XPC (NM_004628) Human Untagged Clone

CAT#: SC117234

XPC (untagged)-Human xeroderma pigmentosum, complementation group C (XPC), transcript variant 1


  "NM_004628" in other vectors (6)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

Product Images

Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol XPC
Synonyms p125; RAD4; XP3; XPCC
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC117234 sequence for NM_004628 edited (data generated by NextGen Sequencing)
ATGGCTCGGAAACGCGCGGCCGGCGGGGAGCCGCGGGGACGCGAACTGCGCAGCCAGAAA
TCCAAGGCCAAGAGCAAGGCCCGGCGTGAGGAGGAGGAGGAGGATGCCTTTGAAGATGAG
AAACCCCCAAAGAAGAGCCTTCTCTCCAAAGTTTCACAAGGAAAGAGGAAAAGAGGCTGC
AGTCATCCTGGGGGTTCAGCAGATGGTCCAGCAAAAAAGAAAGTGGCCAAGGTGACTGTT
AAATCTGAAAACCTCAAGGTTATAAAGGATGAAGCCCTCAGCGATGGGGATGACCTCAGG
GACTTTCCAAGTGACCTCAAGAAGGCACACCATCTGAAGAGAGGGGCTACCATGAATGAA
GACAGCAATGAAGAAGAGGAAGAAAGTGAAAATGATTGGGAAGAGGTTGAAGAACTTAGT
GAGCCTGTGCTGGGTGACGTGAGAGAAAGTACAGCCTTCTCTCGATCTCTTCTGCCTGTG
AAGCCAGTGGAGATAGAGATTGAAACGCCAGAGCAGGCGAAGACAAGAGAAAGAAGTGAA
AAGATAAAACTGGAGTTTGAGACATATCTTCGGAGGGCGATGAAACGTTTCAATAAAGGG
GTCCATGAGGACACACACAAGGTTCACCTTCTCTGCCTGCTAGCAAATGGCTTCTATCGA
AATAACATCTGCAGCCAGCCAGATCTGCATGCTATTGGCCTGTCCATCATCCCAGCCCGC
TTTACCAGAGTGCTGCCTCGAGATGTGGACACCTACTACCTCTCAAACCTGGTGAAGTGG
TTCATTGGAACATTTACAGTTAATGCAGAACTTTCAGCCAGTGAACAAGATAACCTGCAG
ACTACATTGGAAAGGAGATTTGCTATTTACTCTGCTCGAGATGATGAGGAATTGGTCCAT
ATATTCTTACTGATTCTCCGGGCTCTGCAGCTCTTGACCCGGCTGGTATTGTCTCTACAG
CCAATTCCTCTGAAGTCAGCAACAGCAAAGGGAAAGAAACCTTCCAAGGAAAGATTGACT
GCGGATCCAGGAGGCTCCTCAGAAACTTCCAGCCAAGTTCTAGAAAACCACACCAAACCA
AAGACCAGCAAAGGAACCAAACAAGAGGAAACCTTTGCTAAGGGCACCTGCAGGCCAAGT
GCCAAAGGGAAGAGGAACAAGGGAGGCAGAAAGAAACGGAGCAAGCCCTCCTCCAGCGAG
GAAGATGAGGGCCCAGGAGACAAGCAGGAGAAGGCAACCCAGCGACGTCCGCATGGCCGG
GAGCGGCGGGTGGCCTCCAGGGTGTCTTATAAAGAGGAGAGTGGGAGTGATGAGGCTGGC
AGCGGCTCTGATTTTGAGCTCTCCAGTGGAGAAGCCTCTGATCCCTCTGATGAGGATTCC
GAACCTGGCCCTCCAAAGCAGAGGAAAGCCCCCGCTCCTCAGAGGACAAAGGCTGGGTCC
AAGAGTGCCTCCAGGACCCATCGTGGGAGCCATCGTAAGGACCCAAGCTTGCCAGCGGCA
TCCTCAAGCTCTTCAAGCAGTAAAAGAGGCAAGAAAATGTGCAGCGATGGTGAGAAGGCA
GAAAAAAGAAGCATAGCTGGTATAGACCAGTGGCTAGAGGTGTTCTGTGAGCAGGAGGAA
AAGTGGGTATGTGTAGACTGTGTGCACGGTGTGGTGGGCCAGCCTCTGACCTGTTACAAG
TACGCCACCAAGCCCATGACCTATGTGGTGGGCATTGACAGTGACGGCTGGGTCCGAGAT
GTCACACAGAGGTACGACCCAGTCTGGATGACAGTGACCCGCAAGTGCCGGGTTGATGCT
GAGTGGTGGGCCGAGACCTTGAGACCATACCAGAGCCCATTTATGGACAGGGAGAAGAAA
GAAGACTTGGAGTTTCAGGCAAAACACATGGACCAGCCTTTGCCCACTGCCATTGGCTTA
TATAAGAACCACCCTCTGTATGCCCTGAAGCGGCATCTCCTGAAATATGAGGCCATCTAT
CCCGAGACAGCTGCCATCCTTGGGTATTGTCGTGGAGAAGCGGTCTACTCCAGGGATTGT
GTGCACACTCTGCATTCCAGAGACACGTGGCTGAAGAAAGCAAGAGTGGTGAGGCTTGGA
GAAGTACCCTACAAGATGGTGAAAGGCTTTTCTAACCGTGCTCGGAAAGCCCGACTTGCT
GAGCCCCAGCTGCGGGAAGAAAATGACCTGGGCCTGTTTGGCTACTGGCAGACAGAGGAG
TATCAGCCCCCAGTGGCCGTGGACGGGAAGGTGCCCCGGAACGAGTTTGGGAATGTGTAC
CTCTTCCTGCCCAGCATGATGCCTATTGGCTGTGTCCAGCTGAACCTGCCCAATCTACAC
CGCGTGGCCCGCAAGCTGGACATCGACTGTGTCCAGGCCATCACTGGCTTTGATTTCCAT
GGCGGCTACTCCCATCCCGTGACTGATGGATACATCGTCTGCGAGGAATTCAAAGACGTG
CTCCTGACTGCCTGGGAAAATGAGCAGGCAGTCATTGAAAGGAAGGAGAAGGAGAAAAAG
GAGAAGCGGGCTCTAGGGAACTGGAAGTTGCTGGCCAAAGGTCTGCTCATCAGGGAGAGG
CTGAAGCGTCGCTACGGGCCCAAGAGTGAGGCAGCAGCTCCCCACACAGATGCAGGAGGT
GGACTCTCTTCTGATGAAGAGGAGGGGACCAGCTCTCAAGCAGAAGCGGCCAGGATACTG
GCTGCCTCCTGGCCTCAAAACCGAGAAGATGAAGAAAAGCAGAAGCTGAAGGGTGGGCCC
AAGAAGACCAAAAGGGAAAAGAAAGCAGCAGCTTCCCACCTGTTCCCATTTGAGAAGCTG
TGA

Clone variation with respect to NM_004628.4
2061 g=>a;2815 c=>a
>OriGene 5' read for NM_004628 unedited
AATCCGGCGCCCGTTGCCGCATTGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGC
AGAGCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGCGA
ATTCGGCACGAGGCCCAGACAAGCAACATGGCTCGGAAACGCGCGGCCGGCGGGGAGCCG
CGGGGACGCGAACTGCGCAGCCAGAAATCCAAGGCCAAGAGCAAGGCCCGGCGTGAGGAG
GAGGAGGAGGATGCCTTTGAAGATGAGAAACCCCCAAAGAAGAGCCTTCTCTCCAAAGTT
TCACAAGGAAAGAGGAAAAGAGGCTGCAGTCATCCTGGGGGTTCAGCAGATGGTCCAGCA
AAAAAGAAAGTGGCCAAGGTGACTGTTAAATCTGAAAACCTCAAGGTTATAAAGGATGAA
GCCCTCAGCGATGGGGATGACCTCAGGGACTTTCCAAGTGACCTCAAGAAGGCACACCAT
CTGAAGAGAGGGGCTACCATGAATGAAGACAGCAATGAAGAAGAGGAAGAAAGTGAAAAT
GATTGGGAAGAGGTTGAAGAACTTAGTGAGCCTGTGCTGGGTGACGTGAGAGAAAGTACA
GCCTTCTCTCGATCTCTTCTGCCTGTGAAGCCAGTGGAGATAGAGATTGAAACGCCAGAG
CAGGCGAAGACCAGAGGAAGAAGTGAAAAGATAAAACTGGAGTTGGAGACATATCTTCGG
AGGGCGATGAAACGTTTCATAAAGGGGTCCATGAGGACACACCACAAGTTACCTTTCTTG
GCTGCTAGCAAAGGGGTTCTATCGAATAACATCTGCAGCCAGCCAGATCTGCATGCTATT
GGCCTGGCCATTATCCCAGCCCGTTTTCACAGATGCTGCCTCGAGAGGTGAACACCTATA
CCCTTAAACCGGGGGAAGGGTTCATG
>OriGene 3' read for NM_004628 unedited
GGTAATCTATGNACGCGGCCGCATTCTAGATCGAGTTTTTTTTTTTTTTTTTTTTTAGAT
AAATGCTTTATTATTTTCTCAAAATGTTATAAAAGTCATTTCTCCTTAGTACAGAGAGCT
TTATACATTTTATCTAGTAATGAATACAATCTAGTTTAACACTGATCTATTTTACTAACA
TTTCCTTAATTTTCAATTCGTATTTTTCCTTTTCTTTCCTGATTTTAGCTTTTTTTAGGC
TTCTGTCACCACAAAATGTTACTTGGAAAACTAGATCCCAGCAGATGACCTGTACTTCTC
TGCTCTCTCCCCTACTGCAAAGAGGCAGTGAGGGCAGCATTAGTAAGCCTGACTCAGGGG
AAGGTAAGTGGCCTGCAGAGAAATGGTCCTAGGTCCGCAACCGAGGCGAGTGAACTTGTC
GGACAGATGAAGACTCTAACTGGAAGAAACGATCAGCGCATTCACGGATGCACCACCATC
CAGAAATCTCCCGGTGGCTTCCATACAAAAACTGATGTTTCTAAAGATGGAAAGAACAGG
TCTAGGAGGCAGAAGAGTATCTCCTAGCAAAGTGTTCTGTAGCTCAAAGGGTGAGTGGGC
TTTGGTAGCAAAAAGCTTTGAAGGCTTCACCCTGGGTGAATCTGACAAGGGCTGGAGCCA
GACGGGACCTGCAGCACCTCCTCAGCTTGGCCTCGTCTCCCCTGACCCCGCCTCCGTGCA
TGCTGCCTCAGTTTGCCTTCTCAGCAGAGAAGCCCCCACCACCAGGGGCTGGGCATGCCC
AGGGCAGGTGTGGGGCCTGTAGTGGGGCAGCAGCAACTGGTGGGGTGCCCCTCTAGTGGG
CGCTCAGCTCACAGCTTCTCAAATGGGGACCAGGTGGGAAGCTGCTGNCTTTCTTTTTCC
TTTTGGGTCTTCTTGGGGCCC
Restriction Sites NotI-NotI     
ACCN NM_004628
Insert Size 4000 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_004628.3, NP_004619.2
RefSeq Size 3714 bp
RefSeq ORF 2823 bp
Locus ID 7508
Cytogenetics 3p25.1
Domains Rad4
Protein Families Druggable Genome
Protein Pathways Nucleotide excision repair
Gene Summary 'The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]'
Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

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