BCL10 (NM_003921) Human Untagged Clone

CAT#: SC117685

BCL10 (untagged)-Human B-cell CLL/lymphoma 10 (BCL10)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: BCL10
• Synonyms: c-E10; CARMEN; CIPER; CLAP; IMD37; mE10
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC117685 sequence for NM_003921 edited (data generated by NextGen Sequencing)
  ATGGAGCCCACCGCACCGTCCCTCACCGAGGAGGACCTCACTGAAGTGAAGAAGGACGCC
  TTAGAAAATTTACGTGTATACCTGTGTGAGAAAATCATAGCTGAGAGACATTTTGATCAT
  CTACGTGCAAAAAAAATACTCAGTAGAGAAGACACTGAAGAAATTTCTTGTCGAACATCA
  AGTAGAAAAAGGGCTGGAAAATTGTTAGACTACTTACAGGAAAACCCAAAAGGTCTGGAC
  ACCCTTGTTGAATCTATTCGGCGAGAAAAAACACAGAACTTCCTGATACAGAAGATTACA
  GATGAAGTGCTGAAACTTAGAAATATAAAACTAGAACATCTGAAAGGACTAAAATGTAGC
  AGTTGTGAACCTTTTCCAGATGGAGCCACGAACAACCTCTCCAGATCAAATTCAGATGAG
  AGTAATTTCTCTGAAAAACTGAGGGCATCCACTGTCATGTACCATCCAGAAGGAGAATCC
  AGCACGACGCCCTTTTTTTCTACTAATTCTTCTCTGAATTTGCCTGTTCTAGAAGTAGGC
  AGAACTGAAAATACCATCTTCTCTTCAACTACACTTCCCAGACCTGGGGACCCAGGGGCT
  CCTCCTTTGCCACCAGATCTACAGTTAGAAGAAGAAGGAACTTGTGCAAACTCTAGTGAG
  ATGTTTCTTCCCTTAAGATCACGTACTGTTTCACGACAATGA
  
  Clone variation with respect to NM_003921.4
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003921 unedited
  NTTATACCCCCGCCCGTTGNCGCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATA
  AGCAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCC
  GCGAATTGGCACGAGGGCGGGGCGGCGCAGCCCGAGCTCCCGGACCCGGAAGAAGCGCCA
  TCTCCCGCCTCCACCATGGAGCCCACCGCACCGTCCCTCACCGAGGAGGACCTCACTGAA
  GTGAAGAAGGACGCCTTAGAAAATTTACGTGTATACCTGTGTGAGAAAATCATAGCTGAG
  AGACATTTTGATCATCTACGTGCAAAAAAAATACTCAGTAGAGAAGACACTGAAGAAATT
  TCTTGTCGAACATCAAGTAGAAAAAGGGCTGGAAAATTGTTAGACTACTTACAGGAAAAC
  CCAAAAGGTCTGGACACCCTTGTTGAATCTATTCGGCGAGAAAAAACACAGAACTTCCTG
  ATACAGAAGATTACAGATGAAGTGCTGAAACTTAGAAATATAAAACTAGAACATCTGAAA
  GGACTAAAATGTAGCAGTTGTGAACCTTTTCCAGATGGAGCCACGAACAACCTCTCCAGA
  TCAAATTCAGATGAGAGTAATTTCTCTGAAAAACTGAGGGCATCCACTGTCATGTACCAT
  CCAGAAGGAGAATCCAGCACGACGCCCTTTTTTCTACTAATTCTTCTCTGAAATTGCCTG
  TTCTAGAAGTAGGCAGAACTGAAAATACCATCTTTCTCTCAACTACACTTTCCCAGACCT
  GNGGGACCCACGGGCCTCCCTCCCTTGCCACCAGATCTACAGGTAGTAAGAGNAGGAAAC
  TTGTGCAAACCTCTAGTGAGATGTTTCTTTCCCTTAAGACACGTACTTGTTTACGACATG
  ACACTTTATTGCCTTTTATTNTTATG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003921 unedited
  GGGTTGCCCCAATTTGGAAATTTTATGCGATGGCAATTTCCATTTCTTGTTTTTACAATT
  AATAATAGAAATTATAGGAGACAATGTCAGGAAACAGATAAAATTGTAATTTAAATAAAA
  ACAAACAGTGAGAGCATAAGATTTATAAACATGTAAAATTAGTCAAATTTTGTTTTACAA
  CAAAAAGACAAATCTGGCTAATGGCCCACTTGTTCAAATAGCATTAAAAACAGAATTGTC
  ACACACACCAAAAATAATTTGTTCCAGTTATTTCAACTGTACATTGGTCCTCATTAAAAG
  AGAATGAAAAGTACAGAGAAAATATTTTTTAAAAATCTCATCAGGCTAGGTGAGGTGGCT
  CGTGTCTGTAATCCCAGCACTTTGGGAGGCCACGCTGGGTAGGTTGCTTGAGTCCAGGAG
  TTCAAGACCAGCCTGGCCAACATGGCAAAACACCGTCTCTACAAAAATAATACAAAAATT
  AGTGAGGCATGGTGGCACACACTTGTAGTCTCAGCTATATTACTTGAGAGGCTGAGGTGA
  GAGGATCACGTAAGCATGGGAGGCAGAAGTTGCAGTGAGCCTAGAATGGGCCACTGCACT
  CCACCCTGGGCGATAGAAGCAGGACTGTCTCAAANAAAAAAAAACCGCTCAAGGAAAAGG
  GGAAAAATCCCTTATTCAATTACATGTAAATACTGAGGGTTAAGGCCAAAATATTTTTTT
  TTTGGGATGAAAATTGTTTAACCCCAAGATGGGAAAATTCTTACAAAAGTCTTTTAATTA
  GGTAGGTTAAATTAGAAATAAATTTTGGCAAACCCAAATTCCTGGGTGGGCAAACACCCC
  TTAAAT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003921
• ORF Size: 702 bp
• Insert Size: 2250
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_003921.2, NP_003912.1
• RefSeq Size: 2809
• RefSeq ORF: 702
• Locus ID: 8915
• Domains: CARD
• Protein Families: Druggable Genome
• Protein Pathways: B cell receptor signaling pathway, T cell receptor signaling pathway
• Gene Summary: This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
  Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.