E Cadherin (CDH1) (NM_004360) Human Untagged Clone

CAT#: SC117413

CDH1 (untagged)-Human cadherin 1, type 1, E-cadherin (epithelial) (CDH1)


  "NM_004360" in other vectors (6)

Reconstitution Protocol

USD 1,790.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CDH1
Synonyms Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_004360, the custom clone sequence may differ by one or more nucleotides


ACCAGGCTTGCGGAAGTCAGTTCAGACTCCAGCCCGCTCCAGCCCGGCCCGACCCGACCGCACCCGGCGC
CTGCCCTCGCTCGGCGTCCCCGGCCAGCCATGGGCCCTTGGAGCCGCAGCCTCTCGGCGCTGCTGCTGCT
GCTGCAGGTCTCCTCTTGGCTCTGCCAGGAGCCGGAGCCCTGCCACCCTGGCTTTGACGCCGAGAGCTAC
ACGTTCACGGTGCCCCGGCGCCACCTGGAGAGAGGCCGCGTCCTGGGCAGAGTGAATTTTGAAGATTGCA
CCGGTCGACAAAGGACAGCCTATTTTTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTAC
AGTCAAAAGGCCTCTACGGTTTCATAACCCACAGATCCATTTCTTGGTCTACGCCTGGGACTCCACCTAC
AGAAAGTTTTCCACCAAAGTCACGCTGAATACAGTGGGGCACCACCACCGCCCCCCGCCCCATCAGGCCT
CCGTTTCTGGAATCCAAGCAGAATTGCTCACATTTCCCAACTCCTCTCCTGGCCTCAGAAGACAGAAGAG
AGACTGGGTTATTCCTCCCATCAGCTGCCCAGAAAATGAAAAAGGCCCATTTCCTAAAAACCTGGTTCAG
ATCAAATCCAACAAAGACAAAGAAGGCAAGGTTTTCTACAGCATCACTGGCCAAGGAGCTGACACACCCC
CTGTTGGTGTCTTTATTATTGAAAGAGAAACAGGATGGCTGAAGGTGACAGAGCCTCTGGATAGAGAACG
CATTGCCACATACACTCTCTTCTCTCACGCTGTGTCATCCAACGGGAATGCAGTTGAGGATCCAATGGAG
ATTTTGATCACGGTAACCGATCAGAATGACAACAAGCCCGAATTCACCCAGGAGGTCTTTAAGGGGTCTG
TCATGGAAGGTGCTCTTCCAGGAACCTCTGTGATGGAGGTCACAGCCACAGACGCGGACGATGATGTGAA
CACCTACAATGCCGCCATCGCTTACACCATCCTCAGCCAAGATCCTGAGCTCCCTGACAAAAATATGTTC
ACCATTAACAGGAACACAGGAGTCATCAGTGTGGTCACCACTGGGCTGGACCGAGAGAGTTTCCCTACGT
ATACCCTGGTGGTTCAAGCTGCTGACCTTCAAGGTGAGGGGTTAAGCACAACAGCAACAGCTGTGATCAC
AGTCACTGACACCAACGATAATCCTCCGATCTTCAATCCCACCACGTACAAGGGTCAGGTGCCTGAGAAC
GAGGCTAACGTCGTAATCACCACACTGAAAGTGACTGATGCTGATGCCCCCAATACCCCAGCGTGGGAGG
CTGTATACACCATATTGAATGATGATGGTGGACAATTTGTCGTCACCACAAATCCAGTGAACAACGATGG
CATTTTGAAAACAGCAAAGGGCTTGGATTTTGAGGCCAAGCAGCAGTACATTCTACACGTAGCAGTGACG
AATGTGGTACCTTTTGAGGTCTCTCTCACCACCTCCACAGCCACCGTCACCGTGGATGTGCTGGATGTGA
ATGAAGCCCCCATCTTTGTGCCTCCTGAAAAGAGAGTGGAAGTGTCCGAGGACTTTGGCGTGGGCCAGGA
AATCACATCCTACACTGCCCAGGAGCCAGACACATTTATGGAACAGAAAATAACATATCGGATTTGGAGA
GACACTGCCAACTGGCTGGAGATTAATCCGGACACTGGTGCCATTTCCACTCGGGCTGAGCTGGACAGGG
AGGATTTTGAGCACGTGAAGAACAGCACGTACACAGCCCTAATCATAGCTACAGACAATGGTTCTCCAGT
TGCTACTGGAACAGGGACACTTCTGCTGATCCTGTCTGATGTGAATGACAACGCCCCCATACCAGAACCT
CGAACTATATTCTTCTGTGAGAGGAATCCAAAGCCTCAGGTCATAAACATCATTGATGCAGACCTTCCTC
CCAATACATCTCCCTTCACAGCAGAACTAACACACGGGGCGAGTGCCAACTGGACCATTCAGTACAACGA
CCCAACCCAAGAATCTATCATTTTGAAGCCAAAGATGGCCTTAGAGGTGGGTGACTACAAAATCAATCTC
AAGCTCATGGATAACCAGAATAAAGACCAAGTGACCACCTTAGAGGTCAGCGTGTGTGACTGTGAAGGGG
CCGCCGGCGTCTGTAGGAAGGCACAGCCTGTCGAAGCAGGATTGCAAATTCCTGCCATTCTGGGGATTCT
TGGAGGAATTCTTGCTTTGCTAATTCTGATTCTGCTGCTCTTGCTGTTTCTTCGGAGGAGAGCGGTGGTC
AAAGAGCCCTTACTGCCCCCAGAGGATGACACCCGGGACAATGTTTATTACTATGATGAAGAAGGAGGCG
GAGAAGAGGACCAGGACTTTGACTTGAGCCAGCTGCACAGGGGCCTGGACGCTCGGCCTGAAGTGACTCG
TAACGACGTTGCACCAACCCTCATGAGTGTCCCCCGGTATCTTCCCCGCCCTGCCAATCCCGATGAAATT
GGAAATTTTATTGATGAAAATCTGAAAGCGGCTGATACTGACCCCACAGCCCCGCCTTATGATTCTCTGC
TCGTGTTTGACTATGAAGGAAGCGGTTCCGAAGCTGCTAGTCTGAGCTCCCTGAACTCCTCAGAGTCAGA
CAAAGACCAGGACTATGACTACTTGAACGAATGGGGCAATCGCTTCAAGAAGCTGGCTGACATGTACGGA
GGCGGCGAGGACGACTAGGGGACTCGAGAGAGGCGGGCCCCAGACCCATGTGCTGGGAAATGCAGAAATC
ATGTTGCTGGTGGTTTTTCAGCTCCCTTCCCTTGAGATGAGTTTCTGG


>OriGene 5' read for NM_004360 unedited
GGGTTGCAGNATTTTGTAATACGATTCACTATAGGCGGCCCGCGAATCGGCACCAGGCTT
GCGGTAGTCAGTTCAGACTCCAGCCCGCTCCAGCCCGGCCCGACCCGACCGCACCCGGCG
CCTGCCCTCGCTCGGCGTCCCCGGCCAGCCATGGGCCCTTGGAGCCGCAGCCTCTCGGCG
CTGCTGCTGCTGCTGCAGGTCTCCTCTTGGCTCTGCCAGGAGCCGGAGCCCTGCCACCCT
GGCTTTGACGCCGAGAGCTACACGTTCACGGTGCCCCGGCGCCACCTGGAGAGAGGCCGC
GTCCTGGGCAGAGTGAATTTTGAAGATTGCACCGGTCGACAAAGGACAGCCTATTTTTCC
CTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAAGGCCTCTACGG
TTTCATAACCCACAGATCCATTTCTTGGTCTACGCCTGGGACTCCACCTACAGAAAGTTT
TCCACCAAAGTCACGCTGAATACAGTGGGGCACCACCACCGCCCCCCGCCCCATCAGGCC
TCCGTTTCTGGAATCCAAGCAGAATTGCTCACATTTCCCAACTCCTCTCCTGGCCTCAGA
AGACAGAAGAGAGACTGGGTTATTCCTCCCATCAGCTGCCCAGAAAATGAAAAAGGCCCA
TTTCCTAAAAACCTGGTTCAGATCAAATCCAACAAAGACAAAGAAGGCAAGGTTTTCTAC
AGCATCACTGGCCAAGGAGCTGACACACCCCCTGTTGGTGTCTTTATTATTTGAAAGAGA
ACAGTATGGCTGAAGGTGACAGAGCCTCTGCATAGAGAACGCACTGCCCCATACACTCTC
TTTTCTCACGCTGTGTCATCCAACGGAAATGCCGTTGAGGATCCATGGAGAATTTGATCA
CGGTACCGATCAAATGACAACAGCCCGAATCACCG
>OriGene 3' read for NM_004360 unedited
TATGGACCGCGGCCGCATCTAAATCGAGTTTTTTTTTTTTTTTTTTAATGGTTTAACAAA
ATTGTTTAATAAAATTTATAAAAATGCATCTTTGAGAATACTTTTCTCAGCTTGAATTGT
TTTCCTTTTCCACCCCCAAAGAAAATACACAATTATCAGCACCCACACATGTATACACTC
AAAACTACAGTGACATTCTCTACACAGAACTATATTCGATATAGCTTGAACTGCCGAAAA
ATCAAGACAATTCCAAAAAGTGATTGCAGGGTTGATTTTTTTCTCCAAAACACTCGAGAA
ACAGTAAAGCTATTTGAACAAAAGACTTTTGTTTGATTGCCAAAAGTCGAAATCCACATT
TAAATGTACCGAGATGCAACGTCCGATGCCCGCTACCCTTTTTCCCCGCCCCACCCCCGT
TTTTGGACCCACCCTCTTCACCGTTTTCCCCCCCTTTGTCCTTTTTTTCTTTTGCCTCCC
CCCCCCCCCCCCTTTTTCCCCCGCTCCAGCCTAGTTCGCCCGCATATCCCCACCCCGCCC
CGCCCATTGTCTCCCGCCTTGTGTGCCCAGCTGCCACCGCCCTACCCCCACTCCCCCGCG
TATCTGCCAGATGTTGTTCGCGCGGCGGGGCGTCGCGGGGAGGTGCGCCCCCCGCCCCTC
CATTCTGTCGCCGGTTTGCAGTCCCTCTTGTGTGCTTTTTTAGCGCGGGTGGCCTCCGTG
GGGCAACCCGCCCACCCGTCCGCCCCTCTTTGTCTCCTCCAGTCTTGTACATAATCTCCA
TAGTATGCCCTGAAGTCGTCGCTCCCACCCCCCCGCACCCATTGCGCCCCCTCGCGGTTC
TCCCGCCTCATCTTGCCCCACTCCGTCGTCCCGTCGCGTTTCTCAACCAGTGGCGTTCTC
ACCCCGCATCATTTCACCGCCCCCTCTTGTCCCAGCCCCCTTTGCTCCACCGCGGTTACG
TCAGACCCTCACGTATTCCGCCGTCCGGGCCCTCCCGCTAGCCCACTTGCCGCCCTACG
Restriction Sites NotI-NotI     
ACCN NM_004360
Insert Size 5000 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_004360.2, NP_004351.1
RefSeq Size 4815 bp
RefSeq ORF 4815 bp
Locus ID 999
Cytogenetics 16q22.1
Domains Cadherin_C_term, CA
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Adherens junction, Bladder cancer, Cell adhesion molecules (CAMs), Endometrial cancer, Melanoma, Pathogenic Escherichia coli infection, Pathways in cancer, Thyroid cancer
Gene Summary 'This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]'
Transcript Variant: This variant (1) encodes the longest isoform (1).

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