STAT5A (NM_003152) Human Untagged Clone

CAT#: SC118194

STAT5A (untagged)-Human signal transducer and activator of transcription 5A (STAT5A)


  "NM_003152" in other vectors (6)

Reconstitution Protocol

USD 540.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol STAT5A
Synonyms MGF; STAT5
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_003152, the custom clone sequence may differ by one or more nucleotides


TCGGCACGAGGCCGCCAGGAACCCCGGCCGGGAGCGAGAGCCGCGGGGCGCAGAGCCGGCCCGGCTGCCG
GACGGTGCGGCCCCACCAGGTGAACGGCCATGGCGGGCTGGATCCAGGCCCAGCAGCTGCAGGGAGACGC
GCTGCGCCAGATGCAGGTGCTGTACGGCCAGCACTTCCCCATCGAGGTCCGGCACTACTTGGCCCAGTGG
ATTGAGAGCCAGCCATGGGATGCCATTGACTTGGACAATCCCCAGGACAGAGCCCAAGCCACCCAGCTCC
TGGAGGGCCTGGTGCAGGAGCTGCAGAAGAAGGCGGAGCACCAGGTGGGGGAAGATGGGTTTTTACTGAA
GATCAAGCTGGGGCACTACGCCACGCAGCTCCAGAAAACATATGACCGCTGCCCCCTGGAGCTGGTCCGC
TGCATCCGGCACATTCTGTACAATGAACAGAGGCTGGTCCGAGAAGCCAACAATTGCAGCTCTCCGGCTG
GGATCCTGGTTGACGCCATGTCCCAGAAGCACCTTCAGATCAACCAGACATTTGAGGAGCTGCGACTGGT
CACGCAGGACACAGAGAATGAGCTGAAGAAACTGCAGCAGACTCAGGAGTACTTCATCATCCAGTACCAG
GAGAGCCTGAGGATCCAAGCTCAGTTTGCCCAGCTGGCCCAGCTGAGCCCCCAGGAGCGTCTGAGCCGGG
AGACGGCCCTCCAGCAGAAGCAGGTGTCTCTGGAGGCCTGGTTGCAGCGTGAGGCACAGACACTGCAGCA
GTACCGCGTGGAGCTGGCCGAGAAGCACCAGAAGACCCTGCAGCTGCTGCGGAAGCAGCAGACCATCATC
CTGGATGACGAGCTGATCCAGTGGAAGCGGCGGCAGCAGCTGGCCGGGAACGGCGGGCCCCCCGAGGGCA
GCCTGGACGTGCTACAGTCCTGGTGTGAGAAGTTGGCCGAGATCATCTGGCAGAACCGGCAGCAGATCCG
CAGGGCTGAGCACCTCTGCCAGCAGCTGCCCATCCCCGGCCCAGTGGAGGAGATGCTGGCCGAGGTCAAC
GCCACCATCACGGACATTATCTCAGCCCTGGTGACCAGCACATTCATCATTGAGAAGCAGCCTCCTCAGG
TCCTGAAGACCCAGACCAAGTTTGCAGCCACCGTACGCCTGCTGGTGGGCGGGAAGCTGAACGTGCACAT
GAATCCCCCCCAGGTGAAGGCCACCATCATCAGTGAGCAGCAGGCCAAGTCTCTGCTTAAAAATGAGAAC
ACCCGCAACGAGTGCAGTGGTGAGATCCTGAACAACTGCTGCGTGATGGAGTACCACCAAGCCACGGGCA
CCCTCAGTGCCCACTTCAGGAACATGTCACTGAAGAGGATCAAGCGTGCTGACCGGCGGGGTGCAGAGTC
CGTGACAGAGGAGAAGTTCACAGTCCTGTTTGAGTCTCAGTTCAGTGTTGGCAGCAATGAGCTTGTGTTC
CAGGTGAAGACTCTGTCCCTACCTGTGGTTGTCATCGTCCACGGCAGCCAGGACCACAATGCCACGGCTA
CTGTGCTGTGGGACAATGCCTTTGCTGAGCCGGGCAGGGTGCCATTTGCCGTGCCTGACAAAGTGCTGTG
GCCGCAGCTGTGTGAGGCGCTCAACATGAAATTCAAGGCCGAAGTGCAGAGCAACCGGGGCCTGACCAAG
GAGAACCTCGTGTTCCTGGCGCAGAAACTGTTCAACAACAGCAGCAGCCACCTGGAGGACTACAGTGGCC
TGTCCGTGTCCTGGTCCCAGTTCAACAGGGAGAACTTGCCGGGCTGGAACTACACCTTCTGGCAGTGGTT
TGACGGGGTGATGGAGGTGTTGAAGAAGCACCACAAGCCCCACTGGAATGATGGGGCCATCCTAGGTTTT
GTGAATAAGCAACAGGCCCACGACCTGCTCATCAACAAGCCCGACGGGACCTTCTTGTTGCGCTTTAGTG
ACTCAGAAATCGGGGGCATCACCATCGCCTGGAAGTTTGACTCCCCGGAACGCAACCTGTGGAACCTGAA
ACCATTCACCACGCGGGATTTCTCCATCAGGTCCCTGGCTGACCGGCTGGGGGACCTGAGCTATCTCATC
TATGTGTTTCCTGACCGCCCCAAGGATGAGGTCTTCTCCAAGTACTACACTCCTGTGCTGGCTAAAGCTG
TTGATGGATATGTGAAACCACAGATCAAGCAAGTGGTCCCTGAGTTTGTGAATGCATCTGCAGATGCTGG
GGGCAGCAGCGCCACGTACATGGACCAGGCCCCCTCCCCAGCTGTGTGCCCCCAGGCTCCCTATAACATG
TACCCACAGAACCCTGACCATGTACTCGATCAGGATGGAGAATTCGACCTGGATGAGACCATGGATGTGG
CCAGGCACGTGGAGGAACTCTTACGCCGACCAATGGACAGTCTTGACTCCCGCCTCTCGCCCCCTGCCGG
TCTTTTCACCTCTGCCAGAGGCTCCCTCTCATGAATGTTTGAATCCCACGCTTCTCTTTGGAAACAATAT
GCAATGTGAAGCGGTCGTGTTGTGAGTTTAGTAAGGCTGTGTACACTGACACCTTTGCAGGCATTCGGCA
CGAGGCCGCCAGGAACCCCGGCCGGGAGCGAGAGCCGCGGGGCGCAGAGCCGGCCCGGCTGCCGGACGGT
GCGGCCCCACCAGGTGAACGGCCATGGCGGGCTGGATCCAGGCCCAGCAGCTGCAGGGAGACGCGCTGCG
CCAGATGCAGGTGCTGTACGGCCAGCACTTCCCCATCGAGGTCCGGCACTACTTGGCCCAGTGGATTGAG
AGCCAGCCATGGGATGCCATTGACTTGGACAATCCCCAGGACAGAGCCCAAGCCACCCAGCTCCTGGAGG
GCCTGGTGCAGGAGCTGCAGAAGAAGGCGGAGCACCAGGTGGGGGAAGATGGGTTTTTACTGAAGATCAA
GCTGGGGCACTACGCCACGCAGCTCCAGAAAACATATGACCGCTGCCCCCTGGAGCTGGTCCGCTGCATC
CGGCACATTCTGTACAATGAACAGAGGCTGGTCCGAGAAGCCAACAATTGCAGCTCTCCGGCTGGGATCC
TGGTTGACGCCATGTCCCAGAAGCACCTTCAGATCAACCAGACATTTGAGGAGCTGCGACTGGTCACGCA
GGACACAGAGAATGAGCTGAAGAAACTGCAGCAGACTCAGGAGTACTTCATCATCCAGTACCAGGAGAGC
CTGAGGATCCAAGCTCAGTTTGCCCAGCTGGCCCAGCTGAGCCCCCAGGAGCGTCTGAGCCGGGAGACGG
CCCTCCAGCAGAAGCAGGTGTCTCTGGAGGCCTGGTTGCAGCGTGAGGCACAGACACTGCAGCAGTACCG
CGTGGAGCTGGCCGAGAAGCACCAGAAGACCCTGCAGCTGCTGCGGAAGCAGCAGACCATCATCCTGGAT
GACGAGCTGATCCAGTGGAAGCGGCGGCAGCAGCTGGCCGGGAACGGCGGGCCCCCCGAGGGCAGCCTGG
ACGTGCTACAGTCCTGGTGTGAGAAGTTGGCCGAGATCATCTGGCAGAACCGGCAGCAGATCCGCAGGGC
TGAGCACCTCTGCCAGCAGCTGCCCATCCCCGGCCCAGTGGAGGAGATGCTGGCCGAGGTCAACGCCACC
ATCACGGACATTATCTCAGCCCTGGTGACCAGCACATTCATCATTGAGAAGCAGCCTCCTCAGGTCCTGA
AGACCCAGACCAAGTTTGCAGCCACCGTACGCCTGCTGGTGGGCGGGAAGCTGAACGTGCACATGAATCC
CCCCCAGGTGAAGGCCACCATCATCAGTGAGCAGCAGGCCAAGTCTCTGCTTAAAAATGAGAACACCCGC
AACGAGTGCAGTGGTGAGATCCTGAACAACTGCTGCGTGATGGAGTACCACCAAGCCACGGGCACCCTCA
GTGCCCACTTCAGGAACATGTCACTGAAGAGGATCAAGCGTGCTGACCGGCGGGGTGCAGAGTCCGTGAC
AGAGGAGAAGTTCACAGTCCTGTTTGAGTCTCAGTTCAGTGTTGGCAGCAATGAGCTTGTGTTCCAGGTG
AAGACTCTGTCCCTACCTGTGGTTGTCATCGTCCACGGCAGCCAGGACCACAATGCCACGGCTACTGTGC
TGTGGGACAATGCCTTTGCTGAGCCGGGCAGGGTGCCATTTGCCGTGCCTGACAAAGTGCTGTGGCCGCA
GCTGTGTGAGGCGCTCAACATGAAATTCAAGGCCGAAGTGCAGAGCAACCGGGGCCTGACCAAGGAGAAC
CTCGTGTTCCTGGCGCAGAAACTGTTCAACAACAGCAGCAGCCACCTGGAGGACTACAGTGGCCTGTCCG
TGTCCTGGTCCCAGTTCAACAGGGAGAACTTGCCGGGCTGGAACTACACCTTCTGGCAGTGGTTTGACGG
GGTGATGGAGGTGTTGAAGAAGCACCACAAGCCCCACTGGAATGATGGGGCCATCCTAGGTTTTGTGAAT
AAGCAACAGGCCCACGACCTGCTCATCAACAAGCCCGACGGGACCTTCTTGTTGCGCTTTAGTGACTCAG
AAATCGGGGGCATCACCATCGCCTGGAAGTTTGACTCCCCGGAACGCAACCTGTGGAACCTGAAACCATT
CACCACGCGGGATTTCTCCATCAGGTCCCTGGCTGACCGGCTGGGGGACCTGAGCTATCTCATCTATGTG
TTTCCTGACCGCCCCAAGGATGAGGTCTTCTCCAAGTACTACACTCCTGTGCTGGCTAAAGCTGTTGATG
GATATGTGAAACCACAGATCAAGCAAGTGGTCCCTGAGTTTGTGAATGCATCTGCAGATGCTGGGGGCAG
CAGCGCCACGTACATGGACCAGGCCCCCTCCCCAGCTGTGTGCCCCCAGGCTCCCTATAACATGTACCCA
CAGAACCCTGACCATGTACTCGATCAGGATGGAGAATTCGACCTGGATGAGACCATGGATGTGGCCAGGC
ACGTGGAGGAACTCTTACGCCGACCAATGGACAGTCTTGACTCCCGCCTCTCGCCCCCTGCCGGTCTTTT
CACCTCTGCCAGAGGCTCCCTCTCATGAATGTTTGAATCCCACGCTTCTCTTTGGAAACAATATGCAATG
TGAAGCGGTCGTGTTGTGAGTTTAGTAAGGCTGTGTACACTGACACCTTTGCAGGCAT


>OriGene 5' read for NM_003152 unedited
CTTTCCCCCGCCCGTTGNCGCATAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAG
CAGAGCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGCG
AATTCGGCACGAGGCCGCCAGGAACCCCGGCCGGGAGCGAGAGCCGCGGGGCGCAGAGCC
GGCCCGGCTGCCGGACGGTGCGGCCCCACCAGGTGAACGGCCATGGCGGGCTGGATCCAG
GCCCAGCAGCTGCAGGGAGACGCGCTGCGCCAGATGCAGGTGCTGTACGGCCAGCACTTC
CCCATCGAGGTCCGGCACTACTTGGCCCAGTGGATTGAGAGCCAGCCATGGGATGCCATT
GACTTGGACAATCCCCAGGACAGAGCCCAAGCCACCCAGCTCCTGGAGGGCCTGGTGCAG
GAGCTGCAGAAGAAGGCGGAGCACCAGGTGGGGGAAGATGGGTTTTTACTGAAGATCAAG
CTGGGGCACTACGCCACGCAGCTCCAGAAAACATATGACCGCTGCCCCCTGGAGCTGGTC
CGCTGCATCCGGCACATTCTGTACAATGAACAGAGGCTGGTCCGAGAAGCCAACAATTGC
AGCTCTCCGGCTGGGATCCTGGTTGACGCCATGTCCCAGAAGCACCTTCAGATCAACCAG
ACATTTGAGGAGCTGCGACTGGTCACGCAGGACACAGAGAATGAGCTGAAGAAACTGCAG
CAGACTCAGGAGTACTTCATCATCCAGTACCAGGAGAGCCTGANGATCCAAGCTCAGTTT
GCCCAGCTGGGCCAGCTGAGCCCCCAGGAGCGTCTGAGCCAGGAGACGGCCCTNCAGCAG
AAGCAGGTGTCTCTGGNAGCCCTGGNTGCAGCGTGAGCACAGACACTGCAGCAGTACCGC
GTGGAGCTGGCCGAGAAGCACAGAAGACCCTGCAGCTGCTGCGGAAGCAGCAGACATCAT
CC
>OriGene 3' read for NM_003152 unedited
CGTACACTATGNACCGCGCCGCATCTATGATCGGTTTTTTTTTTTTTTTTTTATGAAAAA
AAATTTTATTCCAAAACACTGTTTACACAAATGTGTGGTCTTTGTACAAAGTACAAAAAA
ACCCCTCTTCTCATCCCCACCTCCCTTCAGAGAAGTTTAAACCTTGGGCTCTCAATCTTC
CATGGTCAGCTGCCCCTGACTGCGAGTCCTACAGCCTCAGAGGGAGGAGCGTGTGGGGTT
GGGAGCAAGGCCTCACCAGAACACAGCCAGTTACGCAACAGCGCAAGGCCTGCTCCAGGC
CCCACCTCCAGCGGAGTCAAACCAGATCAGCTTTTACCCCTCACTCCAGATTCCACAGGC
ACGCAGCACATGGCTGATTTGCAGCTTGTCTTTCACTGCAGTTTTTTGTTTTTGTTTTTT
CCAGGAGGCAAGAGGACCAACCCTCCAAGTCCCGGGGCCCCTGTCCACCACCATATCCTA
GACCCAATCTTTTCTACCTCTTTGTCGACAAGGTTACAAACAGAGAGGCAAGCAAAGAAT
GCTGGGGCCCAACGGAGGGGAGAGAATATATATCCCGGGAAACGTGGGCAACAGCATCAT
AGACTTGAATGAAGCCCAAGGCCAAGCAGCCAAGCAAGGACTAATTCAGAGCAGCTCAGA
AACCCTCACTCAAACAGGCGGCCCCCCCTGTGCTAAAGACATGGGCCGGGCCCCAGACGC
GCTCTCATAGGGTCCACAGAGAGTCTGGAGTCCACCGTCACTAAAGTATAAAAATACTAC
TCGAAAATGAACCCCCAGCCTCCCCTTCTGAAGAGATGAAATCGGTTACTTCCAACCCCT
TGAAGACCGAATGCGTTTTTCTTAGGACCCCCCCACTTCTTTCTTTGGTGTGTGTTG
Restriction Sites NotI-NotI     
ACCN NM_003152
ORF Size 4314 bp
Insert Size 4000
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Reference Data
RefSeq NM_003152.2, NP_003143.2
RefSeq Size 4314
RefSeq ORF 4314
Locus ID 6776
Domains SH2, STAT
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Stem cell relevant signaling - JAK/STAT signaling pathway, Transcription Factors
Protein Pathways Acute myeloid leukemia, Chronic myeloid leukemia, ErbB signaling pathway, Jak-STAT signaling pathway, Pathways in cancer
Gene Summary The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).

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