ROCK2 (NM_004850) Human Untagged Clone

CAT#: SC117098

ROCK2 (untagged)-Human Rho-associated, coiled-coil containing protein kinase 2 (ROCK2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ROCK2
• Synonyms: ROCK-II
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_004850 edited
  TGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCATTTAGGTGACACTA
  TAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGAATTCGGCACGAGGGGACCAGC
  GGACCGGCGGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCG
  GCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCGGGCCCCTGGGAGCAGCCCCCAG
  GCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGG
  AGTCCCGGCCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGA
  GCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCATGAGCCGGCCCCCGCCGACGGG
  GAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAG
  GAAGCTGGAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGGA
  TGGCTTAAATTCCTTGGTCCTTGATTTAGATTTTCCTGCTTTGAGGAAAAACAAGAACAT
  AGATAATTTCTTAAATAGATATGAGAAAATTGTGAAAAAAATCAGAGGTCTACAGATGAA
  GGCAGAAGACTATGATGTTGTAAAAGTTATTGGAAGAGGTGCTTTTGGTGAAGTGCAGTT
  GGTTCGTCACAAGGCATCGCAGAAGGTTTATGCTATGAAGCTTCTTAGTAAGTTTGAAAT
  GATAAAAAGATCAGATTCTGCCTTTTTTTGGGAAGAAAGAGATATTATGGCCTTTGCCAA
  TAGCCCCTGGGTGGTTCAGCTTTTTTATGCCTTTCAAGATGATAGGTATCTGTACATGGT
  AATGGAGTACATGCCTGGTGGAGACCTTGTAAACCTTATGAGTAATTATGATGTGCCTGA
  AAAATGGGCCAAATTTTACACTGCTGAAGTTGTTCTTGCTCTGGATGCAATACACTCCAT
  GGGTTTAATACACAGAGATGTGAAGCCTGACAACATGCTCTTGGATAAACATGGACATCT
  AAAATTAGCAGATTTTGGCACGTGTATGAAGATGGATGAAACAGGCATGGTACATTGTGA
  TACAGCAGTTGGAACACCGGATTATATATCACCTGAGGTTCTGAAATCACAAGGGGGTGA
  TGGTTTCTATGGGCGAGAATGTGATTGGTGGTCTGTAGGTGTTTTCCTTTATGAGATGCT
  AGTGGGGGATACTCCATTTTATGCGGATTCACTTGTAGGAACATATAGCAAAATTATGGA
  TCATAAGAATTCACTGTGTTTCCCTGAAGATGCAGAAATTTCCAAACATGCAAAGAATCT
  CATCTGTGCTTTCTTAACAGATAGGGAGGTACGACTTGGGAGAAATGGGGTGGAAGAAAT
  CAGACAGCATCCTTTCTTTAAGAATGATCAGTGGCATTGGGATAACATAAGAGAAACGGC
  AGCTCCTGTAGTACCTGAACTCAGCAGTGACATAGACAGCAGCAATTTCGATGACATTGA
  AGATGACAAAGGAGATGTAGAAACCTTCCCAATTCCTAAAGCTTTTGTTGGAAATCAGCT
  GCCTTTCATCGGATTTACCTACTATAGAGAAAATTTATTATTAAGTGACTCTCCATCTTG
  TAGAGAAACTGATTCCATACAATCAAGGAAAAATGAAGAAAGTCAAGAGATTCAGAAAAA
  ACTGTATACATTAGAAGAACATCTTAGCAATGAGATGCAAGCCAAAGAGGAACTGGAACA
  GAAGTGCAAATCTGTTAATACTCGCCTAGAAAAAACAGCAAAGGAGCTAGAAGAGGAGAT
  TACCTTACGGAAAAGTGTGGAATCAGCATTAAGACAGTTAGAAAGAGAAAAGGCGCTTCT
  TCAGCACAAAAATGCAGAATATCAGAGGAAAGCTGATCATGAAGCAGACAAAAAACGAAA
  TTTGGAAAATGATGTTAACAGCTTAAAAGATCAACTTGAAGATTTGAAAAAAAGAAATCA
  AAACTCTCAAATATCCACTGAGAAAGTGAATCAACTCCAGAGACAACTGGATGAAACCAA
  TGCTTTACTGCGAACAGAGTCTGATACTGCAGCCCGGTTAAGGAAAACCCAGGCAGAAAG
  TTCAAAACAGATTCAGCAGCTGGAATCTAACAATAGAGATCTACAAGATAAAAACTGCCT
  GCTGGAGACTGCCAAGTTAAAACTTGAAAAGGAATTTATCAATCTTCAGTCAGCTCTAGA
  ATCTGAAAGGAGGGATCGAACCCATGGATCAGAGATAATTAATGATTTACAAGGTAGAAT
  ATGTGGCCTAGAAGAAGATTTAAAGAACGGCAAAATCTTACTAGCGAAAGTAGAACTGGA
  GAAGAGACAACTTCAGGAGAGATTTACTGATTTGGAAAAGGAAAAAAGCAACATGGAAAT
  AGATATGACATACCAACTAAAAGTTATACAGCAGAGCCTAGAACAAGAAGAAGCTGAACA
  TAAGGCCACAAAGGCACGACTAGCAGATAAAAATAAGATCTATGAGTCCATCGAAGAAGC
  CAAATCAGAAGCCATGAAAGAAATGGAGAAGAAGCTCTTGGAGGAAAGAACTTTAAAACA
  GAAAGTGGAGAACCTATTGCTAGAAGCTGAGAAAAGATGTTCTCTATTAGACTGTGACCT
  CAAACAGTCACAGCAGAAAATAAATGAGCTCCTTAAACAGAAAGATGTGCTAAATGAGGA
  TGTTAGAAACCTGACATTAAAAATAGAGCAAGAAACTCAGAAGCGCTGCCTTACACAAAA
  TGACCTGAAGATGCAAACACAACAGGTTAACACACTAAAAATGTCAGAAAAGCAGTTAAA
  GCAAGAAAATAACCATCTCATGGAAATGAAAATGAACTTGGAAAAACAAAATGCTGAACT
  TCGAAAAGAACGTCAGGATGCAGATGGGCAAATGAAAGAGCTCCAGGATCAGCTCGAAGC
  AGAACAGTATTTCTCAACCCTTTATAAAACACAAGTTAGGGAGCTTAAAGAAGAATGTGA
  AGAAAAGACCAAACTTGGTAAAGAATTGCAGCAGAAGAAACAGGAATTACAGGATGAACG
  GGACTCTTTGGCTGCCCAACTGGAGATCACCTTGACCAAAGCAGATTCTGAGCAACTGGC
  TCGTTCAATTGCTGAAGAACAATATTCTGATTTGGAAAAAGAGAAGATCATGAAAGAGCT
  GGAGATCAAAGAGATGATGGCTAGACACAAACAGGAACTTACGGAAAAAGATGCTACAAT
  TGCTTCTCTTGAGGAAACTAATAGGACACTAACTAGTGATGTTGCCAATCTTGCAAATGA
  GAAAGAAGAATTAAATAACAAATTGAAAGATGTTCAAGAGCAACTGTCAAGATTGAAAGA
  TGAAGAAATAAGCGCAGCAGCTATTAAAGCACAGTTTGAGAAGCAGCTATTAACAGAAAG
  AACACTCAAAACTCAAGCTGTGAATAAGTTGGCTGAGATCATGAATCGAAAAGAACCTGT
  CAAGCGTGGTAATGACACAGATGTGCGGAGAAAAGAGAAGGAGAATAGAAAGCTACATAT
  GGAGCTTAAATCTGAACGTGAGAAATTGACCCAGCAGATGATCAAGTATCAGAAAGAACT
  GAATGAAATGCAGGCACAAATAGCTGAAGAGAGCCAGATTCGAATTGAACTGCAGATGAC
  ATTGGACAGTAAAGACAGTGACATTGAGCAGCTGCGGTCACAACTCCAAGCCTTGCATAT
  TGGTCTGGATAGTTCCAGTATAGGCAGTGGACCAGGGGATGCTGAGGCAGATGATGGGTT
  TCCAGAATCAAGATTAGAAGGATGGCTTTCATTGCCTGTACGAAACAACACTAAGAAATT
  TGGATGGGTTAAAAAGTATGTGATTGTAAGCAGTAAGAAGATTCTTTTCTATGACAGTGA
  ACAAGATAAAGAACAATCCAATCCTTACATGGTTTTAGATATAGACAAGTTATTTCATGT
  CCGACCAGTTACACAGACAGATGTGTATAGAGCAGATGCTAAAGAAATTCCAAGGATATT
  CCAGATTCTGTATGCCAATGAAGGAGAAAGTAAGAAGGAACAAGAATTTCCAGTGGAGCC
  AGTTGGAGAAAAATCTAATTATATTTGCCACAAGGGACATGAGTTTATTCCTACTCTTTA
  TCATTTCCCAACCAACTGTGAGGCTTGTATGAAGCCCCTGTGGCACATGTTTAAGCCTCC
  TCCTGCTTTGGAGTGCCGCCGTTGCCATATTAAGTGTCATAAAGATCATATGGACAAAAA
  GGAGGAGATTATAGCACCTTGCAAAGTATATTATGATATTTCAACGGCAAAGAATCTGTT
  ATTACTAGCAAATTCTACAGAAGAGCAGCAGAAGTGGGTTAGTCGGTTGGTGAAAAAGAT
  ACCTAAAAAGCCCCCAGCTCCAGACCCTTTTGCCCGATCATCTCCTAGAACTTCAATGAA
  GATACAGCAAAACCAGTCTATTAGACGGCCAAGTCGACAGCTTGCCCCAAACAAACCTAG
  CTAACTGCCTTCTATGAAAGCAGTCATTATTCAAGGTGATCGTATTCTTCCAGTGAAAAC
  AAGACTGAAATATGATGGCCCAAAATTTATTAAAAAGCTATATTTTCCTGAGAGACTGAT
  ACATACACTCATACATATATGTGTTCCCCTTTTCCCTGTAATATAAATTACAAATCTGGG
  CTCCTTTGAAGCAACAGGTTGAACCAACAATGATTGGTTGATAGACTAAG
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004850 unedited
  CCTCATTACCCCGCCCGTTGACGCAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATAT
  AAGCAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGC
  CGCGAATTCGGCACGAGGGGACCAGCGGACCGGCGGCGCGAATCTGACTGAGGGGCGGGG
  ACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCG
  GGCGGGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGC
  TAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGGCCGGAGCTGGTGGTTCGGGGGCGGTG
  CTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGC
  GGCATGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGG
  GACGGTGCAGGCGCGAGCCGCCAGAGGAAGCTGGAGGCGCTGATCCGAGACCCTCGCTCC
  CCCATCAACGTGGAGAGCTTGCTGGATGGCTTAAATTCCTTGGTCCTTGATTTAGATTTT
  CCTGCTTTGAGGAAAAACAAGAACATAGATAATTTCTTACATAGATATGAGAAAATTGTG
  AAAAAAATCAGAGGTCTACAGATGAAGGCAGACGACTATGATGTTGTAAAAGTTATTGGC
  AGAGGTGCTTTTGGTGAAGTGCAGTTGGTTCGTCACAGGCATCGCAGAGGGTTATGCTAT
  GAAGCTTCTTAGTAGTTTGAATGATAAAAAGACAGATTCTGCCTTTNTTTGGGAGCAAGA
  GATATATGGCCTTTGCCATAGCCCCTGGGTGGTTCAGCTTNTTTTAGTCTTTCAGACGAT
  GGTATCTGTACATGTCATG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004850 unedited
  TTACTTGNCCGCGGCCGCAATCTANGATCGAGTTTTTTTTTTTTTTTTTTTTGAGACGGA
  TCTTGTTCAGCTGGCCAGGCTGAGAGTGCACCAGCTCGATCTTCGCTCACTGCAACACAC
  CGACTCCTGGGTTCAAGCGATTCTCCTGTCTCAGCTTCCAAACTCCCTGGGATTACCGGC
  CAGCCTCATTGCGCCCGGCTAATTTTTGCATATTGTTATAGACGGATCTACCCCCTTTTC
  GGGCATGGCTCGGACTCGAAACTCCATCACCACATGCGATCCTGCCCTCTTGGCTCCTCG
  AATTGCTACGATTACATGCGAAGGCCTCCATACCTGGCCAGATGATGTTTTTAAATATGA
  CACCCAACTCTGTGCCTTGATATAAAGAGAGCTGTTCTCTACTTCTGGTGTGTCACTTAA
  CAATAACTTTTCTCAATCTTTACGCATACCAATGATGCGCATTGTGTGCTTGCCAACAAA
  CACTCTCTTATCTGGGAACGTGACAACACCGCCAGAATGACCTGCAATGACTGCAACTTT
  GACAGCGTCTATGACACTAGCAGTCTACTTGAGCGACTTTGAACTCCCGTCTCTCTCATT
  GCCACCTTTCGCAACCGCTCACTCTTATACAGCGCAACCTGGCTGCATTGTTGCAGCCCA
  TTTTTAAAAGTTTAACATGCCTTTCCGTTCGCAAAAACCTTTTATATTACTTGGAAAAAT
  TTAAAATCTTAGATCTTAAAAGGAACACCCAAAGTTCTTACAACCATAATAACCCCTCTG
  GGGCCACCAGCGAATTCCAAACAAAAAAAATTTCTCCCCCCCCCACCCATACGGGAAACC
  CGCAACAAACTCCCTTAATTTTTGCCCCACTAAAGCAAATTCCCTTGGAATCCAAAACCT
  CGGGGACAAAAAAACCAG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_004850
• ORF Size: 4167 bp
• Insert Size: 6900
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_004850.3, NP_004841.2
• RefSeq Size: 6401
• RefSeq ORF: 4167
• Locus ID: 9475
• Domains: pkinase, HR1, PH, M
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Axon guidance, Chemokine signaling pathway, Focal adhesion, Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton, TGF-beta signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway
• Gene Summary: The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]