ZP3 (NM_007155) Human Untagged Clone

CAT#: SC115652

ZP3 (untagged)-Human zona pellucida glycoprotein 3 (sperm receptor) (ZP3), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ZP3
• Synonyms: OOMD3; Zp-3; ZP3A; ZP3B; ZPC
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC115652 sequence for NM_007155 edited (data generated by NextGen Sequencing)
  ATGGTCATGGTCAGCAAAGACCTTTTTGGCACCGGGAAGCTCATCAGGGCTGCTGACCTC
  ACCTTGGGCCCAGAGGCCTGTGAGCCTCTGGTCTCCATGGACACAGAAGATGTGGTCAGG
  TTTGAGGTTGGACTCCACGAGTGTGGCAACAGCATGCAGGTAACTGACGATGCCCTGGTG
  TACAGCACCTTCCTGCTCCATGACCCCCGCCCCGTGGGAAACCTGTCCATCGTGAGGACT
  AACCGCGCAGAGATTCCCATCGAGTGCCGCTACCCCAGGCAGGGCAATGTGAGCAGCCAG
  GCCATCCTGCCCACCTGGTTGCCCTTCAGGACCACGGTGTTCTCAGAGGAGAAGCTGACT
  TTCTCTCTGCGTCTGATGGAGGAGAACTGGAACGCTGAGAAGAGGTCCCCCACCTTCCAC
  CTGGGAGATGCAGCCCACCTCCAGGCAGAAATCCACACTGGCAGCCACGTGCCACTGCGG
  TTGTTTGTGGACCACTGCGTGGCCACACCGACACCAGACCAGAATGCCTCCCCTTATCAC
  ACCATCGTGGACTTCCATGGCTGTCTTGTCGACGGTCTCACTGATGCCTCTTCTGCATTC
  AAAGTTCCTCGACCCGGGCCAGATACACTCCAGTTCACAGTGGATGTCTTCCACTTTGCT
  AATGACTCCAGAAACATGATATACATCACCTGCCACCTGAAGGTCACCCTAGCTGAGCAG
  GACCCAGATGAACTCAACAAGGCCTGTTCCTTCAGCAAGCCTTCCAACAGCTGGTTCCCA
  GTGGAAGGCTCGGCTGACATCTGTCAATGCTGTAACAAAGGTGACTGTGGCACTCCAAGC
  CATTCCAGGAGGCAGCCTCATGTCATGAGCCAGTGGTCCAGGTCTGCTTCCCGTAACCGC
  AGGCATGTGACAGAAGAAGCAGATGTCACCGTGGGGCCACTGATCTTCCTGGACAGGAGG
  GGTGACCATGAAGTAGAGCAGTGGGCTTTGCCTTCTGACACCTCAGTGGTGCTGCTGGGC
  GTAGGCCTGGCTGTGGTGGTGTCCCTGACTCTGACTGCTGTTATCCTGGTTCTCACCAGG
  AGGTGTCGCACTGCCTCCCACCCTGTGTCTGCTTCCGAATAA
  
  Clone variation with respect to NM_007155.5
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_007155 unedited
  GTCTCTCACCCGCCCGTTGCCGCAAAGGGCGGTAGGCGTGTACGGTGGGAAGGTCTATAT
  AAGCAGAGCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCC
  GCGAATTCGGCACGAGGCTATAGGCTCTTCATCTGCCTCCTGCTCTGGGGTAGTACTGAG
  CTGTGCTACCCCCAACCCCTCTGGCTCTTGCAGGGTGGAGCCAGCCATCCTGAGACGTCC
  GTACAGCCCGTACTGGTGGAGTGTCAGGAGGCCACTCTGATGGTCATGGTCAGCAAAGAC
  CTTTTTGGCACCGGGAAGCTCATCAGGGCTGCTGACCTCACCTTGGGCCCAGAGGCCTGT
  GAGCCTCTGGTCTCCATGGACACAGAAGATGTGGTCAGGTTTGAGGTTGGACTCCACGAG
  TGTGGCAACAGCATGCAGGTAACTGACGATGCCCTGGTGTACAGCACCTTCCTGCTCCAT
  GACCCCCGCCCCGTGGGAAACCTGTCCATCGTGAGGACTAACCGCGCAGAGATTCCCATC
  GAGTGCCGCTACCCCAGGCAGGGCAATGTGAGCAGCCAGGCCATCCTGCCCACCTGGTTG
  CCCTTCAAGACCACGGTGTTCTCAGAGGAGAAGCTGACTTTCTCTCTGCGTCTGATGGAG
  GAGAACTGGAACGCTGAGAAGAGGTCCCCCACCTTCCACCTGAGAGATGCAGCCCACCTC
  CAGGCAGAAATCCACACTGGCAGCCACGTGCCACTGCAGTTAGTTTGTAAACCACTGCGT
  GGCCACACCGACACCAGACCATGATGCCTNCCCTTATCACACCATCGTGGACTTCCATGG
  CTGTCTTGTCGACAGTCTCACTGATGCCTCTTCTGCATTCAAAGTTCCTCGACCCGGGCC
  AGNTACACTNCAGTTCA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_007155 unedited
  CATCCGTTAGATCATCNGGCGATGGTCAACTTCCCAGTTCACGGGGAGAGGCACTGGAGG
  CAGGGGCTCACAGGGCATGCCACCCGGGTATCTGTTCAGGAAAACAGCTATGACCGCGGC
  CGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTATTGCTTTCTTCTTTTATTCGGAAG
  CAGACACAGGGTGGGAGGCAGTGCCACACCTCCTGGTGAGAACCAGGATAACAGCAGTCA
  GAGTCAGGGACACCACCACAGCCAGGCCTACGCCCAGCAGCACCACTGAGGTGTCAAAAG
  GCAAAGCCCACTGCTCTACTTCATGGTCACCCCTCCTGTCCAGGAAGATCAGTGGCCCCA
  CGGTGACATCTGCTTCTTCTGTCACATGCCTGCGGTTACGGGAAGCAGACCTGGACCACT
  GGCTCATGACATGAGGCTGCCTCCTGGAATGGCTTGGAGTGCCACAGTCACCTTTGTTAC
  AGCATTGACAGATGTCAGCCGAGCCTTCCACTGGGAACCATCTGTTGGAAGGCTTGCTGA
  AGGAACAGGCCTTGTTGAGTTCATCTGGGTCCTGCTCAGCTAGGGTGACCTTCAGGTGGC
  AGGTGATGTATATCATGTTTCTGGAGTCATTAGCAAAGTGGAACACATCCACTGTGAACT
  GGAGTGTATCTGGCCCGGGTCGAGGAACTTTGAATGCAGAAGAGGCATCAGTGAGACCGT
  CGACAGACAGCCATGGAAGTTCACTATGGTGTGATAAGGGGACGCATTCTGGTCTGGTGT
  TCNGTGTGCCCACGCAGTGGTTCACACACACCCGCAGTGGCACGTGGCTGCCAGTGTGGA
  TTTCTGCCCTGGAGTGCGCTGCATCTCCCAGGTGGAAGGTGGGGGACCTCTCTTCAGCGT
  TTCAGTTCA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_007155
• ORF Size: 1122 bp
• Insert Size: 1500
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_007155.4, NP_009086.4
• RefSeq Size: 1467
• RefSeq ORF: 1122
• Locus ID: 7784
• Protein Families: Secreted Protein, Transmembrane
• Gene Summary: The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) differs in the 5' UTR and 5' CDS compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.