HPS2 (AP3B1) (NM_003664) Human Untagged Clone

CAT#: SC117848

AP3B1 (untagged)-Human adaptor-related protein complex 3, beta 1 subunit (AP3B1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: AP3B1
• Synonyms: ADTB3; ADTB3A; HPS; HPS2; PE
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC117848 sequence for NM_003664 edited (data generated by NextGen Sequencing)
  ATGTCCAGCAATAGTTTTCCTTACAATGAGCAGTCCGGAGGAGGGGAGGCGACGGAGCTG
  GGTCAGGAGGCGACCTCAACCATTTCCCCCTCGGGGGCCTTCGGCCTCTTTAGCAGCGAT
  TTGAAGAAGAATGAAGATCTAAAGCAAATGTTAGAGAGCAACAAAGATTCTGCTAAACTG
  GATGCTATGAAGCGGATTGTTGGGATGATTGCAAAAGGGAAAAATGCATCTGAACTGTTT
  CCTGCTGTTGTGAAGAATGTGGCCAGTAAAAATATTGAGATCAAGAAGTTGGTATATGTT
  TACCTGGTTCGATATGCTGAAGAACAGCAGGATCTTGCACTCCTGTCCATAAGCACTTTT
  CAGCGAGCTCTGAAGGACCCAAACCAACTAATTCGTGCAAGCGCTTTGAGAGTTCTGTCA
  AGTATTAGAGTGCCAATTATTGTACCTATCATGATGCTTGCTATTAAGGAAGCTTCTGCT
  GACTTATCACCATATGTTAGGAAGAATGCAGCCCATGCAATACAAAAATTATACAGCCTT
  GATCCAGAGCAGAAGGAAATGTTAATTGAAGTAATTGAAAAACTTCTGAAAGATAAAAGC
  ACATTGGTAGCTGGCAGTGTTGTGATGGCTTTTGAAGAAGTATGCCCGGACAGAATAGAT
  CTGATTCATAAAAATTACCGCAAGCTATGTAACTTACTAGTGGATGTTGAAGAGTGGGGG
  CAGGTTGTCATAATCCACATGCTAACTCGATATGCTCGGACACAGTTTGTCAGCCCTTGG
  AAAGAGGGTGATGAATTAGAAGACAATGGAAAGAATTTCTACGAATCTGATGATGATCAG
  AAGGAAAAGACTGACAAAAAGAAGAAGCCGTATACTATGGATCCAGATCATAGACTCTTA
  ATTAGAAATACAAAGCCTTTGCTTCAGAGCAGGAATGCTGCGGTGGTTATGGCAGTTGCT
  CAGCTGTATTGGCACATATCACCAAAATCTGAAGCTGGCATAATTTCTAAATCACTAGTG
  CGTTTACTTCGTAGCAATAGGGAGGTGCAGTATATTGTCCTACAAAATRTAGCAACTATG
  TCAATTCAAAGAAAGGGGATGTTTGAACCTTATCTGAAGAGTTTCTATGTTAGGTCAACT
  GATCCAACTATGATCAAGACACTGAAGCTTGAAATTTTGACAAACTTGGCAAATGAAGCC
  AACATATCAACTCTTCTTCGAGAATTTCAGACCTATGTGAAAAGCCAGGATAAACAATTT
  GCAGCAGCCACTATTCAGACTATAGGCAGATGTGCAACCAACATCTTGGAAGTCACTGAC
  ACGTGCCTCAATGGCTTGGTCTGTCTGCTGTCCAACAGGGATGAAATAGTTGTTGCTGAA
  AGTGTGGTTGTTATAAAGAAATTACTGCAAATGCAACCTGCACAACATGGTGAAATTATT
  AAACATATGGCCAAACTCCTGGACAGTATCACTGTTCCTGTTGCTAGAGCAAGTATTCTT
  TGGCTAATTGGAGAAAACTGTGAACGAGTTCCTAAAATTGCCCCTGATGTTTTGAGGAAG
  ATGGCTAAAAGCTTCACTAGTGAAGATGATCTGGTAAAACTGCAGATATTAAATCTGGGA
  GCAAAATTGTATTTAACCAACTCCAAACAGACAAAATTGCTTACCCAGTACATATTAAAT
  CTCGGCAAGTATGATCAAAACTACGACATCAGAGACCGTACAAGATTTATTAGGCAGCTT
  ATTGTTCCGAATGAAAAGAGTGGAGCTTTAAGTAAATATGCCAAAAAAATATTCCTAGCA
  CAAAAGCCTGCACCACTGCTTGAGTCTCCTTTTAAAGATAGAGATCATTTCCAGCTTGGC
  ACCTTATCTCATACTCTCAACATTAAAGCTACTGGGTACCTGGAATTATCTAATTGGCCA
  GAGGTGGCGCCCGACCCATCAGTTCGAAATGTAGAAGTAATAGAGTTGGCAAAAGAATGG
  ACCCCAGCAGGAAAAGCAAAGCAAGAGAATTCTGCTAAGAAGTTTTATTCTGAATCTGAG
  GAAGAGGAGGACTCTTCTGATAGTAGCAGTGACAGTGAGAGTGAATCTGGAAGTGAAAGT
  GGAGAACAAGGCGAAAGTGGGGAGGAAGGAGACAGCAATGAGGACAGCAGTGAGGACTCC
  TCCAGTGAGCAGGACAGTGAGAGTGGACGGGAGTCAGGCCTAGAAAACAAAAGAACAGCC
  AAGAGGAACTCAAAAGCCAAAGGAAAAAGTGATTCTGAAGATGGGGAGAAGGAAAATGAA
  AAATCTAAAACTTCAGATTCTTCAAATGACGAATCTAGTTCAATAGAAGACAGTTCTTCC
  GATTCTGAATCAGAGTCAGAACCTGAAAGTGAATCTGAATCCAGAAGAGTCACTAAGGAG
  AAAGAAAAGAAAACAAAGCAAGATAGAACTCCTCTTACCAAAGATGTTTCACTTCTAGAT
  CTGGATGATTTTAACCCAGTATCCACTCCAGTTGCACTTCCCACACCAGCTCTTTCTCCA
  AGTTTGATGGCTGATCTTGAAGGTTTACACTTGTCAACTTCCTCTTCAGTCATCAGTGTC
  AGTACTCCTGCATTTGTACCAACGAAAACTCACGTGCTGCTTCATCGAATGAGTGGAAAA
  GGACTAGCTGCCCATTATTTCTTTCCAAGACAGCCTTGCATTTTTGGTGATAAGATGGTC
  TCTATACAAATAACACTGAATAACACTACTGATCGAAAGATAGAAAATATCCACATAGGG
  GAAAAAAAACTTCCTATAGGCATGAAAATGCATGTTTTTAATCCAATAGACTCTCTTGAG
  CCTGAGGGATCCATTACAGTTTCAATGGGTATTGACTTTTGTGATTCTACTCAGACTGCC
  AGTTTCCAGTTGTGTACCAAGGATGATTGCTTCAATGTTAATATTCAGCCACCTGTTGGA
  GAACTGCTTTTACCTGTGGCCATGTCAGAGAAAGATTTTAAGAAAGAGCAAGGAGTGCTA
  ACAGGAATGAATGAAACTTCTGCTGTAATCATTGCTGCACCACAGAATTTCACTCCCTCT
  GTGATCTTTCAGAAGGTTGTAAATGTAGCCAATGTAGGTGCAGTCCCTTCTGGCCAGGAT
  AATATACACAGGTTTGCAGCTAAAACTGTGCACAGTGGGTCATTGATGCTAGTCACAGTG
  GAACTGAAGGAAGGCTCTACAGCCCAGCTTATCATAAACACTGAGAAAACTGTGATTGGC
  TCTGTTCTGCTGCGGGAACTGAAGCCTGTCCTGTCTCAGGGGTAA
  
  Clone variation with respect to NM_003664.3
  1069 a=>r;1754 t=>a
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003664 unedited
  NGGGGGAAANNGGGAAACGACTCCTATAGGGCGGCCGCGAATCGGCACGAGGGCCAGGNC
  GGCTCAGGGAGCCGTGACGAGTCCGGCAGCGCCTGCGCGCGCTCCTCCGTACGAGAACTA
  GTTTTGTTCCGTGCCCTCTGGACTGGAACCTTTTGGAGAGAACCCCCGGCAGGACCAACC
  CCGCACCCGCCAGCACCGCGGCAATGTCCAGCAATAGTTTTCCTTACAATGAGCAGTCCG
  GAGGAGGGGAGGCGACGGAGCTGGGTCAGGAGGCGACCTCAACCATTTCCCCCTCGGGGG
  CCTTCGGCCTCTTTAGCAGCGATTTGAAGAACAATGAAGATCTAAAGCACATGTTAGAGA
  GCAACAAAGATTCTGCTAAACTGGATGCTATGAAGCGGATTGTTGGGATGAATGCAAAAG
  GGAAAAATGCATCTGAACCTGTTTCCTGCTGCTGTGAAGAATGTGGCCAGTAAAAATATT
  GAGATCAAGAAGTTGGTATATGTCTACCTGCTTCGATATGCTGAACAACAGCACGATCTT
  GCACTCCCTGTCCATAACCCCTTTTCAGCGAGCTCTGAAGGACCCAAACCAACTAATCTC
  TGCAAGCGCTTTGAGAGTTCTGTCAAGTATTACAGCGCCAATTATTGTACCTATCATGAT
  GCTTTGTATTAAAGAAGCTTTTGCTGACTTATCACCATATGTTAGGAAGAATGCAGCCCA
  TGCCATAACAAAATTATACCGTCTTGATCCATACCAGAAGGAAATGTTTATTGAAGTAAT
  TGAAAAACTTCTCGAAGATAAAAGCCCATCGCTAGCTGGCACTGTTGTGAACGCGCTTCG
  CAACATAATGCCCCGTCCCGATATATTCCCTTTCTTAAAACTACCCGCCAGCTATGTAAC
  TTACTATTGGAGGTTGAAAAG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003664 unedited
  NNTTTTTACTCTGGNACCGCGGCCGCAANCTAGGATCGAGTTTTTTTTTTTTTTTTTTGA
  TTCATATGCTAGTTTATTTATCTTATTATTGAGAGATAATTTCATGATGACAGTTATCAA
  TAATCAATTACAATATCAAGAAATTCAAAGAACAAAATCTTGCAGAGACTATGCTTTTGT
  ATTTGGATTTAAAAAGTATGTGATCTCATTTTCACATACCAAGCTGAGAGGCCATTTAGA
  CTATCTCTTTGCTAATTTTTGCTTACTGCTGTAGGGAAGAAGATTTCCAATGAACTTTAA
  ATATCTCATTCATGTCTACCATTGTCGAAAAAGAGAAGGAAAACGAGGAGGCCAAAAGAA
  GCAGCAGGACAGAGAAAACGCCACATGGATTCAAGAGTTGAGACAACTGACAGTAAAATA
  TATGCTCTTTGGTTAGCAAAGCAAAAAGGGGGAAAGTATTGCATACATGATAGATACACA
  CTAGCATTCTAAAGCAGGAGACAAGAATGTCAAGAGTGTATTCTTCCCCCCACTGCCAGA
  TGGAAGGGCTATTATTATAAATGAAAGGCAGCAGTAGTGGATGCCAGGCACTTTTGTTGT
  GTGCCAGATTCTAAAGTCCAGATGTAAGCAGGTTACCCCTGAGACAGGACAGGCTTTAGT
  TCCCGCAGCAGAACAGAGGCAATCACAGGTTTTCTCAGTGTTTATGATACGCTGGGCTGA
  AGAGCCCTCCTTTTAGTTCCACTGTGACTAGCATACATGACCCCCTGTGCACCAGTTTAG
  CTGCAAACCTGGGTTTATTATCCTTGGCCAGAGGGACTGCCCCTACATTGGCTACATTTA
  CAACCTTCTGAAAGACCCAGAGGAAGTGAATTTTGGGTGGACCATGATTACCACAAATTT
  TTTTCTTCCTGT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003664
• ORF Size: 3285 bp
• Insert Size: 4200
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_003664.3, NP_003655.3
• RefSeq Size: 4009
• RefSeq ORF: 3285
• Locus ID: 8546
• Domains: Adaptin_N
• Protein Pathways: Lysosome
• Gene Summary: This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]
  Transcript Variant: This variant (1) encodes the longer isoform (1).