SQSTM1 (NM_003900) Human Untagged Clone

CAT#: SC117669

SQSTM1 (untagged)-Human sequestosome 1 (SQSTM1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SQSTM1
• Synonyms: A170; DMRV; FTDALS3; NADGP; OSIL; p60; p62; p62B; PDB3; ZIP3
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC117669 sequence for NM_003900 edited (data generated by NextGen Sequencing)
  ATGGCGTCGCTCACCGTGAAGGCCTACCTTCTGGGCAAGGAGGACGCGGCGCGCGAGATT
  CGCCGCTTCAGCTTCTGCTGCAGCCCCGAGCCTGAGGCGGAAGCCGAGGCTGCGGCGGGT
  CCGGGACCCTGCGAGCGGCTGCTGAGCCGGGTGGCCGCCCTGTTCCCCGCGCTGCGGCCT
  GGCGGCTTCCAGGCGCACTACCGCGATGAGGACGGGGACTTGGTTGCCTTTTCCAGTGAC
  GAGGAATTGACAATGGCCATGTCCTACGTGAAGGATGACATCTTCCGAATCTACATTAAA
  GAGAAAAAAGAGTGCCGGCGGGACCACCGCCCACCGTGTGCTCAGGAGGCGCCCCGCAAC
  ATGGTGCACCCCAATGTGATCTGCGATGGCTGCAATGGGCCTGTGGTAGGAACCCGCTAC
  AAGTGCAGCGTCTGCCCAGACTACGACTTGTGTAGCGTCTGCGAGGGAAAGGGCTTGCAC
  CGGGGGCACACCAAGCTCGCATTCCCCAGCCCCTTCGGGCACCTGTCTGAGGGCTTCTCG
  CACAGCCGCTGGCTCCGGAAGGTGAAACACGGACACTTCGGGTGGCCAGGATGGGAAATG
  GGTCCACCAGGAAACTGGAGCCCACGTCCTCCTCGTGCAGGGGAGGCCCGCCCTGGCCCC
  ACGGCAGAATCAGCTTCTGGTCCATCGGAGGATCCGAGTGTGAATTTCCTGAAGAACGTT
  GGGGAGAGTGTGGCAGCTGCCCTTAGCCCTCTGGGCATTGAAGTTGATATCGATGTGGAG
  CACGGAGGGAAAAGAAGCCGCCTGACCCCCGTCTCTCCAGAGAGTTCCAGCACAGAGGAG
  AAGAGCAGCTCACAGCCAAGCAGCTGCTGCTCTGATCCCAGCAAGCCGGGTGGGAATGTT
  GAGGGCGCCACGCAGTCTCTGGCGGAGCAGATGAGAAAGATCGCCTTGGAGTCCGAGGGG
  CGCCCTGAGGAACAGATGGAGTCGGATAACTGTTCAGGAGGAGATGATGACTGGACCCAT
  CTGTCTTCAAAAGAAGTGGACCCGTCTACAGGTGAACTCCAGTCCCTACAGATGCCAGAA
  TCCGAAGGGCCAAGCTCTCTGGACCCCTCCCAGGAGGGACCCACAGGGCTGAAGGAAGCT
  GCCTTGTACCCACATCTCCCGCCAGAGGCTGACCCGCGGCTGATTGAGTCCCTCTCCCAG
  ATGCTGTCCATGGGCTTCTCTGATGAAGGCGGCTGGCTCACCAGGCTCCTGCAGACCAAG
  AACTATGACATCGGAGCGGCTCTGGACACCATCCAGTATTCAAAGCATCCCCCGCCGTTG
  TGA
  
  Clone variation with respect to NM_003900.4
  876 c=>t;936 g=>a
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003900 unedited
  CCCCGTTCGGAATTGTATACGACTCATATAGGCGGCCTGCGAATCGGCACCAGGCCAGCT
  CGCCGCTCGCTATGGCGTCGCTCACCGTGAAGGCCTACCTTCTGGGCAAGGAGGACGCGG
  CGCGCGAGATTCGCCGCTTCAGCTTCTGCTGCAGCCCCGAGCCTGAGGCGGAAGCCGAGG
  CTGCGGCGGGTCCGGGACCCTGCGAGCGGCTGCTGAGCCGGGTGGCCGCCCTGTTCCCCG
  CGCTGCGGCCTGGCGGCTTCCAGGCGCACTACCGCGATGAGGACGGGGACTTGGTTGCCT
  TTTCCAGTGACGAGGAATTGACAATGGCCATGTCCTACGTGAAGGATGACATCTTCCGAA
  TCTACATTAAAGAGAAAAAAGAGTGCCGGCGGGACCACCGCCCACCGTGTGCTCAGGAGG
  CGCCCCGCAACATGGTGCACCCCAATGTGATCTGCGATGGCTGCAATGGGCCTGTGGTAG
  GAACCCGCTACAAGTGCAGCGTCTGCCCAGACTACGACTTGTGTAGCGTCTGCGAGGGAA
  AGGGCTTGCACCGGGGGCACACCAAGCTCGCATTCCCCAGCCCCTTCGGGCACCTGTCTG
  AGGGCTTCTCGCACAGCCGCTGGCTCCGGAAGGTGAAACACGGACACTTCGGGTGGCCAG
  GATGGGAAATGGGTCCACCAGGAAACTGGAGCCCACGTCCTCCTCGTGCAGGGGAGGCCC
  GCCCTGGCCCCACGGCAGAATCAGCTTCTGGTCCATCGGAGGATCCGAGTGTGAATTTCC
  TGAAGACGTTGGGGAGAGTGTGGCAGCTGCCCTTAGCCTCTGGCATTGAAGTGAATCGAT
  GTGGAGCCGGAGGTAAAGAGCCGCTGACCCCGTCTTCCAGAGGTTCAGCCAGAGGAGAG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003900 unedited
  NCCCCCATCCATTGGATCCATTGGCGATGGTCAACCTTTCCAGGNNCCAGGGTAGGAGGC
  ACTTGGGTGAAGGGGTTCACAGGGCATGCCACCCGGGTACTGTTCAGGAAAAGCTATGAC
  CGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGGTTAAAGTGCTGATGCCA
  TTTAATTAGATTGTTTACAAATTTAACAGGATGGCTACAAAGATATTTTATTTTAAAAGC
  ATCTTATGGTTTGGAAATGAGAGAACTACTGTGGTGAAGAGACCAGGAGGCAGCTCTCAG
  TGAAACCAACATTGCGGATGCCCTTCGTGAGCCTTCTCAGTCCCAGCAGGAAGCCCACAA
  CACTGGCCTCCCCAGCCTGCCTGCTGACAACACCTAGGCTTACTTTATCTAAAATCAGAG
  TGTACCAGGTCTGTAGCAGAAAATAATCAACTAAATGTCAGGGACCTATGAGTCATTTAA
  AACAAAAGAGAAAGTGAAAGCCATTAGGCAAGCTATGTGCTGGGCTGCTAACGTAGCCCC
  TGCAGGGAGGGGTCAGGAGCGCGCTGCAGTGAGCCTTGGGTCTCGCAAGCCCAGCCCTGC
  TGCAAGGAGCCAGGGCACCCAGGAAACATCAGCACACACACACACAGGGACCCTCCCTTC
  ATGTCACTTGTTTTGCTGCCCTAAATGGCTTCTTGCACCCTAACCCCTGATCCTGGAAGA
  AGGCAGAGAAACTGGCCCGTACAGAGACCTGCAATTCTACGCAAGCTTAACACAACTATG
  AGACAGAAGAGGGGCACGCAGAAGGAGTGGGCANAAGTGGTCACAACGGCGGGGGATGCT
  TTTGATACTGGATGGT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003900
• ORF Size: 1323 bp
• Insert Size: 2000
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_003900.3, NP_003891.1
• RefSeq Size: 2868
• RefSeq ORF: 1323
• Locus ID: 8878
• Domains: PB1, ZnF_ZZ, UBA
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
  Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).