Caspase 3 (CASP3) (NM_004346) Human Untagged Clone

CAT#: SC117447

CASP3 (untagged)-Human caspase 3, apoptosis-related cysteine peptidase (CASP3), transcript variant alpha


  "NM_004346" in other vectors (4)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CASP3
Synonyms CPP32; CPP32B; SCA-1
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC117447 sequence for NM_004346 edited (data generated by NextGen Sequencing)
ATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATC
ATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGAT
TATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGA
ATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAAC
TTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATG
CGTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGC
CATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACA
AACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATT
CAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGAT
GACATGGCGTGTCATAAAATACCAGTGGAGGCCGACTTCTTGTATGCATACTCCACAGCA
CCTGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGT
GCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAAC
CGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAA
CAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAA

Clone variation with respect to NM_004346.3
>OriGene 5' read for NM_004346 unedited
ATATTTTGTAATACGACTCACTTATAGGGCGGCCGCGAATTCGCACGAGGCGCGGCTCCT
AGCGGATGGGTGCTATTGTGAGGCGGTTGTGGAAGTTAATAAAGGTATCCATGNGAGAAC
ACTNGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATCATACATGG
AAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGATTATCCTGA
GATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGAATGACATC
TCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAACTTGAAATA
TGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATGCGTGATGT
TTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGCCATGGTGA
AGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACAAACTTTTT
CAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATTCAGGCCTG
CCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGATGACATGGC
GTGTCATAAAATACCAGTGGAGGCCGACTTCTTGTATGCATACTCCACAGCACCTGGTTA
TTATTCTTGGCGAAATCANAGGATGGCTCCTGGTTCATCCAGTCGCTTTGTGCCATGCTG
AAACAGTATGCCGGACAGCTTGAAATTATGCACATTCTTACCCGGGTAACCGCAAGGTGG
GCACAGAATTTGAGTCCCTTTCCTTTGACGCTACTTTTCATGCAAAGAAACAGATTCCAT
GGATTGGTTCCATGCTCACCAAAGAACTCTATTTNTATCACTAAAGAAAAGGGTGGNTTG
GTGGGGTTTTTT
>OriGene 3' read for NM_004346 unedited
ACTATGAACCCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTAATTTTAAGTTTGAATGTATATTTTGGAAATAAAAATGGAAAA
TAACAAATTTGTACAAAATTGTCACATAAAAACACACTTTAAAATACCATTACATGCTGG
GGGTATTTACAAAAGTTACAGGTCTAGTAAAAAAAAAAAAACTGTCATTGACAAATGCGA
GCTCATTTTTTGAGCAACAAAAAATCTCCCGTGAAATGTCATACTGACAGCCAGTGAAAC
TTGGTGCAGTGACGGCTCCCCACCTGCTGAGGCCTGGAGCCTGCCTCCCGGGCTGAGTGC
TCAACTTTGGCCTCCGGCTGGATGCCGTCTAAAGTCCTATGGGCTCATAGGTCTTTTTTT
TTCAGTAAACAGTATAAAACATTACTATTTTCCTTTGATTGGAAACTTCAACAGAAAATA
ACATACTTAAAAATTTTGCTACAAAAAGTACTATGATTTTTATTGCCTCACCACCTTTAA
AACATTTCCACTTCACAAGTTTCTGATTTGCTTCACTTTCTTACTTGGCGATGGCGCCCT
GGCAGCATCATCCACACATACCAGTGCGTATGGAAAAATGGGCTGTAGGCCCTTCCTGCG
TGGTCCATGGCTCTGCCTTCATGGAACAGGCTGAGTCATGTCTCTGCTCAGGCTCAAACC
ATCTACTCTCAAGTTACAGGCAGCTTAGCCCATTCATTTATTGCTTTCCTTATATTCCAC
TGTTTATTATTATAAAGTTGGATTTCCATATGTTCCCTATAGAAATTATTCCACATTACC
CTGCCTAATAATCCAACAAGTTGGGGGGTTTTTATATAATAGCTCTCAACATTATTGCTG
GTTTTTGAAGCCTCACTGAATGCCTAGGGACAATCAAAGTATTTTTGCTTGGAGATCAGG
GCATTGTACC
Restriction Sites NotI-NotI     
ACCN NM_004346
Insert Size 2740 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_004346.3, NP_004337.2
RefSeq Size 2689 bp
RefSeq ORF 834 bp
Locus ID 836
Cytogenetics 4q35.1
Domains CASc, ICE_p10, ICE_p20
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Protease
Protein Pathways Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Epithelial cell signaling in Helicobacter pylori infection, Huntington's disease, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, p53 signaling pathway, Parkinson's disease, Pathways in cancer, Viral myocarditis
Gene Summary 'The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]'
Transcript Variant: This variant (1, also known as alpha) encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).

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