CD45 (PTPRC) (NM_002838) Human Untagged Clone

CAT#: SC118363

PTPRC (untagged)-Human protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PTPRC
• Synonyms: B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_002838 edited
  GGCCGCGAATTCGGCACGAGGCAGCTAGCAAGTGGTTTGTTCTTAGGGTAACAGAGGAGG
  AAATTGTTCCTCGTCTGATAAGACAACAGTGGAGAAAGGACGCATGCTGTTTCTTAGGGA
  CACGGCTGACTTCCAGATATGACCATGTATTTGTGGCTTAAACTCTTGGCATTTGGCTTT
  GCCTTTCTGGACACAGAAGTATTTGTGACAGGGCAAAGCCCAACACCTTCCCCCACTGGA
  TTGACTACAGCAAAGATGCCCAGTGTTCCACTTTCAAGTGACCCCTTACCTACTCACACC
  ACTGCATTCTCACCCGCAAGCACCTTTGAAAGAGAAAATGACTTCTCAGAGACCACAACT
  TCTCTTAGTCCAGACAATACTTCCACCCAAGTATCCCCGGACTCTTTGGATAATGCTAGT
  GCTTTTAATACCACAGGTGTTTCATCAGTACAGACGCCTCACCTTCCCACGCACGCAGAC
  TCGCAGACGCCCTCTGCTGGAACTGACACGCAGACATTCAGCGGCTCCGCCGCCAATGCA
  AAACTCAACCCTACCCCAGGCAGCAATGCTATCTCAGATGTCCCAGGAGAGAGGAGTACA
  GCCAGCACCTTTCCTACAGACCCAGTTTCCCCATTGACAACCACCCTCAGCCTTGCACAC
  CACAGCTCTGCTGCCTTACCTGCACGCACCTCCAACACCACCATCACAGCGAACACCTCA
  GATGCCTACCTTAATGCCTCTGAAACAACCACTCTGAGCCCTTCTGGAAGCGCTGTCATT
  TCAACCACAACAATAGCTACTACTCCATCTAAGCCAACATGTGATGAAAAATATGCAAAC
  ATCACTGTGGATTACTTATATAACAAGGAAACTAAATTATTTACAGCAAAGCTAAATGTT
  AATGAGAATGTGGAATGTGGAAACAATACTTGCACAAACAATGAGGTGCATAACCTTACA
  GAATGTAAAAATGCGTCTGTTTCCATATCTCATAATTCATGTACTGCTCCTGATAAGACA
  TTAATATTAGATGTGCCACCAGGGGTTGAAAAGTTTCAGTTACATGATTGTACACAAGTT
  GAAAAAGCAGATACTACTATTTGTTTAAAATGGAAAAATATTGAAACCTTTACTTGTGAT
  ACACAGAATATTACCTACAGATTTCAGTGTGGTAATATGATATTTGATAATAAAGAAATT
  AAATTAGAAAACCTTGAACCCGAACATGAGTATAAGTGTGACTCAGAAATACTCTATAAT
  AACCACAAGTTTACTAACGCAAGTAAAATTATTAAAACAGATTTTGGGAGTCCAGGAGAG
  CCTCAGATTATTTTTTGTAGAAGTGAAGCTGCACATCAAGGAGTAATTACCTGGAATCCC
  CCTCAAAGATCATTTCATAATTTTACCCTCTGTTATATAAAAGAGACAGAAAAAGATTGC
  CTCAATCTGGATAAAAACCTGATCAAATATGATTTGCAAAATTTAAAACCTTATACGAAA
  TATGTTTTATCATTACATGCCTACATCATTGCAAAAGTGCAACGTAATGGAAGTGCTGCA
  ATGTGTCATTTCACAACTAAAAGTGCTCCTCCAAGCCAGGTCTGGAACATGACTGTCTCC
  ATGACATCAGATAATAGTATGCATGTCAAGTGTAGGCCTCCCAGGGACCGTAATGGCCCC
  CATGAACGTTACCATTTGGAAGTTGAAGCTGGAAATACTCTGGTTAGAAATGAGTCGCAT
  AAGAATTGCGATTTCCGTGTAAAAGATCTTCAATATTCAACAGACTACACTTTTAAGGCC
  TATTTTCACAATGGAGACTATCCTGGAGAACCCTTTATTTTACATCATTCAACATCTTAT
  AATTCTAAGGCACTGATAGCATTTCTGGCATTTCTGATTATTGTGACATCAATAGCCCTG
  CTTGTTGTTCTCTACAAAATCTATGATCTACATAAGAAAAGATCCTGCAATTTAGATGAA
  CAGCAGGAGCTTGTTGAAAGGGATGATGAAAAACAACTGATGAATGTGGAGCCAATCCAT
  GCAGATATTTTGTTGGAAACTTATAAGAGGAAGATTGCTGATGAAGGAAGACTTTTTCTG
  GCTGAATTTCAGAGCATCCCGCGGGTGTTCAGCAAGTTTCCTATAAAGGAAGCTCGAAAG
  CCCTTTAACCAGAATAAAAACCGTTATGTTGACATTCTTCCTTATGATTATAACCGTGTT
  GAACTCTCTGAGATAAACGGAGATGCAGGGTCAAACTACATAAATGCCAGCTATATTGAT
  GGTTTCAAAGAACCCAGGAAATACATTGCTGCACAAGGTCCCAGGGATGAAACTGTTGAT
  GATTTCTGGAGGATGATTTGGGAACAGAAAGCCACAGTTATTGTCATGGTCACTCGATGT
  GAAGAAGGAAACAGGAACAAGTGTGCAGAATACTGGCCGTCAATGGAAGAGGGCACTCGG
  GCTTTTGGAGATGTTGTTGTAAAGATCAACCAGCACAAAAGATGTCCAGATTACATCATT
  CAGAAATTGAACATTGTAAATAAAAAAGAAAAAGCAACTGGAAGAGAGGTGACTCACATT
  CAGTTCACCAGCTGGCCAGACCACGGGGTGCCTGAGGATCCTCACTTGCTCCTCAAACTG
  AGAAGGAGAGTGAATGCCTTCAGCAATTTCTTCAGTGGTCCCATTGTGGTGCACTGCAGT
  GCTGGTGTTGGGCGCACAGGAACCTATATCGGAATTGATGCCATGCTAGAAGGCCTGGAA
  GCCGAGAACAAAGTGGATGTTTATGGTTATGTTGTCAAGCTAAGGCGACAGAGATGCCTG
  ATGGTTCAAGTAGAGGCCCAGTACATCTTGATCCATCAGGCTTTGGTGGAATACAATCAG
  TTTGGAGAAACAGAAGTGAATTTGTCTGAATTACATCCATATCTACATAACATGAAGAAA
  AGGGATCCACCCAGTGAGCCGTCTCCACTAGAGGCTGAATTCCAGAGACTTCCTTCATAT
  AGGAGCTGGAGGACACAGCACATTGGAAATCAAGAAGAAAATAAAAGTAAAAACAGGAAT
  TCTAATGTCATCCCATATGACTATAACAGAGTGCCACTTAAACATGAGCTGGAAATGAGT
  AAAGAGAGTGAGCATGATTCAGATGAATCCTCTGATGATGACAGTGATTCAGAGGAACCA
  AGCAAATACATCAATGCATCTTTTATAATGAGCTACTGGAAACCTGAAGTGATGATTGCT
  GCTCAGGGACCACTGAAGGAGACCATTGGTGACTTTTGGCAGATGATCTTCCAAAGAAAA
  GTCAAAGTTATTGTTATGCTGACAGAACTGAAACATGGAGACCAGGAAATCTGTGCTCAG
  TACTGGGGAGAAGGAAAGCAAACATATGGAGATATTGAAGTTGACCTGAAAGACACAGAC
  AAATCTTCAACTTATACCCTTCGTGTCTTTGAACTGAGACATTCCAAGAGGAAAGACTCT
  CGAACTGTGTACCAGTACCAATATACAAACTGGAGTGTGGAGCAGCTTCCTGCAGAACCC
  AAGGAATTAATCTCTATGATTCAGGTCGTCAAACAAAAACTTCCCCAGAAGAATTCCTCT
  GAAGGGAACAAGCATCACAAGAGTACACCTCTACTCATTCACTGCAGGGATGGATCTCAG
  CAAACGGGAATATTTTGTGCTTTGTTAAATCTCTTAGAAAGTGCGGAAACAGAAGAGGTA
  GTGGATATTTTTCAAGTGGTAAAAGCTCTACGCAAAGCTAGGCCAGGCATGGTTTCCACA
  TTCGAGCAATATCAATTCCTATATGACGTCATTGCCAGCACCTACCCTGCTCAGAATGGA
  CAAGTAAAGAAAAACAACCATCAAGAAGATAAAATTGAATTTGATAATGAAGTGGACAAA
  GTAAAGCAGGATGCTAATTGTGTTAATCCACTTGGTGCCCCAGAAAAGCTCCCTGAAGCA
  AAGGAACAGGCTGAAGGTTCTGAACCCACGAGTGGCACTGAGGGGCCAGAACATTCTGTC
  AATGGTCCTGCAAGTCCAGCTTTAAATCAAGGTTCATAGGAAAAGACATAAATGAGGAAA
  CTCCAAACCTCCTGTTAGCTGTTATTTCTATTTTTGTAGAAGTAGGAAGTGAAAATAGGT
  ATACAGTGGATTAATTAAATGCAGCGAACCAATATTTGTAGAAGGGTTATATTTTACTAC
  TGTGGAAAAATATTTAAGATAGTTTTGCCAGAACAGTTTGTACAGACGTATGCTTATTTT
  AAAATTTTATCTCTTATTCAGTAAAAAACAACTTCTTTGTAATCGTTATGTGTGTATATG
  TATGTGTGTATGGGTGTGTGTTTGTGTGAGAGACAGAGAAAGAGAGAGAATTCTTTCAAG
  TGAATCTAAAAGCTTTTGCTTTTCCTTTGTTTTTATGAAGAAAAAATACATTTTATATTA
  GAAGTGTTAACTTAGCTTGAAGGATCTGTTTTTAAAAATCATAAACTGTGTGCAGACTCA
  ATAAAATCATGTACATTTTTGAAATGACCTCAAGATGTCCTCCTTGTTCTACTCATATAT
  ATCTATCTTATATAGTTTACTATTTTACTTCTAGAGATAGTACATAAAGGTGGTATGTGT
  GTGTATGCTACTACAAAAAAGTTGTTAACTAAATTAACATTGGGAAATCTTATATTCCAT
  ATATTAGCATTTAGTCCAATGTCTTTTTAAGCTTATTTAATTAAAAAATTTCCAGTGAGC
  TTATCATGCTGTCTTTACATGGGGTTTTCAATTAAATAAGCTCAAAAAAAAAAAAAAAAA
  AAAAAAAAAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002838 unedited
  GGTCCGCCATTTATGTATACGACTTCACTATAGGGCGGCCGCGAATCGGCACGAGGCAGC
  TAGCAAGTGGTTTGTTCTTAGGGTAACAGAGGAGGAAATTGTTCCTCGTCTGATAAGACA
  ACAGTGGAGAAAGGACGCATGCTGTTTCTTAGGGACACGGCTGACTTCCAGATATGACCA
  TGTATTTGTGGCTTAAACTCTTGGCATTTGGCTTTGCCTTTCTGGACACAGAAGTATTTG
  TGACAGGGCAAAGCCCAACACCTTCCCCCACTGGATTGACTACAGCAAAGATGCCCAGTG
  TTCCACTTTCAAGTGACCCCTTACCTACTCACACCACTGCATTCTCACCCGCAAGCACCT
  TTGAAAGAGAAAATGACTTCTCAGAGACCACAACTTCTCTTAGTCCAGACAATACTTCCA
  CCCAAGTATCCCCGGACTCTTTGGATAATGCTAGTGCTTTTAATACCACAGGTGTTTCAT
  CAGTACAGACGCCTCACCTTCCCACGCACGCAGACTCGCAGACGCCCTCTGCTGGAACTG
  ACACGCAGACATTCAGCGGCTCCGCCGCCAATGCAAAACTCAACCCTACCCCAGGCAGCA
  ATGCTATCTCAGATGTCCCAGGAGAGAGGAGTACAGCCAGCACCTTTCCTACAGACCCAG
  TTTCCCCATTGACAACCACCCTCAGCCTTGCACACCACAGCTCTGCTGCCTTACCTGCAC
  GCACCCTCCACACCACCATCACAGCGAACACCTCAGATGCCTACCTTAATGCCCTCTGAA
  CACCACTCTGAGCCCTTCTGGAAGCGCTGTCATTTCACCCACACATAGCTACTACTCCAT
  CTAAGCCACATGTGATGAANATATGCCAACTCACTGTGGATACTTATTAACACGAAACTA
  ATNTTTACAGCAAGCTAATGTTATGAGATGTGGATGTGGAACATT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002838 unedited
  ATCTGNACCCGGCCGCATTCTANATCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTGAGCT
  TATTTAATTGAAAACCCCATGTAAAGACAGCATGATAAGCTCACTGGAAATTTTTTAATT
  AAATAAGCTTAAAAAGACATTGGACTAAATGCTAATATATGGAATATAAGATTTCCCAAT
  GTTAATTTAGTTAACAACTTTTTTGTAGTAGCATACACACACATACCACCTTTATGTACT
  ATCTCTAGAAGTAAAATAGTAAACTATATAAGATAGATATATATGAGTAGAACAAGGAGG
  ACATCTTGAGGTCATTTCAAAAATGTACATGATTTTATTGAGTCTGCACACAGTTTATGA
  TTTTTAAAAACAGATCCTTCAAGCTAAGTTAACACTTCTAATATAAAATGTATTTTTTCT
  TCATAAAAACAAAGGAAAAGCAAAAGCTTTTAGATTCACTTGAAAGAATTCTCTCTCTTT
  CTCTGGCTCTCACACAAACACACACCCATACACACATACATATACACACATAACGATTAC
  AAAGAAGTTGTTTTTTACTGAATAAGAGATAAAATTTTAAAATAAGCATACGTCTGTACA
  AACTGTTCTGGCAAAACTATCCTAAATATTTTTTCCCAGTAGTAAAATATAACCCTTCTT
  ACAAATTGGGTTCGCTGGATTTAAATTAATCCACTGGATACCCTATTTTCACTTCCTACT
  TCTACCAAAAATAAAAATAACAGCTAACAGGAGGGTTGGGAAGTCCCCCATTAAGGCCTT
  TCCCTAGAACCTTGATTTAAAGCTGGACTTGCAGGAACATTGACAGAATGTTCTGGCCCC
  CTCAGGCCCCTCGGGGGTTAAGAACCTTAAACCTGGTTCCTTTGTTTTAAGGGACCTTTT
  TCGTGGGCACCCAGTGGGTTTAACCCATTTAACTCACCTGCCTTCCTACTGGCACA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002838
• Insert Size: 4700 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002838.2, NP_002829.2
• RefSeq Size: 5026 bp
• RefSeq ORF: 3915 bp
• Locus ID: 5788
• Cytogenetics: 1q31.3-q32.1
• Domains: Y_phosphatase, PTPc_motif, FN3
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Phosphatase, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Fc gamma R-mediated phagocytosis, Primary immunodeficiency, T cell receptor signaling pathway
• Gene Summary: 'The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]'
  Transcript Variant: This variant (1) encodes the longest isoform (1).