SnoN (SKIL) (NM_005414) Human Untagged Clone

CAT#: SC116749

SKIL (untagged)-Human SKI-like oncogene (SKIL), transcript variant 1


  "NM_005414" in other vectors (6)

Reconstitution Protocol

USD 310.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol SKIL
Synonyms SNO; SnoA; SnoI; SnoN
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_005414, the custom clone sequence may differ by one or more nucleotides


ATGGAAAACCTCCAGACAAATTTCTCCTTGGTTCAGGGCTCAACTAAAAAACTGAATGGGATGGGAGATG
ATGGCAGCCCCCCAGCGAAAAAAATGATAACGGACATTCATGCAAATGGAAAAACGATAAACAAGGTGCC
AACAGTTAAGAAGGAACACTTGGATGACTATGGAGAAGCACCAGTGGAAACTGATGGAGAGCATGTTAAG
CGAACCTGTACTTCTGTTCCTGAAACTTTGCATTTAAATCCCAGTTTGAAACACACATTGGCACAATTCC
ATTTAAGTAGTCAGAGCTCGCTGGGTGGACCAGCAGCATTTTCTGCTCGGCATTCCCAAGAAAGCATGTC
GCCTACTGTATTTCTGCCTCTTCCATCACCTCAGGTTCTTCCTGGCCCATTGCTCATCCCTTCAGATAGC
TCCACAGAACTCACTCAGACTGTGTTGGAAGGGGAATCTATTTCTTGTTTTCAAGTTGGAGGAGAAAAGA
GACTCTGTTTGCCCCAAGTCTTAAATTCTGTTCTCCGAGAATTTACACTCCAGCAAATAAATACAGTGTG
TGATGAACTGTACATATATTGTTCAAGGTGTACTTCAGACCAGCTTCATATCTTAAAGGTACTGGGCATA
CTTCCATTCAATGCCCCATCCTGTGGGCTGATTACATTAACTGATGCACAAAGATTATGTAATGCTTTAT
TGCGGCCACGAACTTTTCCTCAAAATGGTAGCGTACTTCCTGCTAAAAGCTCATTGGCCCAGTTAAAGGA
AACTGGCAGTGCCTTTGAAGTGGAGCATGAATGCCTAGGCAAATGTCAGGGTTTATTTGCACCCCAGTTT
TATGTTCAGCCTGATGCTCCGTGTATTCAATGTCTGGAGTGTTGTGGAATGTTTGCACCCCAGACGTTTG
TGATGCATTCTCACAGATCACCTGACAAAAGAACTTGCCACTGGGGCTTTGAATCAGCTAAATGGCATTG
CTATCTTCATGTGAACCAAAAATACTTAGGAACACCTGAAGAAAAGAAACTGAAGATAATTTTAGAAGAA
ATGAAGGAGAAGTTTAGCATGAGAAGTGGAAAGAGAAATCAATCCAAGACAGATGCACCATCAGGAATGG
AATTACAGTCATGGTATCCTGTTATAAAGCAGGAAGGTGACCATGTTTCTCAGACACATTCATTTTTACA
CCCCAGCTACTACTTATACATGTGTGATAAAGTGGTTGCCCCAAATGTGTCACTTACTTCTGCTGTATCC
CAGTCTAAAGAGCTCACAAAGACAGAGGCAAGTAAGTCCATATCAAGACAGTCAGAGAAGGCTCACAGTA
GTGGTAAACTTCAAAAAACAGTGTCTTATCCAGATGTCTCACTTGAGGAACAGGAGAAAATGGATTTAAA
AACAAGTAGAGAATTATGTAGCCGTTTAGATGCATCAATCTCAAATAATTCTACAAGTAAAAGGAAATCT
GAGTCTGCCACTTGCAACTTAGTCAGAGACATAAACAAAGTGGGAATTGGCCTTGTTGCTGCCGCTTCAT
CTCCGCTTCTTGTGAAAGATGTCATTTGTGAGGATGATAAGGGAAAAATCATGGAAGAAGTAATGAGAAC
TTATTTAAAACAACAGGAAAAACTAAACTTGATTTTGCAAAAGAAGCAACAACTTCAGATGGAAGTAAAA
ATGTTGAGTAGTTCAAAATCTATGAAGGAACTCACTGAAGAACAGCAGAATTTACAGAAAGAGCTTGAAT
CTTTGCAGAATGAACATGCTCAAAGAATGGAAGAATTTTATGTTGAACAGAAAGACTTAGAGAAAAAATT
GGAGCAGATAATGAAGCAAAAATGTACCTGTGACTCAAATTTAGAAAAAGACAAAGAGGCTGAATATGCA
GGACAGTTGGCAGAACTGAGGCAGAGATTGGACCATGCTGAGGCCGATAGGCAAGAACTCCAAGATGAAC
TCAGACAGGAACGGGAAGCAAGACAGAAGTTAGAGATGATGATAAAAGAGCTAAAGCTGCAAATTCTGAA
ATCATCAAAGACTGCTAAAGAATAG


>OriGene 5' read for NM_005414 unedited
NGTTCAAAATTGTATACGACTCATATAGGCGGCCGCGAAATTCGCACGAGTGAGACAGAA
AATGCTTGAACCCGGGAGGCGGAGGTTGCAGTATGCCGAGATCGCTGCACTTCAGCCTGG
GCGACAGAGCGAGACTCCGTAAAAAAAAGAAAAAAAAAAAAAATAAAAGAAACTGGTTTC
AAATTGGCCCTTTGGCCTCTGGAGCAAATTCAAATGTAACTCTTCCCCAACCCCCCTTCT
CTTCTTCCAGATTAATTAAAAGAAGAATGAACTATAATCCTTGAAGATAACTGGGCAATT
TTTTAAGTCGGAGGCTGTTCTTACTGGTGTGAGGATTTACACACGTCTTCAGTTTTTCAG
CACAGACCAGCAGACCATCATTTTTAGAGGAAATACTCCCTCTGCCCTCCTTTTTGGTTT
CCTTGGTGGTAAAGATTAAATTTGGTTGCATCATTTTGACTTGTGTTTGAGTCTAGGTTT
TATGGCACAAGGAATGGCATAAACTTTTCATGTGTTTTGGTTAAAACAAACCAGACCATT
GCATTGACCCTGGACATCTTTAATTGAGAAATTGGTAACTTTATTTTAATATGTATATCT
GAAGAATTCAAGAAAACAAAGGCATCCTCAGAGGTGTGCCTCTTTTCTTTATTATTAGAG
GCAAAACGAACAATTTTATAGGATTTGTAGTGAAATTATACCAGATTATAAGGAGAACCA
AAACTAAGTCGCAAAATTTATTAATTTAAGGGGCTCTCGCTTTGAAAGTTTGAGAGTAAG
TTACGATAGGCATTTGTATCCATTCATTACTTTCCTCTTTTCAAATAGCACTAAATAGAA
TGCTAATCTCAGACTTAAATATTACAGNAAGGTGTACATGGGAAAACCNTCAGACAATTC
TNCTTGGNTCAGGNCTCACTC
>OriGene 3' read for NM_005414 unedited
GTACCGCGGCACGCAATCTAGTGTCGAGNTNTTTTTTTTTTTTTTTTTTTTTTTCAAAAA
TTATCACATTTTATTTTTGAAAATTGCTGCTTAAAAAAAAATCTAACTATAACCACATTT
AAACTGAAAAACAAATTACAACTGCTGCTTCTGTTTAGCAGCAGCACATAACAACACATT
CTTCTTCCCCACTGGGCTCATGGGGTATGCTATAACCTCAGTAAAATTCCTCCTAGGGTA
CACATTAAAAAGAAAAGAACTGGGGGAAATTCATTCCACAATCTGAACAAAGTAAAAGTA
AATTTGGGGTATGTTAATGAGTACACCATATCAACTTAAAAAAATTGGGTTAATGAGAAA
AGGGGAGATTCAACTCCTTGAGTAGCTCTATATACTTAAAATATAAAGCCACCATTGTAT
CTAAAATTGAGTCTGAAATATGGATAACAAAATTGACCACAGCTATTTTCCATCACATAT
TGCAGCTTTTAAAAAGTACACAATTGTTAAGTTTGCATTAAAAATATAAGCAGATTACCT
ACTAGTTGAAACCATATAGTATTGTTACTAAGCTGATTTTTAAAAAAGTACAAAGAAACA
TACATTTTCATTCATTTGGAAAATGTAAAAATTTAAGCACTAATATATAATCTCTTCACT
TTCTCTGATCTACAAATGGATAGAATGCCTAGTTATCGTCATGCAGATAAATTCTTCAGA
ATTCAATTACCAAAGCAAGCAACAAACAAAAAAAACCTTGTCAGTAATACACAGATGAAT
CTCTTTAACAGTTTCTATTCTTTAGCAGTCTTTGATGATTTCAGAAATTGCAGCTTTAGC
TCTTTAATATCATCTCTAACTTCTGGCTGGCTTCCCGTCCTGGCTGAGTTATCTGGGAGT
TCTGGCTATCGGCCTCACATGGTCCATCTTGGCCAAGTCTGCCACTGCCTGCTATTAGCC
CCTTGTCTTTTTTAATTGAGCCAGGNACATTTTGTTATTATCGCCCCATTTTTCCTA
Restriction Sites NotI-NotI     
ACCN NM_005414
Insert Size 3700 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_005414.2, NP_005405.1
RefSeq Size 3111 bp
RefSeq ORF 2055 bp
Locus ID 6498
Cytogenetics 3q26.2
Domains Ski_Sno
Protein Families Druggable Genome, Transcription Factors
Gene Summary 'The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]'
Transcript Variant: This variant (1) encodes the longest isoform (1, also known as snoN). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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