SETDB1 (NM_012432) Human Untagged Clone

CAT#: SC115388

SETDB1 (untagged)-Human SET domain, bifurcated 1 (SETDB1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SETDB1
• Synonyms: ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_012432, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGTCTTCCCTTCCTGGGTGCATTGGTTTGGATGCAGCAACAGCTACAGTGGAGTCTGAAGAGATTGCAG
  AGCTGCAACAGGCAGTGGTTGAGGAACTGGGTATCTCTATGGAGGAACTTCGGCATTTCATCGATGAGGA
  ACTGGAGAAGATGGATTGTGTACAGCAACGCAAGAAGCAGCTAGCAGAGTTAGAGACATGGGTAATACAG
  AAAGAATCTGAGGTGGCTCACGTTGACCAACTCTTTGATGATGCATCCAGGGCAGTGACTAATTGTGAGT
  CTTTGGTGAAGGACTTCTACTCCAAGCTGGGACTACAATACCGGGACAGTAGCTCTGAGGACGAATCTTC
  CCGGCCTACAGAAATAATTGAGATTCCTGATGAAGATGATGATGTCCTCAGTATTGATTCAGGTGATGCT
  GGGAGCAGAACTCCAAAAGACCAGAAGCTCCGTGAAGCTATGGCTGCCTTAAGAAAGTCAGCTCAAGATG
  TTCAGAAGTTCATGGATGCTGTCAACAAGAAGAGCAGTTCCCAGGATCTGCATAAAGGAACCTTGAGTCA
  GATGTCTGGAGAACTAAGCAAAGATGGTGACCTGATAGTCAGCATGCGAATTCTGGGCAAGAAGAGAACT
  AAGACTTGGCACAAAGGCACCCTTATTGCCATCCAGACAGTTGGGCCAGGGAAGAAATACAAGGTGAAAT
  TTGACAACAAAGGAAAGAGTCTACTGTCGGGGAACCATATTGCCTATGATTACCACCCTCCTGCTGACAA
  GCTGTATGTGGGCAGTCGGGTGGTCGCCAAATACAAAGATGGGAATCAGGTCTGGCTCTATGCTGGCATT
  GTAGCTGAGACACCAAACGTCAAAAACAAGCTCAGGTTTCTCATTTTCTTTGATGATGGCTATGCTTCCT
  ATGTCACACAGTCGGAACTGTATCCCATTTGCCGGCCACTGAAAAAGACTTGGGAGGACATAGAAGACAT
  CTCCTGCCGTGACTTCATAGAGGAGTATGTCACTGCCTACCCCAACCGCCCCATGGTACTGCTCAAGAGT
  GGCCAGCTTATCAAGACTGAGTGGGAAGGCACGTGGTGGAAGTCCCGAGTTGAGGAGGTGGATGGCAGCC
  TAGTCAGGATCCTCTTCCTGGATGACAAAAGATGTGAGTGGATCTATCGAGGCTCTACACGGCTGGAGCC
  CATGTTCAGCATGAAAACATCCTCAGCCTCTGCACTGGAGAAGAAGCAAGGACAGCTCAGGACACGTCCA
  AATATGGGTGCTGTGAGGAGCAAAGGCCCTGTTGTCCAGTACACACAGGATCTGACCGGTACTGGAACCC
  AGTTCAAGCCAGTGGAACCCCCACAGCCTACAGCTCCACCTGCCCCACCTTTCCCACCTGCTCCACCTCT
  ATCCCCCCAAGCAGGTGACAGTGACTTGGAAAGCCAGCTTGCCCAGTCACGGAAGCAGGTAGCCAAAAAG
  AGCACGTCCTTTCGACCAGGATCTGTGGGCTCTGGTCATTCCTCCCCTACATCTCCTGCACTCAGTGAAA
  ATGTCTCTGGTGGGAAACCTGGGATCAACCAGACATATAGATCACCTTTAGGCTCCACAGCCTCTGCCCC
  AGCACCCTCAGCACTCCCGGCCCCTCCAGCACCCCCAGTCTTCCATGGCATGCTGGAGCGGGCCCCAGCA
  GAGCCCTCCTACCGTGCTCCCATGGAGAAGCTTTTCTACTTACCTCATGTCTGCAGCTATACCTGTCTGT
  CTCGAGTCAGACCTATGAGGAATGAGCAGTACCGGGGCAAGAACCCTCTGCTGGTCCCGTTACTATATGA
  CTTCCGGCGGATGACAGCCCGGCGTCGAGTTAACCGCAAGATGGGCTTTCATGTTATCTATAAGACACCT
  TGTGGTCTCTGCCTTCGGACAATGCAGGAGATAGAACGCTACCTTTTCGAGACTGGCTGTGACTTCCTCT
  TCCTGGAGATGTTCTGTTTGGATCCATATGTTCTTGTGGACCGAAAGTTTCAGCCCTATAAGCCTTTTTA
  CTATATTTTGGACATCACTTATGGGAAGGAAGATGTTCCCCTATCCTGTGTCAATGAGATTGACACAACC
  CCTCCACCCCAGGTGGCCTACAGCAAGGAACGTATCCCGGGCAAGGGTGTTTTCATTAACACAGGCCCTG
  AATTTCTGGTTGGCTGTGACTGCAAGGATGGGTGTCGGGACAAGTCCAAGTGTGCCTGCCATCAACTAAC
  TATCCAGGCTACAGCCTGTACCCCAGGAGGCCAAATCAACCCTAACTCTGGCTACCAGTACAAGAGACTA
  GAAGAGTGTCTACCCACAGGGGTATATGAGTGTAACAAACGCTGCAAATGTGACCCAAACATGTGCACAA
  ACCGGTTGGTGCAACATGGACTACAAGTTCGGCTACAGCTATTCAAGACACAGAACAAGGGCTGGGGTAT
  CCGCTGCTTGGATGACATTGCCAAAGGCTCTTTTGTTTGTATTTATGCAGGCAAAATCCTGACAGATGAC
  TTTGCAGACAAGGAGGGTCTGGAAATGGGTGATGAGTACTTTGCAAATCTGGACCATATCGAGAGCGTGG
  AGAACTTCAAAGAAGGATATGAGAGTGATGCCCCCTGTTCCTCTGACAGCAGTGGTGTAGACTTGAAGGA
  CCAGGAAGATGGCAACAGCGGTACAGAGGACCCTGAAGAGTCCAATGATGATAGCTCAGATGATAACTTC
  TGTAAGGATGAGGACTTCAGCACCAGTTCAGTGTGGCGGAGCTATGCTACCCGGAGGCAGACCCGGGGCC
  AGAAAGAGAACGGACTCTCTGAGACAACTTCCAAGGACTCCCACCCCCCAGATCTTGGACCCCCACATAT
  TCCTGTTCCTCCCTCAATCCCTGTAGGTGGCTGCAATCCACCTTCCTCCGAAGAGACACCCAAGAACAAG
  GTGGCCTCATGGTTGAGCTGCAATAGTGTCAGTGAAGGTGGTTTTGCTGACTCTGATAGCCATTCATCCT
  TCAAGACTAATGAAGGTGGGGAGGGCCGGGCTGGGGGAAGCCGAATGGAGGCTGAGAAGGCCTCCACCTC
  AGGACTAGGCATCAAGGATGAGGGAGACATCAAACAGGCCAAGAAAGAGGACACTGACGACCGAAACAAG
  ATGTCAGTAGTTACTGAAAGCTCTCGAAATTACGGTTACAATCCTTCTCCTGTGAAGCCTGAAGGACTTC
  GCCGCCCACCTAGTAAGACTAGTATGCATCAAAGCCGAAGACTCATGGCTTCTGCTCAGTCCAACCCTGA
  TGATGTCCTGACACTGTCCAGCAGCACAGAAAGTGAGGGGGAAAGTGGGACCAGCCGAAAGCCCACTGCT
  GGTCAGACTTCGGCTACAGCGGTTGACAGTGATGATATCCAGACCATATCCTCTGGCTCTGAAGGGGATG
  ACTTTGAGGACAAGAAGAACATGACTGGTCCAATGAAGCGTCAAGTGGCAGTAAAATCAACCCGAGGCTT
  TGCTCTTAAATCAACCCATGGGATTGCAATTAAATCAACCAACATGGCCTCTGTGGACAAGGGGGAGAGC
  GCACCTGTTCGTAAGAACACACGCCAATTCTATGATGGCGAGGAGTCTTGCTACATCATTGATGCCAAGC
  TTGAAGGCAACCTGGGCCGCTACCTCAACCACAGTTGCAGCCCCAACCTGTTTGTCCAGAATGTCTTCGT
  GGATACCCATGATCTTCGCTTCCCCTGGGTGGCCTTCTTTGCCAGCAAAATCCGGGCTGGGACAGAACTT
  ACTTGGGACTACAACTACGAGGTGGGCAGTGTGGAAGGCAAGGAGCTACTCTGTTGCTGTGGGGCCATTG
  AATGCAGAGGACGTCTTCTTTAG
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_012432 unedited
  GGGGTTCANCATTATGTAATACGACTTCACTATAGGGCGGCCGCGAATTCGCACGAGGCT
  CCCTTATCCCTTCGCTTTCGCTCTTTTCCGTCGAGGCCGACCCCTGAGTTGTGAGTCTGG
  GGTCTGGTTGGTGAAAAAGAGCCCTTGAAGCTGGAAGACGGGAGAGGACAAAAGCATGTC
  TTCCCTTCCTGGGTGCATTGGTTTGGATGCAGCATCAGCTACAGTGGAGTCTGAAGAGAT
  TGCAGAGCTGCAACAGGCAGTGGTTGAGGAACTGGGTATCTCTATGGAGGAACTTCGGCA
  TTTCATCGATGAGGAACTGGAGAAGATGGAATTGTGTACAGCAACGCAAGAAGCAGCTAG
  CAGAGTTAGAGACATGGGTAATACAGAAAGAATCTGAGGTGGCTCACGTTGACCAACTCT
  TTGATGATGCATCCAGGGCAGTGACATAATTGTGAGTCTTTGGTGAAGGACTTCTACTCC
  AAGCTGGGACTACAATACCATGACAGTAGCTCTGAGGACGAATCTTCCCCGGCCTACAGA
  AATAATTGAGATTCCTGATGAAGATGATGATGTCCTCAGTATTGATTCAGGTGATGCTGG
  GAGCAAAACTTCCAAAAGACCAGAAGCTCCGTGAAGCTATGGCTGCCTTAAGAAAGTCAG
  CTCAAGATGTTCAGAAGTTCATGGATGCTGTCAACAAGAAGAGCAGTTCCCAGGATCTGC
  ATAAAGGAACCCTGAGTCAAATGTCTGGAGAACTAAGCAAAGATGGTGACCTGATAATCA
  GCATGCGAAATCCTGGGCAAGAGAGAACTAAGACTTGGCACAAAGCCCCCCTCATGGCAC
  TCCAAACAGTTGGGCCAGGGTAGAAAACCAGCTGAAATTTGTCCATCAAGCTAAGAGTCT
  TCTGTCGGGGAACCATT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_012432 unedited
  NNTTTTTGACTTTGGACCGCGGNCCGCATNCTAGNGATCGGTTTTTTTTTTTTTTTTTTT
  TTAGTTTTATCATATTGGTTAAAAAACTTTCAGGAAATAATACAAACTGGGGAATAGTAG
  ATACACAGGGCTCCATTTCTAAAAACAAAGTCTGTTAGAAGCAGGAACACTTGGACAAAT
  ATGGGATGGGAGGGATGTCAGGCCGAGGTTAGAGTGGTGATCTCTCCCCACCCTTTAGGG
  CCTTTGGAGGTGGAGAAGGGATCCTGCCTGCTAGCACCACATTGGAAGGGATCATCTGGT
  CCAGAACCCCCATTTCTATCAACTAGGAGCTGGGGGGAGTAGCTAGCCCAGAGACTTCGG
  GTCAGGGTTCAACAATCAGGAAGACCCAGTTCCTGAGGAAACGACAGTTCAAGAAGGGTT
  GGGAAGAAGGCTGTCCTCTAAAGAAGACGTCCTCTGCATTCAATGGCCCCACAGCAACAG
  AGTAGCTCCTTGCCTTCCACACTGCCCACCTCGTAGTTGTAGTCCCAAGTAAGTTCTGTC
  CCAGCCCGGATTCTTTTGCTGGCAAAGAAGGCCACCCAGGGGAAGCGAAGATCATGGGTA
  TCCACGAAGACATTCTGGACAAACAGGTTGGGGCTGCAACTGTGGTTGAGGTAGCGGCCC
  AGGTTGCCTTCAAGCTTGGCATCAATGATGTAGCAAGACTCCTCGCCATCATAGAATTGG
  CGTGTGTTCTTACGAACAGGTGCGCTCTCCCCCTTGTCCACAGAGGCCATGTTGGTTGAT
  TTAATTGCAATCCCATGGGTTGATTTAAGAGCAAAGCCTCGGGTTGATTTTACTGCCACT
  TGACGCTTCATTGGACAGNCATGTTCTTCTTTGTCCTCAAGNCATCCCCTTCAAAGCCCA
  GATATGGTCTGGAATCATCACTGGCACCGCTGTACCCGAGTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_012432
• ORF Size: 3873 bp
• Insert Size: 5000
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_012432.2, NP_036564.2
• RefSeq Size: 4420
• RefSeq ORF: 3873
• Locus ID: 9869
• Domains: SET, MBD, TUDOR, PreSET, Pre-SET
• Protein Families: Druggable Genome
• Protein Pathways: Lysine degradation
• Gene Summary: This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jun 2011]
  Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.