Integrin beta 8 (ITGB8) (NM_002214) Human Untagged Clone

CAT#: SC118752

ITGB8 (untagged)-Human integrin, beta 8 (ITGB8)


  "NM_002214" in other vectors (6)

Reconstitution Protocol

USD 1,570.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol ITGB8
Synonyms integrin, beta 8
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_002214, the custom clone sequence may differ by one or more nucleotides


ATGTGCGGCTCGGCCCTGGCTTTTTTTACCGCTGCATTTGTCTGCCTGCAAAACGACCGGCGAGGTCCCG
CCTCGTTCCTCTGGGCAGCCTGGGTGTTTTCACTTGTTCTTGGACTGGGCCAAGGTGAAGACAATAGATG
TGCATCTTCAAATGCAGCATCCTGTGCCAGGTGCCTTGCGCTGGGTCCAGAATGTGGATGGTGTGTTCAA
GAGGATTTCATTTCAGGTGGATCAAGAAGTGAACGTTGTGATATTGTTTCCAATTTAATAAGCAAAGGCT
GCTCAGTTGATTCAATAGAATACCCATCTGTGCATGTTATAATACCCACTGAAAATGAAATTAATACCCA
GGTGACACCAGGAGAAGTGTCTATCCAGCTGCGTCCAGGAGCCGAAGCTAATTTTATGCTGAAAGTTCAT
CCTCTGAAGAAATATCCTGTGGATCTTTATTATCTTGTTGATGTCTCAGCATCAATGCACAATAATATAG
AAAAATTAAATTCCGTTGGAAACGATTTATCTAGAAAAATGGCATTTTTCTCCCGTGACTTTCGTCTTGG
ATTTGGCTCATACGTTGATAAAACAGTTTCACCATACATTAGCATCCACCCCGAAAGGATTCATAATCAA
TGCAGTGACTACAATTTAGACTGCATGCCTCCCCATGGATACATCCATGTGCTGTCTTTGACAGAGAACA
TCACTGAGTTTGAGAAAGCAGTTCATAGACAGAAGATCTCTGGAAACATAGATACACCAGAAGGAGGTTT
TGACGCCATGCTTCAGGCAGCTGTCTGTGAAAGTCATATCGGATGGCGAAAAGAGGCTAAAAGATTGCTG
CTGGTGATGACAGATCAGACGTCTCATCTCGCTCTTGATAGCAAATTGGCAGGCATAGTGGTGCCCAATG
ACGGAAACTGTCATCTGAAAAACAACGTCTATGTCAAATCGACAACCATGGAACACCCCTCACTAGGCCA
ACTTTCAGAGAAATTAATAGACAACAACATTAATGTCATCTTTGCAGTTCAAGGAAAACAATTTCATTGG
TATAAGGATCTTCTACCCCTCTTGCCAGGCACCATTGCTGGTGAAATAGAATCAAAGGCTGCAAACCTCA
ATAATTTGGTAGTGGAAGCCTATCAGAAGCTCATTTCAGAAGTGAAAGTTCAGGTGGAAAACCAGGTACA
AGGCATCTATTTTAACATTACCGCCATCTGTCCAGATGGGTCCAGAAAGCCAGGCATGGAAGGATGCAGA
AACGTGACGAGCAATGATGAAGTTCTTTTCAATGTAACAGTTACAATGAAAAAATGTGATGTCACAGGAG
GAAAAAACTATGCAATAATCAAACCTATTGGTTTTAATGAAACCGCTAAAATTCATATACACAGAAACTG
CAGCTGTCAGTGTGAGGACAACAGAGGACCTAAAGGAAAGTGTGTAGATGAAACTTTTCTAGATTCCAAG
TGTTTCCAGTGTGATGAGAATAAATGTCATTTTGATGAAGATCAGTTTTCTTCTGAGAGTTGCAAGTCAC
ACAAGGATCAGCCTGTTTGCAGTGGTCGAGGAGTTTGTGTTTGTGGGAAATGTTCATGTCACAAAATTAA
GCTTGGAAAAGTGTATGGAAAATACTGTGAAAAGGATGACTTTTCTTGTCCATATCACCATGGAAATCTG
TGTGCTGGGCATGGAGAGTGTGAAGCAGGCAGATGCCAATGCTTCAGTGGCTGGGAAGGTGATCGATGCC
AGTGCCCTTCAGCAGCAGCCCAGCACTGTGTCAATTCAAAGGGCCAAGTGTGCAGTGGAAGAGGCACGTG
TGTGTGTGGAAGGTGTGAGTGCACCGATCCCAGGAGCATCGGCCGCTTCTGTGAACACTGCCCCACCTGT
TATACAGCCTGCAAGGAAAACTGGAATTGTATGCAATGCCTTCACCCTCACAATTTGTCTCAGGCTATAC
TTGATCAGTGCAAAACCTCATGTGCTCTCATGGAACAACAGCATTATGTCGACCAAACTTCAGAATGTTT
CTCCAGCCCAAGCTACTTGAGAATATTTTTCATCATTTTCATAGTTACATTCTTGATTGGGTTGCTTAAA
GTCCTGATCATTAGACAGGTGATACTACAATGGAATAGTAATAAAATTAAGTCCTCATCAGATTACAGAG
TGTCAGCCTCAAAAAAGGATAAGTTGATTCTGCAAAGTGTTTGCACAAGAGCAGTCACCTACCGACGTGA
GAAGCCTGAAGAAATAAAAATGGATATCAGCAAATTAAATGCTCATGAAACTTTCAGGTGCAACTTCTAA


>OriGene 5' read for NM_002214 unedited
GGGCGGCCCGCGAATTCGCACGAGGGGACTGCGGGACGCCTGAGCCGCGCACTGAGGCGA
AAAGGACAAGGGCACGCAGCCCCCGCCCCGCGAAGCCGGGCTCCGGCACCTCGCGGAACC
TCCCCTCCTGCGCTCGCAGCCGCAGGCCCCACTCCCCGCCAGGGAGGGAGCGGCGATGCC
TCGCTCTGTGCCTGCGGGTGTCGGCGGGTGCTTCTAGGGCGCTCCCAGAGCCGCCTCCCC
CTGTTGCTGGCATCCCGAGCTTCCTCCCTTGCCAGCCAGGACGCTGCCGACTTGTCTTTG
CCCGCTGCTCCGCAGACGGGGCTGCAAAGCTGCAACTAATGGTGTTGGCCTCCCTGCCCA
CCTGTGGAAGCAACTGCGCTGATTGATGCGCCACAGACTTTTTTCCCCTCGACCTCGCCG
GCGTCCCCTCCCACAGATCCAGCATCACCCAGTGAATGTACATTAGGGTGGTTTCCCCCC
CAGCTTCGGGCTTTGTTTGGGTTTGATTGTGTTTGGCTCTTCGCTAAGCTGATTTATGCA
GCAGAAGCCCCACCGGCTGGAGAGAAACAAAAGCTCTTTTCTTTGTCCAGGAGCANGCTG
CGGAGCCCTTGCAGAGCCCTCTCTCCAGTCGCCGCCGGAGCCCTTGGCCGTCGAAGGAAG
TGCTTCTCGCGGAGACCGCGGGACCCGCCGTGCCGAGCCGGGAGGGCCGCAGGGGCCCTG
AGATGCCGAGCGGTGCCCGGGCCCGCTTACCTGCACCGCTTGCTCCCGAGCCGGGGGTCC
GNCTGCTNAGCCTGCNGAAAACGTCCTANCGACACTCGGNCCGCGGGCCCCGAGGTGCGC
CGCGGAGGCGCGAGCCCCGGTCCGGAAGGAANCAGCCGGCGGCCGCGGGCGGGCTGTTTG
CATTAGTGCGCCTCGCCCTG
>OriGene 3' read for NM_002214 unedited
GTTTACTTGNACCCGGCCGCATTCTAGGATCGAGTTTTTTTTTTTTTTTTTTTGAAAGAT
GAAACACGAATCATTTATTCATCTAGCTGTTCTTGTCTATTCAACCACCAACTGTTGAAG
TGTTTGGCAACCTTAGAATATACTTGCCAGATTATTTTTTTCCTCACATGTCCAGTGCAG
GGATTACTGTACCCTTGTAGTGACACAATGCTAAACTCTCTCACAGCATTGTTCTCTCTG
GGAAGCGTAGGGATAACAGGTACCTGTAAAGTGTAATCAGTGCTCTTCAGAGGATCTACA
TTCTATGCTGATCTAAATAAGTTATATATTACAGTAAAGTGCTACAACGACACTAGTCTC
AAACAGTAGTAAGACACATTTTTCTCTGAAAAAGTCAGCAGCTATGTGAGTCACATCATG
ATGAGGATACTTGTCAGTCTTCGTTCGAGTGTACAACCAGCAACTGGCATGACCGTGAGC
AATTTGCCTCCTCCTGTGACTTTTAAAATTATAATCTTTAGGAGCAATTATTAACAATTC
CAGTCTTCCCATTAAGTGTTTAAAAATCCTTTTTTACAAGTCGCACCTGAAAGCCCATGA
GCCTTCAATCCCGCTGCTATCCATTCTTATTTCCTCAGGCCTCTCACGTCCGTAGGCGAT
CGCTCTTGGGCCAACACTTTGCAGAATCAACCTATCCTTTTTTGAGGCTGCCCCTCTGCC
ATCCCCGCAGGCCCCAACGCCCCCAGCACCCCCCTCGCAATCTCCACCTGCCCAATGATC
CAGGATTTTCACTCATCCCCATTTCCAATGCTCCCCTTCTACTGATGAAATACCTCCCCC
GGTAGCTTGTCTTGCACCACAATTCCTTAGCCCTGTCATCTTATGCCTCTCTCCCCTTAC
ACCACCCACGCCCCACCCTCAAAC
Restriction Sites NotI-NotI     
ACCN NM_002214
Insert Size 4000 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_002214.1, NP_002205.1
RefSeq Size 8787 bp
RefSeq ORF 8787 bp
Locus ID 3696
Cytogenetics 7p21.1
Domains INB, PSI
Protein Families Druggable Genome, Transmembrane
Protein Pathways Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton
Gene Summary 'This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]'

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