TMEM2 (NM_013390) Human Untagged Clone

CAT#: SC115244

TMEM2 (untagged)-Human transmembrane protein 2 (TMEM2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TMEM2
• Synonyms: TMEM2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC115244 sequence for NM_013390 edited (data generated by NextGen Sequencing)
  ATGTATGCCACTGATTCCAGGGGACACTCCCCTGCTTTCCTCCAACCTCAGAATGGAAAT
  AGTCGTCACCCATCTGGCTATGTTCCAGGGAAGGTTGTCCCATTGCGTCCCCCTCCTCCT
  CCAAAGAGTCAAGCTTCAGCCAAATTTACCTCCATCAGACGAGAAGACCGGGCAACCTTC
  GCATTCTCACCTGAAGAACAGCAAGCCCAGAGAGAAAGTCAAAAGCAAAAGAGACACAAA
  AATACTTTCATTTGTTTTGCTATTACTAGTTTCTCATTTTTTATTGCACTTGCAATCATT
  TTAGGAATATCCTCAAAATATGCTCCAGATGAAAATTGCCCAGATCAAAATCCTCGTCTC
  AGGAATTGGGATCCAGGACAAGATTCTGCAAAGCAAGTTGTTATCAAGGAGGGAGATATG
  CTCCGTCTGACCTCAGACGCCACCGTGCATTCTATAGTCATTCAGGATGGAGGACTGCTT
  GTATTTGGGGACAATAAAGATGGATCCAGAAATATTACTTTGAGGACTCATTACATCCTG
  ATCCAGGATGGTGGGGCGCTTCATATTGGAGCAGAAAAATGCCGCTATAAATCCAAAGCG
  ACAATTACCTTGTATGGCAAGTCAGATGAAGGTGAAAGTATGCCAACATTTGGCAAAAAG
  TTTATTGGTGTGGAAGCTGGCGGGACACTGGAGTTACATGGGGCACGGAAGGCATCGTGG
  ACGTTGTTGGCAAGGACCCTGAATTCCTCAGGCTTGCCCTTTGGGTCCTATACCTTTGAA
  AAGGACTTTTCCCGGGGCCTCAATGTGAGGGTCATTGACCAAGACACGGCCAAAATTTTG
  GAAAGTGAGAGATTTGATACCCATGAATACCGCAATGAGAGCAGGCGGCTTCAGGAGTTT
  CTGAGATTCCAGGATCCAGGTCGGATTGTTGCCATAGCTGTCGGGGATTCAGCCGCTAAA
  AGTCTCTTACAAGGAACCATCCAGATGATCCAGGAACGGTTGGGAAGTGAACTGATCCAA
  GGACTGGGCTACAGGCAAGCTTGGGCTTTAGTTGGTGTCATTGATGGTGGAAGCACTTCT
  TGCAATGAATCCGTGAGAAACTATGAAAATCATAGCAGTGGCGGGAAGGCTCTTGCCCAA
  AGAGAATTTTATACTGTGGATGGCCAGAAGTTCTCTGTGACAGCTTATAGTGAATGGATT
  GAAGGCGTTTCTCTTTCAGGATTCCGGGTAGAGGTTGTAGATGGAGTGAAGCTAAATTTG
  CTAGATGATGTTAGTAGTTGGAAACCTGGAGACCAGATTGTGGTCGCAAGCACAGACTAT
  TCCATGTACCAAGCAGAGGAGTTCACTCTTCTTCCCTGTTCTGAATGCAGCCATTTTCAG
  GTCAAAGTCAAAGAAACCCCTCAGTTCCTGCACATGGGTGAGATCATAGACGGTGTAGAC
  ATGAGAGCTGAGGTTGGAATTCTTACCCGGAATATTGTGATCCAAGGAGAAGTGGAGGAC
  TCATGCTACGCAGAAAATCAGTGCCAATTTTTTGATTATGATACCTTTGGGGGACACATT
  ATGATAATGAAAAATTTTACTTCAGTCCATCTTTCTTATGTGGAATTGAAACACATGGGT
  CAGCAGCAGATGGGGCGATACCCTGTTCATTTTCACCTGTGTGGTGACGTGGATTATAAA
  GGAGGATACAGACATGCAACATTTGTGGACGGCCTGTCTATTCATCACAGCTTCTCAAGG
  TGCATCACTGTGCATGGGACAAATGGCTTGCTAATAAAAGACACCATTGGGTTTGACACA
  CTAGGTCATTGTTTCTTTTTGGAAGATGGTATTGAACAGAGGAATACTTTGTTCCACAAT
  CTGGGACTCCTCACCAAGCCGGGTACTCTCCTGCCCACCGATAGGAACAACTCCATGTGT
  ACCACCATGCGAGATAAAGTGTTTGGAAATTACATTCCTGTGCCTGCTACTGACTGTATG
  GCTGTTTCAACTTTCTGGATTGCTCATCCCAACAATAATCTGATTAATAATGCAGCTGCA
  GGCTCACAGGATGCTGGAATATGGTATTTATTCCACAAGGAACCAACTGGGGAATCCAGT
  GGATTGCAGCTCTTGGCAAAACCAGAACTCACTCCATTGGGTATATTTTATAACAACAGG
  GTCCATTCAAATTTTAAGGCTGGCTTATTTATTGACAAAGGTGTCAAAACAACCAACTCT
  AGTGCTGCTGACCCAAGGGAATACCTCTGTTTGGACAATAGTGCAAGATTTCGACCTCAT
  CAGGATGCAAACTCCGAAAAACCACGTGTTGCTGCTCTAATTGACAGGCTCATTGCTTTT
  AAAAATAATGATAATGGAGCTTGGGTCAGAGGAGGAGATATTATCGTTCAAAATTCAGCA
  TTTGCAGATAATGGAATAGGACTGACCTTTGCCAGTGATGGAAGCTTCCCAAGTGATGAA
  GGTTCCAGCCAAGAGGTATCTGAATCTCTCTTTGTTGGGGAGAGCAGGAATTACGGCTTT
  CAGGGTGGTCAGAACAAGTATGTAGGCACTGGAGGAATAGACCAGAAGCCTCGAACATTA
  CCCAGGAACAGGACGTTCCCAATTAGAGGCTTTCAGATTTATGATGGGCCCATTCATCTC
  ACAAGGAGCACTTTCAAAAAATATGTGCCAACTCCAGATAGGTACAGCAGTGCAATTGGC
  TTCCTCATGAAGAATTCCTGGCAGATAACCCCCAGGAATAATATCTCCCTCGTGAAGTTT
  GGTCCACATGTCTCTCTGAATGTCTTTTTTGGAAAGCCTGGTCCCTGGTTTGAAGATTGT
  GAGATGGATGGTGATAAGAACTCCATATTCCATGACATTGATGGCTCTGTGACAGGATAC
  AAGGATGCTTATGTGGGAAGAATGGACAACTACCTGATCCGCCATCCAAGCTGTGTAAAT
  GTGTCTAAGTGGAATGCAGTGATCTGCAGTGGGACCTATGCACAGGTCTATGTACAGACA
  TGGAGCACTCAGAATCTTTCTATGACCATTACACGAGATGAGTATCCGTCCAACCCTATG
  GTGCTCCGAGGTATTAATCAGAAGGCTGCCTTTCCACAGTACCAGCCTGTCGTCATGCTG
  GAGAAGGGTTATACCATCCACTGGAATGGGCCGGCACCACGGACTACATTTCTATACCTC
  GTCAACTTCAACAAGAATGACTGGATTCGAGTTGGCCTTTGCTATCCATCAAACACAAGT
  TTTCAAGTTACCTTTGGCTATTTGCAGCGGCAGAATGGCTCATTATCCAAAATCGAAGAA
  TATGAGCCTGTGCATTCACTGGAAGAACTGCAAAGAAAGCAATCCGAGAGGAAATTCTAT
  TTTGACTCCAGCACGGGGTTACTGTTTTTGTATCTCAAAGCCAAAAGCCACAGGCATGGC
  CACAGTTACTGTTCATCTCAGGGATGTGAAAGAGTCAAGATCCAAGCAGCCACAGACTCA
  AAGGACATCAGTAACTGCATGGCCAAAGCATACCCACAGTACTACAGAAAGCCGTCAGTG
  GTCAAGCGGATGCCGGCCATGCTCACTGGACTCTGTCAAGGCTGTGGCACTCGGCAGGTG
  GTGTTTACTAGTGATCCTCATAAAAGTTACCTCCCTGTGCAATTCCAGTCACCTGATAAA
  GCAGAAACCCAGCGTGGAGACCCGTCTGTTATTTCTGTCAATGGCACTGACTTTACCTTC
  CGAAGTGCAGGCGTCCTCCTCCTTGTTGTGGATCCGTGCAGCGTTCCATTCCGCTTGACG
  GAAAAAACGGTTTTTCCTCTTGCTGATGTCAGTCGCATTGAAGAGTATTTAAAAACAGGC
  ATCCCTCCAAGGTCCATTGTTCTGTTGAGCACAAGAGGAGAAATAAAGCAGTTAAACATT
  TCACACTTACTAGTACCTCTGGGATTAGCCAAACCAGCTCATCTTTATGACAAAGGGAGT
  ACCATATTTTTGGGATTCAGTGGAAACTTTAAACCATCATGGACTAAGCTATTTACCAGT
  CCTGCTGGACAGGGCCTTGGGGTGCTTGAACAATTCATACCTTTGCAGCTGGACGAATAT
  GGTTGTCCCAGAGCCACCACTGTCCGCAGAAGAGACCTGGAACTGCTAAAGCAAGCTTCA
  AAAGCACATTAG
  
  Clone variation with respect to NM_013390.2
  2293 c=>t
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_013390 unedited
  GGGTTTCGGATTTTGTATACGACTCCTATAGGGCGGCCGCGAATTCGCACGAGCGGCAAT
  CGAGTGGCTTCCTGGCCATGGAGAGGAGATCTGGACCCGAGGACGCCAGGGACTCCTCTC
  CGTCTCCCTGGACCGCTGTGTAGGCACCTGAGTTAACGGACGCTAAGCGGGGTAGGGGAA
  GTAACAGTGTATCATGTATGCCACTGATTCCAGGGGACACTCCCCTGCTTTCCTCCAACC
  TCAGAATGGAAATAGTCGTCACCCATCTGGCTATGTTCCAGGGAAGGTTGTCCCATTGCG
  TCCCCCTCCTCCTCCAAAGAGTCAAGCTTCAGCCAAATTTACCTCCATCAGACGAGAAGA
  CCGGGCAACCTTCGCATTCTCACCTGAAGAACAGCAAGCCCAGAGAGAAAGTCAAAAGCA
  AAAGAGACACAAAAATACTTTCATTTGTTTTGCTATTACTAGTTTCTCATTTTTTATTGC
  ACTTGCAATCATTTTAGGAATATCCTCAAAATATGCTCCAGATGAAAATTGCCCAGATCA
  AAATCCTCGTCTCAGGAATTGGGATCCAGGACAAGATTCTGCAAAGCAAGTTGTTATCAA
  GGAGGGAGATATGCTCCGTCTGACCTCAGACGCCACCGTGCATTCTATAGTCATTCAGGA
  TGGAGGACTGCTTGTATTTTGGGACAATAAAGATGGATCCAGAAATATTACTTTGAGGAC
  TCATTACATCCTGATCCAGGATGGTGGGGCGCTTCATATTGGAGCAGAAAAATGCCGCTA
  TANATCCCAAGCGACCATTACCTTGTATGGCAAGTCAGATGAAGGTGAAAGTATGCCCAC
  ATTTTGGCANAAAGTTTATTGTTGTGGGAAGCTGNCGGGACACTGGAGTTACATGGGGCA
  CCGGAAGCATCGTGGACGTTGTTGGCACGACN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_013390
• ORF Size: 4152 bp
• Insert Size: 4700
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_013390.1, NP_037522.1
• RefSeq Size: 6147
• RefSeq ORF: 4152
• Locus ID: 23670
• Protein Families: Transmembrane
• Gene Summary: This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss. [provided by RefSeq, Mar 2017]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).