APPL (APPL1) (NM_012096) Human Untagged Clone

CAT#: SC115543

APPL1 (untagged)-Human adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1)


  "NM_012096" in other vectors (6)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol APPL1
Synonyms APPL; DIP13alpha; MODY14
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC115543 sequence for NM_012096 edited (data generated by NextGen Sequencing)
ATGCCGGGGATCGACAAGCTGCCCATCGAGGAGACGCTGGAGGACAGCCCGCAGACAAGG
TCTTTACTAGGTGTATTTGAAGAAGATGCCACAGCTATTTCCAACTATATGAACCAGTTG
TATCAAGCTATGCATCGGATTTATGATGCACAGAATGAATTAAGTGCAGCAACACACCTG
ACCTCAAAACTTTTAAAAGAATATGAAAAACAGCGTTTTCCATTGGGAGGTGATGATGAA
GTTATGAGCTCTACATTGCAACAGTTTTCAAAAGTTATAGATGAGCTTAGCTCTTGTCAT
GCAGTGCTTTCAACTCAACTTGCTGATGCCATGATGTTCCCCATTACCCAGTTTAAAGAA
AGAGATCTGAAAGAAATACTAACATTAAAGGAAGTATTTCAGATTGCAAGTAATGATCAT
GATGCTGCGATTAATAGATATAGCCGTTTATCAAAAAAAAGAGAAAATGACAAGGTGAAG
TATGAAGTAACAGAAGATGTGTACACATCCAGAAAGAAACAACACCAGACCATGATGCAT
TATTTTTGTGCATTAAATACTCTTCAGTACAAGAAGAAAATAGCATTGTTAGAACCTCTA
CTTGGGTACATGCAAGCTCAGATAAGTTTCTTTAAGATGGGTTCTGAAAATCTTAATGAA
CAACTGGAAGAATTTTTAGCTAATATTGGAACAAGCGTTCAGAATGTTCGCAGGGAAATG
GACAGTGATATAGAGACCATGCAACAGACAATAGAGGATTTGGAAGTAGCCAGTGATCCC
TTATATGTGCCTGACCCAGACCCCACCAAATTTCCTGTTAATCGAAATTTAACCCGAAAG
GCTGGATACCTTAATGCTAGGAATAAAACAGGCTTGGTGTCATCTACCTGGGACAGACAG
TTTTACTTCACGCAGGGTGGAAATTTAATGAGTCAGGCCCGTGGGGATGTAGCAGGAGGC
CTGGCCATGGACATAGACAACTGTTCAGTGATGGCTGTGGACTGTGAAGACAGACGATAT
TGTTTTCAGATCACCTCTTTCGATGGAAAAAAATCTTCAATTTTGCAAGCAGAGAGTAAA
AAAGATCATGAAGAGTGGATCTGTACAATAAACAACATATCTAAACAAATATACTTAAGT
GAAAATCCAGAGGAAACTGCTGCACGAGTAAATCAATCAGCTCTGGAAGCTGTCACTCCT
TCCCCATCTTTCCAGCAGAGGCACGAGAGCCTGCGGCCAGCAGCAGGACAATCTCGGCCA
CCGACAGCTCGAACCAGCAGTTCAGGATCCTTAGGATCTGAGTCTACAAATTTGGCTGCC
CTCTCTCTAGATTCTCTTGTTGCCCCAGACACCCCAATACAGTTTGACATAATTTCTCCT
GTGTGTGAAGATCAGCCTGGCCAGGCAAAAGCCTTTGGCCAGGGAGGCAGGCGTACAAAT
CCATTTGGAGAATCTGGAGGAAGTACAAAATCTGAAACTGAAGATTCTATTCTTCATCAG
TTATTTATTGTCCGATTCCTTGGTTCAATGGAGGTGAAATCAGATGACCATCCAGATGTT
GTTTATGAAACTATGCGCCAAATCTTAGCTGCCCGGGCCATCCATAACATCTTTCGTATG
ACAGAATCGCATTTATTAGTCACTTGTGACTGTTTAAAGTTAATTGATCCACAGACACAA
GTTACAAGGCTCACGTTTCCATTACCTTGTGTAGTTTTGTATGCTACACACCAGGAAAAT
AAGCGCCTTTTTGGATTTGTTCTTCGGACATCAAGCGGGAGAAGTGAAAGTAATCTGTCA
TCAGTCTGCTATATATTTGAGTCAAACAATGAGGGGGAAAAGATATGTGATTCTGTTGGA
CTGGCAAAACAGATAGCTTTGCATGCTGAACTGGATCGTAGGGCATCAGAAAAACAAAAA
GAAATAGAGAGAGTAAAAGAGAAGCAACAGAAAGAACTCAATAAACAAAAACAGATTGAA
AAGGACTTGGAAGAACAAAGTCGGTTGATAGCTGCTTCCAGTAGACCAAACCAAGCCAGT
AGTGAGGGGCAGTTTGTTGTCCTTAGCAGTAGCCAGTCAGAAGAGAGTGATTTGGGAGAA
GGAGGAAAGAAGAGAGAATCAGAAGCATAA

Clone variation with respect to NM_012096.2
>OriGene 5' read for NM_012096 unedited
TCGGAATTTGTATACGACTACTATAGGGCGGCCGCGAATTCGCACGAGGCGCCTGGNAGA
AGCTGTGCGGGCGGGGACGGCTGCAGCCCTTGCCGGAGAGGGCGGGCCGGGGTCAGCTGC
GGCGGGCGGGCCGGCGCGGGGAGCTGTGGGCGGCAGCTGCGTCTCCTGCCACCGCCCTCC
CTCCGCCACGATGCCGGGGATCGACAAGCTGCCCATCGAGGAGACGCTGGAGGACAGCCC
GCAGACAAGGTCTTTACTAGGTGTATTTGAAGAAGATGCCACAGCTATTTCCAACTATAT
GAACCAGTTGTATCAAGCTATGCATCGGATTTATGATGCACAGAATGAATTAAGTGCAGC
AACACACCTGACCTCAAAACTTTTAAAAGAATATGAAAAACAGCGTTTTCCATTGGGAGG
TGATGATGAAGTTATGAGCTCTACATTGCAACAGTTTTCAAAAGTTATAGATGAGCTTAG
CTCTTGTCATGCAGTGCTTTCAACTCAACTTGCTGATGCCATGATGTTCCCCATTACCCA
GTTTAAAGAAAGAGATCTGAAAGAAATACTAACATTAAAGGAAGTATTTCAGATTGCAAG
TAATGATCATGATGCTGCGATTAATAGATATAGCCGTTTATCAAAAAAAAGAGAAAATGA
CAAGGGTGAAGTATGAAGTAACAGAAAGATGTGTACACATCCAGAAAGAAACAACACCAG
ACCATGATGCATTATTTTTGTGCATTANATACTCTTCAGTACAAGAAGAANATAGCATTG
TTAGAACCTCTACTTGNGTACATGNCAGCTCAGATAAGTTTCTTAAGAATGGGGTTCTGA
AAATCTTAAATGACACTGGNAGAATTTTTAGCTAATATGGAACAGCGTTCAAATGGTCGC
AGGAATGGACAGTGANTAGAGACATGCACAGACATAAGTTTTTGGAGTGC
>OriGene 3' read for NM_012096 unedited
GCTATGGACCGGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTCATTTTATT
CAGGGGGCAGGTTTTACAACATACTAGCTCTTAGGATCTCTCAGCATTAATAGGATTCAA
ATTTTAAATAATATGGTTCCTAGATATAATGCAAAATTAACTCAAATGCCTTTACCATAT
ACGATTTTATCTTCCCTAGGATGCACATCCTACTGACCTTTTCCCAAGTATAGTGGAAAC
ACATTTACCACCCCTAGATTGTAGAGCCTGAGGATTCTTTTGAAATTAAACAATAATCAT
TGCAGATGTGGCAAAAACTAGACTAGCTTTAGGGACTCTGTTCAAGATAATAGCTTTAGT
CCCTGGTTGGCAAGTTCTCAAAATTTTTAAAGGTAGAAGGAATAACTGGTTTCCTATCTA
CTGACTTCATTGCCATAGTTACAAACATACTGTTCAAATAGGTAACAGAATGCATTGTAG
AAGTAGGCAGGCTTAATATCTTTTCTTTTTAAAAAGGAGTTTTGTTGATTTCTAACACCA
TTAAGTGTAAGTCTGAATGTGAGAAAAGATATCCCAAAATCGAATCCAGTTACCCTCAAA
GCATCTCAGAACTAGAAGGGATTTCAAAGGAGGGTAACAATCAGCTTTACCACTAGGCAG
AAACCCATGGGCAGCCTTTTAATAACNAAAAAGAGCTTATTAAAACAGATACTTAAATCT
CTGCAGTAATGGAATAGTTCATATAGTTCAACAGTAATGGAAACAAAAGCTGATCATCTA
ANATTGNTAAACCCACTCATAACTTCTATTTAGCATTGNAATGCACTTCGATCTGACCTA
TGGAGATGAGGGTTTATTTATGTAGAAATNCTGTGAACATGACTTAAACGAACTACAGGT
CTGTCAGCATCCCTAGTCTGCCAGNGCCTAACTTTANCTACCTTGACCCAGGTGCTGATA
AGGN
Restriction Sites NotI-NotI     
ACCN NM_012096
ORF Size 2130 bp
Insert Size 5270
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_012096.1, NP_036228.1
RefSeq Size 5970
RefSeq ORF 2130
Locus ID 26060
Domains PH, PID
Protein Pathways Colorectal cancer, Pathways in cancer
Gene Summary The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]

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