IKK gamma (IKBKG) (NM_003639) Human Untagged Clone

CAT#: SC117828

IKBKG (untagged)-Human inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: IKBKG
• Synonyms: AMCBX1; EDAID1; FIP-3; FIP3; Fip3p; IKK-gamma; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003639 edited
  GAATTCGGCACGAGCGGGGCCCTACCAGCGTTCACAGTCCGCCGCTCCCACCCTTCTCAC
  GTCTGACGGACTCTGCTGACAGCCCTTGCCCTGTTGGATGAATAGGCACCTCTGGAAGAG
  CCAACTGTGTGAGATGGTGCAGCCCAGTGGTGGCCCGGCAGCAGATCAGGACGTACTGGG
  CGAAGAGTCTCCTCTGGGGAAGCCAGCCATGCTGCACCTGCCTTCAGAACAGGGCGCTCC
  TGAGACCCTCCAGCGCTGCCTGGAGGAGAATCAAGAGCTCCGAGATGCCATCCGGCAGAG
  CAACCAGATTCTGCGGGAGCGCTGCGAGGAGCTTCTGCATTTCCAAGCCAGCCAGAGGGA
  GGAGAAGGAGTTCCTCATGTGCAAGTTCCAGGAGGCCAGGAAACTGGTGGAGAGACTCGG
  CCTGGAGAAGCTCGATCTGAAGAGGCAGAAGGAGCAGGCTCTGCGGGAGGTGGAGCACCT
  GAAGAGATGCCAGCAGCAGATGGCTGAGGACAAGGCCTCTGTGAAAGCCCAGGTGACGTC
  CTTGCTCGGGGAGCTGCAGGAGAGCCAGAGTCGCTTGGAGGCTGCCACTAAGGAATGCCA
  GGCTCTGGAGGGTCGGGCCCGGGCGGCCAGCGAGCAGGCGCGGCAGCTGGAGAGTGAGCG
  CGAGGCGCTGCAGCAGCAGCACAGCGTGCAGGTGGACCAGCTGCGCATGCAGGGCCAGAG
  CGTGGAGGCCGCGCTCCGCATGGAGCGCCAGGCCGCCTCGGAGGAGAAGAGGAAGCTGGC
  CCAGTTGCAGGTGGCCTATCACCAGCTCTTCCAAGAATACGACAACCACATCAAGAGCAG
  CGTGGTGGGCAGTGAGCGGAAGCGAGGAATGCAGCTGGAAGATCTCAAACAGCAGCTCCA
  GCAGGCCGAGGAGGCCCTGGTGGCCAAACAGGAGGTGATCGATAAGCTGAAGGAGGAGGC
  CGAGCAGCACAAGATTGTGATGGAGACCGTTCCGGTGCTGAAGGCCCAGGCGGATATCTA
  CAAGGCGGACTTCCAGGCTGAGAGGCAGGCCCGGGAGAAGCTGGCCGAGAAGAAGGAGCT
  CCTGCAGGAGCAGCTGGAGCAGCTGCAGAGGGAGTACAGCAAACTGAAGGCCAGCTGTCA
  GGAGTCGGCCAGGATCGAGGACATGAGGAAGCGGCATGTCGAGGTCTCCCAGGCCCCCTT
  GCCCCCCGCCCCTGCCTACCTCTCCTCTCCCCTGGCCCTGCCCAGCCAGAGGAGGAGCCC
  CCCCGAGGAGCCACCTGACTTCTGCTGTCCCAAGTGCCAGTATCAGGCCCCTGATATGGA
  CACCCTGCAGATACATGTCATGGAGTGCATTGAGTAGGGCCGGCCAGTGCAAGGCCACTG
  CCTGCCGAGGACGTGCCCGGGACCGTGCAGTCTGCGCTTTCCTCTCCCGCCTGCCTAGCC
  CAGGATGAAGGGCTGGGTGGCCACAACTGGGATGCCACCTGGAGCCCCACCCAGGAGCTG
  GCCGCGGCACCTTACGCTTCAGCTGTTGATCCGCTGGTCCCCTCTTTTGGGGTAGATGCG
  GCCCCGATCAGGCCTGACTCGCTGCTCTTTTTGTTCCCTTCTGTCTGCTCGAACCACTTG
  CCTCGGGCTAATCCCTCCCTCTTCCTCCACCCGGCACTGGGGAAGTCAAGAATGGGGCCT
  GGGGCTCTCAGGGAGAACTGCTTCCCCTGGCAGAGCTGGGTGGCAGCTCTTCCTCCCACC
  GGACACCGACCCGCCCGCTGCTGTGCCCTGGGAGTGCTGCCCTCTTACCATGCACACGGG
  TGCTCTCCTTTTGGGCTGCATGCTATTCCATTTTGCAGCCAGACCGATGTGTATTTAACC
  AGTCACTATTGATGGACATTTGGGTTGTTTCCCATCTTTTTGTTACCATAAATAATGGCA
  TAGTAAAAAAAAAAAAAAAAAACTCGAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003639 unedited
  TCAGATTTTGTAATACGACTTCACTATAGGGCGGCCGCGAATTCGCACGAGCGGGNGCCC
  TACCAGCGTTCACAGTCCGCCGCTCCCACCCTTCTCACGTCTGACGGACTCTGCTGACAG
  CCCTTGCCCTGTTGGATGAATAGGCACCTCTGGAAGAGCCAACTGTGTGAGATGGTGCAG
  CCCAGTGGTGGCCCGGCAGCAGATCAGGACGTACTGGGCGAAGAGTCTCCTCTGGGGAAG
  CCAGCCATGCTGCACCTGCCTTCAGAACAGGGCGCTCCTGAGACCCTCCAGCGCTGCCTG
  GAGGAGAATCAAGAGCTCCGAGATGCCATCCGGCAGAGCAACCAGATTCTGCGGGAGCGC
  TGCGAGGAGCTTCTGCATTTCCAAGCCAGCCAGAGGGAGGAGAAGGAGTTCCTCATGTGC
  AAGTTCCAGGAGGCCAGGAAACTGGTGGAGAGACTCGGCCTGGAGAAGCTCGATCTGAAG
  AGGCAGAAGGAGCAGGCTCTGCGGGAGGTGGAGCACCTGAAGAGATGCCAGCAGCAGATG
  GCTGAGGACAAGGCCTCTGTGAAAGCCCAGGTGACGTCCTTGCTCGGGGAGCTGCAGGAG
  AGCCAGAGTCGCTTGGAGGCTGCCACTAAGGAATGCCAGGCTCTGGAGGGTCAGGCCCGG
  GCGGCCAGCGAGCAGGCGCGGCAGCTGGAGAGTGAGCGCGAGGCGCTGCAGCAGCAGCAC
  AGCGTGCAGGTGGACCAGCTGCGCATGCAGGGCCAGAGCGTGGAGGCCGCGCTCCGCATG
  GAGCGCCAGCCCCGCCTCGAGGAGAAAGAGGAGCTGGGCCAGTTGCAGGTGGCCTATCAC
  CAGCTCTTTCCANNGATACGACACCACATCAGAGCANCGTGGTGGGCAGTGAGCGGAACC
  GAGNATGCANCTGGGAGATCTCAACAGCAGCTCAGCAGACCGAGGAGGCCTGGTGGCCAA
  CAGNAGTGATCGATAGCTGAAG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003639 unedited
  CATAAGCCTCATGGCGATCGGCATCTTCCCATGACCAGGAAAGCACTGGGGAGGGTCACA
  GGGCTGCCACCCGGGTTCTGTTCAGGAAAAGCTATGACCGCGGCCGCAATCTAAAGTCGA
  GTTTTTTTTTTTTTTTTTTACTATGCCATTATTTATGGTAACAAAAAATGGGAAACAACC
  CAAATGTCCATCAATAGTGACTGGTTAAATACACATCGGTCTGGCTGCAAAATGGAATAG
  CATGCAGCCCAAAAGGAGAGCACCCGTGTGCATGGTAAGAGGGCAGCACTCCCAGGGCAC
  AGCAGCGGGCGGGTCGGTGTCCGGTGGGAAGAATATCTGCCACCCAGCTCTGCCAGGGGA
  AGCAGTTCTCCCTGAGAGCCCCAGGCCCCATTCTTGACTTCCCCAGTGCCGGGTGGAAGA
  AGAGGGAGGGATTAGCCCGAGGCATGTGGTTCGAGCATACAGAAGGGAACAAAAAGAGCA
  GCGAGTCAGGCCTGATCGGGGCCGCCTCTACCCCAAAAGAGGGGACCAGCGGATCAACAG
  CTGAAGCGTAAGGTGCCGCGGCCAGCTCCTGGGTGGGGCTCCAGGTGGCATCCCAGTTGT
  GGCCACCCAGCCCTTCATCCTGGGCTAGGCAGGCGGGAGAGGAAAGCGCAAACTGCACGG
  TCCCGGGCACGTCCTCGGCAGGCAGTGGCCTTGCACTGGCCGGCCCTACTCAATGCACTC
  CATGACATGTTTCTGCAGGGTGTCCATATCAGGGGCCTGATACTGGCACTTGGGACAACA
  AATGTCATGTGGCTCCTCGGGGGGGCTCCTCCTCTGGCTGGCCNNGGGCCAGGGGAAAAG
  AAAATGTAACCCGGGGCCGGGGGGCAAAGGGGCCCTGGAAAACCTTNNATTGCCCCTTTC
  CCATGTCCCTGATA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003639
• ORF Size: 1260 bp
• Insert Size: 2000
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_003639.2, NP_003630.1
• RefSeq Size: 2121
• RefSeq ORF: 1260
• Locus ID: 8517
• Domains: zf-C2H2
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Acute myeloid leukemia, Adipocytokine signaling pathway, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Cytosolic DNA-sensing pathway, Epithelial cell signaling in Helicobacter pylori infection, MAPK signaling pathway, NOD-like receptor signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prostate cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway
• Gene Summary: This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016]
  Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3 and 5 encode the same isoform (a).