LNK (SH2B3) (NM_005475) Human Untagged Clone

CAT#: SC116715

SH2B3 (untagged)-Human SH2B adaptor protein 3 (SH2B3)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SH2B3
• Synonyms: IDDM20; LNK
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC116715 sequence for NM_005475 edited (data generated by NextGen Sequencing)
  ATGAACGGGCCTGCCCTGCAGCCCTCCTCGCCCTCTTCCGCGCCCTCAGCCTCCCCGGCG
  GCGGCCCCGCGGGGCTGGAGCGAGTTCTGTGAGTTGCACGCCGTAGCGGCGGCCCGGGAG
  CTGGCCCGCCAGTACTGGCTGTTCGCCCGGGAGCATCCGCAGCACGCGCCGCTGCGCGCC
  GAGCTGGTGTCGCTGCAGTTCACCGACCTCTTCCAGCGCTACTTCTGCCGCGAGGTGCGC
  GACGGACGGGCGCCGGGCCGCGACTACCGGGACACAGGCCGTGGGCCCCCAGCCAAGGCC
  GAGGCGTCCCCGGAGCCAGGCCCCGGCCCCGCCGCCCCTGGCCTGCCCAAGGCCCGCAGC
  TCTGAGGAGCTGGCCCCGCCGCGGCCGCCCGGGCCCTGCTCCTTCCAGCACTTTCGCCGC
  AGCCTCCGCCACATCTTCCGCCGCCGCTCGGCCGGGGAGCTGCCAGCGGCCCACACCGCT
  GCCGCCCCCGGGACCCCCGGAGAGGCTGCTGAGACCCCCGCCCGGCCTGGCCTGGCCAAG
  AAGTTCCTGCCCTGGAGCCTGGCCCGGGAGCCGCCACCCGAGGCGCTGAAGGAGGCGGTG
  CTGCGCTACAGCCTGGCCGACGAGGCCTCCATGGACAGCGGGGCACGCTGGCAGCGCGGG
  AGGCTGGCGCTGCGCCGGGCCCCGGGCCCCGATGGCCCCGACCGCGTGCTGGAGCTCTTC
  GACCCACCCAAGAGTTCAAGGCCCAAGCTACAAGCAGCTTGCTCCAGCATCCAGGAGGTC
  CGGCGGTGCACACGGCTTGAGATGCCTGACAACCTTTACACCTTTGTGCTGAAGGTGAAG
  GACCGGACAGACATCATCTTTGAGGTGGGAGACGAGCAGCAGCTGAATTCATGGATGGCT
  GAGCTCTCGGAGTGCACAGGCCGAGGGCTGGAGAGCACAGAAGCAGAGATGCATATTCCC
  TCAGCCCTAGAGCCTAGCACGTCCAGCTCCCCAAGGGGCAGCACAGATTCCCTTAACCAA
  GGTGCTTCTCCTGGGGGGCTGCTGGACCCGGCCTGCCAGAAGACGGACCATTTCCTGTCC
  TGCTACCCCTGGTTCCACGGCCCCATCTCCAGAGTGAAAGCAGCTCAGCTGGTTCAGCTG
  CAGGGCCCTGATGCTCATGGAGTGTTCCTGGTGCGGCAGAGCGAGACGCGGCGTGGGGAA
  TACGTGCTCACTTTCAACTTTCAGGGGATAGCCAAGCACCTGCGCCTGTCGCTGACAGAG
  CGGGGCCAGTGCCGTGTGCAGCACCTCCACTTTCCCTCGGTCGTGGACATGCTCCACCAC
  TTCCAGCGCTCGCCCATCCCACTCGAGTGCGGCGCCGCCTGTGATGTCCGGCTCTCCAGC
  TACGTGGTAGTCGTCTCCCAACCACCAGGTTCCTGCAACACGGTCCTCTTCCCTTTCTCC
  CTTCCTCACTGGGATTCAGAGTCCCTTCCTCACTGGGGTTCAGAGTTGGGCCTTCCCCAC
  CTTAGTTCTTCTGGCTGTCCCCGGGGGCTCAGCCCAGAGGGTCTCCCAGGGCGATCCTCA
  CCCCCCGAGCAGATCTTCCACCTGGTGCCTTCGCCCGAAGAACTGGCCAACAGCCTGCAG
  CACCTGGAGCATGAGCCTGTGAATCGAGCCCGGGACTCGGACTACGAAATGGACTCATCC
  TCCCGGAGCCACCTGCGGGCCATAGACAATCAGTACACACCTCTCTGA
  
  Clone variation with respect to NM_005475.2
  784 t=>c
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_005475 unedited
  TTTCGCCGCCCGTTGNCGCATTGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCA
  GAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGA
  ATTCGGCACGAGGCGGGCCACCGCCTCCGCCCGGCTGCCCGCCCGGACTGTCGCGGCCCG
  CGGTGGCGACGGCGGCCGCTGCAAAGTTTCCCCGGCGGCGGCGGCCCGGGGGCGCATCCT
  CCCGCAACTGTCAAGCGCTGGCGGCGGAAATGATGAGGCGCTGGCCATTTTCCGAGCCCG
  GGTTTCCTGCCTGAGCCCCGCTCGAGCGAGCCGCGAGCGAGGAGCCGGCGGGCGGGAGAG
  GACGCGCCCAGGGCGGGGGCCCGCCCGCCCCCTCGGGATTTCGAGGGCCCGGGGGCGCGC
  GACGCCATGGGCCGGCCGGGCCCAGAGCTCCTGTCTCTCAGCCCGGCCGCACCACCTGGG
  TCTCCGCCATGAACGGGCCTGCCCTGCAGCCCTCCTCGCCCTCTTCCGCGCCCTCAGCCT
  CCCCGGCGGCGGCCCCGCGGGGCTGGAGCGAGTTCTGTGAGTTGCACGCCGTANCGGCGG
  CCCGGGAGCTGGCCCGCCAGTACTGGCTGTTCGCCCGGGAGCATNCGCAGCACGCGCCGC
  TGCGCGCCGAGCTGGTGTCGCTGCAGNTCACCGACCTCTTNCAGCGCTACTTCTGCCCGC
  GAGGTGCGCGACGGACGGGCGCCGGGCCGCGACTACCGGAACAGGGGCCGTGGGCCCCCA
  GCCAGCNCCGAGCGTCCCCGGAGCCAAGCCCCGGCCCGCGCCCTGTCTTGCCAGGCGATN
  TTTTGGANNATTGNCCCCCCCGGGCCCCCGGCCCTGGTCCTCCACATTTGGCGCAACTCG
  GCATTTCGCCGCTGNGGGGGGGGGGAATGTCCGCGGCCCACCGTGCG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_005475 unedited
  CGGTAATACTATGNNACCGCGGCCGCATTCTAGNGATCAGTTTTTTTTTTTTTTTTTTGA
  AAACTTTTTAATTCAATATAGCAATTTGTACATTATAGCAAAATTTGCATTATTCAAGAA
  TAAGTTACTTGTACAGTACATAAAACAATACATAAAAATTTGCCAAATACCTTCTGCCTA
  TAATGATACAAGATGAATCCACTTTATGTTATCACAATGTGCTGTATATTCTAACCAAAC
  ACAGGATGTCAGATGTGTCCTTGTTAATATACTCGCAAGTTCCTCTAGCTTGTGGGAGAT
  GTTAGAGCTAACACATTTGCAGTAAGGGACTTAGTCCTGAATAGAAAGCATGAAGGAATC
  TCAGGCAACCCTCAGGGAAGAGTCCAAGGCCTTGACTTTAGGTTAAGAAACTGTTATGTA
  AAAATAGTGTTCTCTGGCCCAAGATTTTAATGATTGCTATTCCTTTTTCCTACGGTCCAG
  AAATGATCAAAGGCAGAAGATTTATACCAGATAAAGCCATATGGATTGCTGGTCTAAAAT
  TCAAGGCAGGTTAGTTGACTTAATTCTTTGGTGCTGGTGACTGTTAGTTTGTAAAAGTTC
  AATAAGTCAAATGAANGAAGGGATGGTGCCGGGAGCTGTCAAGCTGTACTGGTGGGGTCT
  GTAATTAGAGCTAACTGGAGGGATCATGATGTCTACTGTCCAGTTTGGTGTTGAGCCATG
  GCTCTCGGTAAAATTGCCCGCTGGGGCCCGTTCACGACTGGAAAGAAAATGGTGGGAGTG
  CTTTGCCCTTGGGGGGCAAACTGCACCCATGGGGTGCCTGGCCCCACTGGTGCCCACCCC
  TTCTAAACTGAAATTGTTCCCCATTAAGAAAAGGGTGGGCTAAGGGCACTTTTTCCTAAA
  CCATGGGG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_005475
• ORF Size: 1728 bp
• Insert Size: 4700
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_005475.1, NP_005466.1
• RefSeq Size: 5423
• RefSeq ORF: 1728
• Locus ID: 10019
• Domains: SH2, PH
• Protein Pathways: Neurotrophin signaling pathway
• Gene Summary: This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).