GPNMB (NM_002510) Human Untagged Clone

CAT#: SC118567

GPNMB (untagged)-Human glycoprotein (transmembrane) nmb (GPNMB), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: GPNMB
• Synonyms: HGFIN; NMB; PLCA3
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_002510, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGAATGTCTCTACTATTTCCTGGGATTTCTGCTCCTGGCTGCAAGATTGCCACTTGATGCCGCCAAAC
  GATTTCATGATGTGCTGGGCAATGAAAGACCTTCTGCTTACATGAGGGAGCACAATCAATTAAATGGCTG
  GTCTTCTGATGAAAATGACTGGAATGAAAAACTCTACCCAGTGTGGAAGCGGGGAGACATGAGGTGGAAA
  AACTCCTGGAAGGGAGGCCGTGTGCAGGCGGTCCTGACCAGTGACTCACCAGCCCTCGTGGGCTCAAATA
  TAACATTTGCGGTGAACCTGATATTCCCTAGATGCCAAAAGGAAGATGCCAATGGCAACATAGTCTATGA
  GAAGAACTGCAGAAATGAGGCTGGTTTATCTGCTGATCCGTATGTTTACAACTGGACAGCATGGTCAGAG
  GACAGTGACGGGGAAAATGGCACCGGCCAAAGCCATCATAACGTCTTCCCTGATGGGAAACCTTTTCCTC
  ACCACCCCGGATGGAGAAGATGGAATTTCATCTACGTCTTCCACACACTTGGTCAGTATTTCCAGAAATT
  GGGACGATGTTCAGTGAGAGTTTCTGTGAACACAGCCAATGTGACACTTGGGCCTCAACTCATGGAAGTG
  ACTGTCTACAGAAGACATGGACGGGCATATGTTCCCATCGCACAAGTGAAAGATGTGTACGTGGTAACAG
  ATCAGATTCCTGTGTTTGTGACTATGTTCCAGAAGAACGATCGAAATTCATCCGACGAAACCTTCCTCAA
  AGATCTCCCCATTATGTTTGATGTCCTGATTCATGATCCTAGCCACTTCCTCAATTATTCTACCATTAAC
  TACAAGTGGAGCTTCGGGGATAATACTGGCCTGTTTGTTTCCACCAATCATACTGTGAATCACACGTATG
  TGCTCAATGGAACCTTCAGCCTTAACCTCACTGTGAAAGCTGCAGCACCAGGACCTTGTCCGCCACCGCC
  ACCACCACCCAGACCTTCAAAACCCACCCCTTCTTTAGGACCTGCTGGTGACAACCCCCTGGAGCTGAGT
  AGGATTCCTGATGAAAACTGCCAGATTAACAGATATGGCCACTTTCAAGCCACCATCACAATTGTAGAGG
  GAATCTTAGAGGTTAACATCATCCAGATGACAGACGTCCTGATGCCGGTGCCATGGCCTGAAAGCTCCCT
  AATAGACTTTGTCGTGACCTGCCAAGGGAGCATTCCCACGGAGGTCTGTACCATCATTTCTGACCCCACC
  TGCGAGATCACCCAGAACACAGTCTGCAGCCCTGTGGATGTGGATGAGATGTGTCTGCTGACTGTGAGAC
  GAACCTTCAATGGGTCTGGGACGTACTGTGTGAACCTCACCCTGGGGGATGACACAAGCCTGGCTCTCAC
  GAGCACCCTGATTTCTGTTCCTGACAGAGACCCAGCCTCGCCTTTAAGGATGGCAAACAGTGCCCTGATC
  TCCGTTGGCTGCTTGGCCATATTTGTCACTGTGATCTCCCTCTTGGTGTACAAAAAACACAAGGAATACA
  ACCCAATAGAAAATAGTCCTGGGAATGTGGTCAGAAGCAAAGGCCTGAGTGTCTTTCTCAACCGTGCAAA
  AGCCGTGTTCTTCCCGGGAAACCAGGAAAAGGATCCGCTACTCAAAAACCAAGAATTTAAAGGAGTTTCT
  TAA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002510 unedited
  NGTTCAAAATTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGGTGGACGGG
  CCCAGAGGAATTCAGAGTTAAACCTTGAGTGCCTGCGTCCGTGAGAATTCAGCATGGAAT
  GTCTCTACTATTTCCTGGGATTTCTGCTCCTGGCTGCAAGATTGCCACTTGATGCCGCCA
  AACGATTTCATGATGTGCTGGGCAATGAAAGACCTTCTGCTTACATGAGGGAGCACAATC
  AATTAAATGGCTGGTCTTCTGATGAAAATGACTGGAATGAAAAACTCTACCCAGTGTGGA
  AGCGGGGAGACATGAGGTGGAAAAACTCCTGGAAGGGAGGCCGTGTGCAGGCGGTCCTGA
  CCAGTGACTCACCAGCCCTCGTGGGCTCAAATATAACATTTGCGGTGAACCTGATATTCC
  CTAGATGCCAAAAGGAAGATGCCAATGGCAACATAGTCTATGAGAAGAACTGCAGAAATG
  AGGCTGGTTTATCTGCTGATCCGTATGTTTACAACTGGACAGCATGGTCAGAGGACAGTG
  ACGGGGAAAATGGCACCGGCCAAAGCCATCATAACGTCTTCCCTGATGGGAAACCTTTTC
  CTCACCACCCCGGATGGAGAAGATGGAATTTCATCTACGTCTTCCACACACTTGGTCAGT
  ATTTCCAGAAATTGGGACGATGTTCAGTGAGAGTTTCTGTGAACACAGCCAATGTGACAC
  TTGNGCCTCAACTCATGGAAGTGACTGTCTACAGAAGACATGGACGGGCATATGTTCCCA
  TCGCACAAGTGAAAGATGTGTACGTGGTAACAGATCAGATNCCTGTGTTTGTGACTATGT
  TCCAGAAAGAACGATCGAATTCATCCGACGAAACCTTTCTCAAAGACTCCCCATTATGTT
  GATGTCCTGATNCAGATCC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002510 unedited
  GACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
  TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCCCCCCTTTTTTTTTCAGGAGGGAAAA
  AAAAAAAATGTCTTGTTTAACATTTAGAAAAGGGTTTTATTTCCAAACAGGGGGGAAATC
  CTTTTTGATAAAGTTGCCTTAAAAAACCAGGGCCCTTTTTTTTGGAAAGTTTTAATTTTT
  GATTTAAAATTTGGGCCGGGCCTGTCCAAAATTTTGGAAATTTCCCCAAAAGGGCCCCTC
  ACCTTCTTGCCTGGTTTTTAAAAACCCCTACCTAAGGGCCCTTGGAAAAAAGGAATTTTT
  GAATTTTTTTCTTTCACTCACCCAAACAAAGTAGGTTGTCCCCAAAATCCTCCCCCCCTT
  TTTTGAAAGTATTTTTTTTTTTGAGTTTAACAGGGGGGCCCATTTTACCAAAGGTTTGGG
  CCTGTTTTTGTCCCATCAGGAGTTCATGAGGGGGTTTTGAAGGGGGATTCATTTACCTTG
  GAACATGATTTTAAAAACGGGCCTACTTTGGTTTTATGCTTCCAGTTCCTTGGAAAGCTG
  AAAGTTTCCCCCCTTTTTTTGCAGTTAACCGGGGTAAGGCTTTAATCAATAGGAGTTTTT
  TTCCTTACTTTGGGGACACAGGGTTTTTATCCTACTAGTTCCCTAAAACTTTTTAAAGGG
  AAACTTAAAAATTATGAAAAAACCCCTGCCTAAGTGCTTTTATAAANTTCCCAACATGCC
  TGAAGCTGCCTGCAGTTAAATCCCTCTCCCATTCTTTAATGACCTTTACCTTTAAAAATT
  CCCTTCCCCAACCCAAATTCTTTTAACAATATTTTTAGAAAAAAGGTTATACCCCCTCCA
  CCATTCCATTATG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002510
• ORF Size: 1683 bp
• Insert Size: 2740
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_002510.2, NP_002501.1
• RefSeq Size: 2739
• RefSeq ORF: 1683
• Locus ID: 10457
• Domains: PKD
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.