IKAP (IKBKAP) (NM_003640) Human Untagged Clone

CAT#: SC117829

IKBKAP (untagged)-Human inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (IKBKAP)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: IKBKAP
• Synonyms: DYS; FD; IKAP; IKBKAP; IKI3; TOT1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003640 edited
  ATGCGAAATCTGAAATTATTTCGGACCCTGGAGTTCAGGGATATTCAAGGTCCAGGGAAT
  CCTCAGTGCTTCTCTCTCCGAACTGAACAGGGGACGGTGCTCATTGGTTCAGAACATGGC
  CTGATAGAAGTAGACCCTGTCTCAAGAGAAGTGAAAAATGAAGTTTCTTTGGTGGCAGAA
  GGCTTTCTCCCAGAGGATGGAAGTGGCCGCATTGTTGGTGTTCAGGACTTGCTGGATCAG
  GAGTCTGTGTGTGTGGCCACAGCCTCTGGAGACGTCATACTCTGCAGTCTCAGCACACAA
  CAGCTGGAGTGTGTTGGGAGTGTAGCCAGTGGTATCTCTGTTATGAGTTGGAGTCCTGAC
  CAAGAGCTGGTGCTTCTTGCCACAGGTCAACAGACCCTGATTATGATGACAAAAGATTTT
  GAGCCAATCCTGGAGCAGCAGATCCATCAGGATGATTTTGGTGAAAGCAAGTTTATCACT
  GTTGGATGGGGTAGGAAGGAGACACAGTTCCATGGATCAGAAGGCAGACAAGCAGCTTTT
  CAGATGCAAATGCATGAGTCTGCTTTGCCCTGGGATGACCATAGACCACAAGTTACCTGG
  CGGGGGGATGGACAGTTTTTTGCTGTGAGTGTTGTTTGCCCAGAAACAGGGGCTCGGAAG
  GTCAGAGTGTGGAACCGAGAGTTTGCTTTGCAGTCAACCAGTGAGCCTGTGGCAGGACTG
  GGACCAGCCCTGGCTTGGAAACCCTCAGGCAGTTTGATTGCATCTACACAAGATAAACCC
  AACCAGCAGGATATTGTGTTTTTTGAGAAAAATGGACTCCTTCATGGACACTTTACACTT
  CCCTTCCTTAAAGATGAGGTTAAGGTAAATGACTTGCTCTGGAATGCAGATTCCTCTGTG
  CTTGCAGTCTGGCTGGAAGACCTTCAGAGAGAAGAAAGCTCCATTCCGAAAACCTGTGTT
  CAGCTCTGGACTGTTGGAAACTATCACTGGTATCTCAAGCAAAGTTTATCCTTCAGCACC
  TGTGGGAAGAGCAAGATTGTGTCTCTGATGTGGGACCCTGTGACCCCATACCGGCTGCAT
  GTTCTCTGTCAGGGCTGGCATTACCTCGCCTATGATTGGCACTGGACGACTGACCGGAGC
  GTGGGAGATAATTCAAGTGACTTGTCCAATGTGGCTGTCATTGATGGAAACAGGGTGTTG
  GTGACAGTCTTCCGGCAGACTGTGGTTCCGCCTCCCATGTGCACCTACCAACTGCTGTTC
  CCACACCCTGTGAATCAAGTCACATTCTTAGCACACCCTCAAAAGAGTAATGACCTTGCT
  GTTCTAGATGCCAGTAACCAGATTTCTGTTTATAAATGTGGTGATTGTCCAAGTGCTGAC
  CCTACAGTGAAACTGGGAGCTGTGGGTGGAAGTGGATTTAAAGTTTGCCTTAGAACTCCT
  CATTTGGAAAAGAGATACAAAATCCAGTTTGAGAATAATGAAGATCAAGATGTAAACCCG
  CTGAAACTAGGCCTTCTCACTTGGATTGAAGAAGACGTCTTCCTGGCTGTAAGCCACAGT
  GAGTTCAGCCCCCGGTCTGTCATTCACCATTTGACTGCAGCTTCTTCTGAGATGGATGAA
  GAGCATGGACAGCTCAATGTCAGTTCATCTGCAGCGGTGGATGGGGTCATAATCAGTCTA
  TGTTGCAATTCCAAGACCAAGTCAGTAGTATTACAGCTGGCTGATGGCCAGATATTTAAG
  TACCTTTGGGAGTCACCTTCTCTGGCTATTAAACCATGGAAGAACTCTGGTGGATTTCCT
  GTTCGGTTTCCTTATCCATGCACCCAGACCGAATTGGCCATGATTGGAGAAGAGGAATGT
  GTCCTTGGTCTGACTGACAGGTGTCGCTTTTTCATCAATGACATTGAGGTTGCGTCAAAT
  ATCACGTCATTTGCAGTATATGATGAGTTTTTATTGTTGACAACCCATTCCCATACCTGC
  CAGTGTTTTTGCCTGAGGGATGCTTCATTTAAAACATTACAGGCCGGCCTGAGCAGCAAT
  CATGTGTCCCATGGGGAAGTTCTGCGGAAAGTGGAGAGGGGTTCACGGATTGTCACTGTT
  GTGCCCCAGGACACAAAGCTTGTATTACAGATGCCAAGGGGAAACTTAGAAGTTGTTCAT
  CATCGAGCCCTGGTTTTAGCTCAGATTCGGAAGTGGTTGGACAAACTTATGTTTAAAGAG
  GCATTTGAATGCATGAGAAAGCTGAGAATCAATCTCAATCTGATTTATGATCATAACCCT
  AAGGTGTTTCTTGGAAATGTGGAAACCTTCATTAAACAGATAGATTCTGTGAATCATATT
  AACTTGTTTTTTACAGAATTGAAAGAAGAAGATGTCACGAAGACCATGTACCCTGCACCA
  GTTACCAGCAGTGTCTACCTGTCCAGGGATCCTGACGGGAATAAAATAGACCTTGTCTGC
  GATGCTATGAGAGCAGTCATGGAGAGCATAAATCCTCATAAATACTGCCTATCCATACTT
  ACATCTCATGTAAAGAAGACAACCCCAGAACTGGAAATTGTACTGCAAAAAGTACACGAG
  CTTCAAGGAAATGCTCCCTCTGATCCTGATGCTGTGAGTGCTGAAGAGGCCTTGAAATAT
  TTGCTGCATCTGGTAGATGTTAATGAATTATATGATCATTCTCTTGGCACCTATGACTTT
  GATTTGGTCCTCATGGTAGCTGAGAAGTCACAGAAGGATCCCAAAGAATATCTTCCATTT
  CTTAATACACTTAAGAAAATGGAAACTAATTATCAGCGGTTTACTATAGACAAATACTTG
  AAACGATATGAAAAAGCCATTGGCCACCTCAGCAAATGTGGACCTGAGTACTTCCCAGAA
  TGCTTAAACTTGATAAAAGATAAAAACTTGTATAACGAAGCTCTGAAGTTATATTCACCA
  AGCTCACAACAGTACCAGGATATCAGCATTGCTTATGGGGAGCACCTGATGCAGGAGCAC
  ATGTATGAGCCAGCGGGGCTCATGTTTGCCCGTTGCGGTGCCCACGAGAAAGCTCTCTCA
  GCCTTTCTCACATGTGGCAACTGGAAGCAAGCCCTCTGTGTGGCAGCCCAGCTTAACTTT
  ACCAAAGACCAGCTGGTGGGCCTCGGCAGAACTCTGGCAGGAAAGCTGGTTGAGCAGAGG
  AAGCACATTGATGCGGCCATGGTTTTGGAAGAGTGTGCCCAGGATTATGAAGAAGCTGTG
  CTCTTGCTGTTAGAAGGAGCTGCCTGGGAAGAAGCTTTGAGGCTGGTATACAAATATAAC
  AGACTGGATATTATAGAAACCAACGTAAAGCCTTCCATTTTAGAAGCCCAGAAAAATTAT
  ATGGCATTTCTGGACTCTCAGACAGCCACATTCAGTCGCCACAAGAAACGTTTATTGGTA
  GTTCGAGAGCTCAAGGAGCAAGCCCAGCAGGCAGGTCTGGATGATGAGGTACCCCACGGG
  CAAGAGTCAGACCTCTTCTCTGAAACTAGCAGTGTCGTGAGTGGCAGTGAGATGAGTGGC
  AAATACTCCCATAGTAACTCCAGGATATCAGCGAGATCATCCAAGAATCGCCGAAAAGCG
  GAGCGGAAGAAGCACAGCCTCAAAGAAGGCAGTCCGCTGGAGGACCTGGCCCTCCTGGAG
  GCACTGAGTGAAGTGGTGCAGAACACTGAAAACCTGAAAGATGAAGTATACCATATTTTA
  AAGGTACTCTTTCTCTTTGAGTTTGATGAACAAGGAAGGGAATTACAGAAGGCCTTTGAA
  GATACGCTGCAGTTGATGGAAAGGTCACTTCCAGAAATTTGGACTCTTACTTACCAGCAG
  AATTCAGCTACCCCGGTTCTAGGTCCCAATTCTACTGCAAATAGTATCATGGCATCTTAT
  CAGCAACAGAAGACTTCGGTTCCTGTTCTTGATGCTGAGCTTTTTATACCACCAAAGATC
  AACAGAAGAACCCAGTGGAAGCTGAGCCTGCTAGAC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003640
• ORF Size: 3999 bp
• Insert Size: 4400
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: The ORF of this clone has been fully sequenced and found to be a perfect match to NM_003640.2.

Reference Data

• RefSeq: NM_003640.2, NP_003631.2
• RefSeq Size: 5917
• RefSeq ORF: 3999
• Locus ID: 8518
• Domains: IKI3
• Protein Families: Druggable Genome
• Gene Summary: The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]