Dysadherin (FXYD5) (NM_014164) Human Untagged Clone

CAT#: SC115114

FXYD5 (untagged)-Human FXYD domain containing ion transport regulator 5 (FXYD5), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: FXYD5
• Synonyms: DYSAD; HSPC113; IWU1; KCT1; OIT2; PRO6241; RIC
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC115114 sequence for NM_014164 edited (data generated by NextGen Sequencing)
  ATGTCGCCCTCTGGTCGCCTGTGTCTTCTCACCATCGTTGGCCTGATTCTCCCCACCAGA
  GGACAGACGTTGAAAGATACCACGTCCAGTTCTTCAGCAGACGCAACTATCATGGACATT
  CAGGTCCCGACACGAGCCCCAGATGCAGTCTACACAGAACTCCAGCCCACCTCTCCAACC
  CCAACCTGGCCTGCTGATGAAACACCACAACCCCAGACCCAGACCCAGCAACTGGAAGGA
  ACGGATGGGCCTCTAGTGACAGATCCAGAGACACACAAGAGCACCAAAGCAGCTCATCCC
  ACTGATGACACCACGACGCTCTCTGAGAGACCATCCCCAAGCACAGACGTCCAGACAGAC
  CCCCAGACCCTCAAGCCATCTGGTTTTCATGAGGATGACCCCTTCTTCTATGATGAACAC
  ACCCTCCGGAAACGGGGGCTGTTGGTCGCAGCTGTGCTGTTCATCACAGGCATCATCATC
  CTCACCAGTGGCAAGTGCAGGCAGCTGTCCCNNNNNNGCCGGAATCATTGCAGGTGA
  
  Clone variation with respect to NM_014164.5
  103 t=>g;512 g=>n;513 g=>n;514 t=>n;515 t=>n;516 a=>n;517 t=>n;527 g=>a
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_014164 unedited
  GGNCGGAACGCCCAATTCGCACGAGGCGCAGCAGCCACCGCCGCGTCCCTCTCTCCCGAG
  GCTGCCGGCTTAGGACCCCCAGCTCCGACATGTCGCCCTCTGGTCGCCTGTGTCTTCTCA
  CCATCGTTGGCCTGATTCTCCCCACCAGAGGACAGACGTTGAAAGATACCACGTCCAGTT
  CTTTTTTTTTCTCAACTATCATGGACATTCAGGTCCCGACACGAGCCCCAGATGCAGTCT
  ACACAGAACTCCAGCCCACCTCTCCAACCCCAACCTGGCCTGCTGATGAAACACCACAAC
  CCCAGACCCAGACCCAGCAACTGGAAGGAACGGATGGGCCTCTAGTGACAGATCCAGAGA
  CACACAAGAGCACCAAAGCAGCTCATCCCACTGATGACACCACGACGCTCTCTGAGAGAC
  CATCCCCAAGCACAGACGTCCAGACAGACCCCCAGACCCTCAAGCCATCTGGTTTTCATG
  AGGATGACCCCTTCTTCTATGATGAACACACCCTCCGGAAACGGGGGCTGTTGGTCGCAG
  CTGTGCTGTTCATCACAGGCATCATCATCCTCACCAGTGGCAAGTGCAGGCAGCTGTCCC
  GGTTATGCCGGAATCATTGCAGGTGAGTCCATCAGAAACAGGAGCTGACAACCTGCTGGG
  CACCCGAAGACCAAGCCCCCTGCCAGCTCACCGTGCCCAGCCTCCTGCATCCNCTCGAAG
  AGCCTGGCCAGAGAGGGAAGACACAGATGATGAAGCTGGAGCCCAGGCTGCCGGTCCGAG
  TCTCCTACCTCCCCCAACCTGCCCGCCCCTGAAAGCTACCTGGCGCCTTGGGGCTGTCCC
  TCAGTTATCTCCT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_014164 unedited
  CCAGTGGCTTTTNACCTTTTTGTNNCTTANCAGNAGGANATAACTTGNAGGGNNACAGCC
  CCCAAGGCGCCAGGTAGCCTTCAGGGGCGGGCAGGGTTGGGGGAGGTAGGAGACTCGGAC
  CGGCAGCCCTGGCTCCAGCTTCATCATCTGTGTCTTCCCTCTCTGGCCAGGCTCTTCGAG
  GGGATGCAGGAGGCTGGGCACGGTGAGCTGGCAGGGGGCTTGGTCTTCGGGTGCCCAGCA
  GGTTGTCAGCTCCTGTTTCTGATGGACTCACCTGCAATGATTCCGGCATAACCGGGACAG
  CTGCCTGCACTTGCCACTGGTGAGGATGATGATGCCTGTGATGAACAGCACAGCTGCGAC
  CAACAGCCCCCGTTTCCGGAGGGTGTGTTCATCATAGAAGAAGGGGTCATCCTCATGAAA
  ACCAGATGGCTTGAGGGTCTGGGGGTCTGTCTGGACGTCTGTGCTTGGGGATGGTCTCTC
  AGAGAGCGTCGTGGTGTCATCAGTGGGATGAGCTGCTTTGGTGCTCTTGTGTGTCTCTGG
  ATCTGTCACTAGAGGCCCATCCGTTCCTTCCAGTTGCTGGGTCTGGGTCTGGGGTTGTGG
  TGTTTCATCAGCAGGCCAGGTTGGGGTTGGAGAGGTGGGCTGGAGTTCTGTGTAGACTGC
  ATCTGGGGCTCGTGTCGGGACCTGAATGTCCATGATAGTTGCGTCTGCTGAAGACTGGAC
  GTGGTATCTTTCAACGTCTGTCCTCTGGTGGGGAGAATCACGCCAACGATGGTGAGAAGA
  CACAGGCGACCAGAGGGCGACATGTNCGAGCTGGGGGTCCTAANCCCGCCACCTCNTGGA
  GAGAGGGACCCGCNNGTGCTGCTGCCCCTCCTGCCGAATCGCGGCCGCCCTATATGAGTC
  GTANACAAAATTCTGCNGGTTCACTAACCGGCTCTGCTTATATAGACTCCCACCGTAACG
  CTACCGCCATTTGCGTAACGGGCGGGGTATACGACTTTGGAAAGTCGTGGTTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_014164
• ORF Size: 537 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_014164.4, NP_054883.3
• RefSeq Size: 890
• RefSeq ORF: 537
• Locus ID: 53827
• Domains: ATP1G1_PLM_MAT8
• Protein Families: Druggable Genome, Ion Channels: Other, Transmembrane
• Gene Summary: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009]
  Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.