TGF beta 3 (TGFB3) (NM_003239) Human Untagged Clone

CAT#: SC118071

TGFB3 (untagged)-Human transforming growth factor, beta 3 (TGFB3)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TGFB3
• Synonyms: ARVD; ARVD1; LDS5; RNHF; TGF-beta3
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003239 edited
  GAATTCGGCACGAGGGCTTCTTCGTCCTCAGGGTTGCCAGCGCTTCCTGGAAGTCCTGAA
  GCTCTCGCAGTGCAGTGAGTTCATGCACCTTCTTGCCAAGCCTCAGTCTTTGGGATCTGG
  GGAGGCCGCCTGGTTTTCCTCCCTCCTTCTGCACGTCTGCTGGGGTCTCTTCCTCTCCAG
  GCCTTGCCGTCCCCCTGGCCTCTCTTCCCAGCTCACACATGAAGATGCACTTGCAAAGGG
  CTCTGGTGGTCCTGGCCCTGCTGAACTTTGCCACGGTCAGCCTCTCTCTGTCCACTTGCA
  CCACCTTGGACTTCGGCCACATCAAGAAGAAGAGGGTGGAAGCCATTAGGGGACAGATCT
  TGAGCAAGCTCAGGCTCACCAGCCCCCCTGAGCCAACGGTGATGACCCACGTCCCCTATC
  AGGTCCTGGCCCTTTACAACAGCACCCGGGAGCTGCTGGAGGAGATGCATGGGGAGAGGG
  AGGAAGGCTGCACCCAGGAAAACACCGAGTCGGAATACTATGCCAAAGAAATCCATAAAT
  TCGACATGATCCAGGGGCTGGCGGAGCACAACGAACTGGCTGTCTGTCCTAAAGGAATTA
  CCTCCAAGGTTTTCCGCTTCAATGTGTCCTCAGTGGAGAAAAATAGAACCAACCTATTCC
  GAGCAGAATTCCGGGTCTTGCGGGTGCCCAACCCCAGCTCTAAGCGGAATGAGCAGAGGA
  TCGAGCTCTTCCAGATCCTTCGGCCAGATGAGCACATTGCCAAACAGCGCTATATCGGTG
  GCAAGAATCTGCCCACACGGGGCACTGCCGAGTGGCTGTCCTTTGATGTCACTGACACTG
  TGCGTGAGTGGCTGTTGAGAAGAGAGTCCAACTTAGGTCTAGAAATCAGCATTCACTGTC
  CATGTCACACCTTTCAGCCCAATGGAGATATCCTGGAAAACATTCACGAGGTGATGGAAA
  TCAAATTCAAAGGCGTGGACAATGAGGATGACCATGGCCGTGGAGATCTGGGGCGCCTCA
  AGAAGCAGAAGGATCACCACAACCCTCATCTAATCCTCATGATGATTCCCCCACACCGGC
  TCGACAACCCGGGCCAGGGGGGTCAGAGGAAGAAGCGGGCTTTGGACACCAATTACTGCT
  TCCGCAACTTGGAGGAGAACTGCTGTGTGCGCCCCCTCTACATTGACTTCCGACAGGATC
  TGGGCTGGAAGTGGGTCCATGAACCTAAGGGCTACTATGCCAACTTCTGCTCAGGCCCTT
  GCCCATACCTCCGCAGTGCAGACACAACCCACAGCACGGTGCTGGGACTGTACAACACTC
  TGAACCCTGAAGCATCTGCCTCGCCTTGCTGCGTGCCCCAGGACCTGGAGCCCCTGACCA
  TCCTGTACTATGTTGGGAGGACCCCCAAAGTGGAGCAGCTCTCCAACATGGTGGTGAAGT
  CTTGTAAATGTAGCTGAGACCCCACGTGCGACAGAGAGAGGGGAGAGAGAACCACCACTG
  CCTGACTGCCCGCTCCTCGGGAAACACACAAGCAACAAACCTCACTGAGAGGCCTGGAGC
  CCACAACCTTCGGCTCCGGGCAAATGGCTGAGATGGAGGTTTCCTTTTGGAACATTTCTT
  TCTTGCTGGCTCTGAGAATCACGGTGGTAAAGAAAGTGTGGGTTTGGTTAGAGGAAGGCT
  GAACTCTTCAGAACACACAGACTTTCTGTGACGCAGACAGAGGGGATGGGGATAGAGGAA
  AGGGATGGTAAGTTGAGATGTTGTGTGGCAATGGGATTTGGGCTACCCTAAAGGGAGAAG
  GAAGGGCAGAGAATGGCTGGGTCAGGGCCAGACTGGAAGACACTTCAGATCTGAGGTTGG
  ATTTGCTCATTGCTGTACCACATCTGCTCTAGGGAATCTGGATTATGTTATACAAGGCAA
  GCATTTTTTTTTTTTTTTTAAAGACAGGTTACGAAGACAAAGTCCCAGAATTGTATCTCA
  TACTGTCTGGGATTAAGGGCAAATCTATTACTTTTGCAAACTGTCCTCTACATCAATTAA
  CATCGTGGGTCACTACAGGGAGAAAATCCAGGTCATGCAGTTCCTGGCCCATCAACTGTA
  TTGGGCCTTTTGGATATGCTGAACGCAGAAGAAAGGGTGGAAATCAACCCTCTCCTGTCT
  GCCCTCTGGGTCCCTCCTCTCACCTCTCCCTCGATCATATTTCCCCTTGGACACTTGGTT
  AGACGCCTTCCAGGTCAGGATGCACATTTCTGGATTGTGGTTCCATGCAGCCTTGGGGCA
  TTATGGGTTCTTCCCCCACTTCCCCTCCAAGACCCTGTGTTCATTTGGTGTTCCTGGAAG
  CAGGTGCTACAACATGTGAGGCATTCGGGGAAGCTGCACATGTGCCACACAGTGACTTGG
  CCCCAGACGCATAGACTGAGGTATAAAGACAAGTATGAATATTACTCTCAAAATCTTTGT
  ATAAATAAATATTTTTGGGGCATCCTGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAACTCGAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003239 unedited
  GTGTACATTTGTATACGACTCACTATAGGCGGCCGCGAATCGGCACGAGGGCTTCTTCGT
  CCTCGGGTTGCCAGCGCTTCCTGGAAGTCCTGAAGCTCTCGCAGTGCAGTGAGTTCATGC
  ACCTTCTTGCCAAGCCTCAGTCTTTGGGATCTGGGGAGGCCGCCTGGTTTTCCTCCCTCC
  TTCTGCACGTCTGCTGGGGTCTCTTCCTCTCCAGGCCTTGCCGTCCCCCTGGCCTCTCTT
  CCCAGCTCACACATGAAGATGCACTTGCAAAGGGCTCTGGTGGTCCTGGCCCTGCTGAAC
  TTTGCCACGGTCAGCCTCTCTCTGTCCACTTGCACCACCTTGGACTTCGGCCACATCAAG
  AAGAAGAGGGTGGAAGCCATTAGGGGACAGATCTTGAGCAAGCTCAGGCTCACCAGCCCC
  CCTGAGCCAACGGTGATGACCCACGTCCCCTATCAGGTCCTGGCCCTTTACAACAGCACC
  CGGGAGCTGCTGGAGGAGATGCATGGGGAGAGGGAGGAAGGCTGCACCCAGGAAAACACC
  GAGTCGGAATACTATGCCAAAGAAATCCATAAATTCGACATGATCCAGGGGCTGGCGGAG
  CACAACGAACTGGCTGTCTGTCCTAAAGGAATTACCTCCAAGGTTTTCCGCTTCAATGTG
  TCCTCAGTGGAGAAAAATAGAACCAACCTATTCCGAGCAGAATTCCGGGTCTTGCGGGTG
  CCCAACCCCAGCTCTAAGCGGAATGAGCAGAAGATCGAGCTCTTCCGATCCCTTCGCCAG
  ATGAGCACATTGCCAAACAGCGCTATATCGGTGGCCAGAATCTGCCCACCCGGGCACTGC
  CGAGTGGCTGTCCTTTTGAGTCACTGACACTGTGCGTGAGTGCCTGTTGAAAAAAGAGTC
  CACTTAAGTCTAGAAATCANCT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003239 unedited
  GGGGTGGTTTTTCTTTTTACCAACCCAACCCACACCCTTTTTGGCCCCAAATATATTTTT
  ATACAAATATTTGTGCGTAATATTCATACTTGTCTTTATACCTCAGTCTATGCGTCTGGG
  GCCAAGTCACTGTGTGGCACATGTGCAGCTTCCCCGATGCCTCCATGTTGTAGCACCTGC
  TTCCAGGAACACCAAATGAACACAGGGTCCTTGGAGGGGAAGTGGGGGAAGAACCCATAA
  TGCCCCAAGGCTGCATGGAACCACAATCCAGAAATGTGCATCCTGACCTGGAAGGCGTCT
  AACCAAGTGTCCAAGGGGAAATATGATCGAGGGAGAGGTGAGAGGAGGGACCCATAGGGC
  AGACAGGAGAGGGTTGATTTCCACCCTTTCTTCTGCGTTCAGCATATCCAAAAGGCCCAA
  TACAGTTGATGGGCCAGGAACTGCATGACCTGGATTTTCTCCCTGTAGTGACCCACGATG
  TTAATTGATGTAGAGGACAGTTTGCAAAAGTAATAGATTTGCCCTTTATCCCACACAGTA
  TGAGATACAATTCTGGGACTTTGTCTTCGTAACCTGTCTTTAAAAAAAAAAAAAAAAATG
  CTTGCCCTTGTATAACATAATCCAGATTCCCTAGAGCCAGATGTGGTACAGCAATGAGCA
  AATCCAACCTCAGATCTGAAGTGTCTTCCACTCTGGGCCCCTGACCAAACCATTTTCTGT
  CCTTCTCTTTTCCTTTAAGGTAGCCCAAATCCCATTGCCACACAACATCTTAACTTAACC
  ATCCTTTTCCTTTATCCCCATTCCCCTCTGTCTGCGTCACAAAAAGACTGTGTGGTTCTG
  AAGAGTTCACACTTCCTCTTAACCAACCCCCAATTTTTTTTTACCACCGTGATTTTTATA
  GCCTGTAGAAGAAAAATGTTCCAAAGAG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003239
• Insert Size: 2640 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_003239.1, NP_003230.1
• RefSeq Size: 2574 bp
• RefSeq ORF: 1239 bp
• Locus ID: 7043
• Cytogenetics: 14q24.3
• Domains: TGFb_propeptide, TGF-beta
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Pancreatic cancer, Pathways in cancer, Renal cell carcinoma, TGF-beta signaling pathway
• Gene Summary: 'This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Aug 2016]'
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).