HMGCS2 (NM_005518) Human Untagged Clone

CAT#: SC116704

HMGCS2 (untagged)-Human 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (HMGCS2), nuclear gene encoding mitochondrial protein, transcript variant 1


  "NM_005518" in other vectors (4)

Reconstitution Protocol

USD 310.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol HMGCS2
Synonyms 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial); hydroxymethylglutaryl-CoA synthase 2; OTTHUMP00000013928
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF sequence for NM_005518 edited
GCGGCCGCGAATTCGGCACGAGGCTGAACTGCTGGGTTTCTGCTTGCTCCTCTGGAGATG
CAGCGTCTGTTGACTCCAGTGAAGCGCATTCTGCAACTGACAAGAGCGGTGCAGGAAACC
TCCCTCACACCTGCTCGCCTGCTCCCAGTAGCCCACCAAAGGTTTTCTACAGCCTCTGCT
GTCCCCCTGGCCAAAACAGATACTTGGCCAAAGGACGTGGGCATCCTGGCCCTGGAGGTC
TACTTCCCAGCCCAATATGTGGACCAAACTGACCTGGAGAAGTATAACAATGTGGAAGCA
GGAAAGTATACAGTGGGCTTGGGCCAGACCCGTATGGGCTTCTGCTCAGTCCAAGAGGAC
ATCAACTCCCTGTGCCTGACGGTGGTGCAACGGCTGATGGAGCGCATACAGCTCCCATGG
GACTCTGTGGGCAGGCTGGAAGTAGGCACTGAGACCATCATTGACAAGTCCAAAGCTGTC
AAAACAGTGCTCATGGAACTCTTCCAGGATTCAGGCAATACTGATATTGAGGGCATAGAT
ACCACCAATGCCTGCTACGGTGGTACTGCCTCCCTCTTCAATGCTGCCAACTGGATGGAG
TCCAGTTCCTGGGATGGTCGTTATGCCATGGTGGTCTGTGGAGACATTGCCGTCTATCCC
AGTGGTAATGCTCGTCCCACAGGTGGGGCCGGAGCTGTGGCTATGCTGATTGGGCCCAAG
GCCCCTCTGGCCCTGGAGCGAGGGCTGAGGGGAACCCATATGGAGAATGTGTATGACTTC
TACAAACCAAATTTGGCCTCGGAGTACCCAATAGTGGATGGGAAGCTTTCCATCCAGTGC
TACTTGCGGGCCTTGGATCGATGTTACACATCATACCGTAAAAAAATCCAGAATCAGTGG
AAGCAAGCTGGCAGCGATCGACCCTTCACCCTTGACGATTTACAGTACATGATCTTTCAT
ACACCCTTTTGCAAGATGGTCCAGAAGTCTCTGGCTCGCCTGATGTTCAATGACTTCCTG
TCAGCCAGCAGTGACACACAAACCAGCTTATATAAGGGGCTGGAGGCTTTCGGGGGGCTA
AAGCTGGAAGACACCTACACCAACAAGGACCTGGATAAAGCACTTCTAAAGGCCTCTCAG
GACATGTTCGACAAGAAAACCAAGGCTTCCCTTTACCTCTCCACTCACAATGGGAACATG
TACACCTCATCCCTGTACGGGTGCCTGGCCTCGCTTCTGTCCCACCACTCTGCCCAAGAA
CTGGCTGGCTCCAGGATTGGTGCCTTCTCTTATGGCTCTGGTTTAGCAGCAAGTTTCTTT
TCATTTCGAGTATCCCAGGATGCTGCTCCAGGCTCTCCCCTGGACAAGTTGGTGTCCAGC
ACATCAGACCTGCCAAAACGCCTAGCCTCCCGAAAGTGTGTGTCTCCTGAGGAGTTCACA
GAAATAATGAACCAAAGAGAGCAATTCTACCATAAGGTGAATTTCTCCCCACCTGGTGAC
ACAAACAGCCTTTTCCCAGGTACTTGGTACCTGGAGCGAGTGGACGAGCAGCATCGCCGA
AAGTATGCCCGGCGTCCCGTCTAAAGGTGTTCTGCAGATCCATGGAAAGCTTCCTGGGAA
ACGTATGCTAGCAGAGCTTCTCCCCGTGAATCATATTTTTAAGATCCCACTCTTAGCTGG
TAAATGAATTTGAATCGACATAGTAGCCCCATAAGCATCAGCCCTGTAGAGTGAGGAGCC
ATCTCTAGCGGGCCCTTCATTCCTCTCCATGCTGCAATCACTGTCCTGGGCTTATGGTGC
TATGGACTAGGGGTCCTTTGTGAAAGAGCAAGATGGAGCAATGGAGAGAAGACCTCTTCC
TGAATCACTGGACTCCAGAAATGTGCATGCAGATCAGCTGTTGCCTTCAAGATCCAGATA
AACTTTCCTGTCATGTGTTAGAACTTTATTATTATTAATATTGTTAAACTTCTGTGCTGT
TCCTGTGAATCTCCAAATTTTGTACCTTGTTTTAAGGCTAATATATAGCAATTAAAAAGA
GAGAAAGAGGAAAAAAAAAAAAAAAAAACTCGA
>OriGene 5' read for NM_005518 unedited
TTGTTTCANNATATTTGTNNAATACGACNCACTATAGGGCGGCCGCGAATTCGGCACGAG
GCTGAACTGCTGGGTTTCTGCTTGCTCCTCTGGAGATGCAGCGTCTGTTGACTCCAGTGA
AGCGCATTCTGCAACTGACAAGAGCGGTGCAGGAAACCTCCCTCACACCTGCTCGCCTGC
TCCCAGTAGCCCACCAAAGGTTTTCTACAGCCTCTGCTGTCCCCCTGGCCAAAACAGATA
CTTGGCCAAAGGACGTGGGCATCCTGGCCCTGGAGGTCTACTTCCCAGCCCAATATGTGG
ACCAAACTGACCTGGAGAAGTATAACAATGTGGAAGCAGGAAAGTATACAGTGGGCTTGG
GCCAGACCCGTATGGGCTTCTGCTCAGTCCAAGAGGACATCAACTCCCTGTGCCTGACGG
TGGTGCAACGGCTGATGGAGCGCATACAGCTCCCATGGGACTCTGTGGGCAGGCTGGAAG
TAGGCACTGAGACCATCATTGACAAGTCCAAAGCTGTCAAAACAGTGCTCATGGAACTCT
TCCAGGATTCAGGCAATACTGATATTGAGGGCATAGATACCACCAATGCCTGCTACGGTG
GTACTGCCTCCCTCTTCAATGCTGCCAACTGGATGGAGTCCAGTTCCTGNGATGGTCGTT
ATGCCATGGTGGTCTGTGGAGACATTGCCGTCTATCCCAGTGGTAATGCTCGTCCCACAG
GTGGGGCCGGAGCTGTGGCTATGCTGATTGGGCCCAAAGCCCCTCTGGCCCTGGAGCGAG
GGCTGAAGGGAACCCATATGGAGAATGTGTATGACTTCTACAAACCAAATTTGGCCTCGG
AGTACCCCATAGTGGATGGGAAGCTTTTCATCCAATGCTACCTGCCGGCCTTGGTATCGA
GTTACACATATACCGGAAAAAT
>OriGene 3' read for NM_005518 unedited
CGGCCGCAATCTAGAATCGAGTTTTTTTTTTTTTTTTTTCCTCTTTCTCTCTTTTTAATT
GCTATATATTAGCCTTAAAACAAGGTACAAAATTTGGAGATTCACAGGAACAGCACAGAA
GTTTAACAATATTAATAATAATAAAGTTCTAACACATGACAGGAAAGTTTATCTGGATCT
TGAAGGCAACAGCTGATCTGCATGCACATTTCTGGAGTCCAGTGATTCAGGAAGAGGTCT
TCTCTCCATTGCTCCATCTTGCTCTTTCACAAAGGACCCCTAGTCCATAGCACCATAAGC
CCAGGACAGTGATTGCAGCATGGAGAGGAATGAAGGGCCCGCTAGAGATGGCTCCTCACT
CTACAGGGCTGATGCTTATGGGGCTACTATGTCGATTCAAATTCATTTACCAGCTAAGAG
TGGGATCTTAAAAATATGATTCACGGGGAGAAGCTCTGCTAGCATACGTTCCCCAGGAAG
CTTTCCATGGATCTGCAAAACACCTTTAGACGGGACGCCGGGCATACTTTCGGCGATGCT
GTTCGTCCACTCGCTCCAGGTACCAAGTACCTGCGAAAAGGCTGTTTGTGCCACCACGTG
GGCACAAATCCACCTTATGGTACAATTGCCCTCTTTGCGTCATTATTCCTGTGAACCCCT
TACGAGACACCCACTTTTGGGAAGGCTCCGCGCCTCGCCAGGTCTCGAGTGCTTGGACAC
CAACTCGATCAGGGGAGACCCTGGATCCATTCCTTGGCAACTTTAATGAACACAACCCCC
CGTTCATCCCCCCACCATATATCCCTTTTCTCTGTCCCCCCCCCCCGCCTTATTTCCCCA
TTATTTTGTCCTCTCTCCCCCGTTGAGCTTTCTTTCACCCTGCCCCCCCGTTCCGCTATT
CCCCCCCCCCACTCTGCTTTTTGGCCACCCCCCCCCCCTCATTTTCCCCCC
Restriction Sites NotI-NotI     
ACCN NM_005518
Insert Size 2190 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_005518.2, NP_005509.1
RefSeq Size 2082 bp
RefSeq ORF 1527 bp
Locus ID 3158
Cytogenetics 1p12
Domains HMG_CoA_synt
Protein Families Druggable Genome
Protein Pathways Butanoate metabolism, Metabolic pathways, PPAR signaling pathway, Synthesis and degradation of ketone bodies, Terpenoid backbone biosynthesis, Valine, leucine and isoleucine degradation
Gene Summary 'The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]'
Transcript Variant: This variant (1) encodes the longer isoform (1).

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