MKRN1 (NM_013446) Human Untagged Clone

CAT#: SC115218

MKRN1 (untagged)-Human makorin ring finger protein 1 (MKRN1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MKRN1
• Synonyms: RNF61
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_013446 edited
  GAATTCGGCACGAGGGTAATGGCGGAGGCTGCAACTCCCGGAACAACAGCCACAACATCA
  GGAGCAGGAGCGGCAGCGGCGACGGCGGCAGCAGCCTCCCCCACCCCGATCCCCACAGTC
  ACCGCCCCGTCCCTGGGGGCGGGCGGAGGGGGCGGCGGCAGCGACGGCAGCGGCGGCGGC
  TGGACTAAACAGGTCACCTGCAGGTATTTTATGCATGGGGTTTGTAAGGAAGGAGACAAC
  TGTCGCTACTCGCATGACCTCTCTGACAGTCCGTATAGTGTAGTGTGCAAGTATTTTCAG
  CGAGGGTACTGTATTTATGGAGACCGCTGCAGATATGAACATAGCAAACCATTGAAACAG
  GAAGAAGCAACTGCTACAGAGCTAACTACAAAGTCATCCCTTGCTGCTTCCTCAAGTCTC
  TCATCGATAGTTGGACCACTTGTTGAAATGAATACAGGCGAAGCTGAGTCAAGAAATTCA
  AACTTTGCAACTGTAGGAGCAGGTTCAGAGGACTGGGTGAATGCTATTGAGTTTGTTCCT
  GGGCAACCCTACTGTGGCCGTACTGCGCCTTCCTGCACTGAAGCACCCCTGCAGGGCTCA
  GTGACCAAGGAAGAATCAGAGAAAGAGCAAACCGCCGTGGAGACAAAGAAGCAGCTGTGC
  CCCTATGCTGCAGTGGGAGAGTGCCGATACGGGGAGAACTGTGTGTATCTCCACGGAGAT
  TCTTGTGACATGTGTGGGCTGCAGCTCCTGCATCCAATGGATGCTGCCCAGAGATCGCAG
  CATATCAAATCGTGCATTGAGGCCCATGAGAAGGACATGGAGCTCTCATTTGCCGTGCAG
  CGCAGCAAGGACATGGTGTGTGGGATCTGCATGGAGGTGGTCTATGAGAAAGCCAACCCC
  AGTGAGCGCCGCTTCGGGATCCTCTCCAACTGCAACCACACCTACTGTCTCAAGTGCATT
  CGCAAGTGGAGGAGTGCTAAGCAATTTGAGAGCAAGATCATAAAGTCCTGCCCAGAATGC
  CGGATCACATCTAACTTTGTCATTCCAAGTGAGTACTGGGTGGAGGAGAAAGAAGAGAAG
  CAGAAACTCATTCTGAAATACAAGGAGGCAATGAGCAACAAGGCGTGCAGGTATTTTGAT
  GAAGGACGTGGGAGCTGCCCATTTGGAGGGAACTGTTTTTACAAGCATGCGTACCCTGAT
  GGCCGTAGAGAGGAGCCACAGAGACAGAAAGTGGGAACATCAAGCAGATACCGGGCCCAA
  CGAAGGAACCACTTCTGGGAACTCATTGAGGAAAGAGAGAACAGCAACCCCTTTGACAAC
  GATGAAGAAGAGGTTGTCACCTTTGAGCTGGGCGAGATGTTGCTTATGCTTTTGGCTGCA
  GGTGGGGACGACGAACTAACAGACTCTGAAGATGAGTGGGACTTGTTTCATGATGAGCTG
  GAAGATTTTTATGACTTGGATCTATAGCAACCTTGCGTGGCGTGTGAACTGGTCTGCTGA
  CCTCAGACAGCAGCTGTCCCCTGTGGTGGTGTGGCAGTGCCTGTGTTCTCTCCTAGGCAG
  GCCTCTCAACTCCAGGTGCTGTCCTAAGAATTTTTACCCAGGGCCTGTCTTCTCAACCCC
  TCACCTTTCCCTGAGGAGTGTGTTGTTTTCCCTGTTGAAAAAAGTTACAAAAATAAATCT
  TAAAGTTAGTTTTTTGTAACACGAATTTAACTGTCAGACAGTTAGTGTAGGTGTGTTGCG
  TCATCTGTTTTCAACCAGATTGCATTTATGGACTTTTCACACACTCATTTTGAGGACCCC
  AGGTTCAAAAGTAAAAGCAGTGGCCCTGCTTTGGGGTCCAAGAATAGGAGTGATGGGTGA
  AGGGACCTAAGCTGGCCAATAGCCCTCTGCCCCAGACATGGGATGTGGATCCTTGAGGTT
  TCTGGTGAAATCTGCACATCTGTGTTTTTATATCTGTTCCCTACCCTGTAATCCCTACCA
  CGTGCACTTGTTCTGTGGTTTTGGTCTCTTGTTTAATTGCACACAAGTAATACTACTGGG
  TAACCAGAATCAGGTGTGAATGTGTTGAGATTTTTTACTGTTTTGCATGATAGGAAAATT
  GAGAAAGAATACGTATAAAAGATAGAGAGGCATAACATCAATGCAGAGTTGGAAGTTGGC
  TCCCAAGGGCTGACATGGTGTGAGTGTGTGGGTGTGTGATAAGCTTCTCATCCCTGCATA
  GATGCAGTATTCTTAGCCTTAGTAGAAAAACCTGGTTTAGTGGTTTAAGCCTTGTGTGGC
  AGATAGATCTTAAAGGGCAAAGCAGTATATTGGTAGTTGTCAATATAGCAGTGCTAGCTC
  TGTCTATATAAATAGAGAAATGGGGTTAGCCATAGAGGTTAAAACTACCTGGTTATCCCA
  TATAATAACACAAACTGGGTCTTGGATACACAGTTGTATTTAATGTTTTACGATCTAGCC
  TTTCCAGTACAGGCACTTTCTGAGAAACCTTTGTCCTCACTTGAGGCATTTTGTTGTCGG
  GTTTTTGTGTTTGTTTTTGTGGGTATTTGCCTCATTCCACCCCTGAGCTTTCAGGTAGAC
  AGACGTGATTCAAAACTCTGTTCTAAGGTGTTTATTGTAGTGGAGTAATGGGTTTGCAGT
  GATAAGTCATACTTTTCCACCGAAAGGGAGGGCTTGGGAATCCCTGAGATTAGCTAAAGT
  TAAGTTGTTGGAAGAATTCCTTGATTGGAAATTGTACCTTTGTGTTTTGTTGCTCTGTTT
  CCTGAAAATAACTCGGGGATGCTCCTGGTTTGTCCATCTACTGCTTTGATTCCTTGGATC
  CCACCCATTCTTTCACTTTAAGAAAAAACAAATAATTGTTGCAGAGGTCTCTGTATTTTG
  CAGCTGCCCTTTTGTAAGAAGCACTTTTCCCAAATAAAACAATTAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAACTCGAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_013446 unedited
  GGGTTTAAATTTGTAAACGACTCATATAGGCGGCCCGCGAATCGGCAGGAGGGTAATGGC
  GGAGGCTGCAACTCCCGGNACAACAGCCACAACATCAGGAGCAGGAGCGGCAGCGGCGAC
  GGCGGCAGCAGCCTCCCCCACCCCGATCCCCACAGTCACCGCCCCGTCCCTGGGGGCGGG
  CGGAGGGGGCGGCGGCAGCGACGGCAGCGGCGGCGGCTGGACTAAACAGGTCACCTGCAG
  GTATTTTATGCATGGGGTTTGTAAGGAAGGAGACAACTGTCGCTACTCGCATGACCTCTC
  TGACAGTCCGTATAGTGTAGTGTGCAAGTATTTTCAGCGAGGGTACTGTATTTATGGAGA
  CCGCTGCAGATATGAACATAGCAAACCATTGAAACAGGAAGAAGCAACTGCTACAGAGCT
  AACTACAAAGTCATCCCTTGCTGCTTCCTCAAGTCTCTCATCGATAGTTGGACCACTTGT
  TGAAATGAATACAGGCGAAGCCTGAGTCAAGAAATTCAAACTTTGCAACTGTAGGAGCAG
  GTTCAGAGGACTGGGTGAATGCCTATTGAGTTTGTTCCTGTGCAACCCTACTGTGGCCGT
  ACTGCGCCTTCCTGCACTGAAGCACCCCTGCAGGGCCTCACTGACCACAGGAAGAATCAG
  AGAAAGAGCAAACCCGCCGCTGGAGACCAAAGAACCAGCTGTGCCCCCTCATGCTGCAGT
  GGGGAGAGTGCCCGATACCCGGGAGAACTGTGTGCATCTCCACGGCAGATTCTTGTGAAC
  ATGTGTGGGGCTGCAGGTCCTGCATTCCAAGGGATGCTGCCCCAAAGACCGCAGCATCAT
  CAAATCCTGCATTGAAGCCCCATGAGAAAGACATGAAGCCCTCATTTGCCCGGGCACAGC
  ACCAAGCACAGGGA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_013446 unedited
  CGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
  TTTTAATCGTTTTATTTGGGAAAAAGTGCTTCTTACAAAAGGGCAGCTGCAAAATACAAA
  AACCTCTGCAACAATTATTTGTTTTTTCTTAAAGGGAAAAAATGGGTGGGATCCAAGGAA
  TCAAAGCAGTAGATGGACAAACCAGGAGCCTCCCCGAGTTATTTTCAGGAAACAGACCAA
  CAAAACACAAAGGTCCAATTCCCAATCAAGGAATTCTTCCAACAACTTAACTTTATCTAA
  TCTCAGGGATTCCCAACCCCTCCCTTTCGGTGGAAAAGTATGACTTATCACTGCAAACCC
  ATTACTCCACTACAATAAACACCTTAAAACAAAGCTTTGAATCACGTCTGTCTACCTGAA
  CGCCTAGGGGCGGCATGAGGCAAATCCCCACCAAACCAAACACAAAAACCCCACCACAAA
  ATGCCTTAAGCGAGGACAAAGGTTTCCCAAAAAGTGCCTGTCCTGCAAAGGCCTACACCC
  CAAAACCTTAAACACAACTGGGTTTTCAAAACCCCATTTGTGCTATCATATGGGACAACC
  CAGTCACTCTAACCTTTATGGTTCACCCCCATTTGTCTCTTTCCTATAAACAAACCTACC
  TACTGTCTATTTGCAAATTAACAACCTACTGGCTCGCCCTTTAAAATCCTCCTGCCACAC
  AGGCTTAACTTCTTACACCGTCCTTTTTCTAAGGCCAAAATCTGCCTCCTCTCGGGATGA
  AAACTTACTAACACCCCCCATTTCTCCTTGCCCTCCTTGGAGACACTTCCACTTTCATTG
  CGCCCTGCCCCTTCCCTTTACCCCTTCTTTTCCCTCTCCTTCGCACAAACTTAAATTGTA
  CTTTCCCCCCGTTTGGCCCCCCCCCTTACTTGCGCCCCCAACCTAACCCCCCG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_013446
• ORF Size: 1449 bp
• Insert Size: 3070
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_013446.2, NP_038474.1
• RefSeq Size: 3116
• RefSeq ORF: 1449
• Locus ID: 23608
• Domains: zf-CCCH, RING
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).