TMS1 (PYCARD) (NM_013258) Human Untagged Clone

CAT#: SC115313

PYCARD (untagged)-Human PYD and CARD domain containing (PYCARD), transcript variant 1


  "NM_013258" in other vectors (6)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PYCARD
Synonyms ASC; CARD5; TMS; TMS-1; TMS1
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF sequence for NM_013258 edited
GAATTCGGCACGAGGCATGGGGCGCGCGCGCGACGCCATCCTGGATGCGCTGGAGAACCT
GACCGCCGAGGAGCTCAAGAAGTTCAAGCTGAAGCTGCTGTCGGTGCCGCTGCGCGAGGG
CTACGGGCGCATCCCGCGGGGCGCGCTGCTGTCCATGGACGCCTTGGACCTCACCGACAA
GCTGGTCAGCTTTTACCTGGAGACCTACGGCGCCGAGCTCACCGCTAACGTGCTGCGCGA
CATGGGCCTGCAGGAGATGGCCGGGCAGCTGCAGGCGGCCACGCACCAGGGCTCTGGAGC
CGCGCCAGCTGGGATCCAGGCCCCTCCTCAGTCGGCAGCCAAGCCAGGCCTGCACTTTAT
AGACCAGCACCGGGCTGCGCTTATCGCGAGGGTCACAAACGTTGAGTGGCTGCTGGATGC
TCTGTACGGGAAGGTCCTGACGGATGAGCAGTACCAGGCAGTGCGGGCCGAGCCCACCAA
CCCAAGCAAGATGCGGAAGCTCTTCAGTTTCACACCAGCCTGGAACTGGACCTGCAAGGA
CTTGCTCCTCCAGGCCCTAAGGGAGTCCCAGTCCTACCTGGTGGAGGACCTGGAGCGGAG
CTGAGGCTCCTTCCCAGCAACACTCCGGTCAGCCCCTGGCAATCCCACCAAATCATCCTG
AATCTGATCTTTTTATACACAATATACGAAAAGCCAGCTTGAAAAAAAAAAAAAAAAAAC
TCGAC
>OriGene 5' read for NM_013258 unedited
TACGACTCTCTATAGGGCGGCCGCGAATTCGGCACGAGGCATGGGGCGCGCGCGCGACGC
CATCCTGGATGCGCTGGAGAACCTGACCGCCGAGGAGCTCAAGAAGTTCAAGCTGAAGCT
GCTGTCGGTGCCGCTGCGCGAGGGCTACGGGCGCATCCCGCGGGGCGCGCTGCTGTCCAT
GGACGCCTTGGACCTCACCGACAAGCTGGTCAGCTTTTACCTGGAGACCTACGGCGCCGA
GCTCACCGCTAACGTGCTGCGCGACATGGGCCTGCAGGAGATGGCCGGGCAGCTGCAGGC
GGCCACGCACCAGGGCTCTGGAGCCGCGCCAGCTGGGATCCAGGCCCCTCCTCAGTCGGC
AGCCAAGCCAGGCCTGCACTTTATAGACCAGCACCGGGCTGCGCTTATCGCGAGGGTCAC
AAACGTTGAGTGGCTGCTGGATGCTCTGTACGGGAAGGTCCTGACCGATGAGCAGTACCA
GGCAGTGCGGGCCGAGCCCACCAACCCAAGCAAGATGCGGAAGCTCTTCAGTTTCACACC
AGCCTGGAACTGCACCTGCAAAGACTTGCTCCTCCAGGCCCTAAGGGAGTCCCAGTCCTA
CCTGGTGGAGGACCTGGAACGGAGCTGAAGCTTCTTCCCACACACACTTCCGTTAAGCCC
CTGCCAATCCCACCAAATAATCCTGAATCTGATCTTTTATTCACCTTTTACGAAAAGCCC
CTTTGAAAAAAAAAAAAAAAACTTCACCTTAATTGCGGCCCCGGGCATATTTTTTCCCTG
ACAAATCCCCGGGGGATCTCTGGAACCCTCCCAAAGCCTTTCCTGGGCCTGAAAATTGGA
CCTCCAGGGGCCCCCAACCTTGTCCTAAAAAATAAAATTGCCAATTTGGTCGCCACGGGG
GCCCCTTTAAAATATCGGGGGAAGGGGGGGGTTCTGACCCACGN
>OriGene 3' read for NM_013258 unedited
GTACCGCGGCNCGCATTCTANAGTCGAGTTTTTTTTTTTTTTTTTTCAAGCTGGCTTTTC
GTATATTGTGTATAAAAAGATCAGATTCAGGATGATTTGGTGGGATTGCCAGGGGCTGAC
CGGAGTGTTGCTGGGAAGGAGCCTCAGCTCCGCTCCAGGTCCTCCACCAGGTAGGACTGG
GACTCCCTTAGGGCCTGGAGGAGCAAGTCCTTGCAGGTCCAGTTCCAGGCTGGTGTGAAA
CTGAAAAGCTTCCGCATCTTGCTTGGGTTGGTGGGCTCGGCCCGCACTGCCTGGTACTGC
TCATCCGTCAGGACCTTCCCGTACAGAGCATCCACCAGCCACTCAACGTTTGTGACCCTC
CCGATAAGCGCACCCCGGTGCTGGTCTATAAAGCGCACGCCTGGCTTGGCTGCCGACTGA
GGAGGGGCCTGGATCCCACCTGGGGCGGCTTCACAGCCCTGGTGCCTGGCCGCCTGCCCC
TGCTCCGCCCTCTCCTGCAGGCCCCTTGCCCCCCATCGCCCTCCCGGTCACTTTCGCGCT
CATCGTCTCCCCCGTTCACCCCCTCCCTTTCTTCGCTAGCTCCCCCCTTTTCCTTCACCT
TCCCCCCTCCCCCATACCTCTTCTCCATCTCTCCGTCCTACCCGCCCTATTCTCCGCCCC
GATTCCTGATCTCCCTCCTTTCCCCGCTTTCTCGCCACCCTCCCCTTCTTCTTTCTCCCT
CCCCCCACCCCCCTCCCTGTCCCCACCCTCTTCAACCTCTCCCCCCCTTCTATCCCCCGC
ACCCCCCCCCTACGCCTATACGCCTCTCTAACACCCCCCCCGCTCTTCTCCCCCCCCCCC
GTTCTCCCCCCCCCCACCTCCTATTGCCTCGCCTGCCCTCCTGTTTTTTCCCTGCCGCCC
ACGTCTCTTCACCCCATCCC
Restriction Sites NotI-NotI     
ACCN NM_013258
ORF Size 588 bp
Insert Size 730
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_013258.3, NP_037390.2
RefSeq Size 936
RefSeq ORF 588
Locus ID 29108
Domains PAAD_DAPIN
Protein Families Druggable Genome
Protein Pathways Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway
Gene Summary This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

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