Fibulin 5 (FBLN5) (NM_006329) Human Untagged Clone

CAT#: SC116168

FBLN5 (untagged)-Human fibulin 5 (FBLN5)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: FBLN5
• Synonyms: ADCL2; ARCL1A; ARMD3; DANCE; EVEC; FIBL-5; HNARMD; UP50
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_006329 edited
  GAATTACTGAAGAGGGCTAAGCAAAACCAGGTGCTTGCGCTGAGGGCTCTGCAGTGGCTG
  GGAGGACCCCGGCGCTCTCCCCGTGTCCTCTCCACGACTCGCTCGGCCCCTCTGGAATAA
  AACACCCGCGAGCCCCGAGGGCCCAGAGGAGGCCGACGTGCCCGAGCTCCTCCGGGGGTC
  CCGCCCGCGAGCTTTCTTCTCGCCTTCGCATCTCCTCCTCGCGCGTCTTGGACATGCCAG
  GAATAAAAAGGATACTCACTGTTACCATTCTGGCTCTCTGTCTTCCAAGCCCTGGGAATG
  CACAGGCACAGTGCACGAATGGCTTTGACCTGGATCGCCAGTCAGGACAGTGTTTAGATA
  TTGATGAATGCCGAACCATCCCCGAGGCCTGCCGAGGAGACATGATGTGTGTTAACCAAA
  ATGGCGGGTATTTATGCATTCCCCGGACAAACCCTGTGTATCGAGGGCCCTACTCGAACC
  CCTACTCGACCCCCTACTCAGGTCCGTACCCAGCAGCTGCCCCACCACTCTCAGCTCCAA
  ACTATCCCACGATCTCCAGGCCTCTTATATGCCGCTTTGGATACCAGATGGATGAAAGCA
  ACCAATGTGTGGATGTGGACGAGTGTGCAACAGATTCCCACCAGTGCAACCCCACCCAGA
  TCTGCATCAATACTGAAGGCGGGTACACCTGCTCCTGCACCGACGGATATTGGCTTCTGG
  AAGGCCAGTGCTTAGACATTGATGAATGTCGCTATGGTTACTGCCAGCAGCTCTGTGCGA
  ATGTTCCTGGATCCTATTCTTGTACATGCAACCCTGGTTTTACCCTCAATGAGGATGGAA
  GGTCTTGCCAAGATGTGAACGAGTGTGCCACCGAGAACCCCTGCGTGCAAACCTGCGTCA
  ACACCTACGGCTCTTTCATCTGCCGCTGTGACCCAGGATATGAACTTGAGGAAGATGGCG
  TTCATTGCAGTGATATGGACGAGTGCAGCTTCTCTGAGTTCCTCTGCCAACATGAGTGTG
  TGAACCAGCCCGGCACATACTTCTGCTCCTGCCCTCCAGGCTACATCCTGCTGGATGACA
  ACCGAAGCTGCCAAGACATCAACGAATGTGAGCACAGGAACCACACGTGCAACCTGCAGC
  AGACGTGCTACAATTTACAAGGGGGCTTCAAATGCATTGACCCCATCCGCTGTGAGGAGC
  CTTATCTGAGGATCAGTGATAACCGCTGTATGTGTCCTGCTGAGAACCCTGGCTGCAGAG
  ACCAGCCCTTTACCATCTTGTACCGGGACATGGACGTGGTGTCAGGACGCTCCGTTCCCG
  CTGACATCTTCCAAATGCAAGCCACGACCCGCTACCCTGGGGCCTATTACATTTTCCAGA
  TCAAATCTGGGAATGAGGGCAGAGAATTTTACATGCGGCAAACGGGCCCCATCAGTGCCA
  CCCTGGTGATGACACGCCCCATCAAAGGGCCCCGGGAAATCCAGCTGGACTTGGAAATGA
  TCACTGTCAACACTGTCATCAACTTCAGAGGCAGCTCCGTGATCCGACTGCGGATATATG
  TGTCGCAGTACCCATTCTGAGCCTCGGGCTGGAGCCTCCGACGCTGCCTCTCATTGGCAC
  CAAGGGACAGGAGAAGAGAGGAAATAACAGAGAGAATGAGAGCGACACAGACGTTAGGCA
  TTTCCTGCTGAACGTTTCCCCGAAGAGTCAGCCCCGACTTCCTGACTCTCACCTGTACTA
  TTGCAGACCTGTCACCCTGCAGGACTTGCCACCCCCAGTTCCTATGACACAGTTATCAAA
  AAGTATTATCATTGCTCCCCTGATAGAAGATTGTTGGTGAATTTTCAAGGCCTTCAGTTT
  ATTTCCACTATTTTCAAAGAAAATAGATTAGGTTTGCGGGGGTCTGAGTCTATGTTCAAA
  GACTGTGAACAGCTTGCTGTCACTTCTTCACCTCTTCCACTCCTTCTCTCACTGTGTTAC
  TGCTTTGCAAAGACCCGGGAGCTGGCGGGGAACCCTGGGAGTAGCTAGTTTGCTTTTTGC
  GTACACAGAGAAGGCTATGTAAACAAACCACAGCAGGATCGAAGGGTTTTTAGAGAATGT
  GTTTCAAAACCATGCCTGGTATTTTCAACCATAAAAGAAGTTTCAGTTGTCCTTAAATTT
  GTATAACGGTTTAATTCTGTCTTGTTCATTTTGAGTATTTTTAAAAAATATGTCGTAGAA
  TTCCTTCGAAAGGCCTTCAGACACATGCTATGTTCTGTCTTCCCAAACCCAGTCTCCTCT
  CCATTTTAGCCCAGTGTTTTCTTTGAGGACCCCTTAATCTTGCTTTCTTTAGAATTTTTA
  CCCAATTGGATTGGAATGCAGAGGTCTCCAAACTGATTAAATATTTGAAGAGAAAAAAAA
  AAAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_006329 unedited
  CAGAAATTTGTAATACGAACTCACTATAGGGCGGCCGCGAATTCGCACGAGGGAATTACT
  GAAGAGGGCTAAGCAAAACCAGGTGCTTGCGCTGAGGGCTCTGCAGTGGCTGGGAGGACC
  CCGGCGCTCTCCCCGTGTCCTCTCCACGACTCGCTCGGCCCCTCTGGAATAAAACACCCG
  CGAGCCCCGAGGGCCCAGAGGAGGCCGACGTGCCCGAGCTCCTCCGGGGGTCCCGCCCGC
  GAGCTTTCTTCTCGCCTTCGCATCTCCTCCTCGCGCGTCTTGGACATGCCAGGAATAAAA
  AGGATACTCACTGTTACCATTCTGGCTCTCTGTCTTCCAAGCCCTGGGAATGCACAGGCA
  CAGTGCACGAATGGCTTTGACCTGGATCGCCAGTCAGGACAGTGTTTAGATATTGATGAA
  TGCCGAACCATCCCCGAGGCCTGCCGAGGAGACATGATGTGTGTTAACCAAAATGGCGGG
  TATTTATGCATTCCCCGGACAAACCCTGTGTATCGAGGGCCCTACTCGAACCCCTACTCG
  ACCCCCTACTCAGGTCCGTACCCAGCAGCTGCCCCACCACTCTCAGCTCCAAACTATCCC
  ACGATCTCCAGGCCTCTTATATGCCGCTTTGGATACCAGATGGATGAAAGCAACCAATGT
  GTGGATGTGGACGAGTGTGCAACAGATTCCCACCAGTGCAACCCCACCCAGATCTGCATC
  AATACTGAAGGCGGGTACACCTGCTCCTGCACCGACGGATATTGGCTTCTGGGAAGCCAG
  TGCTTANACATTGATGAATGTCGCTATGGTTACTGCCAGCAGCTCTGTGCGAATGGTCCT
  GGNACCTATNCTTGACATGCAACCCTGNTNTACCCTCATGNAGATGGNAGGTCTTGCCAG
  ATGTGACGATGTGCCACGAAAC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_006329 unedited
  CGCGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCTCTTCAA
  ATATTAAATCAGTTTGGAAACCTCTGCATTCCAATCCAATTGGGTAAAAATTCTAAAAAA
  AGCAAGATTAAGGGGTCCTCAAAAAAAACACTGGGCTAAAATGGAAAGGAAACTGGGTTT
  GGGAAAACAAAACATAGCATGTGTCTGAAGGCCTTTCAAAGGAATTCTACGACATATTTT
  TTAAAAATACTCAAAATGAACAAGACAGAATTAAACCGTTATACAAATTTAAGGACAACT
  GAAACTTCTTTTATGGTTGAAAATACCAGGCATGGTTTTGAAACACATTCTCTAAAAACC
  CTTCGATCCTGCTGGGGTTTGTTTACATAGCCTTCTCTGTGTACGCAAAAAGCAAACTAG
  CTACTCCCAGGGTTCCCCGCCAGCTCCCGGGTCTTTGCAAAGCAGTAACACAGTGAAAGA
  AGGAGTGGAAAAGGTGAAAAAGTGACAGCAAGCTGTTCACAGTCTTTGAACATAAACTCA
  GACCCCCGCAAACCTAATCTATTTTCTTTGAAAATAGTGGAAATAAACTGAAGGCCTTGA
  AAATTCCCAACAATCTTCTATCAGGGGAGCAATGATAAACTTTTTGATAACTGTGTCATA
  GGAACTGGGGGTGGCAAGTCCTGCAGGGTGACAAGTCTGCATANTACAGGTGAAAGTCAA
  GAAGTCCGGGCTGACTCTTCGGGAAACGTTCAGCAGGAAATGCCTAACCTCTGTGGCCGC
  TCTCATTCTCTCTGGTAATTCCTCTCTCCCCCGGCCCTGGGNGCCATGAAAGGCAGCGGT
  CGAAGGTCCANCCCCAGCTCAAATGGGGCCTGCAACCCTATTTCCGCCGTCGGTCCACGA
  ACCTGCCTTTGAATTGAAACAGGGTGACAGGGTTCATTCCCATCCACTGGGTTC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_006329
• ORF Size: 1347 bp
• Insert Size: 2400
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The ORF of this clone has been fully sequenced and found to be a perfect match to NM_006329.

Reference Data

• RefSeq: NM_006329.2, NP_006320.2
• RefSeq Size: 2646
• RefSeq ORF: 1347
• Locus ID: 10516
• Domains: EGF_CA, EGF, EGF
• Protein Families: Secreted Protein
• Gene Summary: The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]