STAT5B (NM_012448) Human Untagged Clone

CAT#: SC115355

STAT5B (untagged)-Human signal transducer and activator of transcription 5B (STAT5B)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: STAT5B
• Synonyms: STAT5
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC115355 sequence for NM_012448 edited (data generated by NextGen Sequencing)
  ATGGCTGTGTGGATACAAGCTCAGCAGCTCCAAGGAGAAGCCCTTCATCAGATGCAAGCG
  TTATATGGCCAGCATTTTCCCATTGAGGTGCGGCATTATTTATCCCAGTGGATTGAAAGC
  CAAGCATGGGACTCAGTAGATCTTGATAATCCACAGGAGAACATTAAGGCCACCCAGCTC
  CTGGAGGGCCTGGTGCAGGAGCTGCAGAAGAAGGCAGAGCACCAGGTGGGGGAAGATGGG
  TTTTTACTGAAGATCAAGCTGGGGCACTATGCCACACAGCTCCAGAACACGTATGACCGC
  TGCCCCATGGAGCTGGTCCGCTGCATCCGCCATATATTGTACAATGAACAGAGGTTGGTC
  CGAGAAGCCAACAATGGTAGCTCTCCAGCTGGAAGCCTTGCTGATGCCATGTCCCAGAAA
  CACCTCCAGATCAACCAGACGTTTGAGGAGCTGCGACTGGTCACGCAGGACACAGAGAAT
  GAGTTAAAAAAGCTGCAGCAGACTCAGGAGTACTTCATCATCCAGTACCAGGAGAGCCTG
  AGGATCCAAGCTCAGTTTGGCCCGCTGGCCCAGCTGAGCCCCCAGGAGCGTCTGAGCCGG
  GAGACGGCCCTCCAGCAGAAGCAGGTGTCTCTGGAGGCCTGGTTGCAGCGTGAGGCACAG
  ACACTGCAGCAGTACCGCGTGGAGCTGGCCGAGAAGCACCAGAAGACCCTGCAGCTGCTG
  CGGAAGCAGCAGACCATCATCCTGGATGACGAGCTGATCCAGTGGAAGCGGCGGCAGCAG
  CTGGCCGGGAACGGCGGGCCCCCCGAGGGCAGCCTGGACGTGCTACAGTCCTGGTGTGAG
  AAGTTGGCCGAGATCATCTGGCAGAACCGGCAGCAGATCCGCAGGGCTGAGCACCTCTGC
  CAGCAGCTGCCCATCCCCGGCCCAGTGGAGGAGATGCTGGCCGAGGTCAACGCCACCATC
  ACGGACATTATCTCAGCCCTGGTGACCAGCACGTTCATCATTGAGAAGCAGCCTCCTCAG
  GTCCTGAAGACCCAGACCAAGTTTGCAGCCACTGTGCGCCTGCTGGTGGGCGGGAAGCTG
  AACGTGCACATGAACCCCCCCCAGGTGAAGGCCACCATCATCAGTGAGCAGCAGGCCAAG
  TCTCTGCTCAAGAACGAGAACACCCGCAATGATTACAGTGGCGAGATCTTGAACAACTGC
  TGCGTCATGGAGTACCACCAAGCCACAGGCACCCTTAGTGCCCACTTCAGGAATATGTCC
  CTGAAACGAATTAAGAGGTCAGACCGTCGTGGGGCAGAGTCGGTGACAGAAGAAAAATTT
  ACAATCTTGTTTGAATCCCAGTTCAGTGTTGGTGGAAATGAGCTGGTTTTTCAAGTCAAG
  ACCCTGTCCCTGCCAGTGGTGGTGATCGTTCATGGCAGCCAGGACAACAATGCGACGGCC
  ACTGTTCTCTGGGACAATGCTTTTGCAGAGCCTGGCAGGGTGCCATTTGCCGTGCCTGAC
  AAAGTGCTGTGGCCACAGCTGTGTGAGGCGCTCAACATGAAATTCAAGGCCGAAGTGCAG
  AGCAACCGGGGCCTGACCAAGGAGAACCTCGTGTTCCTGGCGCAGAAACTGTTCAACAAC
  AGCAGCAGCCACCTGGAGGACTACAGTGGCCTGTCTGTGTCCTGGTCCCAGTTCAACAGG
  GAGAATTTACCAGGACGGAATTACACTTTCTGGCAATGGTTTGACGGTGTGATGGAAGTG
  TTAAAAAAACATCTCAAGCCTCATTGGAATGATGGGGCCATTTTGGGGTTTGTAAACAAG
  CAACAGGCCCATGACCTACTCATTAACAAGCCAGATGGGACCTTCCTCCTGAGATTCAGT
  GACTCAGAAATTGGCGGCATCACCATTGCTTGGAAGTTTGATTCTCAGGAAAGAATGTTT
  TGGAATCTGATGCCTTTTACCACCAGAGACTTCTCCATTCGGTCCCTAGCCGACCGCTTG
  GGAGACTTGAATTACCTTATCTACGTGTTTCCTGATCGGCCAAAAGATGAAGTATACTCC
  AAATACTACACACCAGTTCCCTGCGAGTCTGCTACTGCTAAAGCTGTTGATGGATACGTG
  AAGCCACAGATCAAGCAAGTGGTCCCTGAGTTTGTGAACGCATCTGCAGATGCCGGGGGC
  GGCAGCGCCACGTACATGGACCAGGCCCCCTCCCCAGCTGTGTGTCCCCAGGCTCACTAT
  AACATGTACCCACAGAACCCTGACTCAGTCCTTGACACCGATGGGGACTTCGATCTGGAG
  GACACAATGGACGTAGCGCGGCGTGTGGAGGAGCTCCTGGGCCGGCCAATGGACAGTCAG
  TGGATCCCGCACGCACAATCGTGA
  
  Clone variation with respect to NM_012448.3
  1327 c=>t
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_012448 unedited
  TATTTCCCCGCCCGTTGNCGCAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAG
  CAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGC
  GAATTCGGCACGAGGGTCACCCCGGGCGGGGACCCAGCGCAGGCAACTCCGCGCGGCGGC
  CCGGCCGAGGGAGGGAGCGAGCGGGCGGGCGGGCAAGCCAGACAGCTGGGCCGGAGCAGC
  CGCGGGCGCCCGAGGGGCCGAGCGAGATTGTAAACCATGGCTGTGTGGATACAAGCTCAG
  CAGCTCCAAGGAGAAGCCCTTCATCAGATGCAAGCGTTATATGGCCAGCATTTTCCCATT
  GAGGTGCGGCATTATTTATCCCAGTGGATTGAAAGCCAAGCATGGGACTCAGTAGATCTT
  GATAATCCACAGGAGAACATTAAGGCCACCCAGCTCCTGGAGGGCCTGGTGCAGGAGCTG
  CAGAAGAAGGCAGAGCACCAGGTGGGGGAAGATGGGTTTTTACTGAAGATCAAGCTGGGG
  CACTATGCCACACAGCTCCAGAACACGTATGACCGCTGCCCCATGGAGCTGGTCCGCTGC
  ATCCGCCATATATTGTACAATGAACAGAGGTTGGTCCGAGAAGCCAACAATGGTAGCTCT
  CCAGCTGGAAGCCTTGCTGATGCCATGTCCCAGAAACACCTCCAGATCAACCAGACGTTT
  GAGGAGCTGCGACTGGTCACGCACGACACAGAGAATGAGTTAAAAAAGCTGCAGCAGACT
  CAGGAGTACTTCATCTTCCAGTACCAGGAGAGCCTGAGGATCCCAGCTCAGTTTGGCCCG
  CTGCCCCACTGAGCCCCCAGAGCGTCTGACCGGGAGACGGCCCTCCACAGAAACAGTGTC
  TCTTGGAGCCTCGTTGCACCGTGAGCACANAACTG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_012448 unedited
  NNCCGAAATCTATGTCCGCGGCCGCAATCNANGATCGGTTTTTTTTTTTTTTTTTTAACA
  CTTCACATTATGAGTATTGTTTCAAAANAGAAGCGATTCATGGAATTAAAACATCCACAA
  GAGTGATTCCTCTGGTGAAGATGAAGAAGCTGAAGATGGAGAGGTCGCGGGGTCACGATT
  GTGCGTGCGGGATCCACTGACTGTCCATTGGCCGGCCCAGGAGCTCCTCCACACGCCGCG
  CTACGTCCATTGTGTCCTCCAGATCGAAGTCCCCATCGGTGTCAAGGACTGAGTCAGGGT
  TCTGTGGGTACATGTTATAGTGAGCCTGGGGACACACAGCTGGGGAGGGGGCCTGGTCCA
  TGTACGTGGCGCTGCCGCCCCCGGCATCTGCAGATGCGTTCACAAACTCAGGGACCACTT
  GCTTGATCTGTGGCTTCACGTATCCATCAACAGCTTTAGCAGTAGCAGACTCGCAGGGAA
  CTGGTGTGTAGTATTTGGAGTATACTTCATCTTTTGGCCGATCAGGAAACACGTAGATAA
  GGTAATTCAAGTCTCCCAAGCGGTCGGCTAGGGACCGAATGGAGAAGTCTCTGGTGGTAA
  AAGGCATCAGATTCCAAAACATTCTTTCCTGAGAATCAAACTTCCAAGCAATGGTGATGC
  CGCCAATTTCTGAGTCACTGAATCTCAGGAGGAAAGTCCCATCTGGCTTGGTAATGAGTA
  GGTCATGGGCCTGTTGCTTGGTTACCAACCCCAAATGGCCCCATCATTTCAATGAGGGCT
  GGAGAGTTTTTTTTACACTTTCCTCACACCGGCGAACCATGTCCGAAAGTGTAATTCCGT
  CCTGGGGAATTCTTCCCGTTGGACTGGGACCAGGAACAAACAGGGCCCTGTAGTCCTCC
  
• Restriction Sites: ECoRI-NOT
• ACCN: NM_012448
• ORF Size: 2364 bp
• Insert Size: 2750
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_012448.3, NP_036580.2
• RefSeq Size: 5171
• RefSeq ORF: 2364
• Locus ID: 6777
• Domains: SH2, STAT
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - JAK/STAT signaling pathway, Transcription Factors
• Protein Pathways: Acute myeloid leukemia, Chemokine signaling pathway, Chronic myeloid leukemia, ErbB signaling pathway, Jak-STAT signaling pathway, Pathways in cancer
• Gene Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]