MAN1 (LEMD3) (NM_014319) Human Untagged Clone

CAT#: SC115036

LEMD3 (untagged)-Human LEM domain containing 3 (LEMD3), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LEMD3
• Synonyms: MAN1
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_014319, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTCCGCCGTT
  ACGGCCTGTCTCCCGGACCAGTGACGGAGAGCACCCGCCCGGTCTACCTCAAGAAGCTGAAGAAGCTTCG
  AGAGGAAGAGCAGCAACAGCACCGGTCAGGGGGCCGCGGCAACAAGACGCGGAACAGTAATAACAATAAC
  ACGGCAGCCGCCACGGTCGCAGCCGCGGGACCAGCGGCGGCGGCGGCCGCGGGGATGGGGGTCCGGCCGG
  TCTCGGGCGACCTCTCCTACTTACGGACTCCTGGGGGCCTGTGCCGAATCTCGGCCTCTGGCCCAGAGAG
  CCTCCTGGGAGGGCCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGC
  TCGGACGAGTCGGACGTGGAGGCCAGTCCCCGGGACCAGGCCGGCGGCGGCGGGAGGAAAGACCGGGCTT
  CGCTCCAGTACCGCGGGCTCAAAGCGCCGCCGGCGCCCCTGGCCGCCAGCGAGGTGACTAACAGCAACTC
  TGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGGCCGGCGGGCCCCGAGCTGCAGACCCCG
  CCGGGGAAAGATGGAGCAGTGGAGGACGAGGAAGGGGAGGGAGAGGACGGTGAGGAGAGGGACCCGGAGA
  CCGAGGAGCCGCTCTGGGCGAGCCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGGAAAA
  CTATTCGGACTCAGAGGAAGAGGACGACGACGACGTGGCCTCCAGCAGACAGGTATTAAAGGACGACTCC
  CTTTCCCGGCATCGGCCCAGACGAACCCATAGTAAGCCTCTCCCCCCGCTGACTGCTAAATCGGCCGGCG
  GCAGGCTGGAGACTTCAGTTCAGGGAGGGGGAGGACTCGCGATGAATGACAGGGCGGCGGCTGCCGGGAG
  TCTAGACAGGAGCCGAAACCTCGAAGAGGCGGCGGCCGCGGAGCAGGGAGGAGGGTGTGATCAAGTGGAC
  TCCAGCCCCGTTCCTAGATACCGTGTTAACGCTAAGAAACTGACCCCTCTCCTGCCCCCGCCACTTACTG
  ACATGGACTCAACCTTGGATTCGTCAACAGGCTCCCTTCTGAAAACCAATAATCATATTGGCGGTGGGGC
  CTTCAGTGTGGACTCCCCCAGGATTTATTCTAACAGTCTCCCTCCCAGTGCGGCGGTGGCCGCCTCTAGT
  TCACTCAGGATCAATCACGCCAATCATACGGGCTCCAATCATACCTACCTGAAAAACACATACAACAAAC
  CGAAGCTTTCCGAACCCGAAGAGGAACTTCTCCAGCAATTTAAACGGGAGGAGGTGTCCCCAACAGGGAG
  TTTCAGTGCCCACTACTTGTCGATGTTTCTCTTAACTGCTGCCTGCTTATTTTTCCTAATACTGGGACTG
  ACTTACCTAGGAATGAGAGGGACAGGAGTATCTGAGGATGGAGAACTCAGCATAGAAAACCCCTTTGGTG
  AAACATTTGGAAAAATACAAGAAAGTGAAAAAACTCTTATGATGAACACATTATATAAGCTTCATGATCG
  ATTGGCACAGCTTGCAGGAGATCATGAATGTGGCAGTTCTAGTCAAAGAACGCTTTCTGTTCAAGAGGCA
  GCTGCGTATTTAAAAGATTTAGGTCCTGAATATGAAGGTATATTTAACACTTCATTGCAGTGGATCTTAG
  AAAATGGAAAAGATGTTGGAATAAGGTGTGTTGGTTTTGGCCCTGAGGAAGAATTGACAAATATAACTGA
  TGTGCAGTTTTTACAGTCCACAAGACCACTGATGTCTTTTTGGTGTCGTTTTCGACGTGCTTTTGTTACT
  GTAACTCACAGATTATTGTTGTTATGCTTAGGTGTAGTGATGGTTTGTGTCGTTCTGCGTTACATGAAAT
  ATCGATGGACAAAAGAAGAGGAGGAAACAAGGCAGATGTATGATATGGTGGTAAAGATTATAGATGTTTT
  ACGAAGTCATAATGAAGCCTGCCAGGAAAACAAAGATTTACAACCTTACATGCCTATTCCACATGTACGC
  GATTCCTTAATACAGCCTCATGACAGGAAAAAAATGAAGAAAGTCTGGGATAGAGCTGTTGACTTCCTTG
  CTGCTAATGAGTCTAGAGTTCGCACGGAAACACGAAGAATAGGTGGTGCAGATTTTCTGGTTTGGCGGTG
  GATCCAGCCTTCTGCATCCTGTGACAAAATATTAGTTATACCTTCTAAAGTATGGCAAGGTCAAGCATTT
  CATTTAGATAGAAGAAATTCACCACCAAATAGTTTGACACCGTGTCTAAAGATTCGGAATATGTTTGATC
  CCGTTATGGAAATAGGGGATCAGTGGCATTTGGCAATTCAAGAAGCAATTTTAGAAAAATGCAGTGATAA
  TGATGGCATTGTTCACATTGCAGTAGACAAAAATTCACGTGAGGGTTGTGTATATGTTAAATGTCTGTCT
  CCAGAATATGCTGGAAAGGCTTTTAAAGCATTGCATGGCTCTTGGTTTGATGGGAAATTGGTTACAGTAA
  AATATTTACGACTAGATAGATACCACCATCGCTTTCCCCAGGCTCTCACTTCCAACACTCCATTGAAGCC
  ATCAAATAAACATATGAACTCCATGTCTCATCTTCGTCTTCGGACTGGCCTAACCAATTCTCAAGGAAGT
  TCCTGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_014319 unedited
  NGGGTCGGAATTTGTATACGACTCCTATAGGGCGGCCGCGATTCGGCACGAGGAGAAAAG
  GCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTC
  CGCCGTTACGGCCTGTCTCCCGGACCAGTGACGGAGAGCACCCGCCCGGTCTACCTCAAG
  AAGCTGAAGAAGCTTCGAGAGGAAGAGCAGCAACAGCACCGGTCAGGGGGCCGCGGCAAC
  AAGACGCGGAACAGTAATAACAATAACACGGCAGCCGCCACGGTCGCAGCCGCGGGACCA
  GCGGCGGCGGCGGCCGCGGGGATGGGGGTCCGGCCGGTCTCGGGCGACCTCTCCTACTTA
  CGGACTCCTGGGGGCCTGTGCCGAATCTCGGCCTCTGGCCCAGAGAGCCTCCTGGGAGGG
  CCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGCTCG
  GACGAGTCGGACGTGGAGGCCAGTCCCCGGGACCAGGCCGGCGGCGGCGGGAGGAAAGAC
  CGGGCTTCGCTCCAGTACCGCGGGCTCAAAGCGCCGCCGGCGCCCCTGGCCGCCAGCGAG
  GTGACTAACAGCAACTCTGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGG
  CCGGCGGGCCCCGAGCTGCAGACCCCGCCGGNGAAAGATGGAGCAGTGGAGGACGAAGGA
  AGGGGAGGGAGAGGACGGTGAGGAGAGGGACCCGGNAGACCGAGAGCCGCTCTGGGCGAG
  CCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGNGAAACTATTCGNACTC
  AGAGGAAAGAGACGACGACGACGTGGCCTTCAGCAGACAGGTATTAAAGGACGACTNCCT
  TTTCCGGNCATCGNCCAGACGAN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_014319 unedited
  ATTTGGCCGCGGCCGCAATCTANGATCGAGTTTTTTTTTTTTTTTTTTTTTTTAAAACTA
  ATAAATTTTTAATTAGAATTTTTTCCTTTTTTTAACAGGACAAGTAACAGATTACATCAA
  ACTTCAGAACTTCTCAAATACCTAGTTATTATACACATTCCCATCTGTCTTGCAAGGAGG
  GATCTTGGTCGGCTTAACAGTTTCAGGTAAAATAAGCTGCATAATAGTATATATTACAAT
  AATAAATGTACAATGTTTACATGAAATATGTTTTAGAAGCAAGAAAAAGATGCATCTGCA
  TCAAAGGCGACCTTTTAAAATGCCACAACTATTTTTTACATTCACTCTTGCAACAGGTTA
  CAAGATGGGGGTCACTAAGCTCAGATAAATCACTATGATGCACATAAAATACAGGAAGAC
  TGGTTACTTTATATATTATATATATTTATATTTTCACACGTTAGCATCTGAGACATAAAC
  TGAGAATTTAAAATTTATTCTCTTCAGATAACAAATCATTTTTTATTCTTCATAAACAAG
  GTGCCCACAAAAGCACACAGGTAAGGCACAATAGGGCTTTCTGTTACAGAATAGTGTGCA
  TCATGTTTACTTAACCAGAAAACGTGCATTATCTGTGCAAGTTCATGCTGCAAACCCAAC
  GCATACAATAAAACAAAAAGGAAACTGAGCTTTAAATACAACCAAAATTTGTACAATTCC
  AGCTGTTTCACATATTCATTTGGACTGANCATTATATATCAACAGGTTATTTTTAAAAGC
  CAATTGTAGATTACAAGTAAAATTTACTCAGCAACTATTTTTATCCTGAATCATAAACAG
  TNNATAAGTAAGTTTACTGAAACAAATTAATACTTGAGCACANAGCACAGTCCATCGTGC
  ATTTACTATATTGCAAACTTTATGACCCCAAATGCAAGTTAATTTGTCAAAACACATTTG
  CTGAA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_014319
• ORF Size: 2736 bp
• Insert Size: 4140
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_014319.3, NP_055134.2
• RefSeq Size: 4785
• RefSeq ORF: 2736
• Locus ID: 23592
• Domains: LEM
• Protein Families: Transmembrane
• Gene Summary: This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis. [provided by RefSeq, Nov 2009]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).