GLCNE (GNE) (NM_005476) Human Untagged Clone

CAT#: SC116716

GNE (untagged)-Human glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE), transcript variant 2


  "NM_005476" in other vectors (6)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol GNE
Synonyms DMRV; GLCNE; IBM2; NM; Uae1
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC116716 sequence for NM_005476 edited (data generated by NextGen Sequencing)
ATGGAGAAGAATGGAAATAACCGAAAGCTGCGGGTTTGTGTTGCTACTTGTAACCGTGCA
GATTATTCTAAACTTGCCCCGATCATGTTTGGCATTAAAACCGAACCTGAGTTCTTTGAA
CTTGATGTTGTGGTACTTGGCTCTCACCTGATAGATGACTATGGAAATACATATCGAATG
ATTGAACAAGATGACTTTGACATTAACACCAGGCTACACACAATTGTGAGGGGAGAAGAT
GAGGCAGCCATGGTGGAGTCAGTAGGCCTGGCCCTAGTGAAGCTGCCAGATGTCCTTAAT
CGCCTGAAGCCTGATATCATGATTGTTCATGGAGACAGGTTTGATGCCCTGGCTCTGGCC
ACATCTGCTGCCTTGATGAACATCCGAATCCTTCACATTGAAGGTGGGGAAGTCAGTGGG
ACCATTGATGACTCTATCAGACATGCCATAACAAAACTGGCTCATTATCATGTGTGCTGC
ACCCGCAGTGCAGAGCAGCACCTGATATCCATGTGTGAGGACCATGATCGCATCCTTTTG
GCAGGCTGCCCTTCCTATGACAAACTTCTCTCAGCCAAGAACAAAGACTACATGAGCATC
ATTCGCATGTGGCTAGGTGATGATGTAAAATCTAAAGATTACATTGTTGCACTACAGCAC
CCTGTGACCACTGACATTAAGCATTCCATAAAAATGTTTGAATTAACATTGGATGCACTT
ATCTCATTTAACAAGCGGACCCTAGTCCTGTTTCCAAATATTGACGCAGGGAGCAAAGAG
ATGGTTCGAGTGATGCGGAAGAAGGGCATTGAGCATCATCCCAACTTTCGTGCAGTTAAA
CACGTCCCATTTGACCAGTTTATACAGTTGGTTGCCCATGCTGGCTGTATGATTGGGAAC
AGCAGCTGTGGGGTTCGAGAAGTTGGAGCTTTTGGAACACCTGTGATCAACCTGGGAACA
CGTCAGATTGGAAGAGAAACAGGGGAGAATGTTCTTCATGTCCGGGATGCTGACACCCAA
GACAAAATATTGCAAGCACTGCACCTTCAGTTTGGTAAACAGTACCCTTGTTCAAAGATA
TATGGGGATGGAAATGCTGTTCCAAGGATTTTGAAGTTTCTCAAATCTATCGATCTTCAA
GAGCCACTGCAAAAGAAATTCTGCTTTCCTCCTGTGAAGGAGAATATCTCTCAAGATATT
GACCATATTCTTGAAACTCTAAGTGCCTTGGCCGTTGATCTTGGCGGGACGAACCTCCGA
GTTGCAATAGTCAGCATGAAGGGTGAAATAGTTAAGAAGTATACTCAGTTCAATCCTAAA
ACCTATGAAGAGAGGATTAATTTAATCCTACAGATGTGTGTGGAAGCTGCAGCAGAAGCT
GTAAAACTGAACTGCAGAATTTTGGGAGTAGGCATTTCCACAGGTGGCCGTGTAAATCCT
CGGGAAGGAATTGTGCTGCATTCAACCAAACTGATCCAAGAGTGGAACTCTGTGGACCTT
AGGACCCCCCTTTCTGACACTTTGCATCTCCCTGTGTGGGTAGACAATGATGGCAACTGT
GCTGCCCTGGCGGAAAGGAAATTTGGCCAAGGAAAGGGACTGGAAAACTTTGTTACACTT
ATCACAGGCACAGGAATCGGTGGTGGAATTATCCATCAGCATGAATTGATCCACGGAAGC
TCCTTCTGTGCTGCAGAACTGGGCCACCTTGTTGTGTCTCTGGATGGGCCTGATTGTTCC
TGTGGAAGCCATGGGTGCATTGAAGCATACGCCTCTGGAATGGCCTTGCAGAGGGAGGCA
AAAAAGCTCCATGATGAGGACCTGCTCTTGGTGGAAGGGATGTCAGTGCCAAAAGATGAG
GCTGTGGGTGCGCTCCATCTCATCCAAGCTGCGAAACTTGGCAATGCGAAGGCCCAGAGC
ATCCTAAGAACAGCTGGAACAGCTTTGGGTCTTGGGGTTGTGAACATCCTCCATACCATG
AATCCCTCCCTTGTGATCCTCTCCGGAGTCCTGGCCAGTCACTATATCCACATTGTCAAA
GACGTCATTCGCCAGCAGGCCTTGTCCTCCGTGCAGGACGTGGATGTGGTGGTTTCGGAT
TTGGTTGACCCCGCCCTGCTGGGTGCTGCCAGCATGGTTCTGGACTACACAACACGCAGG
ATCTACTAG

Clone variation with respect to NM_005476.5
>OriGene 5' read for NM_005476 unedited
CCCATTCCCCTCGAGGCTAAACCATTAAACGCTGCTCTGCTCATTATTTCATACTCTACT
AGGGTACAGAGCTCGTGCTTCGGGATGGAAACCTATGGTTATCTGCAGAGGGAGTCATGC
TTTCAAGGACCTCATGAACTCTATTTTAAGAACCTCTCAAAACGAAACAAGCTAAACTGN
GNTTAAGAATGGAAATAACCTTTAGCTGCGGGTTTGTGTTGCTACTTGTAACCGTGCAGA
TTATTCTAAACTTGCCCCTATTATGTTTGGCATTAAAACCGAACCTGAGTTCTTTGAACT
TGATGTTGTGGTACTTGGCTCTCACCTGATAGATGACTATGGAAATACATATCGAATGAT
TGAACAAGATGACTTTGACATTAACACCAGGCTACACACAATTGTGAGGGGAGAAGATGA
GGCAGCCATGGTGGAGTCAGTAGGCCTGGCCCTAGTGAAGCTGCCAGATGTCCTTAATCG
CCTGAAGCCTGATATCATGATTGTTCATGGAGACAGGTTTGATGCCCTGGCTCTGGCCAC
ATCTGCTGCCTTGATGAACATCCGAATCCTTCACATTGAAGGTGGGGAAGTCAGTGGGAC
CATTGATGACTCTATCAGACATGCCATAACAAAACTGGCTCATTATCATGTGTGCTGCAC
CCGCAGTGCATAGCAGCACCTGATATCCATGTGTGAGGACCATGATCGCATCCTTTTGGC
AAGCTGCCCTTCCTATGACAAACTTCTCTCAGCCAAGACAAAGACTACCTGAGCATCATT
CGCATGTGGCTAAGTGATGATGTAAAATCTAAAGATACATTGTTGCACTACGCACCCTGT
GACCACTGACTT
>OriGene 3' read for NM_005476 unedited
NAATCCTGNACGCGGCCGCATTCTANGATCGGTTTTTTTTTTTTTTTTTTAGTAGAGACG
GGGTTTCACCATGTTTCACCATGTTAGCCAGGGCGGTCTCGATCTCCTGACCTCGTGATC
CGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCCGGCCTG
GAAGGATTATTAATGCAAACTTCAGGATGAAGTGATATCCCAGGCAAGGCCTGAAGGTCT
CAGTGGTATTAATACATTAGTAAGCAGAGTTCTAAGAAGGCTTCCTCTCTATTATTGTAG
CTGCTTTGGCACAGAAAATTGTGACTGTAACTTACAGGGTTTGAGCTAAAATGACCCCTA
GTAAGAAGACATCAGAAAGAATAGCATCTACAAAAATAGGAGTGGGGAAAGGTGACTCTG
GAAGAGGAGACCAAAAGTGAAAACATTTCTCTGCCAAAGTCACCTGCAGTTCAATACCAG
ATTTGATTGTTAAGAAACGGTCATCCTAAAGACAAGAACTTGATTCCACTCAGGAGCTCT
GGAGAGAAGGTCCATGTCTGTTCCTGGAGGTCTAGTAGATCCTGCGTGTTGTGTAGTCCA
GAACCATGCTGGCAGCACCCANCAGGGCCGGGTCAACCAAATCCGAACCACCACATCCAC
GTCCTGCACGGAGGACAAGGCCTGCTGGCGAATGACGTCTTTGACAATGGGGATATAGTG
ACTGGCCCAGACTCCGGAGAGATCACCAGGGAGGAATTCTGGTTTGGGGGTGTTCACACC
CCCAAAACCCAAGCTGTTCCGACCTTTCTTAGGAGCCCCGGGCCTTCCCCTTGCCAGTTT
CCCAGCTCGGAGAGAAGGAGCCCCTCCCCGTGCTACATTTTTTTGCCGCAACGCCCTCCA
CCCACACCGAGTACA
Restriction Sites NotI-NotI     
ACCN NM_005476
ORF Size 2169 bp
Insert Size 2940
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_005476.3, NP_005467.1
RefSeq Size 3760
RefSeq ORF 2169
Locus ID 10020
Domains ROK, Epimerase_2
Protein Families Druggable Genome
Protein Pathways Amino sugar and nucleotide sugar metabolism, Metabolic pathways
Gene Summary The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcript Variant: This variant (2) contains a different 5' terminal exon compared to transcript variant 1, which results in translation initiation from an in-frame downstream AUG, and a protein (isoform 2) with a shorter N-terminus compared to isoform 1. This variant has been called GNE1 in the scientific literature. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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