ABCG2 (NM_004827) Human Untagged Clone

CAT#: SC117127

ABCG2 (untagged)-Human ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ABCG2
• Synonyms: ABC15; ABCP; BCRP; BCRP1; BMDP; CD338; CDw338; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1; UAQTL1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_004827 edited
  TGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGG
  ACCGAGCTCTATTAAGCTGAAAAGATAAAAACTCTCCAGATGTCTTCCAGTAATGTCGAA
  GTTTTTATCCCAGTGTCACAAGGAAACACCAATGGCTTCCCCGCGACAGCTTCCAATGAC
  CTGAAGGCATTTACTGAAGGAGCTGTGTTAAGTTTTCATAACATCTGCTATCGAGTAAAA
  CTGAAGAGTGGCTTTCTACCTTGTCGAAAACCAGTTGAGAAAGAAATATTATCGAATATC
  AATGGGATCATGAAACCTGGTCTCAACGCCATCCTGGGACCCACAGGTGGAGGCAAATCT
  TCGTTATTAGATGTCTTAGCTGCAAGGAAAGATCCAAGTGGATTATCTGGAGATGTTCTG
  ATAAATGGAGCACCGCGACCTGCCAATTTCAAATGTAATTCAGGTTACGTGGTACAAGAT
  GATGTTGTGATGGGCACTCTGACGGTGAGAGAAAACTTACAGTTCTCAGCAGCTCTTCGG
  CTTGCAACAACTATGACGAATCATGAAAAAAACGAACGGATTAACAGGGTCATTCAAGAG
  TTAGGTCTGGATAAAGTGGCAGACTCCAAGGTTGGAACTCAGTTTATCCGTGGTGTGTCT
  GGAGGAGAAAGAAAAAGGACTAGTATAGGAATGGAGCTTATCACTGATCCTTCCATCTTG
  TTCTTGGATGAGCCTACAACTGGCTTAGACTCAAGCACAGCAAATGCTGTCCTTTTGCTC
  CTGAAAAGGATGTCTAAGCAGGGACGAACAATCATCTTCTCCATTCATCAGCCTCGATAT
  TCCATCTTCAAGTTGTTTGATAGCCTCACCTTATTGGCCTCAGGAAGACTTATGTTCCAC
  GGGCCTGCTCAGGAGGCCTTGGGATACTTTGAATCAGCTGGTTATCACTGTGAGGCCTAT
  AATAACCCTGCAGACTTCTTCTTGGACATCATTAATGGAGATTCCACTGCTGTGGCATTA
  AACAGAGAAGAAGACTTTAAAGCCACAGAGATCATAGAGCCTTCCAAGCAGGATAAGCCA
  CTCATAGAAAAATTAGCGGAGATTTATGTCAACTCCTCCTTCTACAAAGAGACAAAAGCT
  GAATTACATCAACTTTCCGGGGGTGAGAAGAAGAAGAAGATCACAGTCTTCAAGGAGATC
  AGCTACACCACCTCCTTCTGTCATCAACTCAGATGGGTTTCCAAGCGTTCATTCAAAAAC
  TTGCTGGGTAATCCCCAGGCCTCTATAGCTCAGATCATTGTCACAGTCGTACTGGGACTG
  GTTATAGGTGCCATTTACTTTGGGCTAAAAAATGATTCTACTGGAATCCAGAACAGAGCT
  GGGGTTCTCTTCTTCCTGACGACCAACCAGTGTTTCAGCAGTGTTTCAGCCGTGGAACTC
  TTTGTGGTAGAGAAGAAGCTCTTCATACATGAATACATCAGCGGATACTACAGAGTGTCA
  TCTTATTTCCTTGGAAAACTGTTATCTGATTTATTACCCATGAGGATGTTACCAAGTATT
  ATATTTACCTGTATAGTGTACTTCATGTTAGGATTGAAGCCAAAGGCAGATGCCTTCTTC
  GTTATGATGTTTACCCTTATGATGGTGGCTTATTCAGCCAGTTCCATGGCACTGGCCATA
  GCAGCAGGTCAGAGTGTGGTTTCTGTAGCAACACTTCTCATGACCATCTGTTTTGTGTTT
  ATGATGATTTTTTCAGGTCTGTTGGTCAATCTCACAACCATTGCATCTTGGCTGTCATGG
  CTTCAGTACTTCAGCATTCCACGATATGGATTTACGGCTTTGCAGCATAATGAATTTTTG
  GGACAAAACTTCTGCCCAGGACTCAATGCAACAGGAAACAATCCTTGTAACTATGCAACA
  TGTACTGGCGAAGAATATTTGGTAAAGCAGGGCATCGATCTCTCACCCTGGGGCTTGTGG
  AAGAATCACGTGGCCTTGGCTTGTATGATTGTTATTTTCCTCACAATTGCCTACCTGAAA
  TTGTTATTTCTTAAAAAATATTCTTAAATTTCCCCTTAATTCAGTATGATTTATCCTCAC
  ATAAAAAAGAAGCACTTTGATTGAAGTATTCAATCAAGTTTTTTTGTTGTTTTCTGTTCC
  CTTGCCA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004827 unedited
  NGGCCGCTCAGGATTTTCGTAAACGACTTACTATAGGCGGCCGCGAATTCGCACGAGAAC
  CGAGCTCTATTAAGCTGAAAAAATAAAAACTCTCCAGATGTCTTCCAGTAATGTCGAAGT
  TTTTATCCCAGTGTCACAAGGAAACACCAATGGCTTCCCCGCGACAGCTTCCAATGACCT
  GAAGGCATTTACTGAAGGAGCTGTGTTAAGTTTTCATAACATCTGCTATCGAGTAAAACT
  GAAGAGTGGCTTTCTACCTTGTCGAAAACCAGTTGAGAAAGAAATATTATCGAATATCAA
  TGGGATCATGAAACCTGGTCTCAACGCCATCCTGGGACCCACAGGTGGAGGCAAATCTTC
  GTTATTAGATGTCTTAGCTGCAAGGAAAGATCCAAGTGGATTATCTGGAGATGTTCTGAT
  AAATGGAGCACCGCGACCTGCCAATTTCAAATGTAATTCAGGTTACGTGGTACAAGATGA
  TGTTGTGATGGGCACTCTGACGGTGAGAGAAAACTTACAGTTCTCAGCAGCTCTTCGGCT
  TGCAACAACTATGACGAATCATGAAAAAAACGAACGGATTAACAGGGTCATTCAAGAGTT
  AGGTCTGGATAAAGTGGCAGACTCCAAGGTTGGAACTCAGTTTATCCGTGGTGTGTCTGG
  AGGAGAAAGAAAAAGGACTAGTATAGGAATGGAGCTTATCACTGATCCTTCCATCTTGTT
  CTTGGATGAGCCTACAACTGGCTTAGACTCAAGCACAGCANATGCTGTCCTTTTGCTCCT
  GAAAGGATGTCTAAGCAGGNACGAACAATCATCTTCTCCATTCATCAGCCTCGATATTCC
  ATCTTCAAGTTGTTGATAGCCTCACCTTATTNGCCTCANGAAGACTTATGNTNCACGGNC
  CCTGCTCAGNAGCCTTNGGGATCTTTGAAATCAGCTGTTATCACTGTGGAGGCCTATAT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004827 unedited
  ACTTGGACGCGGCCGCATCTATGATCAGTTTTTTTTTTTTTTTTTTTAAGTTCTATTAAC
  TTTAATGTGCTTATCAAAAAGATTTTTTTCTATCACGGAGGCTTTTTTTACCCTATAAGA
  CAGAATCTTTTTTCCAACATATTTTCAATTTTACATTTCCAGTATAGCATTAATACATTT
  GTCATTTATTAAATAATGGCAAACCATAGCATCATAAAGTATTAAGACTGAAGGGCTACT
  AACCTACCTATTCATTTTAAAGATGAGGAAACAAATGCCAGAGACAGTAATAACTTGTCA
  GGAGTTTCCAGAATTCAATTCTCCTTTTTTAGATTAATAAATTAGACCAGATTTCTTCCC
  CATGGTTACTGTCTGAGGAGATTAACTAATATGCGATACATGATGTCTTGGGTTCTTTCA
  TGTTTAATTCAGTTTGTTGAGATTTCTAAAAATGTATCTCTTTAAAACAATTGCTGCTGT
  GCAACAGTGTGATGGCAAGGGAACAGAAAACAACAAAAAAACTTGATTGAATACTTCAAT
  CAAAGTGCTTCTTTTTTATGTGAGGATAAATCATACTGAATTAAGGGGAAATTTAAGAAT
  ATTTTTTAAGAAATAACAATTTCAGGTAGGCAATTGTGAGGAAAATAACAATCATACAAG
  CCAAGGCCACGTGATTCTTCCACAAGCCCCAGGGTGAGAGATCGATGCCCTGCTTTACCA
  AATATTCTTCGCCAGTACATGTTGCATAGTTACAAAGATTGTTTCCTGTTGCATTGAGTC
  CTGAGCAGAAGTTTTGTCCCAAAATCCATTATGCTGCAAAGCCGTAAATCCATATCGNGG
  AATGCTCGAGTACTGGAGCCATGACAGNCCAGAATGCATGGGTTGTGAGATTGCACANCA
  GACCTGAAAAAATCTCATAAACACAAACAGATGTCCTGANAAATGTGCTACGAAACCCAC
  TCTGTACTGCTGCTATGGCANTGCCATG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_004827
• ORF Size: 1968 bp
• Insert Size: 2700
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_004827.2, NP_004818.2
• RefSeq Size: 4445
• RefSeq ORF: 1968
• Locus ID: 9429
• Domains: ABC_tran, AAA
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: ABC transporters
• Gene Summary: The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
  Transcript Variant: This variant (1) encodes the longest isoform (1).