PDIA6 (NM_005742) Human Untagged Clone

CAT#: SC116546

PDIA6 (untagged)-Human protein disulfide isomerase family A, member 6 (PDIA6)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PDIA6
• Synonyms: ERP5; P5; TXNDC7
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC116546 sequence for NM_005742 edited (data generated by NextGen Sequencing)
  ATGGCTCTCCTGGTGCTCGGTCTGGTGAGCTGTACCTTCTTTCTGGCAGTGAATGGTCTG
  TATTCCTCTAGTGATGATGTGATCGAATTAACTCCATCAAATTTCAACCGAGAAGTTATT
  CAGAGTGATAGTTTGTGGCTTGTAGAATTCTATGCTCCATGGTGTGGTCACTGTCAAAGA
  TTAACACCAGAATGGAAGAAAGCAGCAACTGCATTAAAAGATGTTGTCAAAGTTGGTGCA
  GTTGATGCAGATAAGCATCATTCCCTAGGAGGTCAGTATGGTGTTCAGGGATTTCCTACC
  ATTAAGATTTTTGGATCCAACAAAAACAGACCAGAAGATTACCAAGGTGGCAGAACTGGT
  GAAGCCATTGTAGATGCTGCGCTGAGTGCTCTGCGCCAGCTCGTGAAGGATCGCCTCGGG
  GGACGAAGCGGAGGATACAGTTCTGGAAAACAAGGCAGAAGTGATAGTTCAAGTAAGAAG
  GATGTGATTGAGCTGACAGACGACAGCTTTGATAAGAATGTTCTGGACAGTGAAGATGTT
  TGGATGGTTGAGTTCTATGCTCCTTGGTGTGGACACTGCAAAAACCTAGAGCCAGAGTGG
  GCTGCCGCAGCTTCAGAAGTAAAAGAGCAGACGAAAGGAAGAGTGAAACTGGCAGCTGTG
  GATGCTACAGTCAATCAGGTTCTGGCCTCCCGATACGGGATTAGAGGATTTCCTACAATC
  AAGATATTTCAGAAAGGCGAGTCTCCTGTGGATTATGACGGTGGGCGGACAAGATCCGAC
  ATCGTGTCCCGGGCCCTTGATTTGTTTTCTGATAACGCCCCACCTCCTGAGCTGCTTGAG
  ATTATCAACGAGGACATTGCCAAGAGGACGTGTGAGGAGCACCAGCTCTGTGTTGTGGCT
  GTGCTGCCCCATATCCTTGATACTGGAGCTGCAGGCAGAAATTCTTATCTGGAAGTTCTT
  CTGAAGTTGGCAGACAAATACAAAAAGAAAATGTGGGGGTGGCTGTGGACAGAAGCTGGA
  GCCCAGTCTGAACTTGAGACCGCGTTGGGGATTGGAGGGTTTGGGTACCCCGCCATGGCC
  GCCATCAATGCACGCAAGATGAAATTTGCTCTGCTAAAAGGCTCCTTCAGTGAGCAAGGC
  ATCAACGAGTTTCTCAGGGAGCTCTCTTTTGGGCGTGGCTCCACGGCACCTGTAGGAGGC
  GGGGCTTTCCCTACCATCGTTGAGAGAGAGCCTTGGGACGGCAGGGATGGCGAGCTTCCC
  GTGGAGGATGACATTGACCTCAGTGATGTGGAGCTTGATGACTTAGGGAAAGATGAGTTG
  TGA
  
  Clone variation with respect to NM_005742.2
  99 g=>a;426 g=>a;641 a=>g
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_005742 unedited
  NNGGGGAAACNNNNNNCCACCCCGCNGGGTTCAGAATTGTATACGACTCATATAGGCGGC
  CGCGAAATCGGCACCAGCCGGNCTGGCCTGGGGCGGGACGTGGGCGCGGGGGCGCGGCGT
  GCGGCACGCTGCAGGGCTGAAGCGGCGGCGGCGGTGGGGACTGCACGTAGCCCGGCGCTC
  GGCATGGCTCTCCTGGTGCTCGGTCTGGTGAGCTGTACCTTCTTTCTGGCAGTGAATGGT
  CTGTATTCCTCTAGTGATGATGTGATCGAATTAACTCCATCAAATTTCAACCGAGAAGTT
  ATTCAGAGTGATAGTTTGTGGCTTGTAGAATTCTATGCTCCATGGTGTGGTCACTGTCAA
  AGATTAACACCAGAATGGAAGAAAGCAGCAACTGCATTAAAAGATGTTGTCAAAGTTGGT
  GCAGTTGATGCAGATAAGCATCATTCCCTAGGAGGTCAGTATGGTGTTCAGGGATTTCCT
  ACCATTAAGATTTTTGGATCCAACAAAAACAGACCAGAAGATTACCAAGGTGGCAGAACT
  GGTGAAGCCATTGTAGATGCTGCGCTGAGTGCTCTGCGCCAGCTCGTGAAGGATCGCCTC
  GGGGGACGAAGCGGAGGATACAGTTCTGGAAAACAAGGCAGAAGTGATAGTTCAAGTAAG
  AAGGATGTGATTGAGCTGACAGACGACAGCTNTGATAAGAATGTTCTGGACAGTGAAGAT
  GTTTGGATGGNNTGAGTCTATGCTNCTTTGTGTGGACACTGCAAAAACCTANAGCCCAGA
  GTGGGCTGCCGCAGCTTCAGAAGTAAAAGAGCAGACGAAAGGAAGAAGTGAACTGGCAGC
  TGTGGATGCTACAGTCAAATCAGGTCTGGCCTCCCGATACGGNNATAAAGGATTNCTACA
  TCAAGAAATTNCAAAAGGCCAGTCTCCTGTGGATATGACCGTGGGCGCACAGAAA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_005742 unedited
  NNNTTTTACTCTGNNACCGCGGCCGCATNCTANGATCGAGTTTTTTTTTTTTTTTTTTTT
  TAGTGACAGTTGTATTTATTTTTTTAAGTTACAATAAAATGCTCTCAAGTCCTTTGAATG
  TTCCAACAAATTCAAAACTTCATTTTCTGAATGTTTTACATAAATGCGAACTACCTGTTC
  GCATTGGTAACCTGCTGCTGTATTTCATGTCTTAACGGCTATTTTGAGGTTCATTAACAA
  CATAGAAAGCCTTGAACTGTATAACCAGCTAGATTCCTTAATAATTAGTCACTAGAGACA
  GCCCAAAGACAAATATTGGGCAGGAAATCAGTTCTCACTGAGCCCGGTTTCCATGTAAAA
  TCTCTGTTGTGGTGGGCATAGGTGGCACCATCTAAAGAAAAGAGGTCTTGTTTTTTGTTT
  AAAAAAGTTTGTGGGGAGGAAAGACATCTGTGTATCACTTCAAAATATTGATTTACTGCT
  AAACATCACTCTGAATTTATGATGTGGATACTAACTTCATACATTTATCGGCATTGTCCA
  AAATATTTTATTCTTTAATGGAAAAAGCCATTAATATTCAAATGAAGGGATCACATTAAA
  AAAAACCCATACATAAGAAACAGCCTCCAAGAACATTCAAGCAGCAGTCAGAGAGAAAAA
  TGTTTCGACAGCCAAGTTTTCTTCAAAATATTATGTGACAGAATACGACTCAATTCACCG
  GCTACAACAATTCATAGAATTTTTCAATGTTTTCTTGAGATGCAAAAGNTCACTGTTGCA
  GTGTTTTCAAATGACCCAATCAGTACTACTTCTTGGTTAAAAGCCACTGNTAGAGTCATC
  TGAGTGTANAGGATGTCCCTTCACTGCTGGAAAAATCCCTGGNCTCCAAAGAAAGAAATG
  GTCTGAAGCCTCTGNTGTGGCTCTTACAACTCAC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_005742
• ORF Size: 1323 bp
• Insert Size: 2380
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_005742.2, NP_005733.1
• RefSeq Size: 2344
• RefSeq ORF: 1323
• Locus ID: 10130
• Domains: thiored
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
  Transcript Variant: This variant (4) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.