MKRN1 (NM_013446) Human Untagged Clone

CAT#: SC115218

MKRN1 (untagged)-Human makorin ring finger protein 1 (MKRN1), transcript variant 1


  "NM_013446" in other vectors (6)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol MKRN1
Synonyms RNF61
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_013446 edited
GAATTCGGCACGAGGGTAATGGCGGAGGCTGCAACTCCCGGAACAACAGCCACAACATCA
GGAGCAGGAGCGGCAGCGGCGACGGCGGCAGCAGCCTCCCCCACCCCGATCCCCACAGTC
ACCGCCCCGTCCCTGGGGGCGGGCGGAGGGGGCGGCGGCAGCGACGGCAGCGGCGGCGGC
TGGACTAAACAGGTCACCTGCAGGTATTTTATGCATGGGGTTTGTAAGGAAGGAGACAAC
TGTCGCTACTCGCATGACCTCTCTGACAGTCCGTATAGTGTAGTGTGCAAGTATTTTCAG
CGAGGGTACTGTATTTATGGAGACCGCTGCAGATATGAACATAGCAAACCATTGAAACAG
GAAGAAGCAACTGCTACAGAGCTAACTACAAAGTCATCCCTTGCTGCTTCCTCAAGTCTC
TCATCGATAGTTGGACCACTTGTTGAAATGAATACAGGCGAAGCTGAGTCAAGAAATTCA
AACTTTGCAACTGTAGGAGCAGGTTCAGAGGACTGGGTGAATGCTATTGAGTTTGTTCCT
GGGCAACCCTACTGTGGCCGTACTGCGCCTTCCTGCACTGAAGCACCCCTGCAGGGCTCA
GTGACCAAGGAAGAATCAGAGAAAGAGCAAACCGCCGTGGAGACAAAGAAGCAGCTGTGC
CCCTATGCTGCAGTGGGAGAGTGCCGATACGGGGAGAACTGTGTGTATCTCCACGGAGAT
TCTTGTGACATGTGTGGGCTGCAGCTCCTGCATCCAATGGATGCTGCCCAGAGATCGCAG
CATATCAAATCGTGCATTGAGGCCCATGAGAAGGACATGGAGCTCTCATTTGCCGTGCAG
CGCAGCAAGGACATGGTGTGTGGGATCTGCATGGAGGTGGTCTATGAGAAAGCCAACCCC
AGTGAGCGCCGCTTCGGGATCCTCTCCAACTGCAACCACACCTACTGTCTCAAGTGCATT
CGCAAGTGGAGGAGTGCTAAGCAATTTGAGAGCAAGATCATAAAGTCCTGCCCAGAATGC
CGGATCACATCTAACTTTGTCATTCCAAGTGAGTACTGGGTGGAGGAGAAAGAAGAGAAG
CAGAAACTCATTCTGAAATACAAGGAGGCAATGAGCAACAAGGCGTGCAGGTATTTTGAT
GAAGGACGTGGGAGCTGCCCATTTGGAGGGAACTGTTTTTACAAGCATGCGTACCCTGAT
GGCCGTAGAGAGGAGCCACAGAGACAGAAAGTGGGAACATCAAGCAGATACCGGGCCCAA
CGAAGGAACCACTTCTGGGAACTCATTGAGGAAAGAGAGAACAGCAACCCCTTTGACAAC
GATGAAGAAGAGGTTGTCACCTTTGAGCTGGGCGAGATGTTGCTTATGCTTTTGGCTGCA
GGTGGGGACGACGAACTAACAGACTCTGAAGATGAGTGGGACTTGTTTCATGATGAGCTG
GAAGATTTTTATGACTTGGATCTATAGCAACCTTGCGTGGCGTGTGAACTGGTCTGCTGA
CCTCAGACAGCAGCTGTCCCCTGTGGTGGTGTGGCAGTGCCTGTGTTCTCTCCTAGGCAG
GCCTCTCAACTCCAGGTGCTGTCCTAAGAATTTTTACCCAGGGCCTGTCTTCTCAACCCC
TCACCTTTCCCTGAGGAGTGTGTTGTTTTCCCTGTTGAAAAAAGTTACAAAAATAAATCT
TAAAGTTAGTTTTTTGTAACACGAATTTAACTGTCAGACAGTTAGTGTAGGTGTGTTGCG
TCATCTGTTTTCAACCAGATTGCATTTATGGACTTTTCACACACTCATTTTGAGGACCCC
AGGTTCAAAAGTAAAAGCAGTGGCCCTGCTTTGGGGTCCAAGAATAGGAGTGATGGGTGA
AGGGACCTAAGCTGGCCAATAGCCCTCTGCCCCAGACATGGGATGTGGATCCTTGAGGTT
TCTGGTGAAATCTGCACATCTGTGTTTTTATATCTGTTCCCTACCCTGTAATCCCTACCA
CGTGCACTTGTTCTGTGGTTTTGGTCTCTTGTTTAATTGCACACAAGTAATACTACTGGG
TAACCAGAATCAGGTGTGAATGTGTTGAGATTTTTTACTGTTTTGCATGATAGGAAAATT
GAGAAAGAATACGTATAAAAGATAGAGAGGCATAACATCAATGCAGAGTTGGAAGTTGGC
TCCCAAGGGCTGACATGGTGTGAGTGTGTGGGTGTGTGATAAGCTTCTCATCCCTGCATA
GATGCAGTATTCTTAGCCTTAGTAGAAAAACCTGGTTTAGTGGTTTAAGCCTTGTGTGGC
AGATAGATCTTAAAGGGCAAAGCAGTATATTGGTAGTTGTCAATATAGCAGTGCTAGCTC
TGTCTATATAAATAGAGAAATGGGGTTAGCCATAGAGGTTAAAACTACCTGGTTATCCCA
TATAATAACACAAACTGGGTCTTGGATACACAGTTGTATTTAATGTTTTACGATCTAGCC
TTTCCAGTACAGGCACTTTCTGAGAAACCTTTGTCCTCACTTGAGGCATTTTGTTGTCGG
GTTTTTGTGTTTGTTTTTGTGGGTATTTGCCTCATTCCACCCCTGAGCTTTCAGGTAGAC
AGACGTGATTCAAAACTCTGTTCTAAGGTGTTTATTGTAGTGGAGTAATGGGTTTGCAGT
GATAAGTCATACTTTTCCACCGAAAGGGAGGGCTTGGGAATCCCTGAGATTAGCTAAAGT
TAAGTTGTTGGAAGAATTCCTTGATTGGAAATTGTACCTTTGTGTTTTGTTGCTCTGTTT
CCTGAAAATAACTCGGGGATGCTCCTGGTTTGTCCATCTACTGCTTTGATTCCTTGGATC
CCACCCATTCTTTCACTTTAAGAAAAAACAAATAATTGTTGCAGAGGTCTCTGTATTTTG
CAGCTGCCCTTTTGTAAGAAGCACTTTTCCCAAATAAAACAATTAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAACTCGAC
>OriGene 5' read for NM_013446 unedited
GGGTTTAAATTTGTAAACGACTCATATAGGCGGCCCGCGAATCGGCAGGAGGGTAATGGC
GGAGGCTGCAACTCCCGGNACAACAGCCACAACATCAGGAGCAGGAGCGGCAGCGGCGAC
GGCGGCAGCAGCCTCCCCCACCCCGATCCCCACAGTCACCGCCCCGTCCCTGGGGGCGGG
CGGAGGGGGCGGCGGCAGCGACGGCAGCGGCGGCGGCTGGACTAAACAGGTCACCTGCAG
GTATTTTATGCATGGGGTTTGTAAGGAAGGAGACAACTGTCGCTACTCGCATGACCTCTC
TGACAGTCCGTATAGTGTAGTGTGCAAGTATTTTCAGCGAGGGTACTGTATTTATGGAGA
CCGCTGCAGATATGAACATAGCAAACCATTGAAACAGGAAGAAGCAACTGCTACAGAGCT
AACTACAAAGTCATCCCTTGCTGCTTCCTCAAGTCTCTCATCGATAGTTGGACCACTTGT
TGAAATGAATACAGGCGAAGCCTGAGTCAAGAAATTCAAACTTTGCAACTGTAGGAGCAG
GTTCAGAGGACTGGGTGAATGCCTATTGAGTTTGTTCCTGTGCAACCCTACTGTGGCCGT
ACTGCGCCTTCCTGCACTGAAGCACCCCTGCAGGGCCTCACTGACCACAGGAAGAATCAG
AGAAAGAGCAAACCCGCCGCTGGAGACCAAAGAACCAGCTGTGCCCCCTCATGCTGCAGT
GGGGAGAGTGCCCGATACCCGGGAGAACTGTGTGCATCTCCACGGCAGATTCTTGTGAAC
ATGTGTGGGGCTGCAGGTCCTGCATTCCAAGGGATGCTGCCCCAAAGACCGCAGCATCAT
CAAATCCTGCATTGAAGCCCCATGAGAAAGACATGAAGCCCTCATTTGCCCGGGCACAGC
ACCAAGCACAGGGA
>OriGene 3' read for NM_013446 unedited
CGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTAATCGTTTTATTTGGGAAAAAGTGCTTCTTACAAAAGGGCAGCTGCAAAATACAAA
AACCTCTGCAACAATTATTTGTTTTTTCTTAAAGGGAAAAAATGGGTGGGATCCAAGGAA
TCAAAGCAGTAGATGGACAAACCAGGAGCCTCCCCGAGTTATTTTCAGGAAACAGACCAA
CAAAACACAAAGGTCCAATTCCCAATCAAGGAATTCTTCCAACAACTTAACTTTATCTAA
TCTCAGGGATTCCCAACCCCTCCCTTTCGGTGGAAAAGTATGACTTATCACTGCAAACCC
ATTACTCCACTACAATAAACACCTTAAAACAAAGCTTTGAATCACGTCTGTCTACCTGAA
CGCCTAGGGGCGGCATGAGGCAAATCCCCACCAAACCAAACACAAAAACCCCACCACAAA
ATGCCTTAAGCGAGGACAAAGGTTTCCCAAAAAGTGCCTGTCCTGCAAAGGCCTACACCC
CAAAACCTTAAACACAACTGGGTTTTCAAAACCCCATTTGTGCTATCATATGGGACAACC
CAGTCACTCTAACCTTTATGGTTCACCCCCATTTGTCTCTTTCCTATAAACAAACCTACC
TACTGTCTATTTGCAAATTAACAACCTACTGGCTCGCCCTTTAAAATCCTCCTGCCACAC
AGGCTTAACTTCTTACACCGTCCTTTTTCTAAGGCCAAAATCTGCCTCCTCTCGGGATGA
AAACTTACTAACACCCCCCATTTCTCCTTGCCCTCCTTGGAGACACTTCCACTTTCATTG
CGCCCTGCCCCTTCCCTTTACCCCTTCTTTTCCCTCTCCTTCGCACAAACTTAAATTGTA
CTTTCCCCCCGTTTGGCCCCCCCCCTTACTTGCGCCCCCAACCTAACCCCCCG
Restriction Sites NotI-NotI     
ACCN NM_013446
ORF Size 1449 bp
Insert Size 3070
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_013446.2, NP_038474.1
RefSeq Size 3116
RefSeq ORF 1449
Locus ID 23608
Domains zf-CCCH, RING
Protein Families Druggable Genome
Gene Summary This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

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