HP1 gamma (CBX3) (NM_007276) Human Untagged Clone

CAT#: SC115632

CBX3 (untagged)-Human chromobox homolog 3 (CBX3), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CBX3
• Synonyms: HECH; HP1-GAMMA; HP1Hs-gamma
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_007276, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCCTCCAACAAAACTACATTGCAAAAAATGGGAAAAAAACAGAATGGAAAGAGTAAAAAAGTTGAAG
  AGGCAGAGCCTGAAGAATTTGTCGTGGAAAAAGTACTAGATCGACGTGTAGTGAATGGGAAAGTGGAATA
  TTTCCTGAAGTGGAAGGGATTTACAGATGCTGACAATACTTGGGAACCTGAAGAAAATTTAGATTGTCCA
  GAATTGATTGAAGCGTTTCTTAACTCTCAGAAAGCTGGCAAAGAAAAAGATGGTACAAAAAGAAAATCTT
  TATCTGACAGTGAATCTGATGACAGCAAATCAAAGAAGAAAAGAGATGCTGCTGACAAACCAAGAGGATT
  TGCCAGAGGTCTTGATCCTGAAAGAATAATTGGTGCCACAGACAGCAGTGGAGAATTGATGTTTCTCATG
  AAATGGAAAGATTCAGATGAGGCAGACTTGGTGCTGGCGAAAGAGGCAAATATGAAGTGTCCTCAAATTG
  TAATTGCTTTTTATGAAGAGAGACTAACTTGGCATTCTTGTCCAGAAGATGAAGCTCAATAA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_007276 unedited
  GTGTCACCTTTTGTATACGACTCACTATAGGCGGCCGCGAATCGCACGAGGGCGGAGGGC
  CGGAGACGCTGCAGACCCGCGACCCGGAGCAGCTCGGAGGCGGTGAATAATAGCTCTTCA
  AGTCTGCAATAAAAAAGGCCTCCAACAAAACTACATTGCAAAAAATGGGAAAAAAACAGA
  ATGGAAAGAGTAAAAAAGTTGAAGAGGCAGAGCCTGAAGAATTTGTCGTGGAAAAAGTAC
  TAGATCGACGTGTAGTGAATGGGAAAGTGGAATATTTCCTGAAGTGGAAGGGATTTACAG
  ATGCTGACAATACTTGGGAACCTGAAGAAAATTTAGATTGTCCAGAATTGATTGAAGCGT
  TTCTTAACTCTCAGAAAGCTGGCAAAGAAAAAGATGGTACAAAAAGAAAATCTTTATCTG
  ACAGTGAATCTGATGACAGCAAATCAAAGAAGAAAAGAGATGCTGCTGACAAACCAAGAG
  GATTTGCCAGAGGTCTTGATCCTGAAAGAATAATTGGTGCCACAGACAGCAGTGGAGAAT
  TGATGTTTCTCATGAAATGGAAAGATTCAGATGAGGCAGACTTGGTGCTGGCGAAAGAGG
  CAAATATGAAGTGTCCTCAAATTGTAATTGCTTTTTATGAAGAGAGACTAACTTGGCATT
  CTTGTCCAGAAGATGAAGCTCAATAATTGNTCACATTGNTCTTTTATATATATTTATATA
  TATATATATAAAAATTGCGTCTTAGATTTTGATTTACTAGTGTGACAAATAACTACATNC
  CTATGAAAATCAAGTTTGATATGTTTGTTTTGAAAGTANCGCTGNAAAGATTGTNTGGGG
  TTTTTTTGCATCCATAGCACTGGTTACTTTGAACCAATAAATAAAGCCTTCTGTAGNTGC
  TCCCTTCATCG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_007276 unedited
  GACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGCATAAAGGAATATAA
  AACTATTTATTAACCACTGTTCACCAGTATTTACAATAAAGTAAACAATATACAGTTGGA
  TAACATTTTGATTACTACAAAGTTGTTCTTCCTGGCTTTTGCTGAACCAGTAAAGCAAAC
  TCAAGATTGAGCCTCCATGTAATGAATTGGGGTAAAGAAAAAACATGCAGGTCAATAGGT
  TAGGTTACAAAAGGTTGTTCACACATTTATGACAGCAGGTCCTAAACTGCCAACACCTCT
  AACCATCTGATTAGGTTTCTATGAGCCAAGTCTTACATATTCCATTCATCATGACCTTTT
  AGTCAATGTAGCAACAGGGATTCCAACATTTTGCTAAGGAATGGCCCGCTAGGGAAACTT
  TTAAATGTTCATTTAACTTAGTTTTGTTTAGCTAGTTAAAACACACTAGCATTTGTCTAG
  TTTCCTCATCTGGATGAGGAAACCTGCTGTGATGGCAGTGATAAAATTTTTCCTTTTAGG
  AATTTTGCAAATAAACCACTGCAATTATAGACACTTTAAAATTATCCAATTTAAATTGTC
  CTATCTAGAATTACTTATTTCACTTGAAATGTATGGTTTCAGGAAAATTTTCAATTTAAC
  TTGAAGGGATTATCTCTTATTTTGCTTGGAATAATGGCATCTCAGAAACATGGGTTTACC
  TGTGATTTTTTTGTTTGGGTGAATGCTTAAAAACAAAAAAAATTACATATGCATTTTATG
  GATACACACACACACACACACACACACACACACACAAAAACACGTAATAAATCTAGAATG
  GTCCTTTAGCTCATGAGAACACCAGTTTGACTGAGTATGACTATGGACTTTTCCCCAAAT
  TAAAAAAGCT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_007276
• ORF Size: 552 bp
• Insert Size: 1910
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_007276.3, NP_009207.2
• RefSeq Size: 1837
• RefSeq ORF: 552
• Locus ID: 11335
• Domains: CHROMO
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene. [provided by RefSeq, Mar 2011]
  Transcript Variant: This variant (1) contains an alternate 5' exon but encodes the same protein as transcript variant 2.