Neuropilin 1 (NRP1) (NM_003873) Human Untagged Clone

CAT#: SC117726

NRP1 (untagged)-Human neuropilin 1 (NRP1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NRP1
• Synonyms: BDCA4; CD304; NP1; NRP; VEGF165R
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC117726 sequence for NM_003873 edited (data generated by NextGen Sequencing)
  ATGGAGAGGGGGCTGCCGCTCCTCTGCGCCGTGCTCGCCCTCGTCCTCGCCCCGGCCGGC
  GCTTTTCGCAACGATAAATGTGGCGATACTATAAAAATTGAAAGCCCCGGGTACCTTACA
  TCTCCTGGTTATCCTCATTCTTATCACCCAAGTGAAAAATGCGAATGGCTGATTCAGGCT
  CCGGACCCATACCAGAGAATTATGATCAACTTCAACCCTCACTTCGATTTGGAGGACAGA
  GACTGCAAGTATGACTACGTGGAAGTCTTCGATGGAGAAAATGAAAATGGACATTTTAGG
  GGAAAGTTCTGTGGAAAGATAGCCCCTCCTCCTGTTGTGTCTTCAGGGCCATTTCTTTTT
  ATCAAATTTGTCTCTGACTACGAAACACATGGTGCAGGATTTTCCATACGTTATGAACTT
  TTCAAGAGAGGTCCTGAATGTTCCCAGAACTACACAACACCTAGTGGAGTGATAAAGTCC
  CCCGGATTCCCTGAAAAATATCCCAACAGCCTTGAATGCACTTATATTGTCTTTGCGCCA
  AAGATGTCAGAGATTATCCTGGAATTTGAAAGCTTTGACCTGGAGCCTGACTCAAATCCT
  CCAGGGGGGATGTTCTGTCGCTACGACCGGCTAGAAATCTGGGATGGATTCCCTGATGTT
  GGCCCTCACATTGGGCGTTACTGTGGACAGAAAACACCAGGTCGAATCCGATCCTCATCG
  GGCATTCTCTCCATGGTTTTTTACACCGACAGCGCGATAGCAAAAGAAGGTTTCTCAGCA
  AACTACAGTGTCTTGCAGAGCAGTGTCTCAGAAGATTTCAAATGTATGGAAGCTCTGGGC
  ATGGAATCAGGAGAAATTCATTCTGACCAGATCACAGCTTCTTCCCAGTATAGCACCAAC
  TGGTCTGCAGAGCGCTCCCGCCTGAACTACCCTGAGAATGGGTGGACTCCCGGAGAGGAT
  TCCTACCGAGAGTGGATACAGGTAGACTTGGGCCTTCTGCGCTTTGTCACGGCTGTCGGG
  ACACAGGGCGCCATTTCAAAAGAAACCAAGAAGAAATATTATGTCAAGACTTACAAGATC
  GACGTTAGCTCCAACGGGGAAGACTGGATCACCATAAAAGAAGGAAACAAACCTGTTCTC
  TTTCAGGGAAACACCAACCCTACAGATGTTGTGGTTGCAGTATTCCCCAAACCACTGATA
  ACTCGATTTGTCCGAATCAAGCCTGCAACTTGGGAAACTGGCATATCTATGAGATTTGAA
  GTATATGGTTGCAAGATAACAGATTATCCTTGCTCTGGAATGTTGGGTATGGTGTCTGGA
  CTTATTTCTGACTCCCAGATCACATCATCCAACCAAGGGGACAGAAACTGGATGCCTGAA
  AACATCCGCCTGGTAACCAGTCGCTCTGGCTGGGCACTTCCACCCGCACCTCATTCCTAC
  ATCAATGAGTGGCTCCAAATAGACCTGGGGGAGGAGAAGATCGTGAGGGGCATCATCATT
  CAGGGTGGGAAGCACCGAGAGAACAAGGTGTTCATGAGGAAGTTCAAGATCGGGTACAGC
  AACAACGGCTCGGACTGGAAGATGATCATGGATGACAGCAAACGCAAGGCGAAGTCTTTT
  GAGGGCAACAACAACTATGATACACCTGAGCTGCGGACTTTTCCAGCTCTCTCCACGCGA
  TTCATCAGGATCTACCCCGAGAGAGCCACTCATGGCGGACTGGGGCTCAGAATGGAGCTG
  CTGGGCTGTGAAGTGGAAGCCCCTACAGCTGGACCGACCACTCCCAACGGGAACTTGGTG
  GATGAATGTGATGACGACCAGGCCAACTGCCACAGTGGAACAGGTGATGACTTCCAGCTC
  ACAGGTGGCACCACTGTGCTGGCCACAGAAAAGCCCACGGTCATAGACAGCACCATACAA
  TCAGAGTTTCCAACATATGGTTTTAACTGTGAATTTGGCTGGGGCTCTCACAAGACCTTC
  TGCCACTGGGAACATGACAATCACGTGCAGCTCAAGTGGAGTGTGTTGACCAGCAAGACG
  GGACCCATTCAGGATCACACAGGAGATGGCAACTTCATCTATTCCCAAGCTGACGAAAAT
  CAGAAGGGCAAAGTGGCTCGCCTGGTGAGCCCTGTGGTTTATTCCCAGAACTCTGCCCAC
  TGCATGACCTTCTGGTATCACATGTCTGGGTCCCACGTCGGCACACTCAGGGTCAAACTG
  CGCTACCAGAAGCCAGAGGAGTACGATCAGCTGGTCTGGATGGCCATTGGACACCAAGGT
  GACCACTGGAAGGAAGGGCGTGTCTTGCTCCACAAGTCTCTGAAACTTTATCAGGTGATT
  TTCGAGGGCGAAATCGGAAAAGGAAACCTTGGTGGGATTGCTGTGGATGACATTAGTATT
  AATAACCACATTTCACAAGAAGATTGTGCAAAACCAGCAGACCTGGATAAAAAGAACCCA
  GAAATTAAAATTGATGAAACAGGGAGCACGCCAGGATACGAAGGTGAAGGAGAAGGTGAC
  AAGAACATCTCCAGGAAGCCAGGCAATGTGTTGAAGACCTTAGACCCCATCCTCATCACC
  ATCATAGCCATGAGCGCCCTGGGGGTCCTCCTGGGGGCTGTCTGTGGGGTCGTGCTGTAC
  TGTGCCTGTTGGCATAATGGGATGTCAGAAAGAAACTTGTCTGCCCTGGAGAACTATAAC
  TTTGAACTTGTGGATGGTGTGAAGTTGAAAAAAGACAAACTGAATACACAGAGTACTTAT
  TCGGAGGCATGA
  
  Clone variation with respect to NM_003873.5
  418 a=>c;1161 c=>t;1266 c=>t;2595 t=>c
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003873 unedited
  CGGCACCAGGGGAAAAGGGAGAGGAAGCCGGAGCTAAATGACAGGATGCAGGCGACTTGA
  GACACAAAAAGAGAAGCGTTCCTCTCGGATCCAGGCATTGCCTCGCTGCTTTCTTTTCTC
  CAAGACGGGCTGAGGATTGTACAGCTCTAGGCGGAGTTGGGGCTCTTCGGATCGCTTAGA
  TTCTCCTCTTTGCTGCATTTCCCCCCACGTCCTCGTTCTCCCGCGTCTGCCTGCGGACCC
  GGAGAAGGGAGAATGGAGAGGGGGCTGCCGCTCCTCTGCGCCGTGCTCGCCCTCGTCCTC
  GCCCCGGCCGGCGCTTTTCGCAACGATAAATGTGGCGATACTATAAAAATTGAAAGCCCC
  GGGTACCTTACATCTCCTGGTTATCCTCATTCTTATCACCCAAGTGAAAAATGCGAATGG
  CTGATTCAGGCTCCGGACCCATACCAGAGAATTATGATCAACTTCAACCCTCACTTCGAT
  TTGGAGGACAGAGACTGCAAGTATGACTACGTGGAAGTCTTCGATGGAGAAAATGAANAT
  GGACATTTTAGGGGAAAGTTCTGTGGAAAGATAGCCCCTCCTCCTGTTGTGTCTTCAGGG
  CCATTTCTTTNTATCAAATTTGTCTCTGACTACGAAACACATGGTGCAGGATTTTCCATA
  CGTTATGAACTTTTCAAGAGAGGTCCCTGATGTTCCCAGAACTACCACACACCTAGTGGA
  GTGATAAAAGTCCCCGGATTCCCTGAAAATACCCNACAGCNCTGATGCACTATATTGCTT
  TGCGCAAGA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003873 unedited
  GAACGCGGCACGCATCTATATCGAGTTTTTTTTTTTTTTTTTTTTACCAGTAAAATGAAA
  ACATTTTACTACAGAAAGTTTTATAGATTTCCATAAAGAAAAAAATGTTATTTTACACCT
  TTAAAAATTACAAAACAATCTAAAACAATATAAACTGAACATTTTGTAACACTGCCTTTA
  CAAATTAATAACTTTATAAACATACAATTTTTAAATATATTTATCAGTGCAAGATACTTT
  AAATTTTAAAGTTGCAGTATCATTTTTCCTTGGCTGAAGACAACTTTAAGTCTGTTGCCT
  TTAAAAACAACAAACGAGTGTTTCTTATAGCTTTCCTTCTGGTAGGATTATATCAACTAA
  ATGAATGTCTCTGGGGACAAAAAACTATTCTTCTTTCATGGAGATCAATATTTTCCTGGA
  AACAAAAGGCATTCTCAATCCAATTTAACTAAGATGAATGGACTGTCTCATCTATGATGC
  AAATGTGACTCCCAACAAATGTCTTTGAGTGAGACGTCTAGCAATGTGGGAAGGAAGATC
  TAAAAAATCTCATGTCCAACATGGCATGATAAAAATCCACCAAAACCAACCAAAGCTTCT
  TTGGGTTAATTCATAAGCTGCCTGNTAAGATATTAGCTTCCCTGTGCTGTTAGAAGCTTA
  AATGCTGCCAGCCCTTAAAGCAGTCCTTATTTCTTTGTGAGCCGCTGGGAAGTTCTAGAA
  ACACTCATTTAAGTCTATCTCTTCAAGCTTGCTGTTATGAATTTTAAAACATTTGTTTGA
  CTTTATGAGTTTTCCCCCTCTTATCTAAAATACTGACCCCCAAGCTCAAGATTATAGCTT
  CATTCCTAATTAACAGTCCTTCCTACACTCCCCTGTGGGAACTATTACAAAATAGAAAGT
  TCTCTGAGCCTTTTTCATATTTGGAAGAAAAATCCAGCCTTTGGATTTGAAAATTATCCG
  TTCTTCCTCGGCCCATTGAAACCATTAT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003873
• ORF Size: 2772 bp
• Insert Size: 5480
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_003873.3, NP_003864.3
• RefSeq Size: 5890
• RefSeq ORF: 2772
• Locus ID: 8829
• Domains: F5_F8_type_C, CUB, MAM
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Axon guidance
• Gene Summary: This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
  Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform a).