CD10 (MME) (NM_007287) Human Untagged Clone

CAT#: SC115606

MME (untagged)-Human membrane metallo-endopeptidase (MME), transcript variant 1bis


  "NM_007287" in other vectors (6)

Reconstitution Protocol

USD 760.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol MME
Synonyms CALLA; CD10; CMT2T; NEP; SCA43; SFE
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_007287, the custom clone sequence may differ by one or more nucleotides


ATGGGCAAGTCAGAAAGTCAGATGGATATAACTGATATCAACACTCCAAAGCCAAAGAAGAAACAGCGAT
GGACTCCACTGGAGATCAGCCTCTCGGTCCTTGTCCTGCTCCTCACCATCATAGCTGTGACAATGATCGC
ACTCTATGCAACCTACGATGATGGTATTTGCAAGTCATCAGACTGCATAAAATCAGCTGCTCGACTGATC
CAAAACATGGATGCCACCACTGAGCCTTGTACAGACTTTTTCAAATATGCTTGCGGAGGCTGGTTGAAAC
GTAATGTCATTCCCGAGACCAGCTCCCGTTACGGCAACTTTGACATTTTAAGAGATGAACTAGAAGTCGT
TTTGAAAGATGTCCTTCAAGAACCCAAAACTGAAGATATAGTAGCAGTGCAGAAAGCAAAAGCATTGTAC
AGGTCTTGTATAAATGAATCTGCTATTGATAGCAGAGGTGGAGAACCTCTACTCAAACTGTTACCAGACA
TATATGGGTGGCCAGTAGCAACAGAAAACTGGGAGCAAAAATATGGTGCTTCTTGGACAGCTGAAAAAGC
TATTGCACAACTGAATTCTAAATATGGGAAAAAAGTCCTTATTAATTTGTTTGTTGGCACTGATGATAAG
AATTCTGTGAATCATGTAATTCATATTGACCAACCTCGACTTGGCCTCCCTTCTAGAGATTACTATGAAT
GCACTGGAATCTATAAAGAGGCTTGTACAGCATATGTGGATTTTATGATTTCTGTGGCCAGATTGATTCG
TCAGGAAGAAAGATTGCCCATCGATGAAAACCAGCTTGCTTTGGAAATGAATAAAGTTATGGAATTGGAA
AAAGAAATTGCCAATGCTACGGCTAAACCTGAAGATCGAAATGATCCAATGCTTCTGTATAACAAGATGA
CATTGGCCCAGATCCAAAATAACTTTTCACTAGAGATCAATGGGAAGCCATTCAGCTGGTTGAATTTCAC
AAATGAAATCATGTCAACTGTGAATATTAGTATTACAAATGAGGAAGATGTGGTTGTTTATGCTCCAGAA
TATTTAACCAAACTTAAGCCCATTCTTACCAAATATTCTGCCAGAGATCTTCAAAATTTAATGTCCTGGA
GATTCATAATGGATCTTGTAAGCAGCCTCAGCCGAACCTACAAGGAGTCCAGAAATGCTTTCCGCAAGGC
CCTTTATGGTACAACCTCAGAAACAGCAACTTGGAGACGTTGTGCAAACTATGTCAATGGGAATATGGAA
AATGCTGTGGGGAGGCTTTATGTGGAAGCAGCATTTGCTGGAGAGAGTAAACATGTGGTCGAGGATTTGA
TTGCACAGATCCGAGAAGTTTTTATTCAGACTTTAGATGACCTCACTTGGATGGATGCCGAGACAAAAAA
GAGAGCTGAAGAAAAGGCCTTAGCAATTAAAGAAAGGATCGGCTATCCTGATGACATTGTTTCAAATGAT
AACAAACTGAATAATGAGTACCTCGAGTTGAACTACAAAGAAGATGAATACTTCGAGAACATAATTCAAA
ATTTGAAATTCAGCCAAAGTAAACAACTGAAGAAGCTCCGAGAAAAGGTGGACAAAGATGAGTGGATAAG
TGGAGCAGCTGTAGTCAATGCATTTTACTCTTCAGGAAGAAATCAGATAGTCTTCCCAGCCGGCATTCTG
CAGCCCCCCTTCTTTAGTGCCCAGCAGTCCAACTCATTGAACTATGGGGGCATCGGCATGGTCATAGGAC
ACGAAATCACCCATGGCTTCGATGACAATGGCAGAAACTTTAACAAAGATGGAGACCTCGTTGACTGGTG
GACTCAACAGTCTGCAAGTAACTTTAAGGAGCAATCCCAGTGCATGGTGTATCAGTATGGAAACTTTTCC
TGGGACCTGGCAGGTGGACAGCACCTTAATGGAATTAATACACTGGGAGAAAACATTGCTGATAATGGAG
GTCTTGGTCAAGCATACAGAGCCTATCAGAATTATATTAAAAAGAATGGCGAAGAAAAATTACTTCCTGG
ACTTGACCTAAATCACAAACAACTATTTTTCTTGAACTTTGCACAGGTGTGGTGTGGAACCTATAGGCCA
GAGTATGCGGTTAACTCCATTAAAACAGATGTGCACAGTCCAGGCAATTTCAGGATTATTGGGACTTTGC
AGAACTCTGCAGAGTTTTCAGAAGCCTTTCACTGCCGCAAGAATTCATACATGAATCCAGAAAAGAAGTG
CCGGGTTTGGTGA


>OriGene 5' read for NM_007287 unedited
NNGGTTCGTTTTTGTATACGACTCATATAGGGCGGCCGCGATTCGGCACGAGGGGCTCTG
GAAGTCACGTCAGGTTGGCTCTTCAGGTTCATTTCCATAGTTCCCTGCGGCCTCTGCCTT
GGGGAGTTATGTTTTGTTACCGAGATCCGCGCTACCAGATTGCACCGGGGCTGATTTGGG
GGCTGGGAATTTGCCATTCTGCTGTACAGACACTGATTTTTTTTTCTTCTTTTTAAAAAG
CAAGATTTTAGGTGATGGGCAAGTCAGAAAGTCAGATGGATATAACTGATATCAACACTC
CAAAGCCAAAGAAGAAACAGCGATGGACTCCACTGGAGATCAGCCTCTCGGTCCTTGTCC
TGCTCCTCACCATCATAGCTGTGACAATGATCGCACTCTATGCAACCTACGATGATGGTA
TTTGCAAGTCATCAGACTGCATAAAATCAGCTGCTCGACTGATCCAAAACATGGATGCCA
CCACTGAGCCTTGTACAGACTTTTTCAAATATGCTTGCGGAGGCTGGTTGAAACGTAATG
TCATTCCCGAGACCAGCTCCCGTTACGGCAACTTTGACATTTTAAGAGATGAACTAGAAG
TCGTTTTGAAAGATGTCCTTCAAGAACCCAAAACTGAAGATATAGTAGCAGTGCAGAAAG
CAAAAGCATTGTACAGGTCTTGTATAAATGAATCTGCTATTGATAGCAGAGGTGGAGAAC
CTCTACTCAAACTGTTACCAGACATATATGGGTGGCCAGTAGCAACAGAAAACTGGGAGC
ANNAATATGGTGCTTCTTGGACAGCTGAANAAGCTATTGCACAACTGAATTNCTAATATG
GGAAAAAGTCCTTATTAATTTGTTNGTTGGCACTGATGATAGAAATCTGTGAAATCATGT
ATTCATATTGACCAACCTCG
>OriGene 3' read for NM_007287 unedited
TTTTTTTTTTGGANCGCGGANCCGCATCTCAAGAGCCCAGTTTTTTTTTTTTTTTTGTTT
ATATTAAAAACGTTTGTTTTTATTTTGTATTTTTGAGACTGGAAACTGATAAAAATTTCT
GATTAGGAAACTTTGCAGAAAGAGCCTTTTTTCTTTCCAAAATAACAAATGTCTTTTAGT
TTGAGAGCTGTATGTGTGGCAATAAGGATGATTTTTGCTTTTGATAAAATTAGTTGGCTT
CGCCCCTCTTTTTCCGGCCCCTTTTTCATCTGTGCACCCTGGTTTTGTGTCGTCGTTTTT
CCCGAGCTGCTGTCTGGCGCTTCAATTTTTCTTTTCTTTCCGATAATATTCCCCCCTTCT
TCCCTTTTCCCCCTCTTTTTTTATTCCTCCCTGTGTTCGGCATCGCAGAAGCCGCCTCGT
TTCCTTTTTCTTTCTGGGGTTTAGCTGCTCCTCCTCCGTTTCGTCTTTGTTGCGCTCCCG
CCCCCCACCCCCCCTTATTCGACATCGGGTTGTTTGAGCACAGTGTTATGTTTGCTTTTT
TTGCATCCGAATATTCCCAGTATTTTTTGTTAGCACATTTTTTTTTATCCCATTTTTATT
CCTTTATGCCGCTCAACGTTCTTATATTTTTCTACGAGCATGCGTCTGTCATCTTTGAAT
TTTACAGGTGTGTGTTATTTTTCCCTTTTATTGGCCCAGGTCGTAGTGAGGCGAGTAGCG
TTTTTCCGCACCGTTCGTCGTACTTTTTTTTCGCGCTTCTATTAGGGCCTGCCTATTCGT
GAGAGACGGATATATCCTTTACCTTCACACGCCCTTCTGTTTTTATCCTCCGCCCCTCGC
TTTTTTTTGTTGTTTATTCGCCCCACCCCTGTGCTACCGATCTTTATTTTTGACTCACCC
CCCATATTTTCTTTCTTTCGCCCCGCGCCTTTTATTTTGCTAGTTTTGAAACACCGGACC
CCTTTTGTTTTCTCACGT
Restriction Sites NotI-NotI     
ACCN NM_007287
Insert Size 4700 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_007287.1, NP_009218.1
RefSeq Size 5665 bp
RefSeq ORF 2253 bp
Locus ID 4311
Cytogenetics 3q25.2
Domains Peptidase_M13
Protein Families Druggable Genome, Protease, Transmembrane
Protein Pathways Alzheimer's disease, Hematopoietic cell lineage, Renin-angiotensin system
Gene Summary 'The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]'
Transcript Variant: This variant (1bis) contains an alternate 5' UTR exon compared to variant 2b. Variants 1, 1bis, 2a, 2b, 3, and 4 all encode the same isoform (a).

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