TGF beta 3 (TGFB3) (NM_003239) Human Untagged Clone

CAT#: SC118071

TGFB3 (untagged)-Human transforming growth factor, beta 3 (TGFB3)


  "NM_003239" in other vectors (6)

Reconstitution Protocol

USD 700.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol TGFB3
Synonyms ARVD; ARVD1; LDS5; RNHF; TGF-beta3
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_003239 edited
GAATTCGGCACGAGGGCTTCTTCGTCCTCAGGGTTGCCAGCGCTTCCTGGAAGTCCTGAA
GCTCTCGCAGTGCAGTGAGTTCATGCACCTTCTTGCCAAGCCTCAGTCTTTGGGATCTGG
GGAGGCCGCCTGGTTTTCCTCCCTCCTTCTGCACGTCTGCTGGGGTCTCTTCCTCTCCAG
GCCTTGCCGTCCCCCTGGCCTCTCTTCCCAGCTCACACATGAAGATGCACTTGCAAAGGG
CTCTGGTGGTCCTGGCCCTGCTGAACTTTGCCACGGTCAGCCTCTCTCTGTCCACTTGCA
CCACCTTGGACTTCGGCCACATCAAGAAGAAGAGGGTGGAAGCCATTAGGGGACAGATCT
TGAGCAAGCTCAGGCTCACCAGCCCCCCTGAGCCAACGGTGATGACCCACGTCCCCTATC
AGGTCCTGGCCCTTTACAACAGCACCCGGGAGCTGCTGGAGGAGATGCATGGGGAGAGGG
AGGAAGGCTGCACCCAGGAAAACACCGAGTCGGAATACTATGCCAAAGAAATCCATAAAT
TCGACATGATCCAGGGGCTGGCGGAGCACAACGAACTGGCTGTCTGTCCTAAAGGAATTA
CCTCCAAGGTTTTCCGCTTCAATGTGTCCTCAGTGGAGAAAAATAGAACCAACCTATTCC
GAGCAGAATTCCGGGTCTTGCGGGTGCCCAACCCCAGCTCTAAGCGGAATGAGCAGAGGA
TCGAGCTCTTCCAGATCCTTCGGCCAGATGAGCACATTGCCAAACAGCGCTATATCGGTG
GCAAGAATCTGCCCACACGGGGCACTGCCGAGTGGCTGTCCTTTGATGTCACTGACACTG
TGCGTGAGTGGCTGTTGAGAAGAGAGTCCAACTTAGGTCTAGAAATCAGCATTCACTGTC
CATGTCACACCTTTCAGCCCAATGGAGATATCCTGGAAAACATTCACGAGGTGATGGAAA
TCAAATTCAAAGGCGTGGACAATGAGGATGACCATGGCCGTGGAGATCTGGGGCGCCTCA
AGAAGCAGAAGGATCACCACAACCCTCATCTAATCCTCATGATGATTCCCCCACACCGGC
TCGACAACCCGGGCCAGGGGGGTCAGAGGAAGAAGCGGGCTTTGGACACCAATTACTGCT
TCCGCAACTTGGAGGAGAACTGCTGTGTGCGCCCCCTCTACATTGACTTCCGACAGGATC
TGGGCTGGAAGTGGGTCCATGAACCTAAGGGCTACTATGCCAACTTCTGCTCAGGCCCTT
GCCCATACCTCCGCAGTGCAGACACAACCCACAGCACGGTGCTGGGACTGTACAACACTC
TGAACCCTGAAGCATCTGCCTCGCCTTGCTGCGTGCCCCAGGACCTGGAGCCCCTGACCA
TCCTGTACTATGTTGGGAGGACCCCCAAAGTGGAGCAGCTCTCCAACATGGTGGTGAAGT
CTTGTAAATGTAGCTGAGACCCCACGTGCGACAGAGAGAGGGGAGAGAGAACCACCACTG
CCTGACTGCCCGCTCCTCGGGAAACACACAAGCAACAAACCTCACTGAGAGGCCTGGAGC
CCACAACCTTCGGCTCCGGGCAAATGGCTGAGATGGAGGTTTCCTTTTGGAACATTTCTT
TCTTGCTGGCTCTGAGAATCACGGTGGTAAAGAAAGTGTGGGTTTGGTTAGAGGAAGGCT
GAACTCTTCAGAACACACAGACTTTCTGTGACGCAGACAGAGGGGATGGGGATAGAGGAA
AGGGATGGTAAGTTGAGATGTTGTGTGGCAATGGGATTTGGGCTACCCTAAAGGGAGAAG
GAAGGGCAGAGAATGGCTGGGTCAGGGCCAGACTGGAAGACACTTCAGATCTGAGGTTGG
ATTTGCTCATTGCTGTACCACATCTGCTCTAGGGAATCTGGATTATGTTATACAAGGCAA
GCATTTTTTTTTTTTTTTTAAAGACAGGTTACGAAGACAAAGTCCCAGAATTGTATCTCA
TACTGTCTGGGATTAAGGGCAAATCTATTACTTTTGCAAACTGTCCTCTACATCAATTAA
CATCGTGGGTCACTACAGGGAGAAAATCCAGGTCATGCAGTTCCTGGCCCATCAACTGTA
TTGGGCCTTTTGGATATGCTGAACGCAGAAGAAAGGGTGGAAATCAACCCTCTCCTGTCT
GCCCTCTGGGTCCCTCCTCTCACCTCTCCCTCGATCATATTTCCCCTTGGACACTTGGTT
AGACGCCTTCCAGGTCAGGATGCACATTTCTGGATTGTGGTTCCATGCAGCCTTGGGGCA
TTATGGGTTCTTCCCCCACTTCCCCTCCAAGACCCTGTGTTCATTTGGTGTTCCTGGAAG
CAGGTGCTACAACATGTGAGGCATTCGGGGAAGCTGCACATGTGCCACACAGTGACTTGG
CCCCAGACGCATAGACTGAGGTATAAAGACAAGTATGAATATTACTCTCAAAATCTTTGT
ATAAATAAATATTTTTGGGGCATCCTGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAACTCGAC
>OriGene 5' read for NM_003239 unedited
GTGTACATTTGTATACGACTCACTATAGGCGGCCGCGAATCGGCACGAGGGCTTCTTCGT
CCTCGGGTTGCCAGCGCTTCCTGGAAGTCCTGAAGCTCTCGCAGTGCAGTGAGTTCATGC
ACCTTCTTGCCAAGCCTCAGTCTTTGGGATCTGGGGAGGCCGCCTGGTTTTCCTCCCTCC
TTCTGCACGTCTGCTGGGGTCTCTTCCTCTCCAGGCCTTGCCGTCCCCCTGGCCTCTCTT
CCCAGCTCACACATGAAGATGCACTTGCAAAGGGCTCTGGTGGTCCTGGCCCTGCTGAAC
TTTGCCACGGTCAGCCTCTCTCTGTCCACTTGCACCACCTTGGACTTCGGCCACATCAAG
AAGAAGAGGGTGGAAGCCATTAGGGGACAGATCTTGAGCAAGCTCAGGCTCACCAGCCCC
CCTGAGCCAACGGTGATGACCCACGTCCCCTATCAGGTCCTGGCCCTTTACAACAGCACC
CGGGAGCTGCTGGAGGAGATGCATGGGGAGAGGGAGGAAGGCTGCACCCAGGAAAACACC
GAGTCGGAATACTATGCCAAAGAAATCCATAAATTCGACATGATCCAGGGGCTGGCGGAG
CACAACGAACTGGCTGTCTGTCCTAAAGGAATTACCTCCAAGGTTTTCCGCTTCAATGTG
TCCTCAGTGGAGAAAAATAGAACCAACCTATTCCGAGCAGAATTCCGGGTCTTGCGGGTG
CCCAACCCCAGCTCTAAGCGGAATGAGCAGAAGATCGAGCTCTTCCGATCCCTTCGCCAG
ATGAGCACATTGCCAAACAGCGCTATATCGGTGGCCAGAATCTGCCCACCCGGGCACTGC
CGAGTGGCTGTCCTTTTGAGTCACTGACACTGTGCGTGAGTGCCTGTTGAAAAAAGAGTC
CACTTAAGTCTAGAAATCANCT
>OriGene 3' read for NM_003239 unedited
GGGGTGGTTTTTCTTTTTACCAACCCAACCCACACCCTTTTTGGCCCCAAATATATTTTT
ATACAAATATTTGTGCGTAATATTCATACTTGTCTTTATACCTCAGTCTATGCGTCTGGG
GCCAAGTCACTGTGTGGCACATGTGCAGCTTCCCCGATGCCTCCATGTTGTAGCACCTGC
TTCCAGGAACACCAAATGAACACAGGGTCCTTGGAGGGGAAGTGGGGGAAGAACCCATAA
TGCCCCAAGGCTGCATGGAACCACAATCCAGAAATGTGCATCCTGACCTGGAAGGCGTCT
AACCAAGTGTCCAAGGGGAAATATGATCGAGGGAGAGGTGAGAGGAGGGACCCATAGGGC
AGACAGGAGAGGGTTGATTTCCACCCTTTCTTCTGCGTTCAGCATATCCAAAAGGCCCAA
TACAGTTGATGGGCCAGGAACTGCATGACCTGGATTTTCTCCCTGTAGTGACCCACGATG
TTAATTGATGTAGAGGACAGTTTGCAAAAGTAATAGATTTGCCCTTTATCCCACACAGTA
TGAGATACAATTCTGGGACTTTGTCTTCGTAACCTGTCTTTAAAAAAAAAAAAAAAAATG
CTTGCCCTTGTATAACATAATCCAGATTCCCTAGAGCCAGATGTGGTACAGCAATGAGCA
AATCCAACCTCAGATCTGAAGTGTCTTCCACTCTGGGCCCCTGACCAAACCATTTTCTGT
CCTTCTCTTTTCCTTTAAGGTAGCCCAAATCCCATTGCCACACAACATCTTAACTTAACC
ATCCTTTTCCTTTATCCCCATTCCCCTCTGTCTGCGTCACAAAAAGACTGTGTGGTTCTG
AAGAGTTCACACTTCCTCTTAACCAACCCCCAATTTTTTTTTACCACCGTGATTTTTATA
GCCTGTAGAAGAAAAATGTTCCAAAGAG
Restriction Sites NotI-NotI     
ACCN NM_003239
Insert Size 2640 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_003239.1, NP_003230.1
RefSeq Size 2574 bp
RefSeq ORF 1239 bp
Locus ID 7043
Cytogenetics 14q24.3
Domains TGFb_propeptide, TGF-beta
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Pancreatic cancer, Pathways in cancer, Renal cell carcinoma, TGF-beta signaling pathway
Gene Summary 'This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Aug 2016]'
Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).

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