Retinoid X Receptor alpha (RXRA) (NM_002957) Human Untagged Clone

CAT#: SC118299

RXRA (untagged)-Human retinoid X receptor, alpha (RXRA)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RXRA
• Synonyms: NR2B1
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_002957 edited
  ATGGACACCAAACATTTCCTGCCGCTCGATTTCTCCACCCAGGTGAACTCCTCCCTCACC
  TCCCCGACGGGGCGAGGCTCCATGGCTGCCCCCTCGCTGCACCCGTCCCTGGGGCCTGGC
  ATCGGCTCCCCGGGACAGCTGCATTCTCCCATCAGCACCCTGAGCTCCCCCATCAACGGC
  ATGGGCCCGCCTTTCTCGGTCATCAGCTCCCCCATGGGCCCCCACTCCATGTCGGTGCCC
  ACCACACCCACCCTGGGCTTCAGCACTGGCAGCCCCCAGCTCAGCTCACCTATGAACCCC
  GTCAGCAGCAGCGAGGACATCAAGCCCCCCCTGGGCCTCAATGGCGTCCTCAAGGTCCCC
  GCCCACCCCTCAGGAAACATGGCTTCCTTCACCAAGCACATCTGCGCCATCTGCGGGGAC
  CGCTCCTCAGGCAAGCACTATGGAGTGTACAGCTGCGAGGGGTGCAAGGGCTTCTTCAAG
  CGGACGGTGCGCAAGGACCTGACCTACACCTGCCGCGACAACAAGGACTGCCTGATTGAC
  AAGCGGCAGCGGAACCGGTGCCAGTACTGCCGCTACCAGAAGTGCCTGGCCATGGGCATG
  AAGCGGGAAGCCGTGCAGGAGGAGCGGCAGCGTGGCAAGGACCGGAACGAGAATGAGGTG
  GAGTCGACCAGCAGCGCCAACGAGGACATGCCGGTGGAGAGGATCCTGGAGGCTGAGCTG
  GCCGTGGAGCCCAAGACCGAGACCTACGTGGAGGCAAACATGGGGCTGAACCCCAGCTCG
  CCGAACGACCCTGTCACCAACATTTGCCAAGCAGCCGACAAACAGCTTTTCACCCTGGTG
  GAGTGGGCCAAGCGGATCCCACACTTCTCAGAGCTGCCCCTGGACGACCAGGTCATCCTG
  CTGCGGGCAGGCTGGAATGAGCTGCTCATCGCCTCCTTCTCCCACCGCTCCATCGCCGTG
  AAGGACGGGATCCTCCTGGCCACCGGGCTGCACGTCCACCGGAACAGCGCCCACAGCGCA
  GGGGTGGGCGCCATCTTTGACAGGGTGCTGACGGAGCTTGTGTCCAAGATGCGGGACATG
  CAGATGGACAAGACGGAGCTGGGCTGCCTGCGCGCCATCGTCCTCTTTAACCCTGACTCC
  AAGGGGCTCTCGAACCCGGCCGAGGTGGAGGCGCTGAGGGAGAAGGTCTATGCGTCCTTG
  GAGGCCTACTGCAAGCACAAGTACCCAGAGCAGCCGGGAAGGTTCGCTAAGCTCTTGCTC
  CGCCTGCCGGCTCTGCGCTCCATCGGGCTCAAATGCCTGGAACATCTCTTCTTCTTCAAG
  CTCATCGGGGACACACCCATTGACACCTTCCTTATGGAGATGCTGGAGGCGCCGCACCAA
  ATGACTTAG
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002957 unedited
  ACAAAACTCTCTTCCCCGCCCGTTGNCNCACTAGGGCGGTAGCGTGTACGGTGGGAAGGT
  CTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGG
  GCGGCCGCGAATTCGGCACGAGCCGCCGCCGCCACCGCAGCCGCCGGCTCCCCGCCGCCC
  GGGCCCGGGCCGGCCGCGCCGGGGGCCGCCGCGCCCGCCGCCCGCTGCCTGCGCCGCCGG
  CCGGGCATGAGTTAGTCGCAGACATGGACACCAAACATTTCCTGCCGCTCGATTTCTCCA
  CCCAGGTGAACTCCTCCCTCACCTCCCCGACGGGGCGAGGCTCCATGGCTGCCCCCTCGC
  TGCACCCGTCCCTGGGGCCTGGCATCGGCTCCCCGGGACAGCTGCATTCTCCCATCAGCA
  CCCTGAGCTCCCCCATCAACGGCATGGGCCCGCCTTTCTCGGTCATCAGCTCCCCCATGG
  GCCCCCACTCCATGTCGGTGCCCACCACACCCACCCTGGGCTTCAGCACTGGCAGCCCCC
  AGCTCAGCTCACCTATGAACCCCGTCAGCAGCAGCGAGGACATCAAGCCCCCCCTGGGCC
  TCAATGGCGTCCTCAAGGTCCCCGCCCACCCCTCAAGAAACATGGCTTCCTTCACCAAGC
  ACATCTGCGCCATCTGCGGGGACCGCTCCTCAGCAAGCACTATGGAGTGTACAGCTGCGA
  GGGGTGCAAGGGCTTCTTCAAGCGGACGGTGCGCAAGGACCTGACCTACACCTGCCGCGA
  CAACAAGGACTGCCCTGATTGACAGCGGCAGCGGGAACCGGTGCCAGTACTGCCGCTACC
  ANAAGTGCCTGGCCATGGGCATGAACCGGGAAGCCTTGCAAGAGGACCGCACCTT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002957 unedited
  TGGGCCGAATCACTGTGNACCGCGCCCCTCTTNNCTANGATCGGTTTNCTTTTTTTTTTT
  TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAAAAGGGGGGGGACA
  ACCCATTTTTTAAGCAAAACAGTGACAGGCTGGGCCCCAAAGTCCAAACAGGCCAGGCAA
  AAAAGGGCAGGGACAGGGCTCAGGCTGAAAAAAAATTTGGGGTCCACGCAGGGGGGCCAA
  AACGGGGGGGCACAAAGGATGGGCCCCCAGGCCTAAATCATTTGGGGGGGCGCCTCCAGC
  ATTTCCATAAGGAAGGGGTCAATGGGGGGGTCCCCGATGAGCTTGAAAAAAAAAAAATGT
  TCCAGGCAATTGACCCCCATGGAGCCCAAAACCACCAGGCGGAACAAGAACTTAACGAAC
  CTTCCCGGGTGCTCTGGGTACTTGGGCTTGCAAAAGGCCCCCAAGGACCCATAAACCTTT
  TCCCTCTAGGGCCTCCACCTTGGCCGGGTTCGAAAGCCCCTTGGAGTCAGGGTTAAAAAG
  GACAAAGGCGCCCAGGCAACCCAACTCCGTTTTGGCCATTTGCATGTCCCGCATTTTGGA
  CACAAGCTCCGTCAGCCACCTGTCAAAAATGGCGCCCACCCCTGCCCTATATGGCGCTTT
  TCCGGTGGACGTGCACCCCGGTGGCCAAGAAGATCCCCTCCTTCACGGCGAATGGAACGG
  TGGGAAAAAAGAAGCCAAAAAACACACTTATTCCAACCTGCCCCCCAAAAAGAATGACCC
  TGGTCTTCCAGGGGGCAACTCTTGAAAAATGTGGGGATCCGCCTTGGCCCCCCTCCACCA
  CGGGTGAAAAACCTGTTTTTCCGGCTGCTTGTGCAATGTTTGGGGAAAGGGTCCTCTCCG
  CGAACCTGGGGGTC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002957
• Insert Size: 1600 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002957.3, NP_002948.1
• RefSeq Size: 5449 bp
• RefSeq ORF: 1389 bp
• Locus ID: 6256
• Cytogenetics: 9q34.2
• Domains: HOLI, zf-C4
• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Protein Pathways: Adipocytokine signaling pathway, Non-small cell lung cancer, Pathways in cancer, PPAR signaling pathway, Small cell lung cancer, Thyroid cancer
• Gene Summary: 'Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]'
  Transcript Variant: This variant (1) encodes the longest isoform (a).