n-Myc (MYCN) (NM_005378) Human Untagged Clone

CAT#: SC116780

MYCN (untagged)-Human v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (MYCN)


  "NM_005378" in other vectors (6)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol MYCN
Synonyms bHLHe37; MODED; N-myc; NMYC; ODED
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC116780 sequence for NM_005378 edited (data generated by NextGen Sequencing)
ATGCCGAGCTGCTCCACGTCCACCATGCCGGGCATGATCTGCAAGAACCCAGACCTCGAG
TTTGACTCGCTACAGCCCTGCTTCTACCCGGACGAAGATGACTTCTACTTCGGCGGCCCC
GACTCGACCCCCCCGGGGGAGGACATCTGGAAGAAGTTTGAGCTGCTGCCCACGCCCCCG
CTGTCGCCCAGCCGTGGCTTCGCGGAGCACAGCTCCGAGCCCCCGAGCTGGGTCACGGAG
ATGCTGCTTGAGAACGAGCTGTGGGGCAGCCCGGCCGAGGAGGACGCGTTCGGCCTGGGG
GGACTGGGTGGCCTCACCCCCAACCCGGTCATCCTCCAGGACTGCATGTGGAGCGGCTTC
TCCGCCCGCGAGAAGCTGGAGCGCGCCGTGAGCGAGAAGCTGCAGCACGGCCGCGGGCCG
CCAACCGCCGGTTCCACCGCCCAGTCCCCGGGAGCCGGCGCCGCCAGCCCTGCGGGTCGC
GGGCACGGCGGGGCTGCGGGAGCNGGCCGCGCCNNNNNNNNNCTGCCCGCCGAGCTCGCC
CACCCGGCCGCCGAGTGCGTGGATCCCGCCGTGGTCTTCCCNNNNNNNGTGAACAAGCGC
GAGCCAGCGCCCGTGCCCGCAGCCCCGGCCAGTGCCCCGGCGGCGGGCCCTGCGGTCGCC
TCGGGGGCGGGTATTGCCGCCCCAGCCGGGGCCCCGGGGGTCGCCCCTCCGCGCCCAGGC
GGCCGCCAGACCAGCGGCGGCGACCACAAGGCCCTCAGTACCTCCGGAGAGGACACCCTG
AGCGATTCAGATGATGAAGATGATGAAGAGGAAGATGAAGAGGAAGAAATCGACGTGGTC
ACTGTGGAGAAGCGGCGTTCCTCCTCCAACACCAAGGCTGTCACCACATTCACCATCACT
GTGCGTCCCAAGAACGCAGCCCTGGGTCCCGGGAGGGCTCAGTCCAGCGAGCTGATCCTC
AAACGATGCCTTCCCATCCACCAGCAGCACAACTATGCCGCCCCCTCTCCCTACGTGGAG
AGTGAGGATGCACCCCCACAGAAGAAGATAAAGAGCGAGGCGTCCCCACGTCCGCTCAAG
AGTGTCATCCCCCCAAAGGCTAAGAGCTTGAGCCCCCGAAACTCTGACTCGGAGGACAGT
GAGCGTCGCAGAAACCACAACATCCTGGAGCGCCAGCGCCGCAACGACCTTCGGTCCAGC
TTTCTCACGCTCAGGGACCACGTGCCGGAGTTGGTAAAGAATGAGAAGGCCGCCAAGGTG
GTCATTTTGAAAAAGGCCACTGAGTATGTCCACTCCCTCCAGGCCGAGGAGCACCAGCTT
TTGCTGGAAAAGGAAAAATTGCAGGCAAGACAGCAGCAGTTGCTAAAGAAAATTGAACAC
GCTCGGACTTGCTAG

Clone variation with respect to NM_005378.4
504 c=>n;514 g=>n;515 g=>n;516 g=>n;517 g=>n;518 c=>n;519 c=>n;520 g=>n;521 c=>n;522 c=>n;582 c=>n;583 t=>n;584 t=>n;585 t=>n;586 c=>n;587 c=>n;588 c=>n
>OriGene 5' read for NM_005378 unedited
ATTAGGTCTACGACTCACTATAGGCGGCNCGCGAATCGGCACGAGGGTCGGTTGCAGTGT
TGGAGGTCGGCGCCGGCCCCCGCCTTCCGCGCCCCCCACGGGAAGGAAGCACCCCCGGTA
TTAAAACGAACGGGGCGGAAAGAAGCCCTCAGTCGCCGGCCGGGAGGCGAGCCGATGCCG
AGCTGCTCCACGTCCACCATGCCGGGCATGATCTGCAAGAACCCAGACCTCGAGTTTGAC
TCGCTACAGCCCTGCTTCTACCCGGACGAAGATGACTTCTACTTCGGCGGCCCCGACTCG
ACCCCCCCGGGGGAGGACATCTGGAAGAAGTTTGAGCTGCTGCCCACGCCCCCGCTGTCG
CCCAGCCGTGGCTTCGCGGAGCACAGCTCCGAGCCCCCGAGCTGGGTCACGGAGATGCTG
CTTGAGAACGAGCTGTGGGGCAGCCCGGCCGAGGAGGACGCGTTCGGCCTGGGGGGACTG
GGTGGCCTCACCCCCAACCCGGTCATCCTCCAGGACTGCATGTGGAGCGGCTTCTCCGCC
CGCGAGAAGCTGGAGCGCGCCGTGAGCGAGAAGCTGCAGCACGGCCGCGGGCCGCCAACC
GCCGGTTTCACCGCCCAGTCCCCCGGGAGCCGGCGCCGCCAGCCCTGCGGGTCGCGGGCA
CGGTGGGGCTGCGGGAGCCGGCCGCGCCGGGGCCGACCTGCCCGCCGAGCTCGCCCACCC
GGCCCGCGAGTGCGCGGATCCCGCCGAGGTCTTCCCCTTTCCTGTGAACAAGCGCGAGCC
CGCGCCCGTGCCCGCATCCCCGCCCATGCCCCGGCGGCGGGCCCCTGCGGCGCCTTGGGG
GCGGGTTATGACGCCCCAGCCGGGCCCCGAGGGTTGCCCCTCCCTGCCAGCGGCCGCCAA
AAATCGTCGGCGACCCCAGGCCCTTGATCACTCGGCGAAGAACACTTGAGCGCATCTTAG
CTCATATATATCCACGCAACCCGAC
>OriGene 3' read for NM_005378 unedited
NTTACCTTGGACGCGGCCGCATTCTANGATCGAGGTTTTTTTTTTTTTTTTTTTTTTTGC
ATCATTTAATTTTAAGCTATTTATTTTCATAAACATGAGGTATTTCAAAGTGCTATAAGA
TGCAGCACTAAATATATACATTTTGAAGAAATTAAACACAGAACTTTGCATTTACCCAGT
TCTATGCACCAAACATGAACAAATACATTAACAGGAAGAAACAGGCTAGGAAAAAGGCAT
ATATATATAGTAAATTTCTTTACAAAAGTTTCTTAGTTCAAAAAGTGATAAAGTAATATC
TACTCAAAACTTTCACAACTCATTTTCATACGAAAATATAAGTATCAAATTTAGTTATGT
ATCAGCGTCATACTAAAGTATACAGGCAGTGTAAGAATTAGTACAGTACATAACAGAGAT
TAACAATATATTTGTATACAAAACATGCTCCTCAAACATTGAGGTATTATTACAGTACTT
AGGTATGAACTTCCAGTCTAATACTGGCCGCAAAAGCCACCTCTCATTACCCAGGATGTA
TACAAAAGGCGGATGTGTCAATGGTATTTACAGAAATGTTCCCCAGGGGTATCAAATGGC
AAACCCCTTATGTGGCATCTGCTGGAACTTAAGCACCATTTTAAAAAGAAGGAATGACTT
TCTGTTGTTTGGAAACTTGGAACACACAAGGTGACTTCAACAGCCCCAGAGGCTCCCAAC
CATCACCAACGTTTAGCGCTGTCATGGAGGTGAGGTGGAGGAGGCTGCAAGGCCACCCAG
CATCCTGGGATGCAGGCTCTCCAAGGGTCCAGCAGAACCCACACTGGTGGTCCTACTGGC
CACCCAGAGCCGGACTCGACAGGGGAACGATTTGAAAGAAACCAACATTCTAAAGGCACA
CCATGTTGGTGTAAAAAAATACAAATGTGCAAACGGCAGTGACTGCCACTT
Restriction Sites NotI-NotI     
ACCN NM_005378
Insert Size 2600 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_005378.4, NP_005369.2
RefSeq Size 2613 bp
RefSeq ORF 1395 bp
Locus ID 4613
Cytogenetics 2p24.3
Domains HLH, Myc_N_term
Protein Families Druggable Genome, Transcription Factors
Gene Summary 'This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]'
Transcript Variant: This variant (2) lacks segment 1b in the 5' region, compared to variant 1. This variant includes two open reading frames; the isoform 1 represented by this RefSeq is translated from the downstream open reading frame. This transcript and variant 1 encode the same isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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