Plakophilin 3 (PKP3) (NM_007183) Human Untagged Clone

CAT#: SC115670

PKP3 (untagged)-Human plakophilin 3 (PKP3)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PKP3
• Synonyms: plakophilin 3
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC115670 sequence for NM_007183 edited (data generated by NextGen Sequencing)
  ATGCAGGACGGTAACTTCCTGCTGTCGGCCCTGCAGCCTGAGGCCGGCGTGTGCTCCCTG
  GCGCTGCCCTCTGACCTGCAGCTGGACCGCCGGGGCGCCGAGGGGCCGGAGGCCGAGCGG
  CTGCGGGCAGCCCGCGTCCAGGAGCAGGTCCGCGCCCGCCTCTTGCAGCTGGGACAGCAG
  CCGCGGCACAACGGGGCCGCTGAGCCCGAGCCTGAGGCCGAGACTGCCAGAGGCACATCC
  AGGGGGCAGTACCACACCCTGCAGGCTGGCTTCAGCTCTCGCTCTCAGGGCCTGAGTGGG
  GACAAGACCTCGGGCTTCCGGCCCATCGCCAAGCCGGCCTACAGCCCAGCCTCCTGGTCC
  TCCCGCTCCGCCGTGGATCTGAGCTGCAGTCGGAGGCTGAGTTCAGCCCACAACGGGGGC
  AGCGCCTTTGGGGCCGCTGGGTACGGGGGTGCCCAGCCCACCCCTCCCATGCCCACCAGG
  CCCGTGTCCTTCCATGAGCGCGGTGGGGTTGGGAGCCGGGCCGACTATGACACACTCTCC
  CTGCGCTCGCTGCGGCTGGGGCCCGGGGGCCTGGACGACCGCTACAGCCTGGTGTCTGAG
  CAGCTGGAGCCCGCGGCCACCTCCACCTACAGGGCCTTTGCGTACGAGCGCCAGGCCAGC
  TCCAGCTCCAGCCGGGCAGGGGGGCTGGACTGGCCCGAGGCCACTGAGGTTTCCCCGAGC
  CGGACCATCCGTGCCCCTGCCGTGCGGACCCTGCAGCGATTCCAGAGCAGCCACCGGAGC
  CGCGGGGTAGGCGGGGCAGTGCCGGGGGCCGTCCTGGAGCCAGTGGCTCGAGCGCCATCT
  GTGCGCAGCCTCAGCCTCAGCCTGGCTGACTCGGGCCACCTGCCGGACGTGCATGGGTTC
  AACAGCTACGGTAGCCACCGAACCCTGCAGAGACTCAGCAGCGGTTTTGATGACATTGAC
  CTGCCCTCAGCAGTCAAGTACCTCATGGCTTCAGACCCCAACCTGCAGGTGCTGGGAGCG
  GCCTACATCCAGCACAAGTGCTACAGCGATGCAGCCGCCAAGAAGCAGGCCCGCAGCCTT
  CAGGCCGTGCCTAGGCTGGTGAAGCTCTTCAACCACGCCAACCAGGAAGTGCAGCGCCAT
  GCCACAGGTGCCATGCGCAACCTCATCTACGACAACGCTGACAACAAGCTGGCCCTGGTG
  GAGGAGAACGGGATCTTCGAGCTGCTGCGGACACTGCGGGAGCAGGATGATGAGCTTCGC
  AAAAATGTCACAGGGATCCTGTGGAACCTTTCATCCAGCGACCACCTGAAGGACCGCCTG
  GCCAGAGACACGCTGGAGCAGCTCACAGACCTGGTGTTGAGCCCCCTGTCGGGGGCTGGG
  GGTCCCCCCCTCATCCAGCAGAACGCCTCGGAGGCGGAGATCTTCTACAACGCCACCGGC
  TTCCTCAGGAACCTCAGCTCAGCCTCTCAGGCCACTCGCCAGAAGATGCGGGAGTGCCAC
  GGGCTGGTGGACGCCCTGGTCACCTCTATCAACCACGCCCTGGACGCGGGCAAATGCGAG
  GACAAGAGCGTGGAGAACGCGGTGTGCGTCCTGCGGAACCTGTCCTACCGCCTCTACGAC
  GAGATGCCGCCGTCCGCGCTGCAGCGGCTGGAGGGTCGCGGCCGCAGGGACCTGGCGGGG
  GCGCCGCCGGGAGAGGTCGTGGGCTGCTTCACGCCGCAGAGCCGGCGGCTGCGCGAGCTG
  CCCCTCGCCGCCGATGCGCTCACCTTCGCGGAGGTGTCCAAGGACCCCAAGGGCCTCGAG
  TGGCTGTGGAGCCCCCAGATCGTGGGGCTGTACAACCGGCTGCTGCAGCGCTGCGAGCTC
  AACCGGCACACGACGGAGGCGGCCGCCGGGGCGCTGCAGAACATCACGGCAGGCGACCGC
  AGGTGGGCGGGGGTGCTGAGCCGCCTGGCCCTGGAGCAGGAGCGTATTCTGAACCCCCTG
  CTAGACCGTGTCAGGACCGCCGACCACCACCAGCTGCGCTCACTGACTGGCCTCATCCGA
  AACCTGTCTCGGAACGCTAGGAACAAGGACGAGATGTCCACGAAGGTGGTGAGCCACCTG
  ATCGAGAAGCTGCCGGGCAGCGTGGGTGAGAAGTCGCCCCCAGCCGAGGTGCTGGTCAAC
  ATCATAGCTGTGCTCAACAACCTGGTGGTGGCCAGCCCCATCGCTGCCCGAGACCTGCTG
  TATTTTGACGGACTCCGAAAGCTCATCTTCATCAAGAAGAAGCGGGACAGCCCCGACAGT
  GAGAAGTCCTCCCGGGCAGCATCCAGCCTCCTGGCCAACCTGTGGCAGTACAACAAGCTC
  CACCGTGACTTCCGGGCGAAGGGCTATCGGAAGGAGGACTTCCTGGGCCCATAG
  
  Clone variation with respect to NM_007183.2
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_007183 unedited
  NTAAAGTTCAGGATTTTGTAATACGACTCCACTATAGGCGGCGCGCGAATTCGCACGAGG
  CCAGGCCCAGGCCCGGTGGACCTGCCGCGTGCAGGGAGGGGAACTTCCTGCTGTCGGCCC
  TGCAGCCTGAGGCCGGCGTGTGCTCCCTGGCGCTGCCCTCTGACCTGCAGCTGGACCGCC
  GGGGCGCCGAGGGGCCGGAGGCCGAGCGGCTGCGGGCAGCCCGCGTCCAGGAGCAGGTCC
  GCGCCCGCGGGGGGCAGCTGGGACAGCAGCCGCGGCACAACGGGGCCGCTGAGCCCGAGC
  CTGAGGCCGAGACTGCCAGAGGCACATCCAGGGGGCAGTACCACACCCTGCAGGCTGGCT
  TCAGCTCTCGCTCTCAGGGCCTGAGTGGGGACAAGACCTCGGGCTTCCGGCCCATCGCCA
  AGCCGGCCTACAGCCCAGCCTCCTGGTCCTCCCGCTCCGCCGTGGATCTGAGCTGCAGTC
  GGAGGCTGAGTTCAGCCCACAACGGGGGCAGCGCCTTTGGGGCCGCTGGGTACGGGGGTG
  CCCAGCCCACCCCTCCCATGCCCACCAGGCCCGTGTCCTTCCATGAGCGCGGTGGGGTTG
  GGAGCCGGGCCGACTATGACACACTCTCCCTGCGCTCGCTGCGGCTGGGGCCCCGGGGCC
  TGGACGACCGCTACAGCCTGGTGTCTGAGCAGCTGGAGCCCGCGGCCACCTCCACCTACA
  GGGGCCTTTGCGTACGAGCGCCAGGCCAGCTCCAGCTCCAGCCGGGCAGGGGGGCTTGGA
  CTGGCCCCGAGGCCACTGAGGGTTCCCCGAGCCCGGACATCCGTGGCCCCTGGCGTGCGG
  ACCCTGCGGCGATTCCAGAGCAGCCCCCGGACCCCCGGGGAAGCCGGGCCATGCCCGGGC
  GCCTTCT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_007183 unedited
  TTAACGTCCTATTAGNACCGCGCCGCATTCTANGATCGATTTTTTTTTTTTTTTTTTGAC
  TGTTCATGGCCATCTTTATTCCCATGCTGGCTATCCCAAGAACTGCCAGGCCACAGCCAA
  CCCCCACCTCTGCCAATGTGACTGGGTCACCACCCCATACACCAGAGCAGCCTTGAGCCC
  TGCCCCACCCCCTGCCCTGCGGAAGCCAAGTCCCCAGCTATAAGACCCTGCCCCTCCTGG
  TGGCCCAGGACCCTCAAAGATGCACACAGGGGCCCCAGCGAGGGGCCCCTCCGTCATTAG
  CCTTCTCCTCCAGGCTGGGCTGCCAAGCAGCCTGGAGCTGAGTCTGTCCCTTGGACGCTG
  GGCCACGTCACCTTCTCCTCCAGAAGGCTTCACCTATGGGCCCAGGAAGTCCTCCTTCCG
  ATAGCCCTTCGCCCGGAAGTCACGGTGGAGCTTGTTGTACTGCCACAGGTTGGCCAGGAA
  GCTGGATGCTGCCCGGGAGGACTTCTCACTGTCGGGGCTGTCCCGCTTCTTCTTGATGAA
  GATGAGCTTTCGGAGTCCGTCAAAATACAGCAAGTCTCGGGCAGCGATGGGGCTGGCCAC
  CACCAGGTTGTTGAGCACAGCTATGATGTTGACCAGCACCTCGGCTGGGGGCGACTTCTC
  ACCCACGCTGCCCGGCAGCTTCTCGATCAGGTGGCTCACCACCTTCGTGGACATCTCGTC
  CTTGTTCCTAGCGTTCCGAGACAGGTTTCGGATGATGCCAGTCAGTGAGCGCANCTGGTG
  GTGGTCGGCGGTCCTGACACGGTCTAGCAAGGGGTTCAGAATACGCTCCTGCTCCAAGGC
  CA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_007183
• ORF Size: 2394 bp
• Insert Size: 2850
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_007183.2, NP_009114.1
• RefSeq Size: 2845
• RefSeq ORF: 2394
• Locus ID: 11187
• Domains: Armadillo_seg
• Gene Summary: This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
  Transcript Variant: This variant (1) uses an alternate 5' exon structure and differs in the 5' UTR and coding region, compared to variant 2. The resulting isoform (PKP3a) has a shorter and distinct N-terminus compared to isoform PKP3b.