GEF H1 (ARHGEF2) (NM_004723) Human Untagged Clone

CAT#: SC117176

ARHGEF2 (untagged)-Human Rho/Rac guanine nucleotide exchange factor (GEF) 2 (ARHGEF2), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ARHGEF2
• Synonyms: GEF; GEF-H1; GEFH1; LFP40; NEDMHM; P40
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC117176 sequence for NM_004723 edited (data generated by NextGen Sequencing)
  ATGAAGGAAGCCAAGGATGCCCGCTATACCAATGGGCACCTCTTCACCACCATTTCAGTT
  TCAGGCATGACCATGTGCTATGCCTGTAACAAGAGCATCACAGCCAAGGAAGCCCTCATC
  TGCCCAACCTGCAATGTGACTATCCACAACCGCTGTAAAGACACCCTCGCCAACTGTACC
  AAGGTCAAGCAGAAGCAACAGAAAGCGGCCCTGCTGAAGAACAACACCGCCTTGCAGTCC
  GTTTCTCTTCGAAGTAAGACAACCATCCGGGAGCGGCCAAGCTCGGCCATCTACCCCTCC
  GACAGCTTCCGGCAGTCCCTCCTGGGCTCCCGCCGTGGCCGCTCCTCCTTGTCTTTAGCC
  AAGAGTGTTTCTACCACCAACATTGCTGGACATTTCAATGATGAGTCTCCCCTGGGGCTG
  CGCCGGATCCTCTCACAGTCCACAGACTCCCTCAACATGCGGAACCGAACCCTATCCGTG
  GAATCCCTCATTGACGAAGAGGTAATCTACAGTGAGCTGATGAGTGACTTTGAGATGGAT
  GAGAAGGACTTTGCAGCTGACTCTTGGAGTCTTGCTGTGGACAGCAGCTTCCTGCAGCAG
  CATAAAAAGGAGGTGATGAAGCAGCAAGATGTCATCTATGAGCTAATCCAGACAGAGCTG
  CACCATGTGAGGACACTGAAGATCATGACCCGCCTCTTCCGCACGGGGATGCTGGAAGAG
  CTACACTTGGAGCCAGGAGTGGTCCAGGGCCTGTTCCCCTGCGTGGACGAGCTCAGTGAC
  ATCCATACACGCTTCCTCAGCCAGCTATTAGAACGCCGACGCCAGGCCCTGTGCCCTGGC
  AGCACCCGGAACTTTGTCATCCATCGCTTGGGTGATCTGCTCATCAGCCAGTTCTCAGGT
  CCTAGTGCGGAGCAGATGTGTAAGACCTACTCGGAGTTCTGCAGCCGCCACAGCAAGGCC
  TTAAAGCTCTATAAGGAGCTGTACGCCCGAGACAAACGCTTCCAGCAATTCATCCGGAAA
  GTGACCCGCCCCGCCGTGCTCAAGCGGCACGGGGTACAGGAGTGCATCCTGCTGGTGACT
  CAGCGCATCACCAAGTACCCGTTACTCATCAGCCGCATCCTGCAGCATTCCCACGGGATC
  GAGGAGGAGCGCCAGGACCTGACCACAGCACTGGGGCTAGTGAAGGAGCTGCTGTCCAAT
  GTGGACGAGGGTATTTATCAGCTGGAGAAAGGGGCCCGTCTGCAGGAGATCTACAACCGC
  ATGGACCCTCGGGCCCAAACCCCAGTGCCTGGCAAGGGCCCCTTTGGCCGAGAGGAACTT
  CTGAGGCGCAAACTCATCCACGATGGCTGCCTGCTCTGGAAGACAGCGACGGGGCGCTTC
  AAAGATGTGCTAGTGCTGCTGATGACAGATGTACTGGTGTTTCTCCAGGAAAAGGACCAG
  AAGTACATCTTTCCTACCCTGGACAAGCCTTCAGTGGTATCGCTGCAGAATCTAATCGTA
  CGAGACATTGCCAACCAGGAGAAAGGGATGTTTCTGATCAGCGCAGCCCCACCTGAGATG
  TACGAGGTGCACACAGCATCCCGGGATGACCGGAGCACCTGGATCCGGGTCATTCAGCAG
  AGCGTGCGCACATGCCCATCCAGGGAGGACTTCCCCCTGATTGAGACAGAGGATGAGGCT
  TACCTGCGGCGAATTAAGATGGAGTTGCAGCAGAAGGACCGGGCACTGGTGGAGCTGCTG
  CGAGAGAAGGTCGGGCTGTTTGCTGAGATGACCCATTTCCAGGCCGAAGAGGATGGTGGC
  AGTGGGATGGCCCTGCCCACCCTGCCCAGGGGCCTTTTCCGCTCTGAGTCCCTTGAGTCC
  CCTCGTGGCGAGCGGCTGCTGCAGGATGCCATCCGTGAGGTGGAGGGTCTGAAAGACCTG
  CTGGTGGGGCCAGGAGTGGAACTGCTCTTGACACCCCGAGAGCCAGCCCTGCCCTTGGAA
  CCAGACAGCGGTGGTAACACGAGTCCTGGGGTCACTGCCAATGGTGAGGCCAGAACCTTC
  AATGGCTCCATTGAACTCTGCAGAGCTGACTCAGACTCTAGCCAGAGGGATCGAAATGGA
  AATCAGCTGAGATCACCGCAAGAGGAGGCGTTACAGCGATTGGTCAATCTCTATGGACTT
  CTACATGGCCTACAGGCAGCTGTGGCCCAGCAGGACACTCTGATGGAAGCCCGGTTCCCT
  GAGGGCCCTGAGCGGCGGGAGAAGCTGTGCCGAGCCAACTCTCGGGATGGGGAGGCTGGC
  AGGGCTGGGGCTGCCCCTGTGGCCCCTGAAAAGCAGGCCACGGAACTGGCATTACTGCAG
  CGGCAACATGCGCTGCTGCAGGAGGAGCTACGGCGCTGCCGGCGGCTAGGTGAAGAACGG
  GCAACCGAAGCTGGCAGCCTGGAGGCCCGGCTCCGGGAGAGTGAGCAGGCCCGGGCACTG
  CTGGAGCGTGAGGCCGAAGAGGCTCGAAGGCAGCTGGCCGCCCTGGGCCAGACCGAGCCA
  CTCCCAGCTGAGGCCCCCTGGGCCCGCAGACCTGTGGATCCTCGGCGGCGCAGCCTCCCC
  GCAGGCGATGCCCTGTACTTGAGTTTCAACCCCCCACAGCCCAGCCGAGGCACTGACCGC
  CTGGATCTACCTGTCACTACTCGCTCTGTCCATCGAAACTTTGAGGACCGAGAGAGGCAG
  GAACTGGGGAGCCCCGAAGAGCGGCTGCAAGACAGCAGTGACCCTGACACTGGCAGCGAG
  GAGGAAGGTAGCAGCCGTCTGTCTCCGCCCCACAGTCCACGAGACTTTACCAGAATGCAG
  GACATCCCGGAGGAGACGGAGAGCCGCGACGGGGAGGCTGTAGCCTCCGAGAGCTAA
  
  Clone variation with respect to NM_004723.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004723 unedited
  GATTTGTATACGACTCATATAGGCGGCCGCGAATTCGCACGAGCACAGGGGGTGAGCAGA
  GCTAGGGCTGGGAAGGTGGAGTGAGGACGCAGAGACCTAGAGCCAGGGAGATGAGTGGCA
  ACAGGAGGCAGCCCAGCCGTAGGGGCCAGACCCGGGAAAAGGAGAAGATGAAGGAAGCCA
  AGGATGCCCGCTATACCAATGGGCACCTCTTCACCACCATTTCAGTTTCAGGCATGACCA
  TGTGCTATGCCTGTAACAAGAGCATCACAGCCAAGGAAGCCCTCATCTGCCCAACCTGCA
  ATGTGACTATCCACAACCGCTGTAAAGACACCCTCGCCAACTGTACCAAGGTCAAGCAGA
  AGCAACAGAAAGCGGCCCTGCTGAAGAACAACACCGCCTTGCAGTCCGTTTCTCTTCGAA
  GTAAGACAACCATCCGGGAGCGGCCAAGCTCGGCCATCTACCCCTCCGACAGCTTCCGGC
  AGTCCCTCCTGGGCTCCCGCCGTGGCCGCTCCTCCTTGTCTTTAGCCAAGAGTGTTTCTA
  CCACCAACATTGCTGGACATTTCAATGATGAGTCTCCCCTGGGGCTGCGCCGGATCCTCT
  CACAGTCCACAGACTCCCTCAACATGCGGAACCGAACCCTATCCGTGGAATCCCTCATTG
  ACGAAGCAGAGGTAATCTACAGTGAGCTGATGAGTGACTNTGAGATGGATGAGAAGGACT
  TTGCAGCTGACTCTTGGAGTCTTGCTGTGGACAGCAGCTTCCTGCAGCAGCATAAAAAGG
  GAGTGATGAAGCAGNCAGATGTCATCTATGAGCTAATCCAGACAGAGCTGCACCCATGTG
  AGGACACTGAAGATCATGACCCGCCTCTTNCGCACGGNNGATGCTGAAGAGCT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004723 unedited
  GAAATCCTGNNACCGCGGCCGCAATCTANGATCGAGTTTTTTTTTTTTTTTTTTGGAGTT
  CCAGGTTTTTAATTTTCCCTGAATTTTTTTTTTAAACAACAAAATTGGCAAGAAGAAAAT
  TCTTCGACATTTGGGGGCTGGTCGACATTTGGGGGCAAGGGTTCCACTGAAAAATCCCCC
  AAATTCACGCTGAGGTTTCAGGTCATGGTTGCTGAGGTGGAAGATGAGGTCAGGGCTCTT
  GGAGATTTTCCAACCCACCCTAGAACTTGTTTCTAAATGGCTGGGGAAGAGGTCAGTATA
  GGTCCCCCCGTTACTGCAGATGAAGGCAGAAGTCATTCTCTCCCCCACCCCTCAACTTCT
  TCAGAGATGTGGAGATAGGAGGCTTCGATCTCTAATTGCCTACGATCTCTTAAAAATATA
  AAACACGTGCAGTTGACTTTGGTACAAAAAAGAAAACAAAAGAACAACCAAACATTCTGG
  TCCCTGTGGGTTTTTTCCCTCACCCCCAACAAACCATTATGGCCACCCCAACCTTTATTC
  CATCAACTCCAGGAAGCCAGGTTATCTCCCAGGGCTTCCATGAAGGACGGAGAAAGGGCC
  AACAGCAGTAACAAGCTCAGGGGAAACGACAAAGGGACATGGCCCTGCCCACAGCCCTTC
  TTTATTAAAGGGCAATAAGGGGCTGTGGCTGAAGCCTCCTCTTCCAGACCGATGTTGCAG
  GGGAGGCCCGCTCGGGCAAGAACCCCACCACCTGCCTGGAAGAACCTGAAAATACCCCCA
  AACTGGCCCAAGGACCAAGCCCCTCTGATCCCTATGGTTTGGTTTCCATGCCCCTCGGCC
  CTTAAATTTCCCCTTCCCCCCCTAACTATAAACATCAAAAACACATTTTCCCTAAATTCC
  GCAAAAAGCCTGACTCCT
  
• Restriction Sites: ECoRI-NOT
• ACCN: NM_004723
• ORF Size: 2877 bp
• Insert Size: 4840
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_004723.2, NP_004714.2
• RefSeq Size: 4093
• RefSeq ORF: 2877
• Locus ID: 9181
• Domains: RhoGEF, PH, DAG_PE-bind
• Protein Families: Druggable Genome
• Protein Pathways: Pathogenic Escherichia coli infection
• Gene Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2009]
  Transcript Variant: This variant (3) has an alternate 5' exon, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 1.