TDP43 (TARDBP) (NM_007375) Human Untagged Clone

CAT#: SC115570

TARDBP (untagged)-Human TAR DNA binding protein (TARDBP)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TARDBP
• Synonyms: ALS10; TDP-43
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC115570 sequence for NM_007375 edited (data generated by NextGen Sequencing)
  ATGTCTGAATATATTCGGGTAACCGAAGATGAGAACGATGAGCCCATTGAAATACCATCG
  GAAGACGATGGGACGGTGCTGCTCTCCACGGTTACAGCCCAGTTTCCAGGGGCGTGTGGG
  CTTCGCTACAGGAATCCAGTGTCTCAGTGTATGAGAGGTGTCCGGCTGGTAGAAGGAATT
  CTGCATGCCCCAGATGCTGGCTGGGGAAATCTGGTGTATGTTGTCAACTATCCAAAAGAT
  AACAAAAGAAAAATGGATGAGACAGATGCTTCATCAGCAGTGAAAGTGAAAAGAGCAGTC
  CAGAAAACATCCGATTTAATAGTGTTGGGTCTCCCATGGAAAACAACCGAACAGGACCTG
  AAAGAGTATTTTAGTACCTTTGGAGAAGTTCTTATGGTGCAGGTCAAGAAAGATCTTAAG
  ACTGGTCATTCAAAGGGGTTTGGCTTTGTTCGTTTTACGGAATATGAAACACAAGTGAAA
  GTAATGTCACAGCGACATATGATAGATGGACGATGGTGTGACTGCAAACTTCCTAATTCT
  AAGCAAAGCCAAGATGAGCCTTTGAGAAGCAGAAAAGTGTTTGTGGGGCGCTGTACAGAG
  GACATGACTGAGGATGAGCTGCGGGAGTTCTTCTCTCAGTACGGGGATGTGATGGATGTC
  TTCATCCCCAAGCCATTCAGGGCCTTTGCCTTTGTTACATTTGCAGATGATCAGATTGCG
  CAGTCTCTTTGTGGAGAGGACTTGATCATTAAAGGAATCAGCGTTCATATATCCAATGCC
  GAACCTAAGCACAATAGCAATAGACAGTTAGAAAGAAGTGGAAGATTTGGTGGTAATCCA
  GGTGGCTTTGGGAATCAGGGTGGATTTGGTAATAGCAGAGGGGGTGGAGCTGGTTTGGGA
  AACAATCAAGGTAGTAATATGGGTGGTGGGATGAACTTTGGTGCGTTCAGCATTAATCCA
  GCCATGATGGCTGCCGCCCAGGCAGCACTACAGAGCAGTTGGGGTATGATGGGCATGTTA
  GCCAGCCAGCAGAACCAGTCAGGCCCATCGGGTAATAACCAAAACCAAGGCAACATGCAG
  AAGGAGCCAAACCAGGCCTTCGGTTCTGGAAATAACTCTTATAGTGGCTCTAATTCTGGT
  GCAGCAATTGGTTGGGGATCAGCATCCAATGCAGGGTCGGGCAGTGGTTTTAATGGAGGC
  TTTGGCTCAAGCATGGATTCTAAGTCTTCTGGCTGGGGAATGTAG
  
  Clone variation with respect to NM_007375.3
  1082 g=>a
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_007375 unedited
  NGTTAAATTTGTATACACTCCTATAGGCGGCCGCGCAATTCGCACGAGGGTCGGGCTTCC
  CACACGGCCTACGGGAAAGTAAAAGAGTCTGAATATATTCGGGTAACCGAAGAGAGAACG
  ATGAGCCCATTGAAATACCATCGGAAGACGATGGGACGGTGCTGCTCTCCACGGTTACAG
  CCCAGTTTCCAGGGGCGTGTGGGCTTCGCTACAGGAATCCAGTGTCTCAGTGTATGAGAG
  GTGTCCGGCTGGTAGAAGGAATTCTGCATGCCCCAGATGCTGGCTGGGGAAATCTGGTGT
  ATGTTGTCAACTATCCAAAAGATAACAAAAGAAAAATGGATGAGACAGATGCTTCATCAG
  CAGTGAAAGTGAAAAGAGCAGTCCAGAAAACATCCGATTTAATAGTGTTGGGTCTCCCAT
  GGAAAACAACCGAACAGGACCTGAAAGAGTATTTTAGTACCTTTGGAGAAGTTCTTATGG
  TGCAGGTCAAGAAAGATCTTAAGACTGGTCATTCAAAGGGGTTTGGCTTTGTTCGTTTTA
  CGGAATATGAAACACAAGTGAAAGTAATGTCACAGCGACATATGATAGATGGACGATGGT
  GTGACTGCAAACTTCCTAATTCTAAGCAAAGCCAAGATGAGCCTTTGAGAAGCAGAAAAG
  TGTTTGTGGGGCGCTGTACAGAGGACATGACTGAGGATGAGCTGCGGGAGTTCTTCTCTC
  AGTACGGNGATGTGATGGATGTCTTCATCCCCAAGCCATTCAGGGCCTTTGCCTTTGTTA
  CATTTGCAGATGATCAGATTGCGCAGTCTCTTTGTGGAGAGGACTTGATCATTAAGGAAT
  CAGCGTTCATTATCCCATGCCGAACCCTAGCACAATAGCATAGAAGTTAGAAAGAGTGGA
  AGATTNGTG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_007375 unedited
  GGCACGCAATCTAGTATCGAGTTTTTTTTTTTTTTTTTTATTTAAATCAGTTTTATTTAA
  GAATTTCCAACAATGACAACTCTTATAAAAAGCATCCAAGCACAGGACACAGAACTGCAG
  CAAACAGCATTCTTATGGGTAGCTAACAGACATTAGAACTTCCACCCTTCTTTGAGACAC
  CTGAGCTCACTGGTGAACTCTGCTTCAAGTCCTCCTGCAAAGCACACCACAAGCTCAGTC
  CATGTTCTCAGCCCATCAGCTTCAGTTCACATTGCCACACTTACATATCAGTAACAGAAG
  AGAACACACACCATACAGCATTCACAGCAGTTGACAAAGGGGTAGGGGGAGTACAAGTAT
  CATTTCACTTAACACATTCATCTAATGTGGGTTATCTAAGAACAAAAACTCACTTAAAAG
  TCTTCCAACAGATGTGGATGTCCTTTGAATGCAAAAAACATTCGTACATTATTTGCTATC
  ATTGCTCTCTGCACACTCTCTCACCAAAGCCACAGGATTGAGAGACACATCTCGCCAAGT
  TAAAAAATATCCATTATGCACCACCAAGTCTCTGCACGCGCTCTCTCCTTTTCTCGCTCA
  TACTAGCCTTTCATGCCTCGGCACCACCATCAATCCCACACAAGGTTTCAAAAGTTCAGA
  CAGCCTTCTGGTTCCATATCACAGCCTTGCGTTCATAGCGTTGATACGACTCCATGAAAT
  ANAGAGTAGCGGATAAAAATGGGACACCCACCGTCAAAGACGCGGCCTGTGATGCGTGAT
  GACGAATTCTTGATGAGAAAGCTTAGACAGTATCCTATGCAGATATTACACACTACTTCA
  TGAGNNGCTCCCATAACATTGAATGAAGACTGCGAGATAAGAAGCTCTATGACTTTGGTT
  GAGGAGACAGGTAAACAACAAGACAACTGGCACTGAC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_007375
• ORF Size: 1245 bp
• Insert Size: 3110
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_007375.3, NP_031401.1
• RefSeq Size: 4236
• RefSeq ORF: 1245
• Locus ID: 23435
• Domains: RRM
• Protein Families: Transcription Factors
• Gene Summary: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]