PTPN13 (NM_006264) Human Untagged Clone

CAT#: SC116224

PTPN13 (untagged)-Human protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) (PTPN13), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PTPN13
• Synonyms: FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL; PTP1E; PTPL1; PTPLE
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_006264 edited
  TCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCG
  GCACGAGGCGAGGAGGAGGAGGAGGAGATGCTGCTCCTCTTCTCCCCCTCCCCAGGCTCC
  TTCTACAGCTCCTTCAGCCCACGCCCGCAGCCGCTTGTGGGAGAAGTGGTGGTGGCTCTC
  GGCGCCCGCGGCGGCTGCCGGCGGCCCGCCCCGACGCCGCGTCCCTGCAGCCCTCGCCCG
  GCGCTCCAGTAGCAGGACCCGGTCTCGGGACCAGCCGGTAATATGCACGTGTCACTAGCT
  GAGGCCCTGGAGGTTCGGGGTGGACCACTTCAGGAGGAAGAAATATGGGCTGTATTAAAT
  CAAAGTGCTGAAAGTCTCCAAGAATTATTCAGAAAAGTAAGCCTAGCTGATCCTGCTGCC
  CTTGGCTTCATCATTTCTCCATGGTCTCTGCTGTTGCTGCCATCTGGTAGTGTGTCATTT
  ACAGATGAAAATATTTCCAATCAGGATCTTCGAGCATTCACTGCACCAGAGGTTCTTCAA
  AATCAGTCACTAACTTCTCTCTCAGATGTTGAAAAGATCCACATTTATTCTCTTGGAATG
  ACACTGTATTGGGGGGCTGATTATGAAGTGCCTCAGAGCCAACCTATTAAGCTTGGAGAT
  CATCTCAACAGCATACTGCTTGGAATGTGTGAGGATGTTATTTACGCTCGAGTTTCTGTT
  CGGACTGTGCTGGATGCTTGCAGTGCCCACATTAGGAATAGCAATTGTGCACCCTCATTT
  TCCTACGTGAAACACTTGGTAAAACTGGTTCTGGGAAATCTTTCTGGGACAGATCAGCTT
  TCCTGTAACAGTGAACAAAAGCCTGATCGAAGCCAGGCTATTCGAGATCGATTGCGAGGA
  AAAGGATTACCAACAGAACCAGTTCGAAGATACAAAACTTATCATGGTGATGTCTTTAGT
  ACCTCCAGTGAAAGTCCATCTATTATTTCCTCTGAATCAGATTTCAGACAAGTGAGAAGA
  AGTGAAGCCTCAAAGAGGTTTGAATCCAGCAGTGGTCTCCCAGGGGTAGATGAAACCTTA
  AGTCAAGGCCAGTCACAGAGACCGAGCAGACAATATGAAACACCCTTTGAAGGCAACTTA
  ATTAATCAAGAGATCATGCTAAAACGGCAAGAGGAAGAACTGATGCAGCTACAAGCCAAA
  ATGGCCCTTAGACAGTCTCGGTTGAGCCTATATCCAGGAGACACAATCAAAGCGTCCATG
  CTTGACATCACCAGGGATCCGTTAAGAGAAATTGCCCTAGAAACAGCCATGACTCAAAGA
  AAACTGAGGAATTTCTTTGGCCCTGAGTTTGTGAAAATGACAATTGAACCATTTATATCT
  TTGGATTTGCCACGGTCTATTCTTACTAAGAAAGGGAAGAATGAGGATAACCGAAGGAAA
  GTAAACATAATGCTTCTGAACGGGCAAAGACTGGAACTGACCTGTGATACCAAAACTATA
  TGTAAAGATGTGTTTGATATGGTTGTGGCACATATTGGCTTAGTAGAGCATCATTTGTTT
  GCTTTAGCTACCCTCAAAGATAATGAATATTTCTTTGTTGATCCTGACTTAAAATTAACC
  AAAGTGGCCCCAGAGGGATGGAAAGAAGAACCAAAGAAAAAGACCAAAGCCACTGTTAAT
  TTTACTTTGTTTTTCAGAATTAAATTTTTTATGGATGATGTTAGTCTAATACAACATACT
  CTGACGTGTCATCAGTATTACCTTCAGCTTCGAAAAGATATTTTGGAGGAAAGGATGCAC
  TGTGATGATGAGACTTCCTTATTGCTGGCATCCTTGGCTCTCCAGGCTGAGTATGGAGAT
  TATCAACCAGAGGTTCATGGTGTGTCTTACTTTAGAATGGAGCACTATTTGCCCGCCAGA
  GTGATGGAGAAACTTGATTTATCCTATATCAAAGAAGAGTTACCCAAATTGCATAATACC
  TATGTGGGAGCTTCTGAAAAAGAGACAGAGTTAGAATTTTTAAAGGTCTGCCAAAGACTG
  ACAGAATATGGAGTTCATTTTCACCGAGTGCACCCTGAGAAGAAGTCACAAACAGGAATA
  TTGCTTGGAGTCTGTTCTAAAGGTGTCCTTGTGTTTGAAGTTCACAATGGAGTGCGCACA
  TTGGTCCTTCGCTTTCCATGGAGGGAAACCAAGAAAATATCTTTTTCTAAAAAGAAAATC
  ACATTGCAAAATACATCAGATGGAATAAAACATGGCTTCCAGACAGACAACAGTAAGATA
  TGCCAGTACCTGCTGCACCTCTGCTCTTACCAGCATAAGTTCCAGCTACAGATGAGAGCA
  AGACAGAGCAACCAAGATGCCCAAGATATTGAGAGAGCTTCGTTTAGGAGCCTGAATCTC
  CAAGCAGAGTCTGTTAGAGGATTTAATATGGGACGAGCAATCAGCACTGGCAGTCTGGCC
  AGCAGCACCCTCAACAAACTTGCTGTTCGACCTTTATCAGTTCAAGCTGAGATTCTGAAG
  AGGCTATCCTGCTCAGAGCTGTCGCTTTACCAGCCATTGCAAAACAGTTCAAAAGAGAAG
  AATGACAAAGCTTCATGGGAGGAAAAGCCTAGAGAGATGAGTAAATCATACCATGATCTC
  AGTCAGGCCTCTCTCTATCCACATCGGAAAAATGTCATTGTTAACATGGAACCCCCACCA
  CAAACCGTTGCAGAGTTGGTGGGAAAACCTTCTCACCAGATGTCAAGATCTGATGCAGAA
  TCTTTGGCAGGAGTGACAAAACTTAATAATTCAAAGTCTGTTGCGAGTTTAAATAGAAGT
  CCTGAAAGGAGGAAACATGAATCAGACTCCTCATCCATTGAAGACCCTGGGCAAGCATAT
  GTTCTAGATGTGCTACACAAAAGATGGAGCATAGTATCTTCACCAGAAAGGGAGATCACC
  TTAGTGAACCTGAAAAAAGATGCAAAGTATGGCTTGGGATTTCAAATTATTGGTGGGGAG
  AAGATGGGAAGACTGGACCTAGGCATATTTATCAGTTCAGTTGCCCCTGGAGGACCAGCT
  GACTTGGATGGATGCTTGAAGCCAGGAGACCGTTTGATATCTGTGAATAGTGTGAGTCTG
  GAGGGAGTCAGCCACCATGCTGCAATTGAAATTTTGCAAAATGCACCTGAAGATGTGACA
  CTTGTTATCTCTCAGCCAAAAGAAAAGATATCCAAAGTGCCTTCTACTCCTGTGCATCTC
  ACCAATGAGATGAAAAACTACATGAAGAAATCTTCCTACATGCAAGACAGTGCTATAGAT
  TCTTCTTCCAAGGATCACCACTGGTCACGTGGTACCCTGAGGCACATCTCGGAGAACTCC
  TTTGGGCCGTCTGGGGGCCTGCGGGAAGGAAGCCTGAGTTCTCAAGATTCCAGGACTGAG
  AGTGCCAGCTTGTCTCAAAGCCAGGTCAATGGTTTCTTTGCCAGCCATTTAGGTGACCAA
  ACCTGGCAGGAATCACAGCATGGCAGCCCTTCCCCATCTGTAATATCCAAAGCCACCGAG
  AAAGAGACTTTCACTGATAGTAACCAAAGCAAAACTAAAAAGCCAGGCATTTCTGATGTA
  ACTGATTACTCAGACCGTGGAGATTCAGACATGGATGAAGCCACTTACTCCAGCAGTCAG
  GATCATCAAACACCAAAACAGGAATCTTCCTCTTCAGTGAATACATCCAACAAGATGAAT
  TTTAAAACTTTTTCTTCATCACCTCCTAAGCCTGGAGATATCTTTGAGGTTGAACTGGCT
  AAAAATGATAACAGCTTGGGGATAAGTGTCACGGTACTGTTTGACAAGGGAGGTGTGAAT
  ACGAGTGTCAGACATGGTGGCATTTATGTGAAAGCTGTTATTCCCCAGGGAGCAGCAGAG
  TCTGATGGTAGAATTCACAAAGGTGATCGCGTCCTAGCTGTCAATGGAGTTAGTCTAGAA
  GGAGCCACCCATAAGCAAGCTGTGGAAACACTGAGAAATACAGGACAGGTGGTTCATCTG
  TTATTAGAAAAGGGACAATCTCCAACATCTAAAGAACATGTCCCGGTAACCCCACAGTGT
  ACCCTTTCAGATCAGAATGCCCAAGGTCAAGGCCCAGAAAAAGTGAAGAAAACAACTCAG
  GTCAAAGACTACAGCTTTGTCACTGAAGAAAATACATTTGAGGTAAAATTATTTAAAAAT
  AGCTCAGGTCTAGGATTCAGTTTTTCTCGAGAAGATAATCTTATACCGGAGCAAATTAAT
  GCCAGCATAGTAAGGGTTAAAAAGCTCTTTCCTGGACAGCCAGCAGCAGAAAGTGGAAAA
  ATTGATGTAGGAGATGTTATCTTGAAAGTGAATGGAGCCTCTTTGAAAGGACTATCTCAG
  CAGGAAGTCATATCTGCTCTCAGGGGAACTGCTCCAGAAGTATTCTTGCTTCTCTGCAGA
  CCTCCACCTGGTGTGCTACCGGAAATTGATACTGCGCTTTTGACCCCACTTCAGTCTCCA
  GCACAAGTACTTCCAAACAGCAGTAAAGACTCTTCTCAGCCATCATGTGTGGAGCAAAGC
  ACCAGCTCAGATGAAAATGAAATGTCAGACAAAAGCAAAAAACAGTGCAAGTCCCCATCC
  AGAAGAGACAGTTACAGTGACAGCAGTGGGAGTGGAGAAGATGACTTAGTGACAGCTCCA
  GCAAACATATCAAATTCGACCTGGAGTTCAGCTTTGCATCAGACTCTAAGCAACATGGTA
  TCACAGGCACAGAGTCATCATGAAGCACCCAAGAGTCAAGAAGATACCATTTGTACCATG
  TTTTACTATCCTCAGAAAATTCCCAATAAACCAGAGTTTGAGGACAGTAATCCTTCCCCT
  CTACCACCGGATATGGCTCCTGGGCAGAGTTATCAACCCCAATCAGAATCTGCTTCCTCT
  AGTTCGATGGATAAGTATCATATACATCACATTTCTGAACCAACTAGACAAGAAAACTGG
  ACACCTTTGAAAAATGACTTGGAAAATCACCTTGAAGACTTTGAACTGGAAGTAGAACTC
  CTCATTACCCTAATTAAATCAGAAAAAGGAAGCCTGGGTTTTACAGTAACCAAAGGCAAT
  CAGAGAATTGGTTGTTATGTTCATGATGTCATACAGGATCCAGCCAAAAGTGATGGAAGG
  CTAAAACCTGGGGACCGGCTCATAAAGGTTAATGATACAGATGTTACTAATATGACTCAT
  ACAGATGCAGTTAATCTGCTCCGGGCTGCATCCAAAACAGTCAGATTAGTTATTGGACGA
  GTTCTAGAATTACCCAGAATACCAATGTTGCCTCATTTGCTACCGGACATAACACTAACG
  TGCAACAAAGAGGAGTTGGGTTTTTCCTTATGTGGAGGTCATGACAGCCTTTATCAAGTG
  GTATATATTAGTGATATTAATCCAAGGTCCGTCGCAGCCATTGAGGGTAATCTCCAGCTA
  TTAGATGTCATCCATTATGTGAACGGAGTCAGCACACAAGGAATGACCTTGGAGGAAGTT
  AACAGAGCATTAGACATGTCACTTCCTTCATTGGTATTGAAAGCAACAAGAAATGATCTT
  CCAGTGGTCCCCAGCTCAAAGAGGTCTGCTGTTTCAGCTCCAAAGTCAACCAAAGGCAAT
  GGTTCCTACAGTGTGGGGTCTTGCAGCCAGCCTGCCCTCACTCCTAATGATTCATTCTCC
  ACGGTTGCTGGGGAAGAAATAAATGAAATATCGTACCCCAAAGGAAAATGTTCTACTTAT
  CAGATAAAGGGATCACCAAACTTGACTCTGCCCAAAGAATCTTATATACAAGAAGATGAC
  ATTTATGATGATTCCCAAGAAGCTGAAGTTATCCAGTCTCTGCTGGATGTTGTGGATGAG
  GAAGCCCAGAATCTTTTAAACGAAAATAATGCAGCAGGATACTCCTGTGGTCCAGGTACA
  TTAAAGATGAATGGGAAGTTATCAGAAGAGAGAACAGAAGATACAGACTGCGATGGTTCA
  CCTTTACCTGAGTATTTTACTGAGGCCACCAAAATGAATGGCTGTGAAGAATATTGTGAA
  GAAAAAGTAAAAAGTGAAAGCTTAATTCAGAAGCCACAAGAAAAGAAGACTGATGATGAT
  GAAATAACATGGGGAAATGATGAGTTGCCAATAGAGAGAACAAACCATGAAGATTCTGAT
  AAAGATCATTCCTTTCTGACAAACGATGAGCTCGCTGTACTCCCTGTCGTCAAAGTGCTT
  CCCTCTGGTAAATACACGGGTGCCAACTTAAAATCAGTCATTCGAGTCCTGCGGGGTTTG
  CTAGATCAAGGAATTCCTTCTAAGGAGCTGGAGAATCTTCAAGAATTAAAACCTTTGGAT
  CAGTGTCTAATTGGGCAAACTAAGGAAAACAGAAGGAAGAACAGATATAAAAATATACTT
  CCCTATGATGCTACAAGAGTGCCTCTTGGAGATGAAGGTGGCTATATCAATGCCAGCTTC
  ATTAAGATACCAGTTGGGAAAGAAGAGTTCGTTTACATTGCCTGCCAAGGACCACTGCCT
  ACAACTGTTGGAGACTTCTGGCAGATGATTTGGGAGCAAAAATCCACAGTGATAGCCATG
  ATGACTCAAGAAGTAGAAGGAGAAAAAATCAAATGCCAGCGCTATTGGCCCAACATCCTA
  GGCAAAACAACAATGGTCAGCAACAGACTTCGACTGGCTCTTGTGAGAATGCAGCAGCTG
  AAGGGCTTTGTGGTGAGGGCAATGACCCTTGAAGATATTCAGACCAGAGAGGTGCGCCAT
  ATTTCTCATCTGAATTTCACTGCCTGGCCAGACCATGATACACCTTCTCAACCAGATGAT
  CTGCTTACTTTTATCTCCTACATGAGACACATCCACAGATCAGGCCCAATCATTACGCAC
  TGCAGTGCTGGCATTGGACGTTCAGGGACCCTGATTTGCATAGATGTGGTTCTGGGATTA
  ATCAGTCAGGATCTTGATTTTGACATCTCTGATTTGGTGCGCTGCATGAGACTACAAAGA
  CACGGAATGGTTCAGACAGAGGATCAATATATTTTCTGCTATCAAGTCATCCTTTATGTC
  CTGACACGTCTTCAAGCAGAAGAAGAGCAAAAACAGCAGCCTCAGCTTCTGAAGTGACAT
  GAAAAGAGCCTCTGGATGCATTTCCATTTCTCTCCTTAACCTCCAGCAGACTCCTGCTCT
  CTATCCAAAATAAAGATCACAGAGCAGCAAGTTCATACAACATGCATGTTCTCCTCTATC
  TTAGAGGGGTATTCTTCTTGAAAATAAAAAATATTGAAATGCTGTATTTTTACAGCTACT
  TTAACCTATGATAATTATTTACAAAATTTTAACACTAACCAAACAATGCAGATCTTAGGG
  ATGATTAAAGGCAGCATTTGATGATAGCAGACATTGTTACAAGGACATGGTGAGTCTATT
  TTTAATGCACCAATCTTGTTTATAGCAAAAATGTTTTCCAATATTTTAATAAAGTAGTTA
  TTTTATAGGGGATACTTGAAACCAGTATTTAAGCTTTAAATGACAGTAATATTGGCATAG
  AAAAAAGTAGCAAATGTTTACTGTATCAATTTCTAATGTTTACTATATAGAATTTCCTGT
  AATATATTTATATACTTTTTCATGAAAATGGAGTTATCAGTTATCTGTTTGTTACTGCAT
  CATCTGTTTGTAATCATTATCTCACTTTGTAAATAAAAACA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_006264 unedited
  AACGTTCGTCATTTTGTAATACGACNCACTATTAGGGCGGCCCGCGATTCGGCACGAGGC
  GAGGAGGAGGAGGAGGAGATGCTGCTCCTCTTCTCCCCCTCCCCAGGCTCCTTCTACAGC
  TCCTTCAGCCCACGCCCGCAGCCGCTTGTGGGAGAAGTGGTGGTGGCTCTCGGCGCCCGC
  GGCGGCTGCCGGCGGCCCGCCCCGACGCCGCGTCCCTGCAGCCCTCGCCCGGCGCTCCAG
  TAGCAGGACCCGGTCTCGGGACCAGCCGGTAATATGCACGTGTCACTAGCTGAGGCCCTG
  GAGGTTCGGGGTGGACCACTTCAGGAGGAAGAAATATGGGCTGTATTAAATCAAAGTGCT
  GAAAGTCTCCAAGAATTATTCAGAAAAGTAAGCCTAGCTGATCCTGCTGCCCTTGGCTTC
  ATCATTTCTCCATGGTCTCTGCTGTTGCTGCCATCTGGTAGTGTGTCATTTACAGATGAA
  AATATTTCCAATCAGGATCTTCGAGCATTCACTGCACCAGAGGTTCTTCAAAATCAGTCA
  CTAACTTCTCTCTCAGATGTTGAAAAGATCCACATTTATTCTCTTGGAATGACACTGTAT
  TGGGGGGCTGATTATGAAGTGCCTCAGAGCCAACCTATTAAGCTTGGAGATCATCTCAAC
  AGCATACTGCTTGGAATGTGGNANGGATGTTATTTACGCTCGAGTTTCTGTTCGGACTGT
  GCTGGATGCTTGCAGTGCCCACATTATGAATAGCAATTGTGCACCCTCATTTTCCTACGT
  GAAACACTTGGTAAAACTGGTTCTGGGGAATCTTTCTGGGACAGATCAGCTTTCCTGTTA
  CAGTGAACANAAGCCCTGATCGAGCCAGGCTATTCGAGATCGATTGCGAGGAAAAGGATT
  ACCAACGACCAGTTCN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_006264 unedited
  NNCCTATCTTGNACGCGGCCGCATTCTANGAATCGGTTTTTTTTTTTTTTTTTTGGCTTG
  TTCATGTTTTAAGGGGTGTTTTTATTTACAAAGTGAGATAATGATTACAAACAGATGATG
  CAGTAACAAACAGATAACTGATAACTCCATTTTCATGAAAAAGTATATAAATATATTACA
  GGAAATTCTATATAGTAAACATTAGAAATTGATACAGTAAACATTTGCTACTTTTTTCTA
  TGCCAATATTACTGTCATTTAAAGCTTAAATACTGGTTTCAAGTATCCCCTATAAAATAA
  CTACTTTATTAAAATATTGGAAAACATTTTTGCTATAAACAAGATTGGTGCATTAAAAAT
  AGACTCACCATGTCCTTGTAACAATGTCTGCTATCATCAAATGCTGCCTTTAATCATCCC
  TAAGATCTGCATTGTTTGGTTAGTGTTAAAATTTTGTAAATAATTATCATAGGTTAAAGT
  AGCTGTAAAAATACAGCATTTCAATATTTTTTATTTTCAAGAAGAATACCCCTCTAAGAT
  AGAGGAGAACATGCATGTTGTATGAACTTGCTGCTCTGTGATCTTTATTTTGGATAGAGA
  GCAGGAGTCTGCTGGAGGTTAAGGAGAGAAATGGAAATGCATCCAGAGGCTCTTTTCATG
  TCACTTCAGAAGCTGAAGCTGCTGTTTTTGCTCTTCTTCTGCTTGAAGACGTGTCANGAC
  ATAAAGGATGACTTGATAGCAGAAAATATATTGATCCTTTGTCTGAACCATTCCGGGTCT
  TTGTAGTCTCATGCCCCGCACCAAAATAGAGATGTCAAAATCAAAAACCTGACTGGATAA
  TCCCAGAACCACACTTATGCAAATCAGGGTCCCTGAACCTCCAAAGCCAACACTGCAGTG
  CTTAATGAATGGGCCCTGAACTG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_006264
• Insert Size: 4700 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_006264.1, NP_006255.1
• RefSeq Size: 8062 bp
• RefSeq ORF: 7401 bp
• Locus ID: 5783
• Cytogenetics: 4q21.3
• Domains: Y_phosphatase, B41, PDZ, PTPc_motif
• Protein Families: Druggable Genome, Phosphatase
• Gene Summary: 'The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]'
  Transcript Variant: This variant (2) lacks multiple in-frame segments of the coding region, compared to variant 4. The encoded protein (isoform 2) lacks 19 internal amino acids, compared to isoform 4.