PIK3CB (NM_006219) Human Untagged Clone

CAT#: SC116228

PIK3CB (untagged)-Human phosphoinositide-3-kinase, catalytic, beta polypeptide (PIK3CB)


  "NM_006219" in other vectors (6)

Reconstitution Protocol

USD 2,170.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PIK3CB
Synonyms P110BETA; PI3K; PI3KBETA; PIK3C1
Vector pCMV6-XL6
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_006219 edited
GAATTCGGCACGAGGGGGCTGCTGACTGCGCACTTGGAATAGTAGCAGGCGGCGGCGGCG
GAACGCCAGGCAGGGCCCCGTGGTTATGAATGTGCTTCAGTTTCATAATGCCTCCTGCTA
TGGCAGACATCCTTGACATCTGGGCGGTGGATTCACAGATAGCATCTGATGGCTCCATAC
CTGTGGATTTCCTTTTGCCCACTGGGATTTATATCCAGTTGGAGGTACCTCGGGAAGCTA
CCATTTCTTATATTAAGCAGATGTTATGGAAGCAAGTTCACAATTACCCAATGTTCAACC
TCCTTATGGATATTGACTCCTATATGTTTGCATGTGTGAATCAGACTGCTGTATATGAGG
AGCTTGAAGATGAAACACGAAGACTCTGTGATGTCAGACCTTTTCTTCCAGTTCTCAAAT
TAGTGACAAGAAGTTGTGACCCAGGGGAAAAATTAGACTCAAAAATTGGAGTCCTTATAG
GAAAAGGTCTGCATGAATTTGATTCCTTGAAGGATCCTGAAGTAAATGAATTTCGAAGAA
AAATGCGCAAATTCAGCGAGGAAAAAATCCTGTCACTTGTGGGATTGTCTTGGATGGACT
GGCTAAAACAAACATATCCACCAGAGCATGAACCATCCATCCCTGAAAACTTAGAAGATA
AACTTTATGGGGGAAAGCTCATCGTAGCTGTTCATTTTGAAAACTGCCAGGACGTGTTTA
GCTTTCAAGTGTCTCCTAATATGAATCCTATCAAAGTAAATGAATTGGCAATCCAAAAAC
GTTTGACTATTCATGGGAAGGAAGATGAAGTTAGCCCCTATGATTATGTGTTGCAAGTCA
GCGGGAGAGTAGAATATGTTTTTGGTGATCATCCACTAATTCAGTTCCAGTATATCCGGA
ACTGTGTGATGAACAGAGCCCTGCCCCATTTTATACTTGTGGAATGCTGCAAGATCAAGA
AAATGTATGAACAAGAAATGATTGCCATAGAGGCTGCCATAAATCGAAATTCATCTAATC
TTCCTCTTCCATTACCACCAAAGAAAACACGAATTATTTCTCATGTTTGGGAAAATAACA
ACCCTTTCCAAATTGTCTTGGTTAAGGGAAATAAACTTAACACAGAGGAAACTGTAAAAG
TTCATGTCAGGGCTGGTCTTTTTCATGGTACTGAGCTCCTGTGTAAAACCATCGTAAGCT
CAGAGGTATCAGGGAAAAATGATCATATTTGGAATGAACCACTGGAATTTGATATTAATA
TTTGTGACTTACCAAGAATGGCTCGATTATGTTTTGCTGTTTATGCAGTTTTGGATAAAG
TAAAAACGAAGAAATCAACGAAAACTATTAATCCCTCTAAATATCAGACCATCAGGAAAG
CTGGAAAAGTGCATTATCCTGTAGCGTGGGTAAATACGATGGTTTTTGACTTTAAAGGAC
AATTGAGAACTGGAGACATAATATTACACAGCTGGTCTTCATTTCCTGATGAACTCGAAG
AAATGTTGAATCCAATGGGAACTGTTCAAACAAATCCATATACTGAAAATGCAACAGCTT
TGCATGTTAAATTTCCAGAGAATAAAAAACAACCTTATTATTACCCTCCCTTCGATAAGA
TTATTGAAAAGGCAGCTGAGATTGCAAGCAGTGATAGTGCTAATGTGTCAAGTCGAGGTG
GAAAAAAGTTTCTTCCTGTATTGAAAGAAATCTTGGACAGGGATCCCTTGTCTCAACTGT
GTGAAAATGAAATGGATCTTATTTGGACTTTGCGACAAGACTGCCGAGAGATTTTCCCAC
AATCACTGCCAAAATTACTGCTGTCAATCAAGTGGAATAAACTTGAGGATGTTGCTCAGC
TTCAGGCGCTGCTTCAGATTTGGCCTAAACTGCCCCCCCGGGAGGCCCTAGAGCTTCTGG
ATTTCAACTATCCAGACCAGTACGTTCGAGAATATGCTGTAGGCTGCCTGCGACAGATGA
GTGATGAAGAACTTTCTCAATATCTTTTACAACTGGTGCAAGTGTTAAAATATGAGCCTT
TTCTTGATTGTGCCCTCTCTAGATTCCTATTAGAAAGAGCACTTGGTAATCGGAGGATAG
GGCAGTTTCTATTTTGGCATCTTAGGTCAGAAGTGCACATTCCTGCTGTCTCAGTACAAT
TTGGTGTCATCCTTGAAGCATACTGCCGGGGAAGTGTGGGGCACATGAAAGTGCTTTCTA
AGCAGGTTGAAGCACTCAATAAGTTAAAAACTTTAAATAGTTTAATCAAACTGAATGCCG
TGAAGTTAAACAGAGCCAAAGGGAAGGAGGCCATGCATACCTGTTTAAAACAGAGTGCTT
ACCGGGAAGCCCTCTCTGACCTGCAGTCACCCCTGAACCCATGTGTTATCCTCTCAGAAC
TCTATGTTGAAAAGTGCAAATACATGGATTCCAAAATGAAGCCTTTGTGGCTGGTATACA
ATAACAAGGTATTTGGTGAGGATTCAGTTGGAGTGATTTTTAAAAATGGTGATGATTTAC
GACAGGATATGTTGACACTCCAAATGTTGCGCTTGATGGATTTACTCTGGAAAGAAGCTG
GTTTGGATCTTCGGATGTTGCCTTATGGCTGTTTAGCAACAGGAGATCGCTCTGGCCTCA
TTGAAGTTGTGAGCACCTCTGAAACAATTGCTGACATTCAGCTGAACAGTAGCAATGTGG
CTGCTGCAGCAGCCTTCAACAAAGATGCCCTTCTGAACTGGCTTAAAGAATACAACTCTG
GGGATGACCTGGACCGAGCCATTGAGGAATTTACACTGTCCTGTGCTGGCTACTGTGTAG
CTTCTTATGTCCTTGGGATTGGTGACAGACATAGTGACAACATCATGGTCAAAAAAACTG
GCCAGCTCTTCCACATTGACTTTGGACATATTCTTGGAAATTTCAAATCTAAGTTTGGCA
TTAAAAGGGAGCGAGTGCCTTTTATTCTTACCTATGATTTCATCCATGTCATTCAACAAG
GAAAAACAGGAAATACAGAAAAGTTTGGCCGGTTCCGCCAGTGTTGTGAGGATGCATATC
TGATTTTACGACGGCATGGGAATCTCTTCATCACTCTCTTTGCGCTGATGTTGACTGCAG
GGCTTCCTGAACTCACATCAGTCAAAGATATACAGTATCTTAAGGACTCTCTTGCATTAG
GGAAGAGTGAAGAAGAAGCACTCAAACAGTTTAAGCAAAAATTTGATGAGGCGCTCAGGG
AAAGCTGGACTACTAAAGTGAACTGGATGGCCCACACAGTTCGGAAAGACTACAGATCTT
AACGATCAGCCTTCGCTCCTAATGTATTTGTTGGTTTCATTTCATTTTCATTTTGCACTT
GCACTAAATTGAACATGACCCTGTTAGAGATGTTATAAAGGGAATGAAATCCTGGAACTC
AGAGTTAAATTAAGAACAAGGCATCCCACAGAACCTAATCTGAACAATCCCCGATGATTC
CCTCTGCTTTTTGAATGCTTCCAAGACTTATCATGAAAACTGTCAATGGATAATCATTTC
CTGCTGACTTTGCACGCCAAGGAATGCTACTAGGGATTGTTTCCGTTTTTGTTTGTTTTT
TCTAATATTTGGTACTTCCCAGAATGGTGTAAATACTTCTTTTCAATGTTGTGACCAAGT
ATTGTCACTCAGCCAACAACTTTTCCACACCTGGGGGGTTGGTGGCTGTTCTTACTGTCC
AAATGAAGCTAAAAAGAAAGGCATCTTTCTTCCCTTTTAAAATTGTGTAAACTGCAAATT
ATAATATAATTTGAATTTATGATTATTTTCCAGAAGAAATCTTGTAAACCTGTGGATACT
CATTAATTCTTTTGTTAATATTTATTTCCATGATAGCATCATTCCAGCCAGACTTGCTGA
AAATCTACTGGTGAGGCAAATATAATATATATAAATATGCTACATATATATTTATAAAAT
TTCTAGTGGGAGTTCTATATAAATGTTTCTTTGGTATTCTTCAGCCTGTGATTTAAAGTT
TTACAAAAAGCAGAGCTTTTTCCTAAGTTACTTTTCAGTTAGGTAACTGTGTGATCCAGT
TCTTCCAGCTGCTTCTATAATGAGGCACATATTAATACAGTTTTTATATGGTATCTATGA
AAGAGTTCACTTCATAGAGAATAATACTTGAGCAAATGTATCCAAGAAAGCAAGCAAATG
AAAAGAAACCTATTTATGGAATAAACTCCAGATCTGAAATTCAGTATTTTAGAAAAATGC
CAGCTCTTCTTACTGTATTTATTAAAACTTGTAATAATGTGATTTTTTTCAAGGATATTA
GTTCAAATTGAAATGGTTTCACGCCACACGGAAATCTTTAAGTTATTTGTTGAGGTACCA
TATATTTAGGGTGCTAGGGGCAAGTAATGTTAATATGTGCAATAGGAACTACTGGTTTGA
ATGTGTAAATGGGTGATCTCTCTGAGTCCTGGCAACATCCAGCAAAACTACTGCTTATTC
TCCAAAGAATATTGGGAGCTCTCAATCCTCGGTGATATGGGAAAGAGAACTGAGTATTTG
CCCTATGACTGAGCTTTCTATAGGAATTTTATTAAAGAATGTTTAATTTTGTTGTCCTTC
TTAATGTTCTCAGTCAAATAAATGAGTGAGCTGXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAACTCGAC
>OriGene 5' read for NM_006219 unedited
GCACGAGGGGGCTGCTGACTGCGCACTTGGAATAGTAGCAGGCGGCGGCGGCGGAACGCC
AGGCAGGGCCCCGTGGTTATGAATGTGCTTCAGTTTCATAATGCCTCCTGCTATGGCAGA
CATCCTTGACATCTGGGCGGTGGATTCACAGATAGCATCTGATGGCTCCATACCTGTGGA
TTTCCTTTTGCCCACTGGGATTTATATCCAGTTGGAGGTACCTCGGGAAGCTACCATTTC
TTATATTAAGCAGATGTTATGGAAGCAAGTTCACAATTACCCAATGTTCAACCTCCTTAT
GGATATTGACTCCTATATGTTTGCATGTGTGAATCAGACTGCTGTATATGAGGAGCTTGA
AGATGAAACACGAAGACTCTGTGATGTCAGACCTTTTCTTCCAGTTCTCAAATTAGTGAC
AAGAAGTTGTGACCCAGGGGAAAAATTAGACTCAAAAATTGGAGTCCTTATAGGAAAAGG
TCTGCATGAATTTGATTCCTTGAAGGATCCTGAAGTAAATGAATTTCGAAGAANAATGCG
CAAATTCAGCGAGGAAAAAATCCTGTCACTTGTGGGATTGTCTTGGATGGACTGGCTAAA
ACAAACATATCCACC
Restriction Sites NotI-NotI     
ACCN NM_006219
Insert Size 5000 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_006219.1, NP_006210.1
RefSeq Size 3213 bp
RefSeq ORF 3213 bp
Locus ID 5291
Cytogenetics 3q22.3
Domains PI3K_rbd, PI3_PI4_kinase, PI3Ka, PI3K_C2, PI3K_p85B
Protein Families Druggable Genome
Protein Pathways Acute myeloid leukemia, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Glioma, Inositol phosphate metabolism, Insulin signaling pathway, Jak-STAT signaling pathway, Leukocyte transendothelial migration, Melanoma, mTOR signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Phosphatidylinositol signaling system, Progesterone-mediated oocyte maturation, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, Small cell lung cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, VEGF signaling pathway
Gene Summary 'This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]'
Transcript Variant: This variant (1) represent the longer transcript and encodes the longer protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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