAAAACG
  CTGATGCAGACTTTGGCACAAATGATGGCTGACTCTCCCTCTTCTTATTCTTCCTCCTCT
  TCTTCCTCTTCCTCCTCTTCTTCCTCTTCCTCTTCTTCATCTTCTTCCTCTTCCTCGCTT
  CACAATGAACAGGTGTTACAAGNTTGTGGTTCCTGGTATAAATTTACCCGTCAATCAACT
  GACCTATTTCTTCACGGCAGTTCTCATTAGTGGGTGTNGTACATGAANATGGACATGGGA
  TAGCAGCTATTAGGGAACAAGTTCGATTTAATGGCTTTGGGGATTTTTCTCTTATTATTT
  ATCCTGGAGCATTTNGTGGATCTGTTCACCACTCATTTGCACTTATATTCGCAGTCCAGC
  ACTAAGATAATTTGTGCAGTATCTGCATAATTTTGTCCTGACTCTGGGGAATTTAGCTTT
  GGTCTCTCCAGAATTCTTTGCATTTAAACTGGAGAGGGGGGGCCATACTGAGTGCTGAGG
  ACTTCTCCTTGACAAGCCTTTTTGGGAAAACTTACCCTTCAAGATGTCTGTCTATGGGAG
  ATGGAAAAGGTTAACCCCA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_015884 unedited
  CCAAATTGTGTGTATTGACCCCATATAACGCTTTAATTAAAAACATGCTTAGTTCATGCA
  ATCAAATTAATTATATAAGTATTTCATGGCATTCTCCAGCTCTATACTTGAACAGGTCTG
  ACTGAGCATTACTATGCTAATGTACTCTGATCCCAAATGATTGTCTACCTAAAAATAGAA
  CAAATACTGTATTTTCTGGAATAAACCAATAATTTTTATGGTTTTAGTACTGGTATTAAC
  TGATGACCCAAGTCATTAATAAAATGTTAAAATTATATTCAACATCTAATTACTGTTAAG
  GCAAATTTGTAATACAATCTAAAAAGTTTCTTAAAAATGATTAAAAAGTTTTAGTGCTTA
  CAGAGCAACTCAATAATCTGAAAAAGGTAACCCCATGGAATACATCACTCAGTAAAGAAG
  TTGGATAGATGGCTATTAATGAGTTATTGCCCTTAGTCACTTCTGAGTATACAAGAGAAG
  CATGTATTTTCCATCAAAGAAACAGCAAGCTCATATACTCCTAGGACCAATAGCTTCACA
  CTGGCCTGCTGACTCCCCAAATTTCCCAGGGCTGCATCTCCACTCCAAAAGACCTCAAAG
  CAGGCGTGGCTCTTCTGGGCTCAAGAATCAGTTCCCAAGCCCTGGAAAATCCACGTGTGT
  ACTCACGTATAGCCATTCTCACTATACTACCAAGTCTTCTGTGGACCCAGAGAGGTAGCT
  TAGGAGAGAGACAGAANAACAGGACTAGGTACTTAATAACCTGACACAGGAAAACATGGG
  AGCCGCTGGTGAGGACAGAGTATGGCTCAGAGTTTAAGGTCATTGCTTCTTGGAGACAGA
  AACCCAGNAGCTAGGCCCCAGATGTCCTGAGCAGCACAGGAAAGATGTTTACCCTGGAAG
  GTTTCCN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_015884
• ORF Size: 1560 bp
• Insert Size: 3000
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_015884.1, NP_056968.1
• RefSeq Size: 1759
• RefSeq ORF: 1560
• Locus ID: 51360
• Domains: Peptidase_M50
• Protein Families: Druggable Genome, Protease, Transmembrane
• Gene Summary: This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response. [provided by RefSeq, Aug 2009]